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  1. Book ; Thesis: Haben Männer mit Nierenzellkarzinom (NZK) eine schlechtere Prognose als Frauen?

    Rott, Hendrik

    2012  

    Author's details Hendrik Rott
    Language German ; English
    Size [1] Bl., Bl. 24 - 28, 6 - 19 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Med. Hochsch., Diss., 2013
    Note Enth. 1 Sonderabdr. aus: Onkologie ; 34.2011. S. 24 - 28
    HBZ-ID HT017896216
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2013 E 1127 order for loan Magazin

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  2. Article: Kontrazeption und venöse Thromboembolie

    Rott, H.

    Phlebologie

    2018  Volume 47, Issue 06, Page(s) 338–343

    Abstract: Etwa 20 Millionen Frauen befinden sich aktuell im reproduktiven Alter. Ein Drittel von ihnen wendet kombinierte hormonelle Kontrazeptiva an (KHK), welche meist aus Ethinylestradiol und einem synthetischen Gestagen bestehen. Das Grundrisiko für venöse ... ...

    Abstract Etwa 20 Millionen Frauen befinden sich aktuell im reproduktiven Alter. Ein Drittel von ihnen wendet kombinierte hormonelle Kontrazeptiva an (KHK), welche meist aus Ethinylestradiol und einem synthetischen Gestagen bestehen. Das Grundrisiko für venöse Thromboembolien (VTE) für Frauen im reproduktiven Alter ist gering, steigt aber deutlich an durch Anwendung von KHK oder auch in der Schwangerschaft/Wochenbett. Dies gilt auch für nichtorale KHK. Hierdurch haben junge Frauen ein merklich höheres VTE Risiko als Männer bis zum Alter von 35 Jahren, danach gleicht sich das VTE-Risiko zwischen den Geschlechtern an. Die Erhöhung des VTE Risikos hängt vom verwendeten KHK ab. Ältere KHK mit Norgestimat oder Levonorgestrel als Gestagen haben ein niedrigeres VTE-Risiko als neuere KHK. In vielen internationalen Leitlinien gelten daher mittlerweile die älteren KHK als erste Wahl. Neuere KHK sollten daher nur noch verordnet werden, wenn besondere Gründe hierfür vorliegen. Das VTE-Risiko von KHK mit Estradiol bzw. Estradiolvalerat statt EE ist noch unklar durch fehlende Datenlage. Die Anwendung von rein gestagenhaltiger Kontrazeption erhöht das VTE-Risiko nicht signifikant mit Ausnahme von Depot-Medroxyprogesteronacetat (DMPA). Die Notfallkontrazeption („Pille danach”), welche keine Östrogene enthalten, sondern nur Levonorgestrel bzw. Ulipristalacetat erhöhen das VTERisiko nicht. Orale reine Gestagenkontrazeptiva (mit Desogestrel oder Levonorgestrel), Intrauterine Kontrazeption und Etonogestrel Implantate sind die Verhütungsmittel der Wahl bei Frauen mit erhöhtem VTE-Risiko. Ein Thrombophilie-Screening ist nicht bei jeder Frau indiziert mit Kontrazeptionswunsch. Diese Testung sollte limitiert werden z.B. auf Frauen mit positiver VTE Eigenanamnese oder auf Frauen mit VTE-Fällen in jungen Jahren unter 50 in der nächsten Verwandtschaft.

    In Germany approximately 20 million women are in their reproductive age. One third of them are taking combined oral contraceptives (COC), which consists mostly of Ethinylestradiol (EE) and a synthetic gestagen. Basic risk for venous thromboembolism (VTE) in women of this age is low, but rises during pregnancy or when combined hormonal contraceptives (CHC) are used. Therefore, women have a higher risk than men for VTE until the age of 35, after that time point the risk remains equal. Elevation of the thrombotic risk depends on the selected contraceptive. Older COC with norgestimat or levonorgestrel have a lower risk than newer COC. This is also true for nonoral KHK. Consequently, these older COC are the first choice in many international guidelines. Newer generations of contraceptives should only be prescribed, if a secondary reason other than contraception exists. The risk of newer COC containing Estradiol and not Ethinylestradiol instead of EE is not clear due to missing data. The use of gestagen only hormonal contraception with does not contain any significant increase of the risk for VTE with the exception of depot depot medroxyprogesterone acetate (DMPA). Emergency contraception, which do not contain ee, but only contains Levonorgestrel or Ulipristalacetat does not result in a higher risk for VTE. Oral desogestrel or levonorgestrel only contraceptives, intrauterine device (IUD) and Etonogestrel implants are the contraception of choice in women with a history of VTE or suffering from thrombophilia. These safe contraceptives should be offered to women with high risk of VTE due to the much higher VTE risk in pregnancy. The screening for thrombophilia is not indicated in every woman with the wish for contraception. This should be restricted to certain cases, e. g. to women with a positive history for VTE or with close relatives suffering from VTE in young age under 50 years.
    Keywords Venöse Thromboembolie (VTE) ; Thrombose ; kombinierte Kontrazeptiva ; Gestagene ; reine Gestagen-Kontrazeptiva ; Notfall-Kontrazeption ; Schwangerschaft ; Venous thromboembolism (VTE) ; thrombosis ; combined contraception ; gestagen ; gestagenonly contraception ; emergency contraception ; pregnancy
    Language German
    Publishing date 2018-12-01
    Publisher Georg Thieme Verlag KG Stuttgart · New York
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2031316-0
    ISSN 2567-5826 ; 0939-978X
    ISSN (online) 2567-5826
    ISSN 0939-978X
    DOI 10.12687/phleb2451-6-2018
    Database Thieme publisher's database

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  3. Article: Kontrazeption und venöse Thromboembolie

    Rott, H.

    Phlebologie

    2018  Volume 47, Issue 6, Page(s) 338

    Language German
    Document type Article
    ZDB-ID 1064077-0
    ISSN 0340-305X ; 0939-978X
    Database Current Contents Medicine

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  4. Article: Hormonelle Kontrazeptiva - Die neue S3-Leitlinie

    Rott, H.

    Vasomed

    2018  Volume 30, Issue 5, Page(s) 233

    Language German
    Document type Article
    ZDB-ID 1113360-0
    ISSN 0942-1181 ; 0935-9729
    Database Current Contents Medicine

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  5. Article ; Online: Birth Control Pills and Thrombotic Risks: Differences of Contraception Methods with and without Estrogen.

    Rott, Hannelore

    Hamostaseologie

    2019  Volume 39, Issue 1, Page(s) 42–48

    Abstract: In Germany one-third of the women in fertile age use combined oral contraceptives (COCs), which consist mostly of ethinylestradiol (EE) and a synthetic progestin. Older COCs with norethisterone or levonorgestrel have a lower risk for venous ... ...

    Abstract In Germany one-third of the women in fertile age use combined oral contraceptives (COCs), which consist mostly of ethinylestradiol (EE) and a synthetic progestin. Older COCs with norethisterone or levonorgestrel have a lower risk for venous thromboembolism (VTE) than newer COCs with desogestrel, drospirenone, or gestodene. This is also true for nonoral combined hormonal contraceptives. The risk of newer COCs containing estradiol instead of EE is not clear due to missing data. Progestin-only hormonal contraception is not associated with a significant increase of the risk for VTE with the exception of depot medroxyprogesterone acetate. Emergency contraceptions, which do not contain EE, but only levonorgestrel or ulipristal acetate, do not result in a higher risk for VTE. Oral desogestrel- or levonorgestrel-only contraceptives, intrauterine device, and etonogestrel implants are the contraception of choice in women with a history of VTE and/or suffering from thrombophilia. These safe contraceptives should be offered to women with high risk of VTE due to the much higher VTE risk in pregnancy and postpartum. The screening for thrombophilia is not indicated in every woman with the wish for contraception. This should be restricted to certain cases, for example to women with a positive history for VTE or with close relatives suffering from VTE in younger than 50 years.
    MeSH term(s) Anticoagulants/therapeutic use ; Contraception/methods ; Contraceptives, Oral/adverse effects ; Contraceptives, Oral, Combined/adverse effects ; Estrogens/adverse effects ; Female ; Germany/epidemiology ; Humans ; Progestins/adverse effects ; Risk Factors ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/etiology
    Chemical Substances Anticoagulants ; Contraceptives, Oral ; Contraceptives, Oral, Combined ; Estrogens ; Progestins
    Language English
    Publishing date 2019-01-22
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0039-1677806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Vorbeugung venöser Thromboembolien während Schwangerschaft und Wochenbett

    Rott, H. / Thomas, T.

    Frauenarzt

    2022  Volume 63, Issue 8, Page(s) 510

    Language German
    Document type Article
    ZDB-ID 80364-9
    ISSN 0016-0237
    Database Current Contents Medicine

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  7. Article ; Conference proceedings: The phenotypic and genetic assessment of hereditary antithrombin deficiency in 215 patients from the Rhein-Ruhr area in Germany

    Halimeh, S / Rott, H / Kappert, G / Günther, M

    Hämostaseologie

    2023  Volume 43, Issue S 01

    Event/congress GTH Congress 2023 - 67th Annual Meeting of the Society of Thrombosis and Haemostasis Research - The patient as a benchmark, Frankfurt, Germany, 2023-02-21
    Language English
    Publishing date 2023-02-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0042-1760471
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  8. Article: Contraception, venous thrombosis and biological plausability.

    Rott, H

    Minerva medica

    2013  Volume 104, Issue 2, Page(s) 161–167

    Abstract: Exogenous use of hormones leads to different impact on coagulation. Usually estrogen leads to an activation of coagulation, while use of progestogens alone do not. Combined oral contraceptives (COC) differs significantly regarding VTE risk depending on ... ...

    Abstract Exogenous use of hormones leads to different impact on coagulation. Usually estrogen leads to an activation of coagulation, while use of progestogens alone do not. Combined oral contraceptives (COC) differs significantly regarding VTE risk depending on amount of estrogen and type of progestagen: COC containing desogestrol, gestoden or drospirenone in combination with ethinyl-estradiol (EE) (so called 3rd or 4th generation COC) are associated with a higher VTE risk than COC with EE and levonorgestrel or norethisterone (so called 2nd generation COC). The VTE risk for transdermal COC like vaginal ring (NuvaRing) or patch (Evra) is as high than than for COC of 3rd or 4th generation. 2nd generation COC should therefore be the first choice when prescribing hormonal contraception. Most PROGESTAGEN-only contraceptive methods do not increase VTE risk significantly. In patients with a history of venous thromboembolism (VTE) and /or a known thrombophilic defect COC are contraindicated, but progestagen-only contraceptives can be safely used in this patient group. New kinds of COC without EE but with Estradiolvalerat or Estradiol showed a much lower degree of coagulation activation than "classical" COC containing EE. If newer COC with Estradiolvalerat or Estradiol have a lower VTE risk, remains to be elucidated.
    MeSH term(s) Age Factors ; Blood Coagulation/drug effects ; Contraceptive Devices, Female ; Contraceptives, Oral, Combined/adverse effects ; Contraceptives, Oral, Combined/chemistry ; Estrogens/adverse effects ; Female ; Humans ; Progestins/adverse effects ; Risk ; Venous Thromboembolism/blood ; Venous Thromboembolism/chemically induced
    Chemical Substances Contraceptives, Oral, Combined ; Estrogens ; Progestins
    Language English
    Publishing date 2013-04
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Hormonal contraception in thrombophilic adolescents: risk of thrombosis and recommendations.

    Rott, H

    Hamostaseologie

    2012  Volume 32, Issue 1, Page(s) 15–21

    Abstract: Unlabelled: About 3.2 million women in Germany are between 14 and 19 years old representing about 19% of women. 55% of them use combined oral contraception (COC). The risk of venous thromboembolism (VTE) during the use of COC is increased 2-6 times. For ...

    Abstract Unlabelled: About 3.2 million women in Germany are between 14 and 19 years old representing about 19% of women. 55% of them use combined oral contraception (COC). The risk of venous thromboembolism (VTE) during the use of COC is increased 2-6 times. For thrombophilic patients depending on the kind of thrombophilic defect it is much higher. Pregnancy and postpartum period lead to a much higher increase of VTE than any COC use at all, both in women with and without thrombophilic defect. VTE risk in COC is highly dependent on the content of ethinylestradiol (EE) and the kind of progestagen used in COC. Progestagen-only contraceptives (POC) do not increase the VTE risk, since they do not activate the coagulation system.
    Conclusion: It is not justified to withhold any hormonal contraception to thrombophilic women, especially considering the much higher VTE risk in (maybe unintended) pregnancy. Adolescents thrombophilic women should rather be informed about the opportunity to use POC.
    MeSH term(s) Adolescent ; Comorbidity ; Contraceptives, Oral, Hormonal ; Female ; Germany/epidemiology ; Humans ; Pregnancy ; Pregnancy Complications, Cardiovascular/epidemiology ; Prevalence ; Risk Assessment ; Risk Factors ; Thrombophilia/epidemiology ; Venous Thromboembolism/epidemiology
    Chemical Substances Contraceptives, Oral, Hormonal
    Language English
    Publishing date 2012
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 801512-0
    ISSN 0720-9355
    ISSN 0720-9355
    DOI 10.5482/ha-1177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Conference proceedings: A single-centre approach for a safe and individualized tolerization phase for the treatment of PUPs with severe haemophilia A

    Halimeh, S / Rott, H / Kappert, G / Siebert, M / Reinhardt, D

    Hämostaseologie

    2023  Volume 43, Issue S 01

    Event/congress GTH Congress 2023 - 67th Annual Meeting of the Society of Thrombosis and Haemostasis Research - The patient as a benchmark, Frankfurt, Germany, 2023-02-21
    Language English
    Publishing date 2023-02-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0042-1760538
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