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Article: Review: The Key Factors to Melanomagenesis.

Jitian Mihulecea, Cristina-Raluca / Rotaru, Maria

2023 Volume 13, Issue 1

Abstract: Melanoma is the most dangerous form of skin cancer that develops from the malignant transformation of the melanocytes located in the basal layer of the epidermis (cutaneous melanoma). Melanocytes may also be found in the meninges, eyes, ears, ... ...

Abstract	Melanoma is the most dangerous form of skin cancer that develops from the malignant transformation of the melanocytes located in the basal layer of the epidermis (cutaneous melanoma). Melanocytes may also be found in the meninges, eyes, ears, gastrointestinal tract, genito-urinary system, or other mucosal surfaces (mucosal melanoma). Melanoma is caused by an uncontrolled proliferation of melanocytes, that at first may form a benign lesion (nevogenesis), but in time, it may transition to melanoma, determining what it is named, melanomagenesis. Some tumors may appear spontaneously (de novo melanoma) or on preexisting lesions (nevus-associated melanoma). The exact cause of melanoma may not be fully understood yet, but there are some factors that initiate and promote this malignant process. This study aims to provide a summary of the latest articles regarding the key factors that may lead to melanomagenesis. The secondary objectives are to reveal the relationship between nevi and melanoma, to understand the cause of "de novo" and "nevus-associated melanoma" and highlight the differences between these subtypes.
Language	English
Publishing date	2023-01-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13010181
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evolution of syphilis incidence in Sibiu county (Romania) over a period of 10 years (2009-2018).

Iancu, Gabriela Mariana / Rotaru, Maria

Experimental and therapeutic medicine

2021 Volume 22, Issue 2, Page(s) 803

Abstract: Syphilis is the most common sexually transmitted disease that mainly affects socially active people, with a fluctuating worldwide incidence over the years. A retrospective study was conducted over a period of 10 years (2009-2018) that included 396 ... ...

Abstract	Syphilis is the most common sexually transmitted disease that mainly affects socially active people, with a fluctuating worldwide incidence over the years. A retrospective study was conducted over a period of 10 years (2009-2018) that included 396 patients with syphilis diagnosed and monitored by Sibiu County Emergency Clinical Hospital, Romania. During this period (2009-2018), we observed a decrease in the new cases of syphilis by 35.90%, and the average syphilis incidence was 9.90 new cases per 100,000 inhabitants. Syphilis was diagnosed more frequently in men with an average age of 35.39 years, from urban areas, with and educational level of grades 9-12, unmarried, workers, or without occupation. Out of the 396 patients with syphilis, about 6% were HIV coinfected. Over half of the HIV coinfected cases were declared MSM (men who have sex with men), and 40% of these cases were registered in 2018. The most common clinical stage of syphilis was the latent form (67.93%). Regarding the syphilis treatment regimen, we noted the transition from the classic regimen with benzathine-penicillin G (100% in 2009) to alternative therapies (mainly with cephalosporins) in 2018 (56.86%). Our findings showed that in the last 10 years in our county, the incidence of syphilis had a downward trend, but with an increase in syphilis-HIV co-infection and neurosyphilis cases.
Language	English
Publishing date	2021-05-26
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2021.10235
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Medicine Shortages: From Assumption to Evidence to Action - A Proposal for Using the FMD Data Repositories for Shortages Monitoring.

Bouvy, François / Rotaru, Mihai

Frontiers in medicine

2021 Volume 8, Page(s) 579822

Abstract: Medicine shortages may negatively impact patient care and the patient experience. Shortages should be a priority of industry, supply chain stakeholders and national competent authorities, and deserve more than empathy or "lip-service" but serious ... ...

Abstract	Medicine shortages may negatively impact patient care and the patient experience. Shortages should be a priority of industry, supply chain stakeholders and national competent authorities, and deserve more than empathy or "lip-service" but serious engagement and action. Under the overarching principle that without correct measurements in place there cannot be any improvement in overall performance (1), stakeholders in the pharmaceutical supply chain, notably pharmaceutical manufacturers have made the call for all relevant sources of information to be used in order to provide additional intelligence about the root causes and drivers of shortages, including the identification of bottlenecks in the supply chain. This paper outlines a proposal for using the data stored in the interoperable network of national repositories being set up in the context of the Falsified Medicines Directive (Directive 2011/62/EU) and its Delegated Regulation 2016/161/EU on safety features for providing additional intelligence in monitoring shortages. The paper analyses the potential feasibility and readiness of using this data for monitoring shortages as well as the strengths and weaknesses of the approach. We explore also what are some of the other complementary data sources that could be analyzed in conjunction with the data in the repository system to sharpen the overall analysis. Lastly, we provide a theoretical but concrete use case for using the abovementioned data for better informing decisions to prevent and mitigate shortages. In doing so, we explain the interlink between patient needs at country level, demand from economic actors, intra-EU parallel trade and manufacturer-imposed supply quotas and propose a mechanism for collaboration between national competent authorities and supply chain stakeholders for early detection and action to prevent medicine shortages from occurring.
Language	English
Publishing date	2021-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.579822
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Many Roles of Dermoscopy in Melanoma Detection.

Jitian Mihulecea, Cristina-Raluca / Iancu, Gabriela Mariana / Leventer, Mihaela / Rotaru, Maria

Life (Basel, Switzerland)

2023 Volume 13, Issue 2

Abstract: Dermoscopy is a non-invasive method of examination that aids the clinician in many ways, especially in early skin cancer detection. Melanoma is one of the most aggressive forms of skin cancer that can affect individuals of any age, having an increasing ... ...

Abstract	Dermoscopy is a non-invasive method of examination that aids the clinician in many ways, especially in early skin cancer detection. Melanoma is one of the most aggressive forms of skin cancer that can affect individuals of any age, having an increasing incidence worldwide. The gold standard for melanoma diagnosis is histopathological examination, but dermoscopy is also very important for its detection. To highlight the many roles of dermoscopy, we analyzed 200 melanocytic lesions. The main objective of this study was to detect through dermoscopy hints of melanomagenesis in the studied lot. The most suspicious were 10 lesions which proved to be melanomas confirmed through histopathology. The second objective of this study was to establish if dermoscopy can aid in estimating the Breslow index (tumoral thickness) of the melanomas and to compare the results to the histopathological examination. We found that the tumoral thickness may be estimated through dermoscopy, but the histopathological examination is superior. To conclude, the aim of this study was to showcase the versatility and many roles of dermoscopy, besides being one of the most important tools for early melanoma diagnosis.
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13020477
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A prospective study on hyperhomocysteinemia as an aggravating factor in chronic venous insufficiency.

Rotaru, Maria / Mariana Iancu, Gabriela / Baldovin, Ioana

Experimental and therapeutic medicine

2022 Volume 24, Issue 1, Page(s) 449

Abstract: The role of hyperhomocysteinemia (HH) in the etiopathogenetics of systemic thrombotic events has been confirmed by numerous studies. However, it has been insufficiently studied as an etiopathogenic factor in chronic venous insufficiency (CVI). The ... ...

Abstract	The role of hyperhomocysteinemia (HH) in the etiopathogenetics of systemic thrombotic events has been confirmed by numerous studies. However, it has been insufficiently studied as an etiopathogenic factor in chronic venous insufficiency (CVI). The present prospective study included 166 patients with CVI at stages C3-C6. Homocysteine levels and the inflammatory, metabolic and procoagulant profiles of the patients were determined. High-performance liquid chromatography was used to determine the homocysteine level. Within the patients with HH, the thromboembolic risk was analyzed. Smoking was determined to represent the most common procoagulant factor (21.67%), whereas in the subgroup of women, abortions represented a procoagulant factor for 31.93%. The metabolic profile was altered in approximately half of all cases (42.77%), whereas proinflammatory status was a contributing factor in 23.50% of the cases. HH was present in 54.22% of the CVI patients, mainly in the moderate HH category (53.01%), mostly linked to venous ulcers, thrombophlebitis and pulmonary thromboembolisms. The highest average values of homocysteine were recorded in patients >75 years old and when the venous disease age was >20 years (15.03 µmol/l). In summary, in the present study, HH was a contributing factor of CVI alongside the chronic inflammation that is well known in CVI, which increased thrombogenic risk, especially in elderly patients with an advanced age of venous disease.
Language	English
Publishing date	2022-05-17
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2022.11376
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ophthalmic herpes zoster with severe complications in an immunocompromised patient: A case report and review of the literature.

Iancu, Gabriela Mariana / Stănilă, Dan Mircea / Cipăian, Remus Călin / Rotaru, Maria

Experimental and therapeutic medicine

2022 Volume 23, Issue 3, Page(s) 214

Abstract: The increasing incidence for herpes zoster, including its ophthalmic form, is based on physiological (senescence) and acquired immunosuppression, particularly under oncologic treatment. The immunocompromised status of the patient favors the appearance of ...

Abstract	The increasing incidence for herpes zoster, including its ophthalmic form, is based on physiological (senescence) and acquired immunosuppression, particularly under oncologic treatment. The immunocompromised status of the patient favors the appearance of severe complications. The patient, aged 54, with chronic lymphocytic leukemia, presented 1 week from the onset with an erythematous, vesicular-bullous rash on the right trigeminal nerve's ophthalmic dermatome, marked edema, intense pain and large submandibular ganglion masses. There were cutaneous (necrotic ulcerations superinfected with methicillin-resistant
Language	English
Publishing date	2022-01-11
Publishing country	Greece
Document type	Case Reports
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2022.11138
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Clinical-dermoscopic similarities between atypical nevi and early stage melanoma.

Jitian Mihulecea, Cristina-Raluca / Frățilă, Simona / Rotaru, Maria

Experimental and therapeutic medicine

2021 Volume 22, Issue 2, Page(s) 854

Abstract: Atypical (Clark) nevi are benign tumors that may be considered precursors of melanoma. Many studies acknowledge a linear progression from typical to atypical nevi that eventually transform into melanoma. It is often challenging to differentiate a Clark ... ...

Abstract	Atypical (Clark) nevi are benign tumors that may be considered precursors of melanoma. Many studies acknowledge a linear progression from typical to atypical nevi that eventually transform into melanoma. It is often challenging to differentiate a Clark nevus from melanoma, especially in its early stages, due to their clinical, dermoscopic, and histological resemblance. Dermoscopy is a powerful tool in early melanoma diagnosis, but it is a subjective method of examination. Therefore, the use of dermoscopic algorithms and checklists can overcome this issue. In the case of a difficult diagnosis, since both dermoscopy and histopathological exam are subjective methods of examination, modern molecular biology techniques can be used to distinguish between benign and malignant tumors. This study aimed to test the accuracy of specific clinical and dermoscopic criteria in order to distinguish between benign and malignant tumors, with a secondary objective to provide an overview of the clinical and dermoscopic features of atypical nevi and melanoma. In the present study, dermoscopic algorithms did not necessarily help distinguish benign and malignant tumors but demonstrated that nevi and melanoma have similar characteristics.
Language	English
Publishing date	2021-06-09
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2021.10286
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The expectations of generation Z regarding the university educational act in Romania: optimizing the didactic process by providing feedback.

Bratu, Mihaela Laura / Cioca, Lucian-Ionel / Nerisanu, Raluca Andreea / Rotaru, Mihaela / Plesa, Roxana

Frontiers in psychology

2023 Volume 14, Page(s) 1160046

Abstract: In the university education system, the evaluation and provision of two-way teacher-student feedback are tools within the control function of educational management. Feedback can be defined as the process that takes place in the context of teacher- ... ...

Abstract	In the university education system, the evaluation and provision of two-way teacher-student feedback are tools within the control function of educational management. Feedback can be defined as the process that takes place in the context of teacher-student interaction during university courses, both individually and in groups, for the development and achievement of the performance of the two actors involved through evaluation, appreciation, support, perception, and teaching. The research aims to develop an innovative feedback tool for the higher education engineering sector to support the improvement of learning outcome-oriented curricula and teaching activities to better meet the learning needs of Gen Z students while being relevant to the labor market and to society in general. The research had a number of subjects: 246 students (67.5% women, 32.5% men) and 7 teachers to whom two feedback instruments were applied (the SKS instrument and the standard instrument of Lucian Blaga University of Sibiu). After testing the four hypotheses, it was observed that the feedback provided by Gen Z is focused on four areas of competence: psychological, pedagogical, education management, and general impression. Each field includes a set of professional and transversal competencies. The SKS (STOP, KEEP, and START) evaluation form is more reliable in evaluating different disciplines than the standard evaluation form by providing a more homogenous type of feedback for each discipline or teacher.
Language	English
Publishing date	2023-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1160046
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: SARS-CoV-2 Infection-A Trigger Factor for Telogen Effluvium: Review of the Literature with a Case-Based Guidance for Clinical Evaluation.

Iancu, Gabriela Mariana / Molnar, Estera / Ungureanu, Loredana / Șenilă, Simona Corina / Hașegan, Adrian / Rotaru, Maria

Life (Basel, Switzerland)

2023 Volume 13, Issue 7

Abstract: Telogen effluvium post-COVID-19 is a condition characterized by the diffuse and reversible loss of scalp hair in the period following infection with SARS-CoV-2, and it is currently the second cause of alopecia in women. In the context of the COVID-19 ... ...

Abstract	Telogen effluvium post-COVID-19 is a condition characterized by the diffuse and reversible loss of scalp hair in the period following infection with SARS-CoV-2, and it is currently the second cause of alopecia in women. In the context of the COVID-19 infection, intense psychological stress contributes to alopecia appearance, along with systemic inflammation, autoimmune reactions, oxidative stress, and virally induced hypoxia. Cytokines with proinflammatory action and vasoactive substances negatively modulate the metabolism of some molecules, such as proteoglycans, involved in the hair follicle's growth cycle. Studies show that a large percentage of hairs will suddenly enter the catagen phase during a moderate to severe COVID-19 infection. In the present paper, we update the data from the literature with a clinical example. Our case highlighted that the telogen effluvium after infections with SARS-CoV-2 is reversible with appropriate dermatological treatment. For therapeutic success, informing the patient about this pathology's self-limited and reversible character is essential to reduce the emotional stress that may aggravate the disease.
Language	English
Publishing date	2023-07-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13071576
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Price â Strategic Instrument of EU Market Intervention. Case Study Seurop System

Rotaru, Mihaela

Acta Universitatis Cibiniensis. Series E: Food Technology. 2015 Aug. 4, v. 19, no. 1

2015

Abstract: In 29 October 1975 Council Regulation of European Economic Community (EEC) provided the common organization of the pig meat market. In 1984, EEC considered it necessary to lay down general rules ensuring uniform grading of pig carcasses. The main ... ...

Abstract	In 29 October 1975 Council Regulation of European Economic Community (EEC) provided the common organization of the pig meat market. In 1984, EEC considered it necessary to lay down general rules ensuring uniform grading of pig carcasses. The main objective of this paper is to describe how pig carcass classification implemented by EU legislation has become a core strategic competition between manufacturers. In the European Commission the carcass classification system is assimilated as an instrument of intervention. This guarantees the agricultural community a decent life. The classification and payment system promoted by EU producers ensure greater transparency of the market, providing to the economic agents involved in the sector quick access to information on evolution of prices in different markets.
Keywords	carcass grading ; case studies ; European Union ; Europeans ; laws and regulations ; markets ; meat ; pig carcasses ; prices ; swine
Language	English
Dates of publication	2015-0804
Size	p. 27-34.
Publishing place	De Gruyter Open
Document type	Article
ZDB-ID	2816765-X
ISSN	2344-150X
ISSN	2344-150X
DOI	10.1515/aucft-2015-0004
Database	NAL-Catalogue (AGRICOLA)

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