Article ; Online: Stadification ganglionnaire lombo-aortique dans les cancers du col de stade supérieur ou égal à IB2: comparaison des performances du PETscan au 18FDG et du curage lombo-aortique à partir des données du registre des cancers gynécologiques de Côte d’Or de 2003 à 2016.
Gynecologie, obstetrique, fertilite & senologie
2021 Volume 49, Issue 9, Page(s) 677–683
Abstract: Introduction: Current guidelines (ASCO, ESTRO, and ESGO) recommend para-aortic lymphadenectomy (PAL) for lymph node staging in patients with a negative initial PET-CT in locally advanced cervical cancer (LACC), with the aim to determine the radiation ... ...
Title translation | Para-aortic lymph node staging in grade IB2 and above cervical cancers: Comparison of 18FDG PET-CT with para-aortic lymphadenectomy, using data from the Côte d'Or gynaecological cancer registry from 2003 to 2016. |
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Abstract | Introduction: Current guidelines (ASCO, ESTRO, and ESGO) recommend para-aortic lymphadenectomy (PAL) for lymph node staging in patients with a negative initial PET-CT in locally advanced cervical cancer (LACC), with the aim to determine the radiation fields for radiochemotherapy. The main goal of this study was to compare overall survival (OS) in two groups, which differed according to the para-aortic lymph node staging technique used: imaging alone versus imaging and PAL. Secondary objectives were to determine recurrence-free survival (RFS), the proportion of false negatives on PET-CT, and surgery-related complications. Methods: We conducted a retrospective, observational study on data from the Côte d'Or gynaecological cancer registry collected from 2003 to 2016, and compared two groups of LACC with different techniques for staging para-aortic lymph nodes: PET-CT alone (iN group) (n=99) and PET-CT associated with PAL (pN group) (n=35) for a total of 134 patients. Results: OS (HR=1.04 (95% CI: 0.53-2.03); P=0.9) and RFS (HR=0.65 (95% CI: 0.29-1.45); P=0.29) were similar in both groups. There were 11.4% of false negatives in PET-CT, and 2.9% of patients who underwent PAL experienced complications. The staging method, iN or pN, had no impact on the time to the implementation of concomitant radiochemotherapy. Conclusion: For lymph node staging in LACC, PAL after a PET-CT as compared with PET-CT staging alone, had no significant impact on OS or RFS. |
MeSH term(s) | Female ; Fluorodeoxyglucose F18 ; Humans ; Lymph Node Excision ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Neoplasm Staging ; Positron Emission Tomography Computed Tomography ; Registries ; Retrospective Studies ; Uterine Cervical Neoplasms/diagnostic imaging ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/therapy |
Chemical Substances | Fluorodeoxyglucose F18 (0Z5B2CJX4D) |
Language | French |
Publishing date | 2021-01-20 |
Publishing country | France |
Document type | Journal Article ; Observational Study |
ZDB-ID | 2887456-0 |
ISSN | 2468-7189 |
ISSN (online) | 2468-7189 |
DOI | 10.1016/j.gofs.2021.01.013 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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