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  1. Article ; Online: Anatomical Left Hepatectomy Extended to Caudate Lobe due to Colorectal Metastasis with Intrabiliary Growth: Securing Optimal Margins with a Laennec's Capsule Approach and Vein-Guided Resection.

    Blanco Asensio, Nuria / Aliseda Jover, Daniel / Martí-Cruchaga, Pablo / Lapuente, Fernando / Sabatella, Lucas / Zozaya Larequi, Gabriel / Rotellar Sastre, Fernando

    Annals of surgical oncology

    2024  

    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-024-15174-3
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  2. Article ; Online: Laparoscopic central pancreatectomy.

    Lozano Nájera, Ana / Martí Cruchaga, Pablo / Zozaya Larequi, Gabriel / Rotellar Sastre, Fernando

    Cirugia espanola

    2022  Volume 100, Issue 4, Page(s) 240

    MeSH term(s) Humans ; Laparoscopy ; Pancreatectomy ; Pancreatic Neoplasms/surgery
    Language English
    Publishing date 2022-04-15
    Publishing country Spain
    Document type Video-Audio Media
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.cireng.2021.06.023
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  3. Article ; Online: Laparoscopic central pancreatectomy.

    Lozano Nájera, Ana / Martí Cruchaga, Pablo / Zozaya Larequi, Gabriel / Rotellar Sastre, Fernando

    Cirugia espanola

    2021  

    Title translation Pancreatectomía central laparoscópica.
    Language Spanish
    Publishing date 2021-08-10
    Publishing country Spain
    Document type Video-Audio Media
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.ciresp.2021.06.004
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  4. Article: Risk factors and impact of portal vein thrombosis in liver transplantation.

    Reyes, Lorena / Herrero, José Ignacio / Rotellar Sastre, Fernando / Páramo, José Antonio

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2019  Volume 111, Issue 6, Page(s) 437–444

    Abstract: Introduction: portal vein thrombosis is a relatively common complication of advanced cirrhosis that increases perioperative risk in liver transplant recipients. This condition was characterized in a cohort of patients, including risk factors and their ... ...

    Abstract Introduction: portal vein thrombosis is a relatively common complication of advanced cirrhosis that increases perioperative risk in liver transplant recipients. This condition was characterized in a cohort of patients, including risk factors and their influence on survival.
    Material and methods: a retrospective study of liver transplant recipients at the Clínica Universidad de Navarra was performed between 2000 and 2015. Differences in clinical and biological characteristics and survival were analyzed in subjects with and without portal vein thrombosis. A predictive index was also developed.
    Results: a total of 288 patients were included in the study, portal vein thrombosis was recorded in 46 (16%) cases and seven (15.2%) had stage 3/4 disease according to Yerdel's classification. Factors associated with the presence of esophageal/gastric varices (OR = 3.7; p = 0.03) included variceal ligation or sclerotherapy (OR = 2.3; p = 0.01), being overweight/obesity (OR = 2.1; p = 0.04) and thrombocytopenia (OR = 3.6; p = 0.04). There were no significant differences between the groups with and without portal vein thrombosis in terms of survival according to Kaplan-Meier curve analysis (p = 0.7). However, the mortality rate was higher for Yerdel stages 3-4 (p < 0.01). A predictive index was developed that included varices, body mass index (BMI), thrombocytopenia and activated partial thromboplastin time (APTT). This index had a sensitivity of 76.1% and a specificity of 53.7% for the development of portal thrombosis.
    Conclusions: the presence of esophageal/gastric varices, variceal ligation/sclerotherapy, thrombocytopenia and being overweight/obesity was associated with a higher rate of portal vein thrombosis. Advanced stages had an impact on survival.
    MeSH term(s) Cohort Studies ; Female ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/mortality ; Liver Cirrhosis/surgery ; Liver Transplantation ; Male ; Middle Aged ; Portal Vein ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Survival Rate ; Venous Thrombosis/complications
    Language English
    Publishing date 2019-05-14
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2019.5819/2018
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    Zs.B 199: Show issues Location:
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  5. Article ; Online: Outcome quality standards for surgery of colorectal liver metastasis.

    Bellver Oliver, Manuel / Escrig-Sos, Javier / Rotellar Sastre, Fernando / Moya-Herráiz, Ángel / Sabater-Ortí, Luis

    Langenbeck's archives of surgery

    2020  Volume 405, Issue 6, Page(s) 745–756

    Abstract: Purpose: Liver metastases are the most common malignant solid liver lesions, approximately 40% of which stem from colorectal tumors. Liver resection is currently the only curative treatment for colorectal cancer liver metastases (CRLM). However, there ... ...

    Abstract Purpose: Liver metastases are the most common malignant solid liver lesions, approximately 40% of which stem from colorectal tumors. Liver resection is currently the only curative treatment for colorectal cancer liver metastases (CRLM). However, there is a lack of consensus criteria to assess the results of this treatment. In order to evaluate the quality of surgical outcomes, it is necessary to identify quality indicators (QIs) and their corresponding quality standards (QS). We propose a simple method to determine QI and QS in CRLM surgery (CRLMS) and establish acceptable quality limits (AQL) for each QI.
    Material and methods: A systematic review of CRLMS results published from 2006 to 2016. Clinical guidelines, consensus conferences, and publications related to the CRLMS were reviewed to identify and select QIs. Once selected, a new review of the papers including the results of at least one of the QIs was performed. Statistical process control (SPC) method was applied to calculate the QS and AQL of each QI. The limits of variability were established from mean and confidence intervals at 95% and 99.8%.
    Results: The most relevant QIs and its AQLs were postoperative mortality (2%, < 4.5%), overall postoperative morbidity (33%, < 41%), liver failure (5%, < 8%), postoperative hemorrhage (1%, < 3%), biliary fistula (6%, < 10%), reoperation (3%, < 6%), R1 resection margins (18%, < 25%), and overall survival at 12 and 60 months (84%, > 77%; and 34%, > 25%, respectively).
    Conclusions: Despite its limitations, the present study constitutes the most extensive scientific evidence to date on QI and AQL in CRLMS and may constitute a reference in future studies.
    MeSH term(s) Colorectal Neoplasms/pathology ; Hepatectomy/standards ; Humans ; Liver Neoplasms/surgery ; Quality Indicators, Health Care
    Language English
    Publishing date 2020-06-23
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-020-01908-w
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  6. Article: Comparison of phenotypes and outcomes following resection of incidental versus symptomatic pancreatic neuroendocrine tumors.

    Hurtado-Pardo, Luis / Breeze, Charles E / Cienfuegos, Javier A / Benito, Alberto / Valentí, Víctor / Martí-Cruchaga, Pablo / Zozaya, Gabriel / Martínez Regueira, Fernando / Pardo, Fernando / Rotellar Sastre, Fernando

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2021  Volume 114, Issue 6, Page(s) 317–322

    Abstract: Background and aim: fifty to 70 percent of pancreatic neuroendocrine tumors are diagnosed incidentally. The objective of this study was to compare the phenotype and oncological outcomes of incidental versus symptomatic pancreatic neuroendocrine tumors.!# ...

    Abstract Background and aim: fifty to 70 percent of pancreatic neuroendocrine tumors are diagnosed incidentally. The objective of this study was to compare the phenotype and oncological outcomes of incidental versus symptomatic pancreatic neuroendocrine tumors.
    Methods: a retrospective study was performed, identifying all incidental and symptomatic tumors resected between 2000 and 2019. Baseline characteristics, symptoms, operative variables and pathological stage were all recorded. Patterns of recurrence and overall and disease-free survival were analyzed in both groups.
    Results: fifty-one incidental and 45 symptomatic pancreatic tumor resections were performed. Symptomatic tumors were more frequent in females (29 vs 17; p = 0.005) and younger patients (median years; 50 vs 58; p = 0.012) and were detected at a more advanced stage (p = 0.027). There were no differences in location and most resections (n = 49; 51 %) were performed laparoscopically. There were no operative mortalities and 17 (17.7 %) severe complications (≥ IIIb on the Clavien-Dindo classification) were recorded with no differences between the two groups. With a median follow-up of 64.4 months (range 13.5-90), overall survival at five and ten years was 89.7 % and 72.8 % for the non-incidental tumors and 80.9 % and 54.6 % for the incidental tumors (p = ns), respectively. Disease-free survival in both groups (excluding M1a) was 71.2 % and 47.5 %, and 93.7 % and 78.1 %, respectively (p = ns).
    Conclusions: symptomatic tumors are more frequent in females and present at more advanced pathological stages. There were no significant differences in overall and disease-free survival between the two groups. Resection of incidental tumors ≥ 1.5-2 cm seems advisable, although each case should be assessed on an individual basis.
    MeSH term(s) Female ; Humans ; Incidental Findings ; Neuroendocrine Tumors/pathology ; Pancreatectomy ; Pancreatic Neoplasms/pathology ; Phenotype ; Retrospective Studies
    Language English
    Publishing date 2021-07-27
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2021.8096/2021
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    Zs.B 199: Show issues Location:
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  7. Article: Severe colon ischemia in patients with severe coronavirus-19 (COVID-19).

    Almeida Vargas, Ana / Valentí, Víctor / Sánchez Justicia, Carlos / Martínez Regueira, Fernando / Martí Cruchaga, Pablo / Luján Colás, Juan / Aliseda Jover, Daniel / Esteban Gordillo, Sara / Cienfuegos, Javier A / Rotellar Sastre, Fernando

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2020  Volume 112, Issue 10, Page(s) 784–787

    Abstract: COVID-19 is associated with severe coagulopathy. We present three cases of colonic ischemia that can be attributed to the hypercoagulable state related with SARS-CoV2 and disseminated intravascular coagulation. Three males aged 76, 68 and 56 with ... ...

    Abstract COVID-19 is associated with severe coagulopathy. We present three cases of colonic ischemia that can be attributed to the hypercoagulable state related with SARS-CoV2 and disseminated intravascular coagulation. Three males aged 76, 68 and 56 with respiratory distress presented episodes of rectal bleeding, abdominal distension and signs of peritoneal irritation. Endoscopy (case 1) and computed tomography angiography revealed colonic ischemia. One patient (case 2) in which a computed tomography (CT) scan showed perforation of the gangrenous cecum underwent surgery. D-dimer levels were markedly increased (2,170, 2,100 and 7,360 ng/ml) in all three patients. All three patients died shortly after diagnosis.
    MeSH term(s) Aged ; Betacoronavirus ; COVID-19 ; Colitis, Ischemic/diagnosis ; Colitis, Ischemic/virology ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Fatal Outcome ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; SARS-CoV-2 ; Severity of Illness Index
    Keywords covid19
    Language English
    Publishing date 2020-11-12
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2020.7329/2020
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  8. Article ; Online: Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID).

    Rojas-Holguín, Adela / Fondevila-Campo, Constantino / Sanjuanbenito, Alfonso / Fabregat-Prous, Joan / Secanella-Medayo, Luís / Rotellar-Sastre, Fernando / Pardo-Sánchez, Fernando / Prieto-Calvo, Mikel / Marín-Ortega, Héctor / Sánchez-Cabús, Santiago / Diez-Valladares, Luis / Alonso-Casado, Óscar / González-Serrano, Carmen / Rodríguez-Sanjuan, Juan Carlos / García-Plaza, Gabriel / Jaén-Torrejimeno, Isabel / Suárez-Muñoz, Miguel Ángel / Becerra-Massare, Antonio / Rio, Paula Senra-Del /
    Pando, Elizabeth / López-Andújar, Rafael / Muñoz-Forner, Elena / Rodriguez-López, Mario / Pereira, Fernando / Serrablo-Requejo, Alejandro / Turrión, Víctor Sánchez / Garrido, Manuel Jiménez / Burdío, Fernando / Martín-Pérez, Elena / Estevan-Estevan, Rafael / López-Guerra, Diego / Castell-Gómez, José / Salinas-Gómez, Javier / López-Baena, José Ángel / López-Ben, Santiago / Solar-García, Lorena / Pérez-Alonso, Alejandro J / Martínez-Insfran, Luis Alberto / Blas, Juan Luis / Cornejo, Marian / Gutierrez-Calvo, Alberto / Pozo, Carlos Domingo-Del / Ochando-Cerdan, Federico / Muñoz-Bellvís, Luis / Rebollar-Saenz, José / Sánchez, Belinda / Jover, José María / Gómez-Bravo, Miguel Ángel / Ramia, José M / Blanco-Fernández, Gerardo

    Surgical oncology

    2024  Volume 52, Page(s) 102039

    Abstract: Background and objectives: Recurrent isolated pancreatic metastasis from Renal Cell Carcinoma (RCC) after pancreatic resection is rare. The purpose of our study is to describe a series of cases of relapse of pancreatic metastasis from renal cancer in ... ...

    Abstract Background and objectives: Recurrent isolated pancreatic metastasis from Renal Cell Carcinoma (RCC) after pancreatic resection is rare. The purpose of our study is to describe a series of cases of relapse of pancreatic metastasis from renal cancer in the pancreatic remnant and its surgical treatment with a repeated pancreatic resection, and to analyse the results of both overall and disease-free survival.
    Methods: Multicenter retrospective study of patients undergoing pancreatic resection for RCC pancreatic metastases, from January 2010 to May 2020. Patients were grouped into two groups depending on whether they received a single pancreatic resection (SPS) or iterative pancreatic resection. Data on short and long-term outcome after pancreatic resection were collected.
    Results: The study included 131 pancreatic resections performed in 116 patients. Thus, iterative pancreatic surgery (IPS) was performed in 15 patients. The mean length of time between the first pancreatic surgery and the second was 48.9 months (95 % CI: 22.2-56.9). There were no differences in the rate of postoperative complications. The DFS rates at 1, 3 and 5 years were 86 %, 78 % and 78 % vs 75 %, 50 % and 37 % in the IPS and SPS group respectively (p = 0.179). OS rates at 1, 3, 5 and 7 years were 100 %, 100 %, 100 % and 75 % in the IPS group vs 95 %, 85 %, 80 % and 68 % in the SPS group (p = 0.895).
    Conclusion: Repeated pancreatic resection in case of relapse of pancreatic metastasis of RCC in the pancreatic remnant is justified, since it achieves OS results similar to those obtained after the first resection.
    MeSH term(s) Humans ; Carcinoma, Renal Cell/surgery ; Carcinoma, Renal Cell/pathology ; Retrospective Studies ; Pancreatectomy/methods ; Pancreatic Neoplasms/pathology ; Kidney Neoplasms/surgery ; Kidney Neoplasms/pathology ; Recurrence
    Language English
    Publishing date 2024-01-27
    Publishing country Netherlands
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1107810-8
    ISSN 1879-3320 ; 0960-7404
    ISSN (online) 1879-3320
    ISSN 0960-7404
    DOI 10.1016/j.suronc.2024.102039
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    Zs.A 3409: Show issues Location:
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  9. Article: Pancreatic mucinous cystic neoplasms located in the distal pancreas: a multicenter study.

    Ramia, Jose M / Del Rio Martín, Juan / Blanco-Fernández, Gerardo / Cantalejo-Diaz, Miguel / Pardo, Fernando / Muñoz-Forner, Elena / Carabias, Alberto / Manuel-Vazquez, Alba / Hernández-Rivera, Pedro J / Jaén-Torrejimeno, Isabel / Kälviäinen-Mejia, Helga K / Rotellar-Sastre, Fernando / Garcés-Albir, Marina / Latorre, Raquel / Longoria-Dubocq, Texell / De Armas-Conde, Noelia / Serrablo-Requejo, Alejandro / Esteban Gordillo, Sara / Sabater, Luis /
    Serradilla-Martín, Mario

    Gland surgery

    2021  Volume 11, Issue 5, Page(s) 795–804

    Abstract: Background: Mucinous cysts of the pancreas (MCN) are infrequent, usually unilocular tumors which occur in postmenopausal women and are located in the pancreatic body/tail. The risk of malignancy is low. The objective is to define preoperative risk ... ...

    Abstract Background: Mucinous cysts of the pancreas (MCN) are infrequent, usually unilocular tumors which occur in postmenopausal women and are located in the pancreatic body/tail. The risk of malignancy is low. The objective is to define preoperative risk factors of malignancy in pancreatic MCN and to assess the feasibility of the laparoscopic approach.
    Methods: Retrospective multicenter observational study of prospectively recorded data regarding distal pancreatectomies was carried out at seven hepatopancreatobiliary (HPB) Units between 01/01/08 and 31/12/18 (the ERPANDIS Project).
    Results: Four hundred and forty-four distal pancreatectomies were recorded including 47 MCN (10.6%). Thirty-five were non-invasive tumors (74.5%). In all, 93% of patients were female, and 60% were ASA (American Society of Anaesthesiology) II. The mean preoperative size was 46 mm. Patients with invasive tumors were older (54
    Conclusions: In our surgical series of MCN, patients with malignancy were older and presented larger tumors, although the difference was not statistically significant. Laparoscopy is a safe and feasible approach for MCN. Prospective studies are now needed to define risk factors that can guide the decision whether to administer conservative treatment or to operate.
    Language English
    Publishing date 2021-10-27
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 3016969-0
    ISSN 2227-8575 ; 2227-684X
    ISSN (online) 2227-8575
    ISSN 2227-684X
    DOI 10.21037/gs-21-703
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  10. Article ; Online: Tumor fibroso quístico calcificante. Una extraña forma de carcinomatosis peritoneal benigna.

    Bellver Oliver, Manuel / Arredondo Chaves, Jorge / Queipo Gutierrez, Pachi / Valentí Azcárate, Victor / Rotellar Sastre, Fernando

    Cirugia espanola

    2013  Volume 91, Issue 5, Page(s) 338–339

    Title translation Calcifying cystic fibrous tumour. A rare form of benign peritoneal carcinomatosis.
    MeSH term(s) Adult ; Calcinosis/complications ; Calcinosis/diagnosis ; Carcinoma/complications ; Carcinoma/diagnosis ; Female ; Humans ; Peritoneal Neoplasms/complications ; Peritoneal Neoplasms/diagnosis
    Language Spanish
    Publishing date 2013-05
    Publishing country Spain
    Document type Case Reports ; Letter
    ZDB-ID 730701-9
    ISSN 1578-147X ; 0009-739X
    ISSN (online) 1578-147X
    ISSN 0009-739X
    DOI 10.1016/j.ciresp.2011.12.004
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