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  1. Article: An outreach activity to enhance biochemistry pedagogy.

    Roth, Karl S / Bannerman, Tammy / Gopalan, Venkat

    Trends in biochemical sciences

    2023  Volume 48, Issue 5, Page(s) 410–413

    Abstract: Students are self-motivated to learn when provided opportunities that connect theory and real-world applications. Here, we describe for biochemistry majors a newborn screening-focused outreach activity that seeks to develop students' mastery of ... ...

    Abstract Students are self-motivated to learn when provided opportunities that connect theory and real-world applications. Here, we describe for biochemistry majors a newborn screening-focused outreach activity that seeks to develop students' mastery of disciplinary content and soft skills (e.g., critical thinking, teamwork, effective communication, community engagement) and to enhance student engagement.
    MeSH term(s) Humans ; Biochemistry/education ; Students
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2023.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1207: Show issues Location:
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  2. Book: Biochemistry and disease

    Cohn, Robert M. / Roth, Karl S.

    bridging basic science and clinical practice

    1996  

    Author's details Robert M. Cohn ; Karl S. Roth
    Keywords Medicine ; Biochemistry ; Metabolic Diseases
    Language English
    Size XIV, 587 S. : graph. Darst.
    Publisher Williams & Wilkins
    Publishing place Baltimore u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007558033
    ISBN 0-683-02049-8 ; 978-0-683-02049-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1997 A 4717 order for loan Magazin

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  3. Book: Pediatric endocrinology and inborn errors of metabolism

    Sarafoglou, Kyriakie / Hoffmann, Georg F / Roth, Karl S

    2017  

    Author's details editor, Kyriakie Sarafoglou ; associate editors, Georg F. Hoffmann, Karl S. Roth
    MeSH term(s) Endocrine System Diseases ; Child ; Metabolism, Inborn Errors ; Infant
    Language English
    Size p. ;, cm.
    Edition Second edition.
    Document type Book
    ISBN 9780071773140 ; 0071773142
    Database Catalogue of the US National Library of Medicine (NLM)

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  4. Article: Hyperammonemia, bane of the brain.

    Cohn, Robert M / Roth, Karl S

    Clinical pediatrics

    2004  Volume 43, Issue 8, Page(s) 683–689

    Abstract: Ammonia, normally produced from catabolism of amino acids, is a deadly neurotoxin. As such, the concentration of free ammonia in the blood is very tightly regulated and is exceeded by two orders of magnitude by its physiologic derivative, urea. The ... ...

    Abstract Ammonia, normally produced from catabolism of amino acids, is a deadly neurotoxin. As such, the concentration of free ammonia in the blood is very tightly regulated and is exceeded by two orders of magnitude by its physiologic derivative, urea. The normal capacity for urea production far exceeds the rate of free ammonia production by protein catabolism under normal circumstances, such that any increase in free blood ammonia concentration is a reflection of either biochemical or pharmacologic impairment of urea cycle function or fairly extensive hepatic damage. Clinical signs of hyperammonemia occur at concentrations > 60 micromol/L and include anorexia, irritability, lethargy, vomiting, somnolence, disorientation, asterixis, cerebral edema, coma, and death; appearance of these findings is generally proportional to free ammonia concentration, is progressive, and is independent of the primary etiology. Causes of hyperammonemia include genetic defects in the urea cycle ("primary") or organic acidemias ("secondary"), as well as genetic or acquired disorders resulting in significant hepatic dysfunction. Thus, because of the neurotoxic implications of hyperammonemia and the typical absence of other specific laboratory abnormalities, appearance of the clinical signs should trigger an emergent search for elevated blood ammonia concentration.
    MeSH term(s) Brain Diseases, Metabolic/diagnosis ; Brain Diseases, Metabolic/etiology ; Brain Diseases, Metabolic/physiopathology ; Brain Diseases, Metabolic/therapy ; Humans ; Hyperammonemia/diagnosis ; Hyperammonemia/etiology ; Hyperammonemia/physiopathology ; Hyperammonemia/therapy
    Language English
    Publishing date 2004-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207678-0
    ISSN 1938-2707 ; 0009-9228
    ISSN (online) 1938-2707
    ISSN 0009-9228
    DOI 10.1177/000992280404300801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Cystinosis and cystinuria: differences in outcome.

    Roth, Karl S / Chan, James Cm

    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

    2003  Volume 14, Issue 3, Page(s) 351–357

    Abstract: Cystinosis and cystinuria, both recessive genetic disorders, are fundamentally different in their pathophysiologic mechanisms. Cystinosis is a disease of cystine storage in which the kidney is the initial, but not the sole target organ. Cystinuria is a ... ...

    Abstract Cystinosis and cystinuria, both recessive genetic disorders, are fundamentally different in their pathophysiologic mechanisms. Cystinosis is a disease of cystine storage in which the kidney is the initial, but not the sole target organ. Cystinuria is a disease of renal tubular cystine transport in which excessive loss of this insoluble amino acid causes precipitation at physiologic urine pH and concentration. The former disorder uniformly results in the need for renal allograft despite recent advances in medical therapy. Cystinuria has a variable severity of expression and may be amenable to long-term medical treatment in some patients. Others may have frequent stone recurrence and infection and progress to chronic renal failure in the long term. It is the purpose of this review to provide the reader with an understanding of the respective diseases and the reasons for the differences in their prognoses and long-term outcomes.
    Language English
    Publishing date 2003-07
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 1379955-1
    ISSN 1319-2442
    ISSN 1319-2442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Progressive kidney disease and obstructive uropathy: an overview on clinical research].

    Chan, James C M / Scheinman, Jonathan I / Roth, Karl S

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2005  Volume 43, Issue 6, Page(s) 406–409

    MeSH term(s) Child ; Disease Progression ; Humans ; Kidney/abnormalities ; Kidney/physiopathology ; Kidney Diseases/congenital ; Kidney Diseases/physiopathology ; Kidney Diseases/therapy ; Kidney Failure, Chronic/etiology ; Kidney Failure, Chronic/physiopathology ; Kidney Failure, Chronic/prevention & control ; Ureteral Obstruction/etiology ; Ureteral Obstruction/physiopathology ; Ureteral Obstruction/therapy
    Language Chinese
    Publishing date 2005-06
    Publishing country China
    Document type Journal Article
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3292: Show issues Location:
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  7. Article: The role of nutrition in chronic renal insufficiency of childhood: how much do we know?

    Roth, Karl S / Duncan, Laura L / Chan, J C M

    Critical reviews in food science and nutrition

    2005  Volume 45, Issue 4, Page(s) 259–263

    Abstract: Dietary protein restriction in the treatment of symptomatic renal failure has been utilized for many years, especially as a means for reduction of 'fixed acid" load. Studies in animal models of renal failure suggest that low protein intake may retard the ...

    Abstract Dietary protein restriction in the treatment of symptomatic renal failure has been utilized for many years, especially as a means for reduction of 'fixed acid" load. Studies in animal models of renal failure suggest that low protein intake may retard the progression of renal disease as well. However, large, well-organized investigations into this question in humans have fallen prey to difficulties that are almost impossible to overcome. Chief among these difficulties is the problem of chronically reducing protein intake in patients with a lifelong intake far above the recommended daily allowance (RDA). Another is the fact that all previous studies have been performed in patients with moderate to severe compromise of renal function. Thus, the potential efficacy of reduced protein intake in the retardation of the progression of renal disease remains an open question. In this article, we discuss the current state of knowledge and propose an approach to answering this question.
    MeSH term(s) Animals ; Child ; Child Nutritional Physiological Phenomena/physiology ; Dietary Proteins/administration & dosage ; Humans ; Kidney Failure, Chronic
    Chemical Substances Dietary Proteins
    Language English
    Publishing date 2005-07-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1037504-1
    ISSN 1549-7852 ; 1040-8398
    ISSN (online) 1549-7852
    ISSN 1040-8398
    DOI 10.1080/10408690490478109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Pediatric obstructive uropathy: clinical trials.

    Chan, James Cm / Scheinman, Jonathan I / Roth, Karl S

    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

    2005  Volume 16, Issue 3, Page(s) 271–276

    Abstract: As the powerful tools of molecular biology continue to delineate new concepts of pathogenesis of diseases, new molecular-level therapeutic modalities are certain to emerge. In order to design and execute clinical trials to evaluate outcomes of these new ... ...

    Abstract As the powerful tools of molecular biology continue to delineate new concepts of pathogenesis of diseases, new molecular-level therapeutic modalities are certain to emerge. In order to design and execute clinical trials to evaluate outcomes of these new treatment modalities, we will soon need a new supply of investigators with training and experience in clinical research. The slowly-progressive nature of chronic pediatric kidney disease often results in diagnosis being made at a time remote from initial insult, and the inherently slow rate of progression makes changes difficult to measure. Thus, development of molecular markers for both diagnosis and rate of progression will be critical to studies of new therapeutic modalities. We will review general aspects of clinical trials and will use current and past studies as examples to illustrate specific points, especially as these apply to chronic kidney disease associated with obstructive uropathy in children.
    Language English
    Publishing date 2005-07
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 1379955-1
    ISSN 1319-2442
    ISSN 1319-2442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Clinical research and training: an overview.

    Chan, James C M / Roth, Karl S / Salusky, Isidro B

    The Journal of pediatrics

    2002  Volume 140, Issue 3, Page(s) 293–298

    MeSH term(s) Academic Medical Centers/economics ; Academic Medical Centers/organization & administration ; Financing, Government ; Forecasting ; Humans ; National Institutes of Health (U.S.) ; Research/economics ; Research/education ; Research/organization & administration ; Research/trends ; United States
    Language English
    Publishing date 2002-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1067/mpd.2002.122722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Nephrotic syndrome: pathogenesis and management.

    Roth, Karl S / Amaker, Barbara H / Chan, James C M

    Pediatrics in review

    2002  Volume 23, Issue 7, Page(s) 237–248

    MeSH term(s) Albumins/therapeutic use ; Biopsy ; Child ; Diuretics/therapeutic use ; Glucocorticoids/therapeutic use ; Humans ; Kidney/pathology ; Nephrotic Syndrome/complications ; Nephrotic Syndrome/diagnosis ; Nephrotic Syndrome/therapy ; Prednisone/therapeutic use ; Prognosis ; Proteinuria/diagnosis ; Proteinuria/etiology
    Chemical Substances Albumins ; Diuretics ; Glucocorticoids ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2002-05-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 774515-1
    ISSN 1526-3347 ; 0191-9601
    ISSN (online) 1526-3347
    ISSN 0191-9601
    DOI 10.1542/pir.23-7-237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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