LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 483

Search options

  1. Article ; Online: Examining psychedelic drug action.

    Kocak, D Dewran / Roth, Bryan L

    Nature chemistry

    2024  Volume 16, Issue 1, Page(s) 142

    MeSH term(s) Hallucinogens/pharmacology
    Chemical Substances Hallucinogens
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2464596-5
    ISSN 1755-4349 ; 1755-4330
    ISSN (online) 1755-4349
    ISSN 1755-4330
    DOI 10.1038/s41557-023-01412-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Introduction to the Biochemistry of Pain Special Issue.

    Roth, Bryan L

    Biochemistry

    2021  Volume 60, Issue 18, Page(s) 1379–1380

    MeSH term(s) Analgesics/chemistry ; Analgesics/pharmacology ; Biological Products ; Drug Delivery Systems ; Drug Design ; Drug Discovery ; Humans ; Machine Learning ; Models, Molecular ; Pain/diagnosis ; Pain/drug therapy ; Receptors, Opioid, kappa/chemistry ; Structure-Activity Relationship
    Chemical Substances Analgesics ; Biological Products ; Receptors, Opioid, kappa
    Language English
    Publishing date 2021-05-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.1c00274
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 217: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book: The serotonin receptors

    Roth, Bryan L.

    from molecular pharmacology to human therapeutics

    (The receptors)

    2006  

    Author's details ed. by Bryan L. Roth
    Series title The receptors
    Keywords Serotoninrezeptor ; Molekularpharmakologie ; Physiologie
    Subject Humanphysiologie ; Mensch ; Körperfunktion
    Language English
    Size XVII, 618 S., [2] Bl. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT014669898
    ISBN 1-58829-568-0 ; 978-1-58829-568-2
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 3412 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: G protein-coupled receptors as targets for transformative neuropsychiatric therapeutics.

    Schmitz, Gavin P / Roth, Bryan L

    American journal of physiology. Cell physiology

    2023  Volume 325, Issue 1, Page(s) C17–C28

    Abstract: G protein-coupled receptors (GPCRs) constitute the largest family of druggable genes in the human genome. Even though perhaps 30% of approved medications target GPCRs, they interact with only a small number of them. Here, we consider whether there might ... ...

    Abstract G protein-coupled receptors (GPCRs) constitute the largest family of druggable genes in the human genome. Even though perhaps 30% of approved medications target GPCRs, they interact with only a small number of them. Here, we consider whether there might be new opportunities for transformative therapeutics for neuropsychiatric disorders by specifically targeting both known and understudied GPCRs. Using psychedelic drugs that target serotonin receptors as an example, we show how recent insights into the structure, function, signaling, and cell biology of these receptors have led to potentially novel therapeutics. We next focus on the possibility that nonpsychedelic 5-HT2A receptor agonists might prove to be safe and rapidly acting antidepressants. Finally, we examine understudied and orphan GPCRs using the MRGPR family of receptors as an example.
    MeSH term(s) Humans ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/agonists ; Signal Transduction
    Chemical Substances Receptors, G-Protein-Coupled
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00397.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: CryoEM structures of adhesion in GPCR CD97: Filling in some of the gaps.

    Krumm, Brian E / Roth, Bryan L

    Cell chemical biology

    2023  Volume 30, Issue 11, Page(s) 1327–1329

    Abstract: CD97 (ADGRE5) is an adhesion GPCR (aGPCR) that plays crucial roles in the immune system and cancer. In this issue of Cell Chemical Biology, Wang et al. ...

    Abstract CD97 (ADGRE5) is an adhesion GPCR (aGPCR) that plays crucial roles in the immune system and cancer. In this issue of Cell Chemical Biology, Wang et al.
    MeSH term(s) Receptors, G-Protein-Coupled/metabolism ; GTP-Binding Proteins/metabolism
    Chemical Substances Receptors, G-Protein-Coupled ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2023.10.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: The structure, function, and pharmacology of MRGPRs.

    Cao, Can / Roth, Bryan L

    Trends in pharmacological sciences

    2023  Volume 44, Issue 4, Page(s) 237–251

    Abstract: Mas-related G protein-coupled receptor (MRGPR) family members play important roles in the sensation of noxious stimuli and represent novel targets for the treatment of itch and pain. MRGPRs recognize a diversity of agonists and display complicated ... ...

    Abstract Mas-related G protein-coupled receptor (MRGPR) family members play important roles in the sensation of noxious stimuli and represent novel targets for the treatment of itch and pain. MRGPRs recognize a diversity of agonists and display complicated downstream signaling profiles, high sequence diversity across species, and many polymorphisms in humans. The recent structural advances on MRGPRs reveal unique structural features and diverse agonist recognition modes of this receptor family, which should facilitate the structure-based drug discovery at MRGPRs. In addition, the newly discovered ligands also provide valuable tools to explore the function and the therapeutic potential of MRGPRs. In this review, we discuss these progresses in our understanding of MRGPRs and highlight the challenges and potential opportunities for the future drug discovery at these receptors.
    MeSH term(s) Humans ; Sensory Receptor Cells ; Receptors, G-Protein-Coupled ; Signal Transduction ; Pain/drug therapy ; Pruritus ; Ligands
    Chemical Substances Receptors, G-Protein-Coupled ; Ligands
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2023.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1513: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 6: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: SnapShot: Psychedelics and serotonin receptor signaling.

    Gumpper, Ryan H / Roth, Bryan L

    Cell

    2023  Volume 186, Issue 1, Page(s) 232–232.e1

    Abstract: Serotonin (5-hydroxytryptamine; 5HT) signaling regulates processes in every major organ system, but it is most widely known for its role as a neurotransmitter in modulating a plethora of human behaviors. Psychedelics target the ... ...

    Abstract Serotonin (5-hydroxytryptamine; 5HT) signaling regulates processes in every major organ system, but it is most widely known for its role as a neurotransmitter in modulating a plethora of human behaviors. Psychedelics target the 5HT
    MeSH term(s) Humans ; Hallucinogens/pharmacology ; Hallucinogens/therapeutic use ; Serotonin ; Signal Transduction ; Receptors, Serotonin
    Chemical Substances Hallucinogens ; Serotonin (333DO1RDJY) ; Receptors, Serotonin
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.12.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 58: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Psychedelics as Transformative Therapeutics.

    Roth, Bryan L / Gumpper, Ryan H

    The American journal of psychiatry

    2023  Volume 180, Issue 5, Page(s) 340–347

    Abstract: Over the past decade, psychedelic compounds have emerged as potentially transformative therapeutics for a variety of intractable neuropsychiatric conditions. However, historically most of the basic science has utilized these compounds as probes to ... ...

    Abstract Over the past decade, psychedelic compounds have emerged as potentially transformative therapeutics for a variety of intractable neuropsychiatric conditions. However, historically most of the basic science has utilized these compounds as probes to interrogate various endogenous neurotransmitter systems-mainly the serotonin 5-HT
    MeSH term(s) Humans ; Hallucinogens/therapeutic use ; Obsessive-Compulsive Disorder/drug therapy ; Obsessive-Compulsive Disorder/psychology ; Anxiety/drug therapy ; Serotonin/therapeutic use
    Chemical Substances Hallucinogens ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.20230172
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.30: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Built-in functional selectivity in neurons is mediated by the neuronal protein, GINIP.

    Kapolka, Nicholas J / Roth, Bryan L

    Molecular cell

    2023  Volume 83, Issue 14, Page(s) 2392–2394

    Abstract: In this issue of Molecular Cell, Park et al. ...

    Abstract In this issue of Molecular Cell, Park et al.
    MeSH term(s) Neurons/metabolism
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.06.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5055: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Sensing unsaturated fatty acids: insights from GPR120 signaling.

    Zhang, Shicheng / Roth, Bryan L

    Cell research

    2023  Volume 33, Issue 9, Page(s) 657–658

    MeSH term(s) Fatty Acids, Unsaturated ; Signal Transduction
    Chemical Substances Fatty Acids, Unsaturated
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-023-00814-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5283: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top