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  1. Article ; Online: The origin of Plasmodium vivax: science or story telling?

    Rougeron, Virginie / Boundenga, Larson / Arnathau, Céline / Durand, Patrick / Prugnolle, Franck

    FEMS microbiology reviews

    2022  Volume 46, Issue 4

    MeSH term(s) Genetic Variation ; Plasmodium falciparum ; Plasmodium vivax
    Language English
    Publishing date 2022-05-02
    Publishing country England
    Document type Letter
    ZDB-ID 283740-7
    ISSN 1574-6976 ; 0168-6445
    ISSN (online) 1574-6976
    ISSN 0168-6445
    DOI 10.1093/femsre/fuac016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evolutionary history of Plasmodium vivax and Plasmodium simium in the Americas.

    Rougeron, Virginie / Daron, Josquin / Fontaine, Michael C / Prugnolle, Franck

    Malaria journal

    2022  Volume 21, Issue 1, Page(s) 141

    Abstract: Malaria is a vector-borne disease caused by protozoan parasites of the genus Plasmodium. Plasmodium vivax is the most prevalent human-infecting species in the Americas. However, the origins of this parasite in this continent are still debated. Similarly, ...

    Abstract Malaria is a vector-borne disease caused by protozoan parasites of the genus Plasmodium. Plasmodium vivax is the most prevalent human-infecting species in the Americas. However, the origins of this parasite in this continent are still debated. Similarly, it is now accepted that the existence of Plasmodium simium is explained by a P. vivax transfer from humans to monkey in America. However, many uncertainties still exist concerning the origin of the transfer and whether several transfers occurred. In this review, the most recent studies that addressed these questions using genetic and genomic approaches are presented.
    MeSH term(s) Biological Evolution ; Genome ; Humans ; Malaria/parasitology ; Plasmodium/genetics ; Plasmodium vivax/genetics
    Language English
    Publishing date 2022-05-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2091229-8
    ISSN 1475-2875 ; 1475-2875
    ISSN (online) 1475-2875
    ISSN 1475-2875
    DOI 10.1186/s12936-022-04132-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Population Genomic Evidence of Adaptive Response during the Invasion History of Plasmodium falciparum in the Americas.

    Lefebvre, Margaux J M / Daron, Josquin / Legrand, Eric / Fontaine, Michael C / Rougeron, Virginie / Prugnolle, Franck

    Molecular biology and evolution

    2023  Volume 40, Issue 5

    Abstract: Plasmodium falciparum, the most virulent agent of human malaria, spread from Africa to all continents following the out-of-Africa human migrations. During the transatlantic slave trade between the 16th and 19th centuries, it was introduced twice ... ...

    Abstract Plasmodium falciparum, the most virulent agent of human malaria, spread from Africa to all continents following the out-of-Africa human migrations. During the transatlantic slave trade between the 16th and 19th centuries, it was introduced twice independently to the Americas where it adapted to new environmental conditions (new human populations and mosquito species). Here, we analyzed the genome-wide polymorphisms of 2,635 isolates across the current P. falciparum distribution range in Africa, Asia, Oceania, and the Americas to investigate its genetic structure, invasion history, and selective pressures associated with its adaptation to the American environment. We confirmed that American populations originated from Africa with at least two independent introductions that led to two genetically distinct clusters, one in the North (Haiti and Colombia) and one in the South (French Guiana and Brazil), and an admixed Peruvian group. Genome scans revealed recent and more ancient signals of positive selection in the American populations. Particularly, we detected positive selection signals in genes involved in interactions with hosts (human and mosquito) cells and in genes involved in resistance to malaria drugs in both clusters. Analyses suggested that for five genes, adaptive introgression between clusters or selection on standing variation was at the origin of this repeated evolution. This study provides new genetic evidence on P. falciparum colonization history and on its local adaptation in the Americas.
    MeSH term(s) Humans ; Animals ; Plasmodium falciparum/genetics ; Metagenomics ; Malaria, Falciparum/genetics ; Americas ; Polymorphism, Genetic
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 998579-7
    ISSN 1537-1719 ; 0737-4038
    ISSN (online) 1537-1719
    ISSN 0737-4038
    DOI 10.1093/molbev/msad082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The enigmatic mechanisms by which Plasmodium vivax infects Duffy-negative individuals.

    Popovici, Jean / Roesch, Camille / Rougeron, Virginie

    PLoS pathogens

    2020  Volume 16, Issue 2, Page(s) e1008258

    Abstract: The absence of the Duffy protein at the surface of erythrocytes was considered for decades to confer full protection against Plasmodium vivax as this blood group is the receptor for the key parasite ligand P. vivax Duffy binding protein (PvDBP). However, ...

    Abstract The absence of the Duffy protein at the surface of erythrocytes was considered for decades to confer full protection against Plasmodium vivax as this blood group is the receptor for the key parasite ligand P. vivax Duffy binding protein (PvDBP). However, it is now clear that the parasite is able to break through this protection and induce clinical malaria in Duffy-negative people, although the underlying mechanisms are still not understood. Here, we briefly review the evidence of Duffy-negative infections by P. vivax and summarize the current hypothesis at the basis of this invasion process. We discuss those in the perspective of malaria-elimination challenges, notably in African countries.
    MeSH term(s) Africa ; Antigens, Protozoan/metabolism ; Duffy Blood-Group System/metabolism ; Humans ; Malaria, Vivax/metabolism ; Malaria, Vivax/prevention & control ; Plasmodium vivax/metabolism ; Plasmodium vivax/pathogenicity ; Protozoan Proteins/metabolism ; Receptors, Cell Surface/metabolism
    Chemical Substances Antigens, Protozoan ; Duffy Blood-Group System ; Duffy antigen binding protein, Plasmodium ; Protozoan Proteins ; Receptors, Cell Surface
    Language English
    Publishing date 2020-02-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1008258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correction: a population genetic perspective on the origin, spread and adaptation of the human malaria agents Plasmodium falciparum and Plasmodium vivax.

    Rougeron, Virginie / Boundenga, Larson / Arnathau, Céline / Durand, Patrick / Renaud, François / Prugnolle, Franck

    FEMS microbiology reviews

    2022  Volume 46, Issue 4

    Language English
    Publishing date 2022-06-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 283740-7
    ISSN 1574-6976 ; 0168-6445
    ISSN (online) 1574-6976
    ISSN 0168-6445
    DOI 10.1093/femsre/fuac021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: A population genetic perspective on the origin, spread and adaptation of the human malaria agents Plasmodium falciparum and Plasmodium vivax.

    Rougeron, Virginie / Boundenga, Larson / Arnathau, Céline / Durand, Patrick / Renaud, François / Prugnolle, Franck

    FEMS microbiology reviews

    2021  Volume 46, Issue 1

    Abstract: Malaria is considered one of the most important scourges that humanity has faced during its history, being responsible every year for numerous deaths worldwide. The disease is caused by protozoan parasites, among which two species are responsible of the ... ...

    Abstract Malaria is considered one of the most important scourges that humanity has faced during its history, being responsible every year for numerous deaths worldwide. The disease is caused by protozoan parasites, among which two species are responsible of the majority of the burden, Plasmodium falciparum and Plasmodium vivax. For these two parasite species, the questions of their origin (how and when they appeared in humans), of their spread throughout the world, as well as how they have adapted to humans have long been of interest to the scientific community. In this paper we review the existing body of knowledge, including current research dealing with these questions, focusing particularly on genetic and genomic analyses of these parasites and comparison with related Plasmodium species infecting other species of host (such as non-human primates).
    MeSH term(s) Animals ; Genetics, Population ; Humans ; Malaria/parasitology ; Malaria, Falciparum ; Plasmodium/genetics ; Plasmodium falciparum/genetics ; Plasmodium vivax/genetics
    Language English
    Publishing date 2021-11-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 283740-7
    ISSN 1574-6976 ; 0168-6445
    ISSN (online) 1574-6976
    ISSN 0168-6445
    DOI 10.1093/femsre/fuab047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article: Molecular Identification of Trypanosome Diversity in Domestic Animals Reveals the Presence of

    Boundenga, Larson / Mombo, Illich Manfred / Augustin, Mouinga-Ondeme / Barthélémy, Ngoubangoye / Nzassi, Patrice Makouloutou / Moukodoum, Nancy D / Rougeron, Virginie / Prugnolle, Franck

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 9

    Abstract: Human African Trypanosomiasis (HAT) is an infectious disease caused by protozoan parasites belonging to ... ...

    Abstract Human African Trypanosomiasis (HAT) is an infectious disease caused by protozoan parasites belonging to the
    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11090992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Molecular Identification of Trypanosome Diversity in Domestic Animals Reveals the Presence of Trypanosoma brucei gambiense in Historical Foci of Human African Trypanosomiasis in Gabon

    Boundenga, Larson / Mombo, Illich Manfred / Augustin, Mouinga-Ondeme / Barthélémy, Ngoubangoye / Nzassi, Patrice Makouloutou / Moukodoum, Nancy D. / Rougeron, Virginie / Prugnolle, Franck

    Pathogens. 2022 Aug. 30, v. 11, no. 9

    2022  

    Abstract: Human African Trypanosomiasis (HAT) is an infectious disease caused by protozoan parasites belonging to the Trypanosoma genus. In sub-Saharan Africa, there is a significant threat as many people are at risk of infection. Despite this, HAT is classified ... ...

    Abstract Human African Trypanosomiasis (HAT) is an infectious disease caused by protozoan parasites belonging to the Trypanosoma genus. In sub-Saharan Africa, there is a significant threat as many people are at risk of infection. Despite this, HAT is classified as a neglected tropical disease. Over the last few years, several studies have reported the existence of a wide diversity of trypanosome species circulating in African animals. Thus, domestic and wild animals could be reservoirs of potentially dangerous trypanosomes for human populations. However, very little is known about the role of domestic animals in maintaining the transmission cycle of human trypanosomes in central Africa, especially in Gabon, where serious cases of infection are recorded each year, sometimes leading to hospitalization or death of patients. Komo-Mondah, located within Estuaries (Gabonese province), stays the most active HAT disease focus in Gabon, with a mean of 20 cases per year. In this study, we evaluated the diversity and prevalence of trypanosomes circulating in domestic animals using the Polymerase Chain Reaction (PCR) technique. We found that 19.34% (53/274) of the domestic animals we studied were infected with trypanosomes. The infection rates varied among taxa, with 23.21% (13/56) of dogs, 16.10% (19/118) of goats, and 21.00% (21/100) of sheep infected. In addition, we have observed a global mixed rate of infections of 20.75% (11/53) among infected individuals. Molecular analyses revealed that at least six Trypanosome species circulate in domestic animals in Gabon (T. congolense, T. simiae, T. simiae Tsavo, T. theileri, T. vivax, T. brucei (including T. brucei brucei, and T. brucei gambiense)). In conclusion, our study showed that domestic animals constitute important potential reservoirs for trypanosome parasites, including T. brucei gambiense, which is responsible for HAT.
    Keywords African trypanosomiasis ; Trypanosoma gambiense ; death ; humans ; infectious diseases ; people ; polymerase chain reaction ; risk ; sheep ; tropical diseases ; Gabon
    Language English
    Dates of publication 2022-0830
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11090992
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Absence of Coronavirus RNA in Faecal Samples from Wild Primates in Gabon, Central Africa.

    Mombo, Illich Manfred / Rieu, Océane / Fritz, Matthieu / Boundenga, Larson / Mebaley, Telstar Ndong / Mbou-Boutambe, Clark / Lenguiya, Léadisaelle Hosanna / Maganga, Gael Darren / Rougeron, Virginie / Prugnolle, Franck / Thomas, Fredéric / Leroy, Eric M

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 10

    Abstract: Coronaviruses (CoVs, ...

    Abstract Coronaviruses (CoVs,
    Language English
    Publishing date 2023-10-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12101272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Detection of

    Imboumy-Limoukou, Roméo Karl / Biteghe-Bi-Essone, Jean-Claude / Lendongo Wombo, Judicael Boris / Lekana-Douki, Sonia Etenna / Rougeron, Virginie / Ontoua, Steede-Seinnat / Oyegue-Liabagui, Lydie Sandrine / Mbani Mpega Ntigui, Cherone Nancy / Kouna, Lady Charlène / Lekana-Douki, Jean-Bernard

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 20

    Abstract: Due to the difficulty of obtaining blood samples, which is the invasive method that is currently used for the detection ... ...

    Abstract Due to the difficulty of obtaining blood samples, which is the invasive method that is currently used for the detection of
    Language English
    Publishing date 2023-10-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13203271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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