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Article ; Online: Circular Dichroism Study of Orexin B under Oxidative Stress Conditions.

Rotondo, Martina / Honisch, Claudia / Tartaggia, Stefano / Ruzza, Paolo

2023 Volume 28, Issue 2

Abstract: The neuropeptides orexin A and B regulate various vital functions of the body, such as sleep/wake states, metabolism, and energy homeostasis. A loss of their physiological activity, with reduced ability to recognize their receptors, is suspected to be ... ...

Abstract	The neuropeptides orexin A and B regulate various vital functions of the body, such as sleep/wake states, metabolism, and energy homeostasis. A loss of their physiological activity, with reduced ability to recognize their receptors, is suspected to be associated with oxidative stress conditions. These are related to excessive presence of reactive oxygen and nitrogen species, as well as of reactive lipoxidation byproducts. With the aim of evaluating the effects of oxidative stress on the secondary structure of orexin peptides, orexin B was synthesized and characterized by circular dichroism spectroscopy under different conditions. In aqueous solution it presents an unordered conformation, while in a membrane mimetic environment it assumes a helical structure. The effects of oxidative stress were evaluated exposing it to both oxygen and nitrogen radicals as well as to lipoxidation byproducts. The results showed that ROS, but not NRS, induced appreciable conformational changes, and only in the membrane mimetic environment. Lipoxidation byproducts, instead, led to secondary structure modifications much more evident than those induced by the direct action of ROS and RNS, and in both analyzed media. Additionally, MALDI-TOF analyses detected mass variations in the peptide attributable to oxidation of the C-terminal Met residue and deamination of asparagine in the Asn-His sequence. Taken together, all these data seem to confirm the involvement of oxidative processes in dysfunctions of the orexinergic system.
MeSH term(s)	Orexins/metabolism ; Reactive Oxygen Species/metabolism ; Circular Dichroism ; Peptides/metabolism ; Oxidative Stress ; Oxygen
Chemical Substances	Orexins ; Reactive Oxygen Species ; Peptides ; Oxygen (S88TT14065)
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28020484
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Article ; Online: Current use of artificial intelligence in the diagnosis and management of acute appendicitis.

Cappuccio, Micaela / Bianco, Paolo / Rotondo, Marco / Spiezia, Salvatore / D'Ambrosio, Marco / Menegon Tasselli, Francesco / Guerra, Germano / Avella, Pasquale

Minerva surgery

2024

Abstract: Introduction: Acute appendicitis is a common and time-sensitive surgical emergency, requiring rapid and accurate diagnosis and management to prevent complications. Artificial intelligence (AI) has emerged as a transformative tool in healthcare, offering ...

Abstract	Introduction: Acute appendicitis is a common and time-sensitive surgical emergency, requiring rapid and accurate diagnosis and management to prevent complications. Artificial intelligence (AI) has emerged as a transformative tool in healthcare, offering significant potential to improve the diagnosis and management of acute appendicitis. This review provides an overview of the evolving role of AI in the diagnosis and management of acute appendicitis, highlighting its benefits, challenges, and future perspectives. Evidence acquisition: We performed a literature search on articles published from 2018 to September 2023. We included only original articles. Evidence synthesis: Overall, 121 studies were examined. We included 32 studies: 23 studies addressed the diagnosis, five the differentiation between complicated and uncomplicated appendicitis, and 4 studies the management of acute appendicitis. Conclusions: AI is poised to revolutionize the diagnosis and management of acute appendicitis by improving accuracy, speed and consistency. It could potentially reduce healthcare costs. As AI technologies continue to evolve, further research and collaboration are needed to fully realize their potential in the diagnosis and management of acute appendicitis.
Language	English
Publishing date	2024-03-13
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3067899-7
ISSN	2724-5438
ISSN (online)	2724-5438
DOI	10.23736/S2724-5691.23.10156-0
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Article ; Online: Allele frequency data for 23 aSTR for different ethnic groups from Republic of Zimbabwe.

Borosky, Alicia / Rotondo, Martina / Eppel, Shari / Gusmão, Leonor / Vullo, Carlos

International journal of legal medicine

2021 Volume 135, Issue 5, Page(s) 1753–1765

Abstract: In order to determine the population allele frequencies of autosomal STR markers of forensic interest in the Zimbabwean population, we analyzed a sample of 478 individuals from 19 different ethnic groups using the PowerPlex® Fusion 6C Kit (Promega Corp, ... ...

Abstract	In order to determine the population allele frequencies of autosomal STR markers of forensic interest in the Zimbabwean population, we analyzed a sample of 478 individuals from 19 different ethnic groups using the PowerPlex® Fusion 6C Kit (Promega Corp, Madison, Wisconsin). The data obtained were compared among the different Zimbabwean ethnic groups as well as with several African populations to establish whether significant differences exist among them. No significant differences were found among the ethnic groups in Zimbabwe. Statistically significant differences were observed between allele frequencies in Zimbabwe and some other African populations, although F
MeSH term(s)	African Continental Ancestry Group/genetics ; Ethnic Groups/genetics ; Female ; Gene Frequency ; Genetics, Population ; Humans ; Male ; Microsatellite Repeats ; Sequence Analysis, DNA ; Zimbabwe/ethnology
Language	English
Publishing date	2021-02-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1055109-8
ISSN	1437-1596 ; 0937-9827
ISSN (online)	1437-1596
ISSN	0937-9827
DOI	10.1007/s00414-021-02514-1
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Article: Pancreatic Ductal Adenocarcinoma: Update of CT-Based Radiomics Applications in the Pre-Surgical Prediction of the Risk of Post-Operative Fistula, Resectability Status and Prognosis.

Pacella, Giulia / Brunese, Maria Chiara / D'Imperio, Eleonora / Rotondo, Marco / Scacchi, Andrea / Carbone, Mattia / Guerra, Germano

Journal of clinical medicine

2023 Volume 12, Issue 23

Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) is the seventh leading cause of cancer-related deaths worldwide. Surgical resection is the main driver to improving survival in resectable tumors, while neoadjuvant treatment based on chemotherapy (and ...

Abstract	Background: Pancreatic ductal adenocarcinoma (PDAC) is the seventh leading cause of cancer-related deaths worldwide. Surgical resection is the main driver to improving survival in resectable tumors, while neoadjuvant treatment based on chemotherapy (and radiotherapy) is the best option-treatment for a non-primally resectable disease. CT-based imaging has a central role in detecting, staging, and managing PDAC. As several authors have proposed radiomics for risk stratification in patients undergoing surgery for PADC, in this narrative review, we have explored the actual fields of interest of radiomics tools in PDAC built on pre-surgical imaging and clinical variables, to obtain more objective and reliable predictors. Methods: The PubMed database was searched for papers published in the English language no earlier than January 2018. Results: We found 301 studies, and 11 satisfied our research criteria. Of those included, four were on resectability status prediction, three on preoperative pancreatic fistula (POPF) prediction, and four on survival prediction. Most of the studies were retrospective. Conclusions: It is possible to conclude that many performing models have been developed to get predictive information in pre-surgical evaluation. However, all the studies were retrospective, lacking further external validation in prospective and multicentric cohorts. Furthermore, the radiomics models and the expression of results should be standardized and automatized to be applicable in clinical practice.
Language	English
Publishing date	2023-11-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12237380
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Article: Artificial Intelligence to Early Predict Liver Metastases in Patients with Colorectal Cancer: Current Status and Future Prospectives.

Avella, Pasquale / Cappuccio, Micaela / Cappuccio, Teresa / Rotondo, Marco / Fumarulo, Daniela / Guerra, Germano / Sciaudone, Guido / Santone, Antonella / Cammilleri, Francesco / Bianco, Paolo / Brunese, Maria Chiara

Life (Basel, Switzerland)

2023 Volume 13, Issue 10

Abstract: Background: Artificial Intelligence (AI)-based analysis represents an evolving medical field. In the last few decades, several studies have reported the diagnostic efficiency of AI applied to Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) ...

Abstract	Background: Artificial Intelligence (AI)-based analysis represents an evolving medical field. In the last few decades, several studies have reported the diagnostic efficiency of AI applied to Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) to early detect liver metastases (LM), mainly from colorectal cancer. Despite the increase in information and the development of different procedures in several radiological fields, an accurate method of predicting LM has not yet been found. This review aims to compare the diagnostic efficiency of different AI methods in the literature according to accuracy, sensibility, precision, and recall to identify early LM. Methods: A narrative review of the literature was conducted on PubMed. A total of 336 studies were screened. Results: We selected 17 studies from 2012 to 2022. In total, 14,475 patients were included, and more than 95% were affected by colorectal cancer. The most frequently used imaging tool to early detect LM was found to be CT (58%), while MRI was used in three cases. Four different AI analyses were used: deep learning, radiomics, machine learning, and fuzzy systems in seven (41.18%), five (29.41%), four (23.53%), and one (5.88%) cases, respectively. Four studies achieved an accuracy of more than 90% after MRI and CT scan acquisition, while just two reported a recall rate ≥90% (one method using MRI and CT and one CT). Conclusions: Routinely acquired radiological images could be used for AI-based analysis to early detect LM. Simultaneous use of radiomics and machine learning analysis applied to MRI or CT images should be an effective method considering the better results achieved in the clinical scenario.
Language	English
Publishing date	2023-10-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13102027
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Article ; Online: Intrathecal baclofen therapy for severe spasticity: analysis on a series of 112 consecutive patients and future prospectives.

Natale, M / Mirone, G / Rotondo, M / Moraci, A

Clinical neurology and neurosurgery

2012 Volume 114, Issue 4, Page(s) 321–325

Abstract: Objective: Intrathecal baclofen therapy (ITB) is a well-known treatment for spasticity. Despite this fact, several topics have to be still discussed: new indications and screening tools, appropriate surgical timing and complicance avoidance.: Methods!# ...

Abstract	Objective: Intrathecal baclofen therapy (ITB) is a well-known treatment for spasticity. Despite this fact, several topics have to be still discussed: new indications and screening tools, appropriate surgical timing and complicance avoidance. Methods: A total of 112 consecutive patients all with a severe, progressive and refractory to medical therapy spasticity from different causes were treated using ITB, after a bolus test. Every patient was assessed by means of Modified Ashworth Scale (MAS), Penn spasm frequency scale (SFS) and Visual Analog Scale for pain. Since available, a Gait analysis was also performed. Results: There were 63 males (56%) and 49 females (44%). Seventy-four (66%) had a quadriparesis, 34 (30.4%) had a paraparesis and 4 (3.6%) were hemiplegic. Among these patients 77 (68.7%) were non ambulatory, while 35 (31.3%) were ambulatory. These patients suffered from spasticity due to many different diseases. Mean follow-up was 55 months. The mean Modified Ashworth score decreased from 4.5±0.5 preoperatively to 1.2±0.4 on chronic intrathecal baclofen. Daily baclofen dose varied between 23 and 500 mcg. Drug-induced complications and catheter related problems occurred, respectively in 7 (6.3%) and 10 patients (8.9%). Conclusions: Although ITB is a well known and good treatment option in the management of severe spasticity, because of the different goals and subgroups of patients treated, a variety of techniques are needed to evaluate the benefits of this therapy. New indications, effects of ITB on central nervous system and cognitive functions needs yet to be fully clarified.
MeSH term(s)	Adolescent ; Adult ; Baclofen/administration & dosage ; Baclofen/adverse effects ; Baclofen/therapeutic use ; Child ; Consciousness Disorders/chemically induced ; Disabled Persons ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Gait Disorders, Neurologic/diagnosis ; Gait Disorders, Neurologic/etiology ; Humans ; Infusion Pumps, Implantable/adverse effects ; Injections, Spinal ; Male ; Middle Aged ; Muscle Relaxants, Central/administration & dosage ; Muscle Relaxants, Central/adverse effects ; Muscle Relaxants, Central/therapeutic use ; Muscle Rigidity/physiopathology ; Muscle Spasticity/drug therapy ; Muscle Spasticity/etiology ; Pain Measurement ; Skin Ulcer/etiology ; Spinal Puncture ; Young Adult
Chemical Substances	Muscle Relaxants, Central ; Baclofen (H789N3FKE8)
Language	English
Publishing date	2012-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2011.10.046
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Article ; Online: A model for rural trauma care.

McSwain, N / Rotondo, M / Meade, P / Duchesne, J

The British journal of surgery

2012 Volume 99, Issue 3, Page(s) 309–314

Abstract: Background: In the United States and many other countries, there has been limited attempt to develop a trauma system that addresses the unique trauma situations that occur in rural areas. Rather the planners have attempted to simply extend the urban ... ...

Abstract	Background: In the United States and many other countries, there has been limited attempt to develop a trauma system that addresses the unique trauma situations that occur in rural areas. Rather the planners have attempted to simply extend the urban based trauma system into rural communities. This extension does not address the needs of the majority of patients who are injured in rural communities. Methods: A review of the types of patients seen in the rural communities, the volume of these patients and the destination protocols used in the rural communities as taught by the ACS/ATLS and the implications of the CDC Guidelines for Field Triage of Injured Patients Recommendations of the National Expert Panel on Field Triage were reviewed, assessed and compared to the needs in the rural areas for a rural trauma system. In addition, a quality assessment tool was used from a major trauma centre whereby the frequency of patients transported to the centre that were inappropriate for the trauma centre was indicated by the volume that were discharged in 6 h. Results: Most of the patients injured in the rural communities can be treated in the critical access and rural hospital (> 90 per cent) and can be provided with good care without the need for emergency medical service (EMS) transportation long distances to the trauma centre, inappropriate use of air EMS vehicles thus circumventing families having to travel long distances to see patients, incurring expense and inconvenience, and avoiding loss of revenue to the local hospitals and the overload of urban trauma centres. Rather triage criteria can be taught as per the EMS systems, training given to rural hospital personnel, hospital administrators instructed as to the benefit of such a system, citizens educated as to the advantage of keeping their loved ones closer to home and trauma system registries used to enhance the correct use of the trauma system. Conclusion: Only 5-10 per cent of trauma injuries require the resources of a trauma centre. Proper triage and medical provider education can be used for the benefit of the patient, the EMS system, the rural and urban hospital, and proper quality assurance to assure that the 'right patient is treated at the right hospital at the right time', for the benefit of the patient.
MeSH term(s)	Clinical Competence/standards ; Emergency Medical Services/organization & administration ; Emergency Medical Services/standards ; Emergency Medicine/education ; Health Facility Size ; Hospitals, Rural/organization & administration ; Hospitals, Rural/standards ; Humans ; Medical Staff, Hospital/education ; Quality of Health Care ; Referral and Consultation/organization & administration ; Rural Health Services/organization & administration ; Rural Health Services/standards ; Transportation of Patients/organization & administration ; Triage/organization & administration ; Workload ; Wounds and Injuries/therapy
Language	English
Publishing date	2012-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1002/bjs.7734
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Article: Peripheral median nerve stimulation for the treatment of iatrogenic complex regional pain syndrome (CRPS) type II after carpal tunnel surgery.

Mirone, G / Natale, M / Rotondo, M

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2009 Volume 16, Issue 6, Page(s) 825–827

Abstract: We report on the use and follow-up of direct peripheral nerve stimulation of the median nerve for the treatment of iatrogenic complex regional pain syndrome (CRPS). A 56-year-old woman presented with CRPS type II in the right forearm and hand, which had ... ...

Abstract	We report on the use and follow-up of direct peripheral nerve stimulation of the median nerve for the treatment of iatrogenic complex regional pain syndrome (CRPS). A 56-year-old woman presented with CRPS type II in the right forearm and hand, which had started after multiple carpal tunnel surgeries and had lasted for 2 years. The visual analogue scale (VAS) score was 8-10 out of 10. After a successful 15-day trial of median nerve peripheral nerve stimulation via a quadripolar lead in the right carpal tunnel space, an implantable pulse generator was inserted in the right infraclavicular space. The VAS score decreased to 1-2 out of 10 and the patient regained the ability to sleep. After 36 months of follow-up, the patient was still experiencing good pain relief without other treatment. We conclude that peripheral nerve stimulation is easy to use in pain management and could offer a valid treatment option for iatrogenic CRPS type II.
MeSH term(s)	Carpal Tunnel Syndrome/surgery ; Causalgia/etiology ; Causalgia/physiopathology ; Causalgia/therapy ; Electric Stimulation Therapy/methods ; Electrodes, Implanted ; Female ; Humans ; Iatrogenic Disease ; Median Nerve/injuries ; Median Nerve/physiopathology ; Median Nerve/surgery ; Middle Aged ; Neurosurgical Procedures/adverse effects ; Pain Measurement ; Treatment Outcome
Language	English
Publishing date	2009-06
Publishing country	Scotland
Document type	Case Reports ; Journal Article
ZDB-ID	1193674-5
ISSN	0967-5868
ISSN	0967-5868
DOI	10.1016/j.jocn.2008.09.006
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Article ; Online: Lateral sellar angiolipomas: a therapeutic challenge. Our experience on two cases and review of the literature.

Rotondo, M / D'Avanzo, R / Natale, M / Oliva, G / Scuotto, A

British journal of neurosurgery

2013 Volume 27, Issue 3, Page(s) 359–363

Abstract: Angiolipomas are rare benign mesenchymal tumours, most commonly found in the subcutaneous tissue of the extremities. These neoplasms are rarely located in the central nervous system (CNS), with spinal localization being the most common in this group. ... ...

Abstract	Angiolipomas are rare benign mesenchymal tumours, most commonly found in the subcutaneous tissue of the extremities. These neoplasms are rarely located in the central nervous system (CNS), with spinal localization being the most common in this group. Intracranial location is extremely infrequent, and only ten cases have been described in the sellar region. We report on two more patients with skull-base (intracranial) angiolipomas, the former presented with a long history of headache and the latter complained diplopia. Both patients were postoperatively verified as angiolipoma. Neuroimaging studies and peroperative features are presented and the role of microsurgery is discussed. On the basis of these tumours' characteristics, the management strategy of choice usually does not consist on surgical total removal, often a partial excision could be satisfying to improve the patient symptomatology. Nowadays, Gamma Knife surgery is standing out as an effective, additional and/or alternative, treatment modality.
MeSH term(s)	Angiolipoma/diagnosis ; Angiolipoma/surgery ; Diagnosis, Differential ; Female ; Humans ; Magnetic Resonance Imaging ; Microsurgery/methods ; Middle Aged ; Sella Turcica ; Skull Base Neoplasms/diagnosis ; Skull Base Neoplasms/surgery
Language	English
Publishing date	2013-06
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.3109/02688697.2012.739218
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Article ; Online: Longer epidermal cells underlie a quantitative source of variation in wheat flag leaf size.

Zanella, Camila M / Rotondo, Marilena / McCormick-Barnes, Charlie / Mellers, Greg / Corsi, Beatrice / Berry, Simon / Ciccone, Giulia / Day, Rob / Faralli, Michele / Galle, Alexander / Gardner, Keith A / Jacobs, John / Ober, Eric S / Sánchez Del Rio, Ana / Van Rie, Jeroen / Lawson, Tracy / Cockram, James

The New phytologist

2022 Volume 237, Issue 5, Page(s) 1558–1573

Abstract: The wheat flag leaf is the main contributor of photosynthetic assimilates to developing grains. Understanding how canopy architecture strategies affect source strength and yield will aid improved crop design. We used an eight-founder population to ... ...

Abstract	The wheat flag leaf is the main contributor of photosynthetic assimilates to developing grains. Understanding how canopy architecture strategies affect source strength and yield will aid improved crop design. We used an eight-founder population to investigate the genetic architecture of flag leaf area, length, width and angle in European wheat. For the strongest genetic locus identified, we subsequently created a near-isogenic line (NIL) pair for more detailed investigation across seven test environments. Genetic control of traits investigated was highly polygenic, with colocalisation of replicated quantitative trait loci (QTL) for one or more traits identifying 24 loci. For QTL QFll.niab-5A.1 (FLL5A), development of a NIL pair found the FLL5A+ allele commonly conferred a c. 7% increase in flag and second leaf length and a more erect leaf angle, resulting in higher flag and/or second leaf area. Increased FLL5A-mediated flag leaf length was associated with: (1) longer pavement cells and (2) larger stomata at lower density, with a trend for decreased maximum stomatal conductance (G
MeSH term(s)	Chromosome Mapping ; Triticum/anatomy & histology ; Quantitative Trait Loci/genetics ; Plant Leaves/anatomy & histology ; Phenotype ; Epidermal Cells
Language	English
Publishing date	2022-12-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.18676
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