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Article ; Online: Redox Out of the Box: Catalytic Versatility Across NAD(P)H-Dependent Oxidoreductases.

Roth, Sebastian / Niese, Richard / Müller, Michael / Hall, Mélanie

Angewandte Chemie (International ed. in English)

2024 Volume 63, Issue 13, Page(s) e202314740

Abstract: The asymmetric reduction of double bonds using NAD(P)H-dependent oxidoreductases has proven to be an efficient tool for the synthesis of important chiral molecules in research and on industrial scale. These enzymes are commercially available in screening ...

Abstract	The asymmetric reduction of double bonds using NAD(P)H-dependent oxidoreductases has proven to be an efficient tool for the synthesis of important chiral molecules in research and on industrial scale. These enzymes are commercially available in screening kits for the reduction of C=O (ketones), C=C (activated alkenes), or C=N bonds (imines). Recent reports, however, indicate that the ability to accommodate multiple reductase activities on distinct C=X bonds occurs in different enzyme classes, either natively or after mutagenesis. This challenges the common perception of highly selective oxidoreductases for one type of electrophilic substrate. Consideration of this underexplored potential in enzyme screenings and protein engineering campaigns may contribute to the identification of complementary biocatalytic processes for the synthesis of chiral compounds. This review will contribute to a global understanding of the promiscuous behavior of NAD(P)H-dependent oxidoreductases on C=X bond reduction and inspire future discoveries with respect to unconventional biocatalytic routes in asymmetric synthesis.
MeSH term(s)	NAD/chemistry ; Oxidation-Reduction ; Oxidoreductases/metabolism ; Catalysis ; Biocatalysis
Chemical Substances	NAD (0U46U6E8UK) ; Oxidoreductases (EC 1.-)
Language	English
Publishing date	2024-01-16
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202314740
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Die Behandlung des frischen arteriellen Verschlusses der Beinarterien mittels Katheterlyse, Aspirationsembolektomie und Angioplastie

Roth, Sebastian

1999

Author's details	vorgelegt von Sebastian Ph. Roth
Language	German
Size	136 Bl. : Ill., graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Heidelberg, Univ., Diss., 1999
HBZ-ID	HT010190967
Database	Catalogue ZB MED Medicine, Health

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99 E 929	order for loan	Magazin

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Book ; Thesis: Kompensatorisches Laufen als sozialpädagogische Hilfestellung in der Suchtkrankenhilfe

Roth, Sebastian

vom Werde-Gang zum Lebens-Lauf

(Theorie und Forschung : Sozialpädagogik ; 9 ; Theorie und Forschung ; 691)

2001

Author's details	Sebastian Roth
Series title	Theorie und Forschung : Sozialpädagogik ; 9 Theorie und Forschung ; 691 Theorie und Forschung ; Sozialpädagogik
Collection	Theorie und Forschung ; Sozialpädagogik
Keywords	Drogentherapie ; Dauerlauf ; Sporttherapie
Subject	Ausdauerlauf ; Joggen ; Jogging ; Trablauf ; Drogenabhängigkeit ; Suchttherapie ; Entzug ; Entziehung ; Drogenentzug ; Arzneimittelentzug
Language	German
Size	118 S. : Ill., graph. Darst.
Publisher	Roderer
Publishing place	Regensburg
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Hildesheim/Holzminden, Fachhochschule, Diplomarbeit, 1999
HBZ-ID	HT012973605
ISBN	3-89783-214-3 ; 978-3-89783-214-5
Database	Catalogue ZB MED Medicine, Health

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2001 A 5484	order for loan	Magazin

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Article ; Online: Die Rolle von kardialen Biomarkern in der perioperativen Risikoevaluation von nichtkardiochirurgischen Patienten – eine Zusammenfassung der ESAIC-Leitlinie 2023.

M'Pembele, René / Roth, Sebastian / Lurati Buse, Giovanna

Die Anaesthesiologie

2023 Volume 73, Issue 1, Page(s) 44–50

Abstract: Background: The recently published ESAIC guidelines highlight the clinical value of cardiac troponins (cTn) and B‑type natriuretic peptides (BNP) for risk assessment in patients undergoing noncardiac surgery.: Objective: Summary of the ESAIC ... ...

Title translation	The role of cardiac biomarkers in perioperative risk evaluation of noncardiac surgery patients-A summary of the ESAIC guidelines 2023.
Abstract	Background: The recently published ESAIC guidelines highlight the clinical value of cardiac troponins (cTn) and B‑type natriuretic peptides (BNP) for risk assessment in patients undergoing noncardiac surgery. Objective: Summary of the ESAIC guideline recommendations. Material and methods: The evidence for the recommendations was extracted from studies that investigated the perioperative role of cTn and BNP as prognostic factors, for risk prediction and for therapeutic guidance. To collate this evidence 12 relevant endpoints as well as risk benefit analyses of systematic screening were considered to issue the strength of the recommendations. Results: The body of evidence for these guidelines was based on 115 studies. The evidence varied significantly across the 12 predefined endpoints. Additionally, there was a gradient in evidence for the use of cTn and BNP as prognostic factors, for risk prediction and for therapeutic guidance. The guidelines issue a weak recommendation for the use of preoperative, postoperative and combined measurement of cTn as well as for preoperative BNP measurement to assess the prognosis. For risk prediction a weak recommendation was formulated for combined and postoperative cTn and preoperative BNP measurements. No recommendation could be given for the evidence on biomarkers as data were very limited. Conclusion: Both cTn and BNP can be used as prognostic factors or to predict the risk for selected endpoints. Therapeutic interventions should not be guided by cardiac biomarker levels.
MeSH term(s)	Humans ; Prognosis ; Biomarkers ; Natriuretic Peptide, Brain/analysis
Chemical Substances	Biomarkers ; Natriuretic Peptide, Brain (114471-18-0)
Language	German
Publishing date	2023-12-08
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ISSN	2731-6866
ISSN (online)	2731-6866
DOI	10.1007/s00101-023-01363-4
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Article: Mild hydrolysis of chemically stable valerolactams by a biocatalytic ATP-dependent system fueled by metaphosphate.

Roth, Sebastian / Gandomkar, Somayyeh / Rossi, Federico / Hall, Mélanie

Green chemistry : an international journal and green chemistry resource : GC

2023 Volume 26, Issue 8, Page(s) 4498–4505

Abstract: Medium-sized 5- and 6-membered ring lactams are molecules with remarkable stability, in contrast to smaller β-lactams. As monomers, they grant access to nylon-4 and nylon-5, which are alternative polyamides to widespread caprolactam-based nylon-6. ... ...

Abstract	Medium-sized 5- and 6-membered ring lactams are molecules with remarkable stability, in contrast to smaller β-lactams. As monomers, they grant access to nylon-4 and nylon-5, which are alternative polyamides to widespread caprolactam-based nylon-6. Chemical hydrolysis of monocyclic γ- and δ-lactams to the corresponding amino acids requires harsh reaction conditions and up to now, no mild (enzymatic) protocol has been reported. Herein, the biocatalytic potential of a pair of heterologously expressed bacterial ATP-dependent oxoprolinases - OplA and OplB - was exploited. Strong activity in the presence of excess of ATP was monitored on δ-valerolactam and derivatives thereof, while trace activity was detected on γ-butyrolactam. An ATP recycling system based on cheap Graham's salt (sodium metaphosphate) and a polyphosphate kinase allowed the use of catalytic amounts of ATP, leading to up to full conversion of 10 mM δ-valerolactam at 30 °C in aqueous medium. Further improvements were obtained by co-expressing OplA and OplB using the pETDuet1 vector, a strategy which enhanced the soluble expression yield and the protein stability. Finally, a range of phosphodonors was investigated in place of ATP. With acetyl phosphate and carbamoyl phosphate, turnover numbers up to 176 were reached, providing hints on a possible mechanism, which was studied by
Language	English
Publishing date	2023-12-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2006274-6
ISSN	1463-9270 ; 1463-9262
ISSN (online)	1463-9270
ISSN	1463-9262
DOI	10.1039/d3gc04434c
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Article ; Online: Neue kardiale Biomarker zur frühen Detektion des Myokardinfarktes in der Herzchirurgie.

Roth, Sebastian / Lurati Buse, Giovanna

Der Anaesthesist

2021 Volume 70, Issue 12, Page(s) 1040–1043

Abstract: In-hospital mortality after cardiac surgery ranges from 2% to 8%. Many patients suffer from major adverse cardiovascular events, e.g. myocardial infarction, which in the long term can result in severe limitations in routine activities. Troponin plays the ...

Title translation	New cardiac biomarkers for early detection of myocardial infarction in cardiac surgery.
Abstract	In-hospital mortality after cardiac surgery ranges from 2% to 8%. Many patients suffer from major adverse cardiovascular events, e.g. myocardial infarction, which in the long term can result in severe limitations in routine activities. Troponin plays the central role in identifying myocardial infarction; however, interpretation after cardiac surgery is difficult due to ischemia reperfusion injury and direct surgical trauma. Thus, the distinction between procedure-related myocardial injury and additional myocardial injury due to a new event is difficult. The fourth universal definition of type 5 myocardial infarction uses the 10 × upper limit of normal (ULN) as cut-off and notably > 90% of patients after on-pump procedures exceed this cut-off. Clinical consequences are mostly unclear. The dynamics of copeptin and heart-type fatty acid binding protein (H-FABP) concentrations start very early, i.e. several hours before troponin. The characteristics of copeptin and H‑FABP might help to overcome the limitations of troponin. This short narrative review gives a concise overview on this topic. Moreover, a brief view of future perspectives in this field is given.
MeSH term(s)	Biomarkers ; Cardiac Surgical Procedures/adverse effects ; Early Diagnosis ; Humans ; Myocardial Infarction/diagnosis ; Troponin I
Chemical Substances	Biomarkers ; Troponin I
Language	German
Publishing date	2021-05-04
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	260-4
ISSN	1432-055X ; 0003-2417
ISSN (online)	1432-055X
ISSN	0003-2417
DOI	10.1007/s00101-021-00974-z
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Zs.MO 232: Show issues
Uk I Zs.184: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article: Effect of a processing delay between direct and delayed sound in simulated open fit hearing aids on speech intelligibility in noise.

Roth, Sebastian / Müller, Franz-Ullrich / Angermeier, Julian / Hemmert, Werner / Zirn, Stefan

Frontiers in neuroscience

2024 Volume 17, Page(s) 1257720

Abstract: Introduction: Subjects with mild to moderate hearing loss today often receive hearing aids (HA) with open-fitting (OF). In OF, direct sound reaches the eardrums with minimal damping. Due to the required processing delay in digital HA, the amplified HA ... ...

Abstract	Introduction: Subjects with mild to moderate hearing loss today often receive hearing aids (HA) with open-fitting (OF). In OF, direct sound reaches the eardrums with minimal damping. Due to the required processing delay in digital HA, the amplified HA sound follows some milliseconds later. This process occurs in both ears symmetrically in bilateral HA provision and is likely to have no or minor detrimental effect on binaural hearing. However, the delayed and amplified sound are only present in one ear in cases of unilateral hearing loss provided with one HA. This processing alters interaural timing differences in the resulting ear signals. Methods: In the present study, an experiment with normal-hearing subjects to investigate speech intelligibility in noise with direct and delayed sound was performed to mimic unilateral and bilateral HA provision with OF. Results: The outcomes reveal that these delays affect speech reception thresholds (SRT) in the unilateral OF simulation when presenting speech and noise from different spatial directions. A significant decrease in the median SRT from -18.1 to -14.7 dB SNR is observed when typical HA processing delays are applied. On the other hand, SRT was independent of the delay between direct and delayed sound in the bilateral OF simulation. Discussion: The significant effect emphasizes the development of rapid processing algorithms for unilateral HA provision.
Language	English
Publishing date	2024-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2023.1257720
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Article ; Online: Cardiovascular-Kidney-Metabolic Syndrome: Association with Adverse Events After Major Noncardiac Surgery.

Roth, Sebastian / M'Pembele, René / Matute, Purificación / Kotfis, Katarzyna / Larmann, Jan / Lurati Buse, Giovanna

Anesthesia and analgesia

2024

Abstract: Background: The American Heart Association (AHA) recently defined the cardiovascular-kidney-metabolic syndrome (CKM) as a new entity to address the complex interactions between heart, kidneys, and metabolism. The aim of this study was to assess the ... ...

Abstract	Background: The American Heart Association (AHA) recently defined the cardiovascular-kidney-metabolic syndrome (CKM) as a new entity to address the complex interactions between heart, kidneys, and metabolism. The aim of this study was to assess the outcome impact of CKM syndrome in patients undergoing noncardiac surgery. Methods: This is a secondary analysis of a prospective international cohort study including patients aged ≥45 years with increased cardiovascular risk undergoing noncardiac surgery. Main exposure was CKM syndrome according to the AHA definition. The primary end point was a composite of major adverse cardiovascular events (MACE) 30 days after surgery. Secondary end points included all-cause mortality and non-MACE complications (Clavien-Dindo class ≥3). Results: This analysis included 14,634 patients (60.8% male, mean age = 72±8 years). MACE occurred in 308 patients (2.1%), and 335 patients (2.3%) died. MACE incidence by CKM stage was as follows: CKM 0: 5/367 = 1.4% (95% confidence interval [CI], 0.4%-3.2%); CKM 1: 3/367 = 0.8% (95% CI, 0.2%-2.4%); CKM 2: 102/7440 = 1.4% (95% CI, 1.1%-1.7%); CKM 3: 27/953 = 2.8% (95% CI, 1.9%-4.1%); CKM 4a: 164/5357 = 3.1% (95% CI, 2.6%-3.6%); CKM 4b: 7/150 = 4.7% (95% CI, 1.9%-9.4%). In multivariate logistic regression, CKM stage ≥3 was independently associated with MACE, mortality, and non-MACE complications, respectively (MACE: OR 2.26 [95% CI, 1.78-2.87]; mortality: OR 1.42 [95% CI: 1.13 -1.78]; non-MACE complications: OR 1.11 [95% CI: 1.03-1.20]). Conclusion: The newly defined CKM syndrome is associated with increased morbidity and mortality after non-cardiac surgery. Thus, cardiovascular, renal, and metabolic disorders should be regarded in mutual context in this setting.
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000006975
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Uk I Zs.78: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 149: Show issues

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Article ; Online: Assessment of Medical Cannabis and Health-Related Quality of Life.

Arkell, Thomas R / Downey, Luke A / Hayley, Amie C / Roth, Sebastian

JAMA network open

2023 Volume 6, Issue 5, Page(s) e2312522

Abstract: Importance: The use of cannabis as a medicine is becoming increasingly prevalent. Given the diverse range of conditions being treated with medical cannabis, as well as the vast array of products and dose forms available, clinical evidence incorporating ... ...

Abstract	Importance: The use of cannabis as a medicine is becoming increasingly prevalent. Given the diverse range of conditions being treated with medical cannabis, as well as the vast array of products and dose forms available, clinical evidence incorporating patient-reported outcomes may help determine safety and efficacy. Objective: To assess whether patients using medical cannabis report improvements in health-related quality of life over time. Design, setting, and participants: This retrospective case series study was conducted at a network of specialist medical clinics (Emerald Clinics) located across Australia. Participants were patients who received treatment for any indication at any point between December 2018 and May 2022. Patients were followed up every mean (SD) 44.6 (30.1) days. Data for up to 15 follow-ups were reported. Statistical analysis was conducted from August to September 2022. Exposure: Medical cannabis. Product types and cannabinoid content varied over time in accordance with the treating physician's clinical judgement. Main outcomes and measures: The main outcome measure was health-related quality of life as assessed using the 36-Item Short Form Health Survey (SF-36) questionnaire. Results: In this case series of 3148 patients, 1688 (53.6%) were female; 820 (30.2%) were employed; and the mean (SD) age was 55.9 (18.7) years at baseline before treatment. Chronic noncancer pain was the most common indication for treatment (68.6% [2160 of 3148]), followed by cancer pain (6.0% [190 of 3148]), insomnia (4.8% [152 of 3148]), and anxiety (4.2% [132 of 3148]). After commencing treatment with medical cannabis, patients reported significant improvements relative to baseline on all 8 domains of the SF-36, and these improvements were mostly sustained over time. After controlling for potential confounders in a regression model, treatment with medical cannabis was associated with an improvement of 6.60 (95% CI, 4.57-8.63) points to 18.31 (95% CI, 15.86-20.77) points in SF-36 scores, depending on the domain (all P < .001). Effect sizes (Cohen d) ranged from 0.21 to 0.72. A total of 2919 adverse events were reported, including 2 that were considered serious. Conclusions and relevance: In this case series study, patients using medical cannabis reported improvements in health-related quality of life, which were mostly sustained over time. Adverse events were rarely serious but common, highlighting the need for caution with prescribing medical cannabis.
MeSH term(s)	Humans ; Female ; Middle Aged ; Male ; Medical Marijuana/therapeutic use ; Quality of Life ; Analgesics, Opioid ; Retrospective Studies ; Chronic Pain ; Cannabis ; Cannabinoid Receptor Agonists ; Hallucinogens
Chemical Substances	Medical Marijuana ; Analgesics, Opioid ; Cannabinoid Receptor Agonists ; Hallucinogens
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.12522
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Conference proceedings: Vergleich zweier kontinuierlicher Eingabemethoden für Lokalisationstests mit abgehängtem Lautsprecher-Array

Müller, Franz-Ullrich / Roth, Sebastian / Hemmert, Werner / Zirn, Stefan

2024 , Page(s) 164

Event/congress	26. Jahrestagung der Deutschen Gesellschaft für Audiologie; Aalen; Deutsche Gesellschaft für Audiologie e.V.; 2024
Keywords	Medizin, Gesundheit
Publishing date	2024-03-05
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/24dga164
Database	German Medical Science

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