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  1. AU="Rotaru, Luciana Teodora"
  2. AU="Nash, Kevin M"
  3. AU="Kubo, Sousuke"
  4. AU="Ingo Eitel"
  5. AU="van der Horst, A."
  6. AU="Di Mattia, A" AU="Di Mattia, A"
  7. AU="Di Pumpo, Marcello"
  8. AU="Doung, Yee-Cheen"
  9. AU="Saha, Moumita"
  10. AU="Wertz, Ashlee E"
  11. AU="Cowan, Michael J"
  12. AU=Togliatto Gabriele
  13. AU="Bassett, Dani S."
  14. AU="James Lemon"
  15. AU="Gros, Stephanie J"
  16. AU="Saeed Khademi"
  17. AU="Lallet-Daher, Helene"
  18. AU="Greenblatt, M"
  19. AU="Patwa, Ajay K"
  20. AU=Mastaglia F L
  21. AU="De Croock, Femke"
  22. AU=Robinson Michael J
  23. AU=Singh Romil
  24. AU="Martin, S J"
  25. AU="Szendrői, Miklós"
  26. AU="Moncel, Marie-Hélène"
  27. AU=Otu Akaninyene AU=Otu Akaninyene
  28. AU="Chiba, Kentaro"
  29. AU="Zhou, Jihua"
  30. AU="Ronald Bartels"
  31. AU="Liñares, J"
  32. AU="Valle, Valentina"
  33. AU="Tóth, András"
  34. AU="Pawar, Atul Darasing"
  35. AU="Semper, Chelsea"
  36. AU="Kraus, Joanne F"

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  1. Artikel ; Online: How to Personalize General Anesthesia-A Prospective Theoretical Approach to Conformational Changes of Halogenated Anesthetics in Fire Smoke Poisoning.

    Truicu, Flavius Nicușor / Damian, Roni Octavian / Butoi, Mihai Alexandru / Belghiru, Vlad Ionuț / Rotaru, Luciana Teodora / Puticiu, Monica / Văruț, Renata Maria

    International journal of molecular sciences

    2024  Band 25, Heft 9

    Abstract: Smoke intoxication is a central event in mass burn incidents, and toxic smoke acts at different levels of the body, blocking breathing and oxygenation. The majority of these patients require early induction of anesthesia to preserve vital functions. We ... ...

    Abstract Smoke intoxication is a central event in mass burn incidents, and toxic smoke acts at different levels of the body, blocking breathing and oxygenation. The majority of these patients require early induction of anesthesia to preserve vital functions. We studied the influence of hemoglobin (HMG) and myoglobin (MGB) blockade by hydrochloric acid (HCl) in an interaction model with gaseous anesthetics using molecular docking techniques. In the next part of the study, molecular dynamics (MD) simulations were performed on the top-scoring ligand-receptor complexes to investigate the stability of the ligand-receptor complexes and the interactions between ligands and receptors in more detail. Through docking analysis, we observed that hemoglobin creates more stable complexes with anesthetic gases than myoglobin. Intoxication with gaseous hydrochloric acid produces conformational and binding energy changes of anesthetic gases to the substrate (both the pathway and the binding site), the most significant being recorded in the case of desflurane and sevoflurane, while for halothane and isoflurane, they remain unchanged. According to our theoretical model, the selection of anesthetic agents for patients affected by fire smoke containing hydrochloric acid is critical to ensure optimal anesthetic effects. In this regard, our model suggests that halothane and isoflurane are the most suitable choices for predicting the anesthetic effects in such patients when compared to sevoflurane and desflurane.
    Mesh-Begriff(e) Humans ; Molecular Dynamics Simulation ; Anesthesia, General ; Molecular Docking Simulation ; Myoglobin/chemistry ; Hydrochloric Acid/chemistry ; Smoke/adverse effects ; Anesthetics, Inhalation/chemistry ; Hemoglobins/chemistry ; Hemoglobins/metabolism ; Halothane/chemistry ; Binding Sites
    Chemische Substanzen Myoglobin ; Hydrochloric Acid (QTT17582CB) ; Smoke ; Anesthetics, Inhalation ; Hemoglobins ; Halothane (UQT9G45D1P)
    Sprache Englisch
    Erscheinungsdatum 2024-04-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25094701
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Immune Responses of Healthy Pregnant Women following an Elective Cesarean Section: Effects of Anesthetic Procedures.

    Novac, Marius Bogdan / Boldeanu, Lidia / Dijmărescu, Anda Lorena / Boldeanu, Mihail Virgil / Neamțu, Simona Daniela / Radu, Lucreţiu / Manolea, Maria Magdalena / Șerbănescu, Mircea-Sebastian / Stoica, Maria / Rotaru, Luciana Teodora / Văduva, Constantin-Cristian

    Diagnostics (Basel, Switzerland)

    2024  Band 14, Heft 9

    Abstract: A weakened immune system and more inflammatory cytokines being released are possible effects of the surgical stress that a cesarean section induces. This kind of reaction, in addition to the altered reaction to catecholamines, has the potential to ... ...

    Abstract A weakened immune system and more inflammatory cytokines being released are possible effects of the surgical stress that a cesarean section induces. This kind of reaction, in addition to the altered reaction to catecholamines, has the potential to significantly affect the immune system of the mother and the patients' general postoperative course. This prospective study compared the plasma levels of catecholamines and cytokines in healthy pregnant patients having cesarean sections under spinal anesthesia versus general anesthesia. A total of 30 pregnant women undergoing elective cesarean sections were divided into two groups: 15 who received general anesthesia (GA) and 15 who received spinal anesthesia (SA). Blood samples were collected from all subjects before anesthesia induction (pre-OP), 6 h postoperatively (6 h post-OP), and 12 h (12 h post-OP), to measure levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), IL-8, IL-4, IL-10, norepinephrine (NE), and epinephrine (EPI). When we compared the two groups, we discovered that only IL-6 and IL-4 had significantly higher levels pre-OP, whereas all studied cytokines exhibited an increase in the GA versus SA group at 6 and 12 h post-OP. In the case of catecholamines, we discovered that serum levels are positively related with pro-inflammatory or anti-inflammatory cytokines, depending on the time of day and type of anesthetic drugs. Compared to SA, GA has a more consistent effect on the inflammatory response and catecholamine levels. The findings of this study confirm that the type of anesthesia can alter postoperative immunomodulation to various degrees via changes in cytokine and catecholamine production. SA could be a preferable choice for cesarean section because it is an anesthetic method that reduces perioperative stress and allows for less opioid administration, impacting cytokine production with proper immunomodulation.
    Sprache Englisch
    Erscheinungsdatum 2024-04-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14090880
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: A challenge for Europe

    Rotaru, Luciana Teodora / Voicescu, Sorin

    meeting the national specifics in disaster and emergency management systems, towards attaining efficiency, resiliency and integration

    2017  

    Abstract: This paper highlights the advantages a more integrated European emergency care and disaster management system would bring in this very divided field of work through the lens of emergency physicians and contributors with a specific focus on the example ... ...

    Abstract This paper highlights the advantages a more integrated European emergency care and disaster management system would bring in this very divided field of work through the lens of emergency physicians and contributors with a specific focus on the example Romania has to offer in matters of legislation, financing, dispatch centres, education and training of professionals, pre- and in-hospital care and European cooperation mechanisms. At the same time, we share the belief that this desiderate of attaining a certain degree of homogeneity inside the European Union is more likely to be reached by following slightly different paths, according to national specifics of the countries. To sustain this theory, we will bring various examples in our study of such events that already happened and together concurred to prove the above mentioned ideas. We do believe that the dream of a Europe without borders transforms unfortunately into a nightmare when it comes to disasters, which definitely know no borders. Our response to their threat should be standing together in unity and acting in solidarity.
    Schlagwörter ddc:330 ; European Union ; emergency care ; disaster management ; resiliency ; cooperation
    Thema/Rubrik (Code) 710
    Sprache Englisch
    Verlag Iasi: Alexandru Ioan Cuza University of Iasi, Centre for European Studies
    Erscheinungsland de
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  4. Artikel ; Online: The perioperative effect of anesthetic drugs on the immune response in total intravenous anesthesia in patients undergoing minimally invasive gynecological surgery.

    Novac, Marius Bogdan / Boldeanu, Lidia / Rotaru, Luciana Teodora / Dijmărescu, Anda Lorena / Şerbănescu, Mircea Sebastian / Radu, Lucreţiu / Neamţu, Simona Daniela / Vîlcea, Alina Maria / Niculescu, Mihaela / Mirea, Cecil Sorin / Boldeanu, Mihail Virgil / Manolea, Maria Magdalena

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2022  Band 62, Heft 4, Seite(n) 961–969

    Abstract: Background: The specific mechanism of action of each anesthetic drug on the immune system is still incompletely known. It is important to know how the various anesthetics used in minimally invasive surgery (MIS) act on the inflammatory response because ... ...

    Abstract Background: The specific mechanism of action of each anesthetic drug on the immune system is still incompletely known. It is important to know how the various anesthetics used in minimally invasive surgery (MIS) act on the inflammatory response because the choice of the anesthetic agent can influence the patient's immune system.
    Aim: Evaluation of the effect of anesthetic drugs used for total intravenous anesthesia (Propofol and Midazolam) on the inflammatory response after minimally invasive gynecological surgery.
    Patients, materials and methods: The inflammatory response in 20 female patients who underwent minimally invasive gynecological surgery under which intravenous anesthesia was performed. Depending on the combination of anesthetics used, we subdivided the study group into two groups, Group 1 consisting of the patients (n=10) who were given for total intravenous anesthesia, the combination with Midazolam+Fentanyl, and Group 2 (n=10) the patients who received the combination of Propofol+Fentanyl, respectively. Surgical interventional procedures included day surgery: diagnostic and operative hysteroscopy, endometrial ablation, surgical treatment of vulvar disorders. Serological profiling of patients was performed by dosing the serum concentration of nucleotide-binding domain (NOD) and leucine-rich repeat protein 3 (NLRP3) inflammasomes, interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), IL-10 before and two hours after the surgical procedure.
    Results: In our study, we found that in both groups of patients (Midazolam+Fentanyl - Group 1, Propofol+Fentanyl - Group 2), NLRP3 and cytokines concentrations in the serum were higher after MIS than those before MIS.
    Conclusions: It appears that both Midazolam and Fentanyl and Propofol and Fentanyl have an immunomodulatory action due to the anti-inflammatory effect of both anesthetics. Therefore, anesthesiologists must choose an anesthetic method that uses individualized anesthetic agents, depending on the patient's immune status and disease.
    Mesh-Begriff(e) Anesthesia, Intravenous/methods ; Anesthetics, Intravenous/pharmacology ; Female ; Fentanyl/pharmacology ; Fentanyl/therapeutic use ; Gynecologic Surgical Procedures ; Humans ; Immunity ; Midazolam/pharmacology ; Midazolam/therapeutic use ; Minimally Invasive Surgical Procedures ; NLR Family, Pyrin Domain-Containing 3 Protein ; Propofol/pharmacology ; Propofol/therapeutic use
    Chemische Substanzen Anesthetics, Intravenous ; NLR Family, Pyrin Domain-Containing 3 Protein ; Midazolam (R60L0SM5BC) ; Fentanyl (UF599785JZ) ; Propofol (YI7VU623SF)
    Sprache Englisch
    Erscheinungsdatum 2022-06-07
    Erscheinungsland Romania
    Dokumenttyp Journal Article
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
    DOI 10.47162/RJME.62.4.08
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Maternal obesity and placental pathology in correlation with adverse pregnancy outcome.

    Tabacu, Maria Carmen / Istrate-Ofiţeru, Anca Maria / Manolea, Maria Magdalena / Dijmărescu, Anda Lorena / Rotaru, Luciana Teodora / Boldeanu, Mihail Virgil / Şerbănescu, Mircea Sebastian / Tudor, Adriana / Novac, Marius Bogdan

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2022  Band 63, Heft 1, Seite(n) 99–104

    Abstract: Maternal obesity is associated with increased maternal and fetal morbidity and mortality, with an increased risk of gestational diabetes mellitus (GDM) and preeclampsia (PE). This prospective study histopathologically analyzes the placentas obtained from ...

    Abstract Maternal obesity is associated with increased maternal and fetal morbidity and mortality, with an increased risk of gestational diabetes mellitus (GDM) and preeclampsia (PE). This prospective study histopathologically analyzes the placentas obtained from 34 pregnant obese women studied between October 2016 and May 2020. The 10 cases of term placentas from obese pregnancies with GDM and the 12 cases with PE were examined by the Hematoxylin-Eosin (HE), Masson's trichrome (MT) and Periodic Acid-Schiff-Hematoxylin (PAS-H) classical stainings, and by the immunohistochemical evaluation and compared to placentae from uncomplicated term obese pregnancies (12 cases). We did not meet placental histopathological (HP) abnormalities that we could classify as characteristic only for the state of obese pregnancy, but we did find placental changes associated with PE and GDM, in the context of obese pregnancy. In the case of association with PE, there were common lesions, manifested by intra- and perivillous fibrinoid deposition, calcification, and placental infarction area, to which were added numerous syncytial knots. In the case of obese pregnancy associated with GDM, we found, in addition to common placental lesions of obesity, intravillositary vascular edema and in the terminal villi appearing chorangiosis. This study revealed a number of HP changes that occur in maternal obesity, even in uncomplicated obese pregnancies. A characteristic of obese pregnancies associated with PE was the presence of numerous syncytial knots, and in obese pregnancies associated with GDM, the most common HP lesion was placental chorangiosis. Certainly, we cannot conclude that these HP lesions are specific to a particular pathology, but they belong primarily to the status of maternal obesity.
    Mesh-Begriff(e) Diabetes, Gestational/pathology ; Female ; Hematoxylin ; Humans ; Obesity/complications ; Obesity/pathology ; Obesity, Maternal ; Placenta/pathology ; Pre-Eclampsia/pathology ; Pregnancy ; Pregnancy Outcome ; Prospective Studies
    Chemische Substanzen Hematoxylin (YKM8PY2Z55)
    Sprache Englisch
    Erscheinungsdatum 2022-09-26
    Erscheinungsland Romania
    Dokumenttyp Journal Article
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
    DOI 10.47162/RJME.63.1.09
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  6. Artikel: Evaluation of iNOS -2087A>G polymorphism in recurrent pregnancy loss.

    Boldeanu, Lidia / Dijmărescu, Anda Lorena / Novac, Marius Bogdan / Rotaru, Luciana Teodora / Pădureanu, Vlad / Neamţu, Simona Daniela / Siloşi, Cristian Adrian / Geormăneanu, Cristiana / Boldeanu, Mihail Virgil / Siloşi, Isabela / Novac, Liliana Victoria

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2020  Band 60, Heft 4, Seite(n) 1137–1142

    Abstract: Background: Due to its role in angiogenesis, the inducible nitric oxide synthase (iNOS) gene promoter polymorphism may have a presumed role in recurrent spontaneous abortions (RSA). It is an intensely studied protein, a biological mediator, a modulator ... ...

    Abstract Background: Due to its role in angiogenesis, the inducible nitric oxide synthase (iNOS) gene promoter polymorphism may have a presumed role in recurrent spontaneous abortions (RSA). It is an intensely studied protein, a biological mediator, a modulator and an effector molecule by implication in numerous physiological processes: vasodilatation, angiogenesis, immunity, tissue remodeling, smooth muscle activity.
    Aim: Our study aims to investigate a possible association between iNOS -2087A>G (rs2297518) polymorphism and the occurrence of idiopathic recurrent pregnancy loss (RPL).
    Patients, materials and methods: In this study, as in the previously published one, 169 women, diagnosed with RPL, in the Clinics of Obstetrics and Gynecology, "Filantropia" Municipal Hospital, Craiova, Romania, were subjected to the analysis, from October 2009 to October 2016. As a control group, we used 145 women. Subjects from both groups were genotyped using specific probes for TaqMan polymerase chain reaction (PCR), allelic discrimination technique.
    Results: We evaluated in this study a possible association between iNOS -2087A>G (rs2297518) polymorphism and the occurrence of idiopathic RPL. The chi-square test showed no significant association between the presence of this polymorphism and the increased risk to develop RPL. When we performed a comparative analysis of the frequency of genotypes and our statistical data, it was observed that this polymorphism, iNOS -2087A>G (rs2297518), has not been associated with an increased risk of developing RPL. Also, when one genotype was compared with another, we did not obtain any association that would have statistical significance, between the presence of this polymorphism and the increased risk for patients to develop RPL [in dominant - A allele carriers, iNOS 2087 AG+AA vs. GG: odds ratio (OR) 1.31, 95% confidence interval (CI) 0.83-2.07, p=0.24]. Analyzing the overall risk of developing RPL by iNOS 2087 single-nucleotide polymorphism (SNP) genotype frequencies, between controls and RPL patients (which were stratified by number of consecutive PLs), taking into account the number of consecutive pregnancies, the chi-square test showed no association between the presence of this polymorphism and the increased risk for developing RPL in all three subgroups we analyzed (in a dominant model - A allele carriers, iNOS 2087 AG+AA vs. GG: the first subgroup, OR 1.31, 95% CI 0.83-2.07, p=0.24; the second subgroup, OR 1.26, 95% CI 0.76-2.11, p=0.37; the three subgroup, OR 1.4, 95% CI 0.77-2.53, p=0.272).
    Conclusions: The iNOS -2087A>G (rs2297518) gene polymorphism does not influence RPL in the study area of Dolj County, Romania.
    Mesh-Begriff(e) Abortion, Habitual/enzymology ; Abortion, Habitual/epidemiology ; Abortion, Habitual/genetics ; Adult ; Female ; Humans ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Polymorphism, Genetic ; Romania/epidemiology
    Chemische Substanzen NOS2 protein, human (EC 1.14.13.39) ; Nitric Oxide Synthase Type II (EC 1.14.13.39)
    Sprache Englisch
    Erscheinungsdatum 2020-04-01
    Erscheinungsland Romania
    Dokumenttyp Journal Article
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1105: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  7. Artikel: Placental findings in pregnancies complicated with IUGR - histopathological and immunohistochemical analysis.

    Novac, Maria Violeta / Niculescu, Mihaela / Manolea, Maria Magdalena / Dijmărescu, Anda Lorena / Iliescu, Dominic Gabriel / Novac, Marius Bogdan / Rotaru, Luciana Teodora / Stoenescu, Manuela Florica / Tabacu, Maria Carmen / Tudorache, Ştefania / Busuioc, Cristina Jana / Gheonea, Ioana Andreea

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2018  Band 59, Heft 3, Seite(n) 715–720

    Abstract: Objective: Placental lesions and placental ischemia are typical elements of intrauterine growth restriction (IUGR). The aim of this study is to analyze histological and immunohistochemical (IHC) changes in the placentas of IUGR fetuses.: Materials and ...

    Abstract Objective: Placental lesions and placental ischemia are typical elements of intrauterine growth restriction (IUGR). The aim of this study is to analyze histological and immunohistochemical (IHC) changes in the placentas of IUGR fetuses.
    Materials and methods: In this prospective study, 126 placentas from small for gestational age (SGA) pregnancies (newborns with birth weight <10th percentile) that formed the study group and 31 placentas from pregnancies without SGA representing control group, were included. Placentas were examined according to standard protocol. Histopathological and IHC examinations of placentas were performed for analysis.
    Results: A certain type of lesion of placental injury is increased in placentas from SGA pregnancies. These placental lesions were placental infarction (over 5%), increased syncytial knots, intervillous fibrinoid deposition, villous thrombohematoma. Other common placental lesions were probably related to fetal adaptation to placental ischemia or represent a placental change characteristic of pregnancy evolution.
    Conclusions: It seems that although IUGR∕SGA fetuses are more commonly associated with histological placental abnormalities, it cannot be established whether these abnormalities certainly contribute to IUGR, as there are no specific placental lesions in SGA placentas. Pseudo-angiomatous aspect, associated with increased syncytial knots, was specific for vascular hypoxia. Especially the magnitude of modifications of the placental structure beyond the qualitative modifications, which also lead to functional changes, are involved in this pathology of pregnancy, the onset of lesions being triggered at the level of stem villi.
    Mesh-Begriff(e) Adult ; Female ; Fetal Growth Retardation/pathology ; Fetus/pathology ; Giant Cells/pathology ; Humans ; Immunohistochemistry ; Nitric Oxide Synthase Type III/metabolism ; Placenta/pathology ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Pregnancy ; Vascular Endothelial Growth Factor A/metabolism
    Chemische Substanzen Platelet Endothelial Cell Adhesion Molecule-1 ; Vascular Endothelial Growth Factor A ; Nitric Oxide Synthase Type III (EC 1.14.13.39)
    Sprache Englisch
    Erscheinungsdatum 2018-12-10
    Erscheinungsland Romania
    Dokumenttyp Journal Article
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1105: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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