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  1. Article ; Online: Commentary on a Classic JHC Article on the Development of Highly Sensitive Fluorochrome-labeled Tyramides for Immunocytochemistry.

    Roth, Kevin A

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

    2023  Volume 71, Issue 5, Page(s) 289–290

    Abstract: This commentary reflects on the significance and impact of the highly cited companion article that was published in ... ...

    Abstract This commentary reflects on the significance and impact of the highly cited companion article that was published in the
    MeSH term(s) Fluorescent Dyes ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Histocytochemistry ; Tyramine
    Chemical Substances Fluorescent Dyes ; Tyramine (X8ZC7V0OX3)
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218208-7
    ISSN 1551-5044 ; 0022-1554
    ISSN (online) 1551-5044
    ISSN 0022-1554
    DOI 10.1369/00221554231178068
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  2. Article ; Online: The American Journal of Pathology, Value Beyond Simple Metrics.

    Roth, Kevin A

    The American journal of pathology

    2017  Volume 187, Issue 1, Page(s) 2–3

    Abstract: This Editorial highlights the value of The American Journal of Pathology beyond normal metrics. ...

    Abstract This Editorial highlights the value of The American Journal of Pathology beyond normal metrics.
    MeSH term(s) Bibliometrics ; Periodicals as Topic ; Publishing/economics
    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2016.10.018
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  3. Article ; Online: Advances in Experimental Neuropathology: New Methods and Insights.

    Roth, Kevin A

    The American journal of pathology

    2016  Volume 186, Issue 3, Page(s) 462–463

    Abstract: This Editorial introduces this month's special Neuropathology Theme Issue, a series of Reviews on advances in our understanding of rare human hereditary neuropathies, peripheral nervous system tumors, and common degenerative diseases. ...

    Abstract This Editorial introduces this month's special Neuropathology Theme Issue, a series of Reviews on advances in our understanding of rare human hereditary neuropathies, peripheral nervous system tumors, and common degenerative diseases.
    MeSH term(s) Animals ; Axonal Transport/genetics ; Dementia/physiopathology ; Dopamine/metabolism ; Dopaminergic Neurons/physiology ; Dysautonomia, Familial/etiology ; Genomics ; Hereditary Sensory and Autonomic Neuropathies/physiopathology ; Humans ; Nervous System Neoplasms/genetics ; Neurilemmoma/genetics ; Neurofibroma/genetics ; Neurofibromatosis 1/genetics ; Neurogenesis ; Parkinson Disease/physiopathology ; Peripheral Nervous System Diseases/physiopathology ; Precision Medicine ; Signal Transduction/genetics ; Wnt Signaling Pathway
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2015.12.007
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  4. Article ; Online: The American Journal of Pathology Centennial Project: the centennial celebration is over, but the science moves forward.

    Roth, Kevin A

    The American journal of pathology

    2013  Volume 182, Issue 4, Page(s) 1050–1051

    MeSH term(s) Animals ; Anniversaries and Special Events ; Humans ; Pathology ; Periodicals as Topic ; Science
    Language English
    Publishing date 2013-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2013.02.001
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  5. Article ; Online: The American Journal of Pathology Centennial Project: celebrating 100 years of the American Society for Investigative Pathology.

    Roth, Kevin A

    The American journal of pathology

    2012  Volume 180, Issue 4, Page(s) 1337–1339

    MeSH term(s) Animals ; Biomedical Research/history ; History, 20th Century ; History, 21st Century ; Humans ; Pathology/history ; Periodicals as Topic/history ; Societies, Medical/history ; United States
    Language English
    Publishing date 2012-04
    Publishing country United States
    Document type Editorial ; Historical Article
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2012.02.002
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  6. Article ; Online: Understanding Lung Development, Injury, and Repair.

    Chauhan, Chhavi / Roth, Kevin A

    The American journal of pathology

    2016  Volume 186, Issue 10, Page(s) 2518

    Abstract: This Editorial introduces the Lung Ontogeny and Injury Theme Issue, which provides critical insights into lung development, injury, and repair as well as key pulmonary diseases. ...

    Abstract This Editorial introduces the Lung Ontogeny and Injury Theme Issue, which provides critical insights into lung development, injury, and repair as well as key pulmonary diseases.
    MeSH term(s) Fibroblasts/physiology ; Hernias, Diaphragmatic, Congenital/pathology ; Humans ; Lung/embryology ; Lung Injury/therapy ; Organogenesis ; Pericytes/physiology ; Stem Cells/physiology ; Wound Healing
    Language English
    Publishing date 2016-08-22
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2016.08.002
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  7. Article ; Online: RAB38 Facilitates Energy Metabolism and Counteracts Cell Death in Glioblastoma Cells.

    Bianchetti, Elena / Bates, Sierra J / Nguyen, Trang T T / Siegelin, Markus D / Roth, Kevin A

    Cells

    2021  Volume 10, Issue 7

    Abstract: Glioblastoma is a high-grade glial neoplasm with a patient survival of 12-18 months. Therefore, the identification of novel therapeutic targets is an urgent need. RAB38 is a GTPase protein implicated in regulating cell proliferation and survival in ... ...

    Abstract Glioblastoma is a high-grade glial neoplasm with a patient survival of 12-18 months. Therefore, the identification of novel therapeutic targets is an urgent need. RAB38 is a GTPase protein implicated in regulating cell proliferation and survival in tumors. The role of RAB38 in glioblastoma is relatively unexplored. Here, we test the hypothesis that RAB38 regulates glioblastoma growth using human glioblastoma cell lines. We found that genetic interference of RAB38 resulted in a decrease in glioblastoma growth through inhibition of proliferation and cell death induction. Transcriptome analysis showed that RAB38 silencing leads to changes in genes related to mitochondrial metabolism and intrinsic apoptosis (e.g., Bcl-xL). Consistently, rescue experiments demonstrated that loss of RAB38 causes a reduction in glioblastoma viability through downregulation of Bcl-xL. Moreover, RAB38 knockdown inhibited both glycolysis and oxidative phosphorylation. Interference with RAB38 enhanced cell death induced by BH3-mimetics. RAB38 antagonists are under development, but not yet clinically available. We found that FDA-approved statins caused a rapid reduction in RAB38 protein levels, increased cell death, and phenocopied some of the molecular changes elicited by loss of RAB38. In summary, our findings suggest that RAB38 is a potential therapeutic target for glioblastoma treatment.
    MeSH term(s) Astrocytes/drug effects ; Astrocytes/metabolism ; Biomarkers, Tumor/metabolism ; Cell Cycle/drug effects ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Down-Regulation/drug effects ; Energy Metabolism/drug effects ; Gene Silencing/drug effects ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Mitochondria/metabolism ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Prognosis ; Proto-Oncogene Proteins c-myc/metabolism ; Simvastatin/pharmacology ; bcl-X Protein/metabolism ; rab GTP-Binding Proteins/metabolism
    Chemical Substances Biomarkers, Tumor ; MCL1 protein, human ; Myeloid Cell Leukemia Sequence 1 Protein ; Proto-Oncogene Proteins c-myc ; bcl-X Protein ; Simvastatin (AGG2FN16EV) ; RAB38 protein, human (EC 3.6.1.-) ; rab GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2021-06-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10071643
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  8. Article ; Online: Coming into focus: computational pathology as the new big data microscope.

    Roth, Kevin A / Almeida, Jonas S

    The American journal of pathology

    2015  Volume 185, Issue 3, Page(s) 600–601

    Abstract: This editorial discusses the rise of computational pathology as a major driver of experimental pathology research. ...

    Abstract This editorial discusses the rise of computational pathology as a major driver of experimental pathology research.
    MeSH term(s) Computational Biology ; Humans ; Pathology ; Research
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2015.01.002
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  9. Article ; Online: Science isn't science if it isn't reproducible.

    Roth, Kevin A / Cox, Audra E

    The American journal of pathology

    2015  Volume 185, Issue 1, Page(s) 2–3

    Abstract: This Editorial introduces readers to the US National Institutes of Health's Proposed Principles and Guidelines for Reporting Preclinical Research. ...

    Abstract This Editorial introduces readers to the US National Institutes of Health's Proposed Principles and Guidelines for Reporting Preclinical Research.
    MeSH term(s) Editorial Policies ; Guidelines as Topic ; Humans ; National Institutes of Health (U.S.) ; Pathology/standards ; Publications ; Reproducibility of Results ; Science/methods ; Science/trends ; United States
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2014.11.001
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  10. Article: Journal of Histochemistry and Cytochemistry editorial policies and ethical guidelines.

    Roth, Kevin A

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

    2006  Volume 54, Issue 2, Page(s) 129–130

    MeSH term(s) Conflict of Interest ; Editorial Policies ; Ethics, Research ; Guidelines as Topic ; Histocytochemistry ; Peer Review, Research ; Periodicals as Topic/ethics ; Periodicals as Topic/standards
    Language English
    Publishing date 2006-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 218208-7
    ISSN 1551-5044 ; 0022-1554
    ISSN (online) 1551-5044
    ISSN 0022-1554
    DOI 10.1369/jhc.5E6890.2006
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