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  1. Article ; Online: Chimeric antigen receptors in the brain: Can we tackle glioblastoma with engineered NK cells?

    Roth, Patrick

    Neuro-oncology

    2023  Volume 25, Issue 11, Page(s) 2072–2073

    MeSH term(s) Humans ; Receptors, Chimeric Antigen/immunology ; Glioblastoma/immunology ; Killer Cells, Natural/immunology ; Brain/metabolism
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2023-07-31
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noad131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5307: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Treatment of gliomas with temozolomide: Rather at sunrise or sunset?

    Roth, Patrick

    Neuro-oncology practice

    2022  Volume 9, Issue 3, Page(s) 161–162

    Language English
    Publishing date 2022-03-17
    Publishing country England
    Document type Editorial
    ZDB-ID 2768945-1
    ISSN 2054-2585 ; 2054-2577
    ISSN (online) 2054-2585
    ISSN 2054-2577
    DOI 10.1093/nop/npac024
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  3. Article: Neuro-Oncology Practice

    Roth, Patrick

    Neuro-oncology practice

    2021  Volume 8, Issue 2, Page(s) 107–108

    Language English
    Publishing date 2021-04-15
    Publishing country England
    Document type Editorial
    ZDB-ID 2768945-1
    ISSN 2054-2585 ; 2054-2577
    ISSN (online) 2054-2585
    ISSN 2054-2577
    DOI 10.1093/nop/npab019
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  4. Book ; Thesis: Die Rolle von KATP-Kanälen bei der evozierten Noradrenalin-Freisetzung während kurz- und langdauernder Blockade des Noradrenalin-Transporters

    Roth, Patrick

    2002  

    Author's details vorgelegt von Patrick Roth
    Language German
    Size 79 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg, Univ., Diss., 2003
    HBZ-ID HT013856746
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 MB 5771 order for loan Magazin

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  5. Article ; Online: Immune checkpoint inhibitors induced side effects of the peripheral nervous system.

    Hundsberger, Thomas / Schreiner, Bettina / Roth, Patrick

    Current opinion in neurology

    2023  Volume 36, Issue 5, Page(s) 427–431

    Abstract: Purpose of review: This review highlights recent knowledge on the diagnosis and treatment of immune checkpoint inhibitor-induced neurological side effects (irNAE) focussing on the neuromuscular system.: Recent findings: irNAEs mainly resemble ... ...

    Abstract Purpose of review: This review highlights recent knowledge on the diagnosis and treatment of immune checkpoint inhibitor-induced neurological side effects (irNAE) focussing on the neuromuscular system.
    Recent findings: irNAEs mainly resemble sporadic neuromuscular autoimmune diseases and paraneoplastic neurological syndromes. However, neurological symptoms may be unspecific (muscle weakness, fatigue) in the oncological setting and carry the risk of misdiagnosis and delayed therapeutic intervention. The role of disease-specific neuromuscular autoantibodies in the diagnosis is controversial as preexisting autoantibodies may otherwise be present before immune checkpoint inhibitor (ICI) treatment without clinical symptoms and may not develop in case of irNAE manifestation. A new necrotising form of myositis (irMyositis) has been described presenting with facial weakness and ptosis mimicking myasthenia gravis. It comes along with a high rate of severe myocarditis accounting for a triad overlap syndrome (myasthenia/myositis/myocarditis). The role of modern biologicals in the treatment of irNAEs has to be determined.
    Summary: irNAEs are rare but carry the risk of permanent morbidity and mortality. Early suspicion and diagnosis are key to prevent neurological sequelae. Beyond interruption of ICI administration, treatment corresponds to sporadic autoimmune diseases. The myasthenia/myositis/myocarditis overlap syndrome deserves special attention as it carries the highest risk of mortality. The role of neurotoxic pretreatment regimens, preexisting subclinical neurological autoimmune diseases and the risk of ICI-re-challenge after irNAEs has to be further investigated.
    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/adverse effects ; Myocarditis ; Drug-Related Side Effects and Adverse Reactions ; Peripheral Nervous System ; Myasthenia Gravis/chemically induced ; Myasthenia Gravis/drug therapy ; Myositis/chemically induced ; Myositis/drug therapy ; Autoantibodies
    Chemical Substances Immune Checkpoint Inhibitors ; Autoantibodies
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000001188
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2524: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Improving Patient Satisfaction in the Hispanic American Community.

    Kelson, Michael / Nguyen, Andrew / Chaudhry, Asaad / Roth, Patrick

    Cureus

    2022  Volume 14, Issue 8, Page(s) e27739

    Abstract: Hispanic Americans are the fastest growing ethnic group in the United States, with an ever-growing gap in the communicative capacity between patients and healthcare providers. This leads to linguistic marginalization and worse healthcare outcomes. There ... ...

    Abstract Hispanic Americans are the fastest growing ethnic group in the United States, with an ever-growing gap in the communicative capacity between patients and healthcare providers. This leads to linguistic marginalization and worse healthcare outcomes. There is an increasing need for Spanish literacy in healthcare professionals, including medical students. However, approximately half of medical schools don't offer a Spanish elective. We performed a scoping review of the literature to assess the relationship between medical Spanish electives, verbal fluency, auditory comprehension, and student comfort. This study was conducted using PubMed and Google Scholar to evaluate articles on Spanish electives in medical schools. Nine articles met inclusion criteria. Almost all studies demonstrated benefit as per outcome measures assessed with statistical significance. The available literature supports the need for Spanish elective courses, with numerous advantages conferred, e.g. increased self-perceived knowledge about specific health issues in the Hispanic American community and reduction in inadvertent communication errors in the patient-provider-interpreter interaction. However, most of the reports analyzed exhibited numerous limitations that warrant future research studies in order to eliminate variables such as bias and issues with generalizability. The authors suggest that more medical schools offer virtual Spanish electives with a focus on empathetic language strategies and patient satisfaction.
    Language English
    Publishing date 2022-08-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.27739
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  7. Article: The role of integrins in glioma biology and anti-glioma therapies.

    Roth, Patrick

    SpringerPlus

    2015  Volume 4, Issue Suppl 1, Page(s) L12

    Language English
    Publishing date 2015-06-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661116-8
    ISSN 2193-1801
    ISSN 2193-1801
    DOI 10.1186/2193-1801-4-S1-L12
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  8. Article ; Online: Programmed death ligand 1 gene silencing in murine glioma models reveals cell line-specific modulation of tumor growth in vivo.

    Blomberg, Evelina / Silginer, Manuela / Roth, Patrick / Weller, Michael

    Neuro-oncology advances

    2022  Volume 4, Issue 1, Page(s) vdac148

    Abstract: Background: Glioblastoma is the most common brain tumor in adults and virtually incurable. Therefore, new therapeutic strategies are urgently needed. Immune checkpoint inhibition has not shown activity in various phase III trials and intra- as well as ... ...

    Abstract Background: Glioblastoma is the most common brain tumor in adults and virtually incurable. Therefore, new therapeutic strategies are urgently needed. Immune checkpoint inhibition has not shown activity in various phase III trials and intra- as well as intertumoral expression of programmed death ligand 1 (PD-L1) varies in glioblastoma.
    Methods: We abrogated constitutive PD-L1 gene expression by CRISPR/Cas9 in murine glioma models and characterized the consequences of gene deletion in vitro and in vivo.
    Results: A heterogeneous expression of
    Conclusions: PD-L1 is expressed and interferon-inducible in murine glioma cell lines. PD-L1 has model-specific roles for tumor growth. Future studies need to determine which subset of glioblastoma patients may benefit from PD-L1 antagonism as part of a multimodality therapeutic approach to glioblastoma.
    Language English
    Publishing date 2022-09-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 3009682-0
    ISSN 2632-2498 ; 2632-2498
    ISSN (online) 2632-2498
    ISSN 2632-2498
    DOI 10.1093/noajnl/vdac148
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  9. Article: [No title information]

    Jerusalem, Anna / Löffler, Kerstin / Roth, Patrick

    Procare : das forbildungsmagazin fur pflegeberufe

    2022  Volume 27, Issue 1-2, Page(s) 48–51

    Abstract: The shortage of nursing staff has become even more noticeable and visible since the COVID 19 pandemic, and the experts know that urgent action is needed. An expert from the field of work/organizational psychology describes the reasons why people decide ... ...

    Title translation „Wenn ich groß bin, geh‘ ich in die Pflege“.
    Abstract The shortage of nursing staff has become even more noticeable and visible since the COVID 19 pandemic, and the experts know that urgent action is needed. An expert from the field of work/organizational psychology describes the reasons why people decide to work in nursing and then stay in their job or turn their backs on it. These range from salary and working conditions to career opportunities. This is also reflected in the descriptions of health and nursing staff about their experiences, wishes and needs.
    Language German
    Publishing date 2022-02-17
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 2011381-X
    ISSN 1613-7574 ; 0949-7323
    ISSN (online) 1613-7574
    ISSN 0949-7323
    DOI 10.1007/s00735-022-1524-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5191: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Thesis ; Online: Secondary Organic Aerosol Formation from Gasoline Direct Injection Vehicles

    Roth, Patrick Richard

    The Impact of Exhaust After-Treatment and Fuel Composition

    2019  

    Abstract: A majority of atmospheric aerosol in urban areas is attributed to transportation emissions, and particularly, gasoline vehicle emissions. The particulate matter (PM) emitted directly from the tailpipe consists of primary organic aerosol (POA) and black ... ...

    Abstract A majority of atmospheric aerosol in urban areas is attributed to transportation emissions, and particularly, gasoline vehicle emissions. The particulate matter (PM) emitted directly from the tailpipe consists of primary organic aerosol (POA) and black carbon. In addition to the particulate emissions, common gaseous pollutants include, nitrogen oxides (NOx), and non-methane organic gases (NMOG), which can photochemically react in the atmosphere to produce secondary organic aerosol (SOA). SOA formation from gasoline vehicles has received considerable attention in recent years, with the majority of studies focusing on older technology port-fuel injection (PFI) engines. There is limited information on the SOA formation from current technology gasoline direct injection (GDI) engines, despite the abundance of information on the primary emissions from these engines. GDI technology is considered a major pathway to reduce greenhouse gas emissions. However, GDI engines have been measured to emit increased PM mass when compared to similar PFI engines. To counteract the increased PM emissions, manufacturers and regulators may need to utilize various emission control strategies. The goal of this work was to investigate the effects of select emission control strategies on the secondary aerosol potential of newer technology GDI vehicles. First, the effects of a catalyzed gasoline particulate filter (GPF) were explored. The addition of a GPF has shown drastic reduction in tailpipe PM mass for GDI vehicles, however its effect on secondary emissions were unknown. This study aided to understand if a catalyzed GPF is effective in the removal of secondary aerosol precursors, thus increasing the significance of the after-treatment technology. Next, the impacts of high ethanol fuel blends, and varying driving conditions on secondary aerosol were assessed. This study analyzed the variations in composition and morphology of the emissions from vehicles operated on 10% to 78% ethanol fuels (% volume). In addition to the effects of vehicle exhaust from high ethanol fuel blends, this study investigated how a controlled surrogate environment can affects the reaction potential of vehicle exhaust. The effects of aromatic and ethanol content were further explored with lower ethanol blends (0%–20% by volume). These fuels were more similar to current commercial fuel blends and focused on the effects of smaller variations in ethanol and aromatic content on the physicochemical properties of the secondary aerosol. Finally, connections between the different vehicle certification standards, fuels, driving cycles, and reaction conditions were explored to form relationships between measured tailpipe emission concentrations and the resulting SOA formation potential from vehicles.
    Keywords Atmospheric Chemistry|Chemical engineering|Environmental engineering
    Subject code 660
    Language ENG
    Publishing date 2019-01-01 00:00:01.0
    Publisher University of California, Riverside
    Publishing country us
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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