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Article ; Online: Perceived barriers to the development of the antimicrobial stewardship role of the nurse in intensive care: Views of healthcare professionals.

Rout, J / Brysiewicz, P

The Southern African journal of critical care : the official journal of the Critical Care Society

2020 Volume 36, Issue 1

Abstract: Background: Antimicrobial stewardship has become an important initiative within intensive care units in the global fight against antimicrobial resistance. Support for nurses to participate in and actively direct antimicrobial stewardship interventions ... ...

Abstract	Background: Antimicrobial stewardship has become an important initiative within intensive care units in the global fight against antimicrobial resistance. Support for nurses to participate in and actively direct antimicrobial stewardship interventions is growing however, there may be barriers that impede the development of this nursing role. Objectives: To explore the views of healthcare professionals regarding barriers to the antimicrobial stewardship role of the nurse in intensive care in a private hospital in KwaZulu-Natal, South Africa. Methods: Using a qualitative research approach, purposive sampling was used to identify fifteen participants from the disciplines of nursing, surgery, anaesthetics, internal medicine, microbiology, and pharmacy in a general intensive care unit. Content analysis was used to code data obtained from each individual interview. Results: The following categories and subcategories were derived: regarding barriers to the role of the nurse in antimicrobial stewardship: (i) lack of collaboration (subcategories: not participating in the antimicrobial stewardship programme, no feedback about antimicrobial resistance in the unit, and not part of decision-making); (ii) inadequate knowledge (subcategories: not understanding infection prevention and control, missing the link between laboratory results and start of treatment, and poor knowledge of antibiotics and their administration); and (iii) inexperienced nurses (subcategories: shortage of intensive care nurses, lack of experienced nurses, and inadequate nursing staff to provide in-service training). Conclusion: The nursing role within antimicrobial stewardship was negatively affected by both staffing and collaborative difficulties, which impacted on the implementation of antimicrobial stewardship within the unit. Contributions of the study: Nurses are not well-integrated into antimicrobial stewardship. Insufficient training and education on aspects of antimicrobial stewardship are available to nurses.
Language	English
Publishing date	2020-07-30
Publishing country	South Africa
Document type	Journal Article
ZDB-ID	1218506-1
ISSN	2078-676X ; 1562-8264
ISSN (online)	2078-676X
ISSN	1562-8264
DOI	10.7196/SAJCC.2020.v36i1.410
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Article ; Online: Guidelines for the hospital role of the clinical nurse in antimicrobial stewardship: A scoping review.

Rout, J / Essack, S / Brysiewicz, P

The Southern African journal of critical care : the official journal of the Critical Care Society

2021 Volume 37, Issue 2

Abstract: Background: Antimicrobial stewardship aims to optimise the use of antimicrobial medicines to preserve the efficacy of these medicines and to contain antimicrobial resistance where possible. Nurses constitute the largest group of healthcare workers; ... ...

Abstract	Background: Antimicrobial stewardship aims to optimise the use of antimicrobial medicines to preserve the efficacy of these medicines and to contain antimicrobial resistance where possible. Nurses constitute the largest group of healthcare workers; however, the role played by nurses within current antimicrobial stewardship strategies is largely unacknowledged despite nurses being at point-of-care at the hospital bedside. Objectives: To identify recommendations for the antimicrobial stewardship role of the bedside nurse in key global antimicrobial stewardship guidelines. Methods: Scoping review methodology was used to systematically search published and 'grey' literature in PubMed, EBSCOhost, Google Scholar, government websites, and websites of professional societies and organisations. Search dates were 1990 to 2020. Inclusion criteria were English language antimicrobial stewardship guidelines for hospitals. Screening was conducted in two stages for title and abstract and then full text relevancy and documented according to the PRISMA Extension for Scoping Reviews. Results: Of the 1 824 articles that were retrieved, only 43 met the inclusion criteria. Inclusion of the bedside nurse on the antimicrobial stewardship team occurred in 13.9% ( Conclusion: This scoping review highlights a slow but incremental increase in recognition of the role of the bedside nurse within the operational hub of antimicrobial stewardship strategies. Contributions of the study: The present study was undertaken to fill the gap in the literature on clinical nurses' contribution in antimicrobial stewardship. The findings of the review largely demonstrate that multidisciplinary antimicrobial stewardship guidelines fail to view the bedside nurse as a contributor within antimicrobial stewardship strategies.
Language	English
Publishing date	2021-08-24
Publishing country	South Africa
Document type	Journal Article ; Review
ZDB-ID	1218506-1
ISSN	2078-676X ; 1562-8264
ISSN (online)	2078-676X
ISSN	1562-8264
DOI	10.7196/SAJCC.2021.v37i2.481
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Article ; Online: Guideline recommendations for antimicrobial stewardship education for clinical nursing practice in hospitals: A scoping review.

Rout, J / Essack, S / Brysiewicz, P

The Southern African journal of critical care : the official journal of the Critical Care Society

2021 Volume 37, Issue 3

Abstract: Background: Antimicrobial stewardship (AMS) is a proactive healthcare intervention to improve patient outcomes by optimising antimicrobial use. Although nursing involvement is a recognised necessity, bedside nurses may not yet possess competencies to ... ...

Abstract	Background: Antimicrobial stewardship (AMS) is a proactive healthcare intervention to improve patient outcomes by optimising antimicrobial use. Although nursing involvement is a recognised necessity, bedside nurses may not yet possess competencies to fulfil this role. Objectives: To identify recommendations for AMS education for the bedside nurse in key global AMS guidelines. Methods: Scoping review methodology was used to systematically search published and 'grey' literature in PubMed, EBSCOhost, Google Scholar, government websites and websites of professional societies and organisations. Search dates were from 1990 to 2020. Inclusion criteria were English language AMS guidelines for hospitals. Results: Literature searches retrieved 1 824 articles, with 43 meeting the review inclusion criteria. Reference was made to AMS nursing education in 23 (53.4%) of the articles. Educational opportunities for nurses were recommended: inclusion of AMS concepts/content into undergraduate and postgraduate nursing curricula (n=12; 27.9%), in-hospital training (n=14; 32.5%) and continuing professional development (n=6; 13.9%). Recommendations for nursing education were as follows: role of AMS in preventing antimicrobial resistance (n=7; 16.2%), infection prevention and control (n=3; 6.9%), diagnostics in AMS (n=5; 11.6%), pharmacology (n=11; 25.5%) and collaboration (n=2; 4.6%). Identified nursing educational gaps were: nurses not recognising their role within AMS (n=5; 11.6%), inadequate nursing resources and expertise for dosing, pharmacokinetic/pharmacodynamic strategies and managing possible drug incompatibilities with extended/prolonged infusions (n=3; 6.9%), and inappropriate nurse disposal of antibiotic waste (n=1; 2.3%). Conclusion: Although recommendations for nursing education were found in many key AMS guidelines, few guidelines provided detailed descriptions of the nursing competencies that were required for this role. Contributions of the study: This study serves to compile and highlight previously little-known recommendations within key international antimicrobial stewardship (AMS) guidelines for the education of clinical nurses in their AMS role. It provides a summary of expected clinical nurse competencies. It adds to current discussion within the literature on how to improve and support this critical nursing role.
Language	English
Publishing date	2021-12-31
Publishing country	South Africa
Document type	Journal Article ; Review
ZDB-ID	1218506-1
ISSN	2078-676X ; 1562-8264
ISSN (online)	2078-676X
ISSN	1562-8264
DOI	10.7196/SAJCC.2021.v37i3.482
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Article ; Online: Phytoconstituents of Ashwagandha as potential inhibitors of human islet amyloid polypeptide (hIAPP): an

Nandeshwar / Rout, Janmejaya / Panda, Smita Manjari / Tripathy, Umakanta

Journal of biomolecular structure & dynamics

2023 , Page(s) 1–17

Abstract: Amylin or human islet amyloid polypeptide (hIAPP) is a small peptide co-secreted with insulin. Its peripheral aggregation on the lipid bilayer leads to fibril formation. The formation of hIAPP fibrils is hypothesized to rupture the membrane of β -cells, ... ...

Abstract	Amylin or human islet amyloid polypeptide (hIAPP) is a small peptide co-secreted with insulin. Its peripheral aggregation on the lipid bilayer leads to fibril formation. The formation of hIAPP fibrils is hypothesized to rupture the membrane of β -cells, which culminates in β-cell death. Following additional studies, amylin fibril formation is a hallmark of T2DM and is also implicitly responsible for Alzheimer's disease. This study reports the virtual screening of 1000 phytoconstituents of traditional Indian medicinal plants to get potential inhibitors of amylin, which will likely restrict and block amyloid aggregation, preventing the progression of T2DM and Alzheimer's illness. The compounds having drug-likeness properties (acquired from ADMET calculations) and highest binding affinities (from molecular docking) are subjected to molecular dynamics (MD) simulation to investigate the temporal stability of the conformations of the complexes. This study discovers that Withaferin A and Withacoagulin have the highest binding affinity for amylin, and their stability with amylin was verified further by parameters such as RMSD, RMSF, number of H-bonds and MMPBSA. Individual principle component analysis (PCA) confirms the stable complex formation of amylin with Withaferin A and Withacoagulin. We strongly believe that wet-lab experiments and clinical trials will help to validate our computational findings.Communicated by Ramaswamy H. Sarma.
Language	English
Publishing date	2023-09-27
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2259491
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Article ; Online: Dark or light? Preference of anuran tadpoles to background illumination in response to food and predators.

Rout, Jasmin / Panda, Sujogya Kumar / Sahoo, Gunanidhi

Journal of biosciences

2023 Volume 48

Abstract: Background illumination and its intensity are crucial factors in visual interaction among organisms. In the present study, we used tadpoles of eight sympatric anuran species ( ...

Abstract	Background illumination and its intensity are crucial factors in visual interaction among organisms. In the present study, we used tadpoles of eight sympatric anuran species (
MeSH term(s)	Animals ; Anura/physiology ; Feeding Behavior ; Lighting ; Predatory Behavior ; Larva
Language	English
Publishing date	2023-07-26
Publishing country	India
Document type	Journal Article
ZDB-ID	756157-x
ISSN	0973-7138 ; 0250-5991
ISSN (online)	0973-7138
ISSN	0250-5991
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Article ; Online: Evaluation of intermittent antimicrobial infusion documentation practices in intensive care units: A cross-sectional study.

Allison Rout, Joan / Yusuf Essack, Sabiha / Brysiewicz, Petra

Intensive & critical care nursing

2023 Volume 79, Page(s) 103527

Abstract: Objective: To observe nurse administration of carbapenem antibiotics, in the context of medication safety measures, in intensive care units.: Research methodology/design: A quantitative study was conducted using observation principles.: Setting: ... ...

Abstract	Objective: To observe nurse administration of carbapenem antibiotics, in the context of medication safety measures, in intensive care units. Research methodology/design: A quantitative study was conducted using observation principles. Setting: Three adult private and public Intensive Care Units in the health district of a capital city in KwaZulu-Natal, South Africa. Main outcome measures: Nurse practices were observed for double-checking of the medication order, medication vial, and method of preparation and administration. Infusion bags were inspected for nurse labelling of medication and patient details. Patient medication treatment charts were inspected for nurse signature. Results: Carbapenem infusion administrations (n = 223) to twenty patients were observed. Adherence to the scheduled time occurred in 34.9% administrations, 5.4% doses were not given, and an incorrect dose given on 1.4% administrations. One hundred and forty-four (64.6%) infusion bags were inspected during the administrations: there was no medication label affixed to 21.5% bags, and only 8.3% of bags were labelled with essential details; the patient's name, drug, dose, date, time, signature of the nurse mixing and administering the dose, and signature of the secondary nurse. Conclusion: There was a lack of compliance with accepted medication risk mitigation measures. Sub-optimal double-checking resulted in the incorrect dose given, missed dose, and non-adherence to scheduled administration time. This has implications for the optimal administration of antimicrobial medications, raising concerns about the efficacy of treatment for critically ill patients. Implications for clinical practice: Parenteral administration errors pose a challenge in acute care areas. Risk mitigation measures include double-checking of medications. If antimicrobial treatment is not administered at the prescribed dosing intervals, this may have implications for the efficacy of time-dependent broad-spectrum antibiotics such as carbapenems. Medication administration errors involving antimicrobial medications should therefore be considered as high-risk errors, with the potential to contribute towards antimicrobial resistance.
MeSH term(s)	Adult ; Humans ; Cross-Sectional Studies ; South Africa ; Anti-Infective Agents ; Intensive Care Units ; Carbapenems ; Documentation
Chemical Substances	Anti-Infective Agents ; Carbapenems
Language	English
Publishing date	2023-08-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1105892-4
ISSN	1532-4036 ; 0964-3397
ISSN (online)	1532-4036
ISSN	0964-3397
DOI	10.1016/j.iccn.2023.103527
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Article ; Online: Are nursing infusion practices delivering full-dose antimicrobial treatment?

Rout, J / Essack, S / Brysiewicz, P

The Journal of antimicrobial chemotherapy

2019 Volume 74, Issue 12, Page(s) 3418–3422

Abstract: Antimicrobial stewardship (AMS) has developed over the past decade as a critical tool to promote the appropriate use of antimicrobials in order to contain antimicrobial resistance (AMR) and conserve antimicrobial medicines. Current literature supports ... ...

Abstract	Antimicrobial stewardship (AMS) has developed over the past decade as a critical tool to promote the appropriate use of antimicrobials in order to contain antimicrobial resistance (AMR) and conserve antimicrobial medicines. Current literature supports the role of the nurse in AMR, with a strong focus on the responsibilities of the nurse in infection prevention and control (IPC), both in the formal role of the IPC nurse specialist, and the more general IPC role of the bedside nurse. There is also growing support for the collaborative role of the nurse in the multidisciplinary AMS team. There is, however, very little literature examining the clinical practice role of the nurse in AMS. In this discussion, we contend that nursing practice may unknowingly contribute to AMR owing to varying methods of administration of intermittent intravenous infusions, resulting in under-dosing of antimicrobial medicines.
MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Antimicrobial Stewardship/methods ; Attitude of Health Personnel ; Dose-Response Relationship, Drug ; Humans ; Infection Control/methods ; Infusions, Intravenous/methods ; Nurse's Role ; Nurses ; Nursing/methods ; Surveys and Questionnaires
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2019-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkz365
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Article: Oral and Buccophryngeal Morphology of the Tadpoles of Polypedates maculatus with Notes on their Diet pattern

Rout, Jasmin / Mahapatra, Susmita / Sahoo, Gunanidhi

Current herpetology. 2022 Aug. 26, v. 41, no. 2

2022

Abstract: Oral morphological features and the diet of the tadpoles of Polypedates maculatus were described in this study. The tadpoles were collected from various water bodies of the state of Odisha over three consecutive breeding seasons (2018–2020). Oral and ... ...

Abstract	Oral morphological features and the diet of the tadpoles of Polypedates maculatus were described in this study. The tadpoles were collected from various water bodies of the state of Odisha over three consecutive breeding seasons (2018–2020). Oral and internal buccal characters were analysed independently for Gosner developmental stages 25 to 46. The upper labium has four labial tooth rows with a medial gap in the three rows proximal to the mouth, whereas the lower labium has three rows with a medial gap in the row proximal to the mouth. The order of length of denticle rows is A2>P1>P2>A1>P3>A3>A4 with a dental formula of A4(3)/P3(1). The food spectrum of the tadpoles included mostly phytoplanktons (represented by six classes and 51 genera) followed by zooplankton (two classes and four genera). Three Bacillariophyceae genera (Navicula, Pinnularia, and Synedra) contributed most of the gut contents. Scenedesmus was the major food items in Chlorophyceae family and had the highest numeric frequency (7.63%) among all the food items. Other prevalent food items included Zygnematophyceae, Cyanophyceae, Euglenophyceae, Rotifera, Ulvophyceae and Copepoda.
Keywords	Conjugatophyceae ; Copepoda ; Cyanophyceae ; Euglenophyceae ; Navicula ; Pinnularia ; Polypedates ; Rotifera ; Scenedesmus ; Synedra ; Ulvophyceae ; diet ; eating habits ; herpetology ; mouth
Language	English
Dates of publication	2022-0826
Size	p. 180-195.
Publishing place	UniBio Press
Document type	Article
ZDB-ID	2276299-1
ISSN	1881-1019 ; 1345-5834
ISSN (online)	1881-1019
ISSN	1345-5834
DOI	10.5358/hsj.41.180
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Efficient biodegradation of low-density polyethylene by cyanobacteria isolated from submerged polyethylene surface in domestic sewage water.

Sarmah, Pampi / Rout, Jayashree

Environmental science and pollution research international

2018 Volume 25, Issue 33, Page(s) 33508–33520

Abstract: Two dominant cyanobacterial species, Phormidium lucidum and Oscillatoria subbrevis, isolated from submerged polyethylene carry bags in domestic sewage water were found to be capable of degrading low-density polyethylene (LDPE) sheets efficiently. The FT- ... ...

Abstract	Two dominant cyanobacterial species, Phormidium lucidum and Oscillatoria subbrevis, isolated from submerged polyethylene carry bags in domestic sewage water were found to be capable of degrading low-density polyethylene (LDPE) sheets efficiently. The FT-IR, SEM, NMR, CHN content, thermal, and tensile strength of PE were monitored for structural, morphological, and chemical changes of PE. The CHN analysis corroborated about 4% carbon utilization by the cyanobacterial species from the PE. The rapid growth of cyanobacterial species on the PE surface suggested that the microorganisms continued to gain energy from the PE. The reduction in lamellar thickness, weight, and crystallinity of the cyanobacterial-treated PE pointed to an efficient biodegradation process without any pro-oxidant additives or pretreatment. Alteration in bond indices computed from FT-IR spectroscopy revealed changes in functional group and side chain features indicating biodegradation. The enhanced laccase and manganese peroxidase activity corroborated the biodegradation. The
MeSH term(s)	Biodegradation, Environmental ; Cyanobacteria/growth & development ; Environmental Pollutants/analysis ; Models, Theoretical ; Polyethylene/analysis ; Sewage/microbiology ; Surface Properties ; Waste Management/methods
Chemical Substances	Environmental Pollutants ; Sewage ; Polyethylene (9002-88-4)
Language	English
Publishing date	2018-09-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-018-3079-7
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Article ; Online: Interaction of vitamin B12 with β-lactoglobulin: a computational study.

Swain, Bikash Chandra / Rout, Janmejaya / Tripathy, Umakanta

Journal of biomolecular structure & dynamics

2020 Volume 40, Issue 5, Page(s) 2146–2155

Abstract: The β-Lactoglobulin (βLG) is a major whey protein that has the potential to bind various ligands; hence it is used as a model protein in protein-ligand interaction studies. Vitamin B12 is an essential nutrient for the human body, which helps in the ... ...

Abstract	The β-Lactoglobulin (βLG) is a major whey protein that has the potential to bind various ligands; hence it is used as a model protein in protein-ligand interaction studies. Vitamin B12 is an essential nutrient for the human body, which helps in the synthesis of DNA, proteins, and the production of red blood cells. Binding interaction of vitamin B12 with βLG will help to understand the potency of βLG as a transporter for vitamin B12. Our experimental findings already showed that βLG binds with vitamin B12 successfully (Swain et al., 2020). Nevertheless, to further support our experimental results firmly, here, we have employed computational tools such as molecular docking and molecular dynamics (MD) simulation. The molecular docking technique was used to elucidate the probable binding sites and binding affinity of vitamin B12 on βLG. The docked complex of vitamin B12 with βLG was subjected to MD simulation to investigate its stability and other interaction properties over a time frame. The study revealed that the compound is stable, and vitamin B12 imposes no change to the secondary structure of the βLG. The computational results agree reasonably well with our experimental study.
MeSH term(s)	Binding Sites ; Humans ; Lactoglobulins/chemistry ; Molecular Docking Simulation ; Protein Binding ; Vitamin B 12/chemistry ; Vitamin B 12/metabolism
Chemical Substances	Lactoglobulins ; Vitamin B 12 (P6YC3EG204)
Language	English
Publishing date	2020-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2020.1835731
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