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Article: Urodynamic Studies and Pelvic Floor Surgery.

Rotem, Reut / Weintraub, Adi Y

The Israel Medical Association journal : IMAJ

2023 Volume 25, Issue 1, Page(s) 66–67

MeSH term(s)	Humans ; Pelvic Floor/surgery ; Urodynamics ; Urinary Bladder ; Urologic Surgical Procedures
Language	English
Publishing date	2023-02-14
Publishing country	Israel
Document type	Editorial ; Comment
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Zs.A 5470: Show issues

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Article ; Online: Effect of direct oral anticoagulants on bleeding during and after cataract surgery.

Maytal, Anat / Naidorf Rosenblatt, Hadar / Rotem, Reut / Segev, Fani

International ophthalmology

2024 Volume 44, Issue 1, Page(s) 100

Abstract: Purpose: To assess the risk for intraoperative and postoperative ocular bleeding associated with direct oral anticoagulant treatment in patients undergoing phacoemulsification surgery.: Methods: Consecutive patients had phacoemulsification and ... ...

Abstract	Purpose: To assess the risk for intraoperative and postoperative ocular bleeding associated with direct oral anticoagulant treatment in patients undergoing phacoemulsification surgery. Methods: Consecutive patients had phacoemulsification and intraocular lens implantation while taking uninterrupted direct oral anticoagulants (dabigatran, rivaroxaban, or apixaban). Gender and age-matched patients without antithrombotic therapy were used as the control group. Patients were examined one week postoperatively. Intraoperative and postoperative hemorrhagic and non-hemorrhagic complications were assessed. Results: Forty patients (56 eyes) on direct oral anticoagulants and 120 patients (172 eyes) without anticoagulation, at a mean age of 77 years, had phacoemulsification. There was no significant difference between the groups in the rate of intraoperative and postoperative bleeding. One eye (1.8%) in the treatment group and 3 eyes (1.7%) in the control group had hyphema (p = 0.72). No patient had thromboembolic event during or after surgery. Conclusions: Cataract surgery was safely performed while continuing direct oral anticoagulation.
MeSH term(s)	Humans ; Aged ; Cataract Extraction/adverse effects ; Eye ; Postoperative Hemorrhage/chemically induced ; Postoperative Hemorrhage/epidemiology ; Anticoagulants/adverse effects ; Cataract
Chemical Substances	Anticoagulants
Language	English
Publishing date	2024-02-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-024-02944-x
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Zs.A 1479: Show issues

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Article ; Online: The Correlation Between the Total Decelerations and Accelerations Areas and Cord Blood pH in Women with Low-Risk Pregnancies.

Shema, Noam / Weintraub, Adi Y / Rotem, Reut / Salem, Shimrit Yaniv

Reproductive sciences (Thousand Oaks, Calif.)

2024 Volume 31, Issue 5, Page(s) 1401–1407

Abstract: Fetal acidosis among low-risk pregnancies is not common; however, identifying those at risk for this complication antenatally is of great interest. We aimed to assess the correlation between the total decelerations area during the last 120 min of fetal ... ...

Abstract	Fetal acidosis among low-risk pregnancies is not common; however, identifying those at risk for this complication antenatally is of great interest. We aimed to assess the correlation between the total decelerations area during the last 120 min of fetal monitoring prior to delivery and neonatal acidemia in low-risk pregnancies and whether the total acceleration area has a protective effect in the presence of decelerations. A retrospective cohort study was conducted among women with term low-risk pregnancies. A researcher blinded to fetal outcomes interpreted electronic fetal monitor patterns during the 120 min prior to delivery. The primary outcome was fetal acidemia, defined as umbilical artery pH below 7.10. The correlation between the total decelerations and accelerations areas and cord blood pH was tested using the Spearman correlation coefficient. A total of 109 women were included and of these, six (5.5%) delivered infants with cord blood pH < 7.10. A significant correlation was demonstrated between the total decelerations area and cord blood pH (p = 0.01). No correlation was found between the total accelerations area and cord blood pH. Among low-risk pregnancies, a correlation was found between the total decelerations area but not the total accelerations area during the final 120 min of labor and cord blood pH.
MeSH term(s)	Humans ; Female ; Fetal Blood/chemistry ; Fetal Blood/metabolism ; Pregnancy ; Hydrogen-Ion Concentration ; Retrospective Studies ; Adult ; Acidosis/blood ; Acidosis/physiopathology ; Infant, Newborn ; Heart Rate, Fetal/physiology ; Cardiotocography ; Fetal Monitoring/methods
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1007/s43032-024-01455-5
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Article ; Online: Robot-assisted laparoscopic pelvic floor surgery: Review.

Daykan, Yair / Rotem, Reut / O'Reilly, Barry A

Best practice & research. Clinical obstetrics & gynaecology

2023 Volume 91, Page(s) 102418

Abstract: Minimally invasive surgical techniques have become more common in pelvic floor reconstructive urogynaecological surgery, specifically, robotic-assisted pelvic floor surgery. Female pelvic floor anatomy is complex, and some repairs require highly ... ...

Abstract	Minimally invasive surgical techniques have become more common in pelvic floor reconstructive urogynaecological surgery, specifically, robotic-assisted pelvic floor surgery. Female pelvic floor anatomy is complex, and some repairs require highly experienced surgical skills that can be gained more easily using robotic-assisted surgery. A common application of the robotic platform in urogynaecological surgeries includes sacrocolpopexy, which has become the gold standard approach in the last decade for the correction of apical prolapse. Additional procedures include sacrohysteropexy, sacrocervicopexy, fistula repair, and complex procedures involving the bladder and other pelvic organs. Despite its increasing use and clear benefit in our field, data in the literature and, in particular, randomised controlled trials are sparse. This review provides an update, incorporating recently published literature and our personal experience in that field.
MeSH term(s)	Female ; Humans ; Robotic Surgical Procedures/methods ; Robotics ; Pelvic Floor/surgery ; Gynecologic Surgical Procedures/methods ; Pelvic Organ Prolapse/surgery ; Laparoscopy/methods ; Treatment Outcome
Language	English
Publishing date	2023-09-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2050090-7
ISSN	1532-1932 ; 1521-6934
ISSN (online)	1532-1932
ISSN	1521-6934
DOI	10.1016/j.bpobgyn.2023.102418
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Article ; Online: Response to: vacuum assisted vaginal birth after cesarean: the indication for vacuum assistance matters.

Rottenstreich, Misgav / Rotem, Reut

Archives of gynecology and obstetrics

2021 Volume 305, Issue 3, Page(s) 795

MeSH term(s)	Delivery, Obstetric ; Female ; Humans ; Parturition ; Pregnancy ; Vacuum Extraction, Obstetrical/adverse effects ; Vaginal Birth after Cesarean
Language	English
Publishing date	2021-04-17
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-021-06035-5
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Article ; Online: Pelvic floor disorders among amateur runners.

Sade, Shanny / Naor, Inbar / Rotem, Reut / Waichenberg, Lauren / Kravits, Dana Zilberman / Weintraub, Adi Y

Archives of gynecology and obstetrics

2024 Volume 309, Issue 5, Page(s) 2223–2228

Abstract: Background: Sports and physical activity are known risk factors for pelvic floor dysfunction (PFD). The aim of this study is to examine the impact of amateur running on PFD, quality of life (QoL), and sexual function.: Methods: Amateur runners were ... ...

Abstract	Background: Sports and physical activity are known risk factors for pelvic floor dysfunction (PFD). The aim of this study is to examine the impact of amateur running on PFD, quality of life (QoL), and sexual function. Methods: Amateur runners were contacted through social media. Their PFD, sexual function, and QoL were evaluated by self-reporting validated questionnaires (PFDI-20, PISQ-12, IIQ-7). They were divided by degree of effort into two categories, 'High effort' and 'Moderate effort'. The differences between the two groups were examined by a Mann-Whitney U Test, T-Test, and Chi-square test. Results: 180 women were included. A high incidence of PFD was found among 'High effort' runners in comparison to 'Moderate effort' runners. In addition, women who scored above the median in the PFDI-20 showed significantly greater impairment in QoL and sexual function. Interestingly, the 'High effort' group reported experiencing higher intensity orgasms compared with women in the 'Moderate effort' group. A correlation was also found between the weekly running distance and the intensity of orgasm experienced (P value = 0.004). Conclusion: 'High effort' runners present a higher incidence of PFD in comparison to 'Moderate effort' runners. Professional pelvic floor muscle training counselling should be considered even for amateur runners. Future interventional physical therapy studies should be carried out in order to investigate preventative strategies.
MeSH term(s)	Female ; Humans ; Pelvic Floor Disorders/epidemiology ; Pelvic Floor Disorders/etiology ; Quality of Life ; Pelvic Floor ; Surveys and Questionnaires ; Exercise ; Pelvic Organ Prolapse
Language	English
Publishing date	2024-02-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-023-07351-8
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Article ; Online: Urodynamic insights: exploring the relationship between detrusor overactivity and pelvic organ prolapse in women with urge incontinence.

Rotem, Reut / Craven, Simon / Daykan, Yair / Murphy, Jessica / Galvin, Daniel / O'Reilly, Barry A

Archives of gynecology and obstetrics

2024

Abstract: Purpose: Pelvic organ prolapse (POP) and overactive bladder (OAB) commonly affect the aging female population. We aimed to investigate the possible relationship between the two, as reflected by urodynamic studies.: Methods: A retrospective analysis ... ...

Abstract	Purpose: Pelvic organ prolapse (POP) and overactive bladder (OAB) commonly affect the aging female population. We aimed to investigate the possible relationship between the two, as reflected by urodynamic studies. Methods: A retrospective analysis was conducted on women who underwent urodynamic studies at a university-affiliated tertiary medical center from January 2018 to January 2021. Women presenting with urge incontinence and diagnosed with detrusor overactivity (DO) were included in the study. Based on the presence or absence of a modified POP-Q ≥ grade 2, these women were categorized into two groups. Data on general demographics, clinical symptoms, and urodynamic findings were extracted and compared using SPSS. Results: During the study period, 949 urodynamic evaluations were performed. Of these, 303 (31.92%) reported urge incontinence. Out of this subset, 151 (49.83%) were diagnosed with DO. Within this group, 18 (11.9%) had POP, while 134 (88.1%) did not. The POP group had a notably higher incidence of prior vaginal hysterectomy and anterior colporrhaphy (p = 0.02 and p = 0.01, respectively). While most urodynamic parameters were similar between groups, there was a significant increase in hesitancy in the POP group (13 s vs 8 s, p = 0.03). There was a trend indicating a reduced median Q max (12 ml/s vs. 18 ml/s, p = 0.06) and an increased flow time (55 s vs 40 s, p = 0.08) in the POP group. Conclusion: The urodynamic profile of the POP group suggests an obstructive voiding pattern. Further longitudinal research is essential to fully understand the relationship between POP and OAB.
Language	English
Publishing date	2024-03-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-024-07414-4
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Article: Pravastatin and placental insufficiency associated disorders: A systematic review and meta-analysis.

Hirsch, Ayala / Rotem, Reut / Ternovsky, Natali / Hirsh Raccah, Bruria

Frontiers in pharmacology

2022 Volume 13, Page(s) 1021548

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-11-09
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.1021548
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Article: Labor Induction in Women with Isolated Polyhydramnios at Term: A Multicenter Retrospective Cohort Analysis.

Lerner, Yael / Peled, Tzuria / Yehushua, Morag / Rotem, Reut / Weiss, Ari / Sela, Hen Y / Grisaru-Granovsky, Sorina / Rottenstreich, Misgav

Journal of clinical medicine

2024 Volume 13, Issue 5

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-02-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13051416
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Article ; Online: Planned oocyte cryopreservation: a systematic review and meta-regression analysis.

Hirsch, Ayala / Hirsh Raccah, Bruria / Rotem, Reut / Hyman, Jordana H / Ben-Ami, Ido / Tsafrir, Avi

Human reproduction update

2024

Abstract: Background: Awareness of the age-related decline in fertility potential has increased the popularity of planned oocyte cryopreservation (POC). However, data regarding outcomes of POC, including rates of women returning to thaw oocytes, as well as ... ...

Abstract	Background: Awareness of the age-related decline in fertility potential has increased the popularity of planned oocyte cryopreservation (POC). However, data regarding outcomes of POC, including rates of women returning to thaw oocytes, as well as pregnancy and live birth rates, are scarce and based mostly on small case series. Objective and rationale: POC was defined as cryopreservation exclusively for prevention of future age-related fertility loss. The primary outcome was live birth rate per patient. The secondary outcomes included the return to thaw rate and laboratory outcomes. A meta-regression analysis examining the association between live birth and age above 40 or below 35 was conducted. Search methods: We conducted a systematic database search from inception to August 2022. The search included PubMed (MEDLINE) and EMBASE. Our search strategies employed a combination of index terms (Mesh) and free text words to compile relevant concepts. The systematic review and meta-regression were undertaken following registration of systematic review (PROSPERO registration number CRD42022361791) and were reported following guidelines of Preferred Reporting Items for Systematic Review and Meta-Analyses 2020 (PRISMA 2020). Outcomes: The database search yielded 3847 records. After the selection process, 10 studies, conducted from 1999 to 2020, were included. Overall, 8750 women underwent POC, with a mean cryopreservation age of 37.2 (±0.8). Of those, 1517 women returned to use their oocytes with a return rate of 11.1% (± 4.7%). The mean age at the time of cryopreservation for women who returned to use their oocytes was 38.1 (±0.4), with an average of 12.6 (±3.6) cryopreserved oocytes per woman. In a meta-analysis, the oocyte survival rate was 78.5% with a 95% CI of 0.74-0.83 (I2 = 93%). The live birth rate per patient was 28% with a 95% CI of 0.24-0.33 (I2 = 92%). Overall, 447 live births were reported. In a sub-group analysis, women who underwent cryopreservation at age ≥40 achieved a live birth rate per patient of 19% (95% CI 0.13-0.29, I2 = 6%), while women aged ≤35 years old or younger had a higher live birth rate per patient of 52% (95% CI 0.41-0.63, I2 = 7%). Wider implications: POC emerges as a feasible option for women aiming to improve their chances of conceiving at a later reproductive age. Nonetheless, it must be acknowledged that the overall success rates of POC are limited and that the likelihood of successful live birth declines as the age at cryopreservation rises. With increasing interest in POC, the collation of comprehensive and high-quality data is imperative to clearly define the outcomes for various age groups. Registration number: CRD42022361791.
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1286738-x
ISSN	1460-2369 ; 1355-4786
ISSN (online)	1460-2369
ISSN	1355-4786
DOI	10.1093/humupd/dmae009
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