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  1. Article ; Online: Resurgence of Cholera in Haiti amidst Humanitarian Crises.

    Severe, Karine / Alcenat, Nadalette / Rouzier, Vanessa

    The New England journal of medicine

    2022  

    Language English
    Publishing date 2022-11-30
    Publishing country United States
    Document type Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2213782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical outcomes and risk factors for immune recovery and all-cause mortality in Latin Americans living with HIV with virological success: a retrospective cohort study.

    Castillo-Rozas, Gabriel / Tu, Shengxin / Luz, Paula Mendes / Mejia, Fernando / Sierra-Madero, Juan / Rouzier, Vanessa / Shepherd, Bryan E / Cortes, Claudia P

    Journal of the International AIDS Society

    2024  Volume 27, Issue 3, Page(s) e26214

    Abstract: Introduction: Immune reconstitution following antiretroviral therapy (ART) initiation is crucial to prevent AIDS and non-AIDS-related comorbidities. Patients with suppressed viraemia who fail to restore cellular immunity are exposed to an increased risk ...

    Abstract Introduction: Immune reconstitution following antiretroviral therapy (ART) initiation is crucial to prevent AIDS and non-AIDS-related comorbidities. Patients with suppressed viraemia who fail to restore cellular immunity are exposed to an increased risk of morbidity and mortality during long-term follow-up, although the underlying mechanisms remain poorly understood. We aim to describe clinical outcomes and factors associated with the worse immune recovery and all-cause mortality in people living with HIV (PLWH) from Latin America following ART initiation.
    Methods: Retrospective cohort study using the CCASAnet database: PLWH ≥18 years of age at ART initiation using a three drug-based combination therapy and with medical follow-up for ≥24 months after ART initiation and undetectable viral load were included. Patients were divided into four immune recovery groups based on rounded quartiles of increase in CD4 T-cell count at 2 years of treatment (<150, [150, 250), [250, 350] and >350 cells/mm
    Results: In our cohort of 4496 Latin American PLWH, we found that patients with the lowest CD4 increase (<150) had the lowest survival probability at 10 years of follow-up. Lower increase in CD4 count following therapy initiation (and remarkably not a lower baseline CD4 T-cell count) and older age were risk factors for all-cause mortality. We also found that older age, male sex and higher baseline CD4 T-cell count were associated with lower CD4 count increase following therapy initiation.
    Conclusions: Our study shows that PLWH with lower increases in CD4 count have lower survival probabilities. CD4 increase during follow-up might be a better predictor of mortality in undetectable PLWH than baseline CD4 count. Therefore, it should be included as a routine clinical variable to assess immune recovery and overall survival.
    MeSH term(s) Humans ; Male ; Retrospective Studies ; HIV Infections ; Acquired Immunodeficiency Syndrome/drug therapy ; Risk Factors ; Drug Therapy, Combination ; CD4 Lymphocyte Count ; Viral Load ; Anti-HIV Agents/therapeutic use ; Antiretroviral Therapy, Highly Active
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2024-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2467110-1
    ISSN 1758-2652 ; 1758-2652
    ISSN (online) 1758-2652
    ISSN 1758-2652
    DOI 10.1002/jia2.26214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Facing the Monster in Haiti.

    Rouzier, Vanessa / Liautaud, Bernard / Deschamps, Marie Marcelle

    The New England journal of medicine

    2020  Volume 383, Issue 1, Page(s) e4

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Developing Countries ; Haiti/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Public Health Practice ; SARS-CoV-2 ; Tuberculosis, Pulmonary/complications
    Keywords covid19
    Language English
    Publishing date 2020-06-16
    Publishing country United States
    Document type Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2021362
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  4. Article ; Online: The impact of earthquakes in Latin America on the continuity of HIV care: A retrospective observational cohort study.

    Gorsline, Chelsea A / Lotspeich, Sarah C / Belaunzarán-Zamudio, Pablo F / Mejia, Fernando / Cortes, Claudia P / Crabtree-Ramírez, Brenda / Severe, Damocles Patrice / Rouzier, Vanessa / McGowan, Catherine C / Rebeiro, Peter F

    Public health in practice (Oxford, England)

    2024  Volume 7, Page(s) 100479

    Abstract: Objectives: As earthquakes occur frequently in Latin America and can cause significant disruptions in HIV care, we sought to analyze patterns of HIV care for adults at Latin American clinical sites experiencing a significant earthquake within the past ... ...

    Abstract Objectives: As earthquakes occur frequently in Latin America and can cause significant disruptions in HIV care, we sought to analyze patterns of HIV care for adults at Latin American clinical sites experiencing a significant earthquake within the past two decades.
    Study design: Retrospective clinical cohort study.
    Methods: Adults receiving HIV care at sites experiencing at least a "moderate intensity" (Modified Mercalli scale) earthquake in the Caribbean, Central and South America network for HIV epidemiology (CCASAnet) contributed data from 2003 to 2017. Interrupted Time Series models were fit with discontinuities at site-specific earthquake dates (Sept. 16, 2015 in Chile; Apr. 18, 2014 and Sept. 19, 2017 in Mexico; and Aug. 15, 2007 in Peru) to assess clinical visit, CD4 measure, viral load lab, and ART initiation rates 3- and 6-months after versus before earthquakes.
    Results: Comparing post-to pre-earthquake periods, there was a sharp drop in median visit (incidence rate ratio [IRR] = 0.79, 95% confidence interval [CI]: 0.68-0.91) and viral load lab (IRR = 0.78, 95% CI: 0.62-0.99) rates per week, using a 3-month window. CD4 measurement rates also decreased (IRR = 0.43; 95% CI: 0.37-0.51), though only using a 6-month window.
    Conclusions: Given that earthquakes occur frequently in Latin America, disaster preparedness plans must be more broadly implemented to avoid disruptions in HIV care and attendant poor outcomes.
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ISSN 2666-5352
    ISSN (online) 2666-5352
    DOI 10.1016/j.puhip.2024.100479
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  5. Article: Pediatric Tuberculosis Research and Development: Progress, Priorities and Funding Opportunities

    McKenna, Lindsay / Sari, Ani Herna / Mane, Sushant / Scardigli, Anna / Brigden, Grania / Rouzier, Vanessa / Becerra, Mercedes C. / Hesseling, Anneke C. / Amanullah, Farhana

    Pathogens. 2022 Jan. 21, v. 11, no. 2

    2022  

    Abstract: In this article, we highlight technological pediatric TB research advances across the TB care cascade; discuss recently completed or ongoing work in adults and corresponding significant research gaps for children; and offer recommendations and ... ...

    Abstract In this article, we highlight technological pediatric TB research advances across the TB care cascade; discuss recently completed or ongoing work in adults and corresponding significant research gaps for children; and offer recommendations and opportunities to increase investments and accelerate pediatric TB R&D.
    Keywords adults ; children ; funding ; pathogens ; research and development ; tuberculosis
    Language English
    Dates of publication 2022-0121
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11020128
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Embracing oral cholera vaccine--shifting response to cholera.

    Pape, Jean William / Rouzier, Vanessa

    The New England journal of medicine

    2014  Volume 370, Issue 22, Page(s) 2067–2069

    MeSH term(s) Administration, Oral ; Cholera/prevention & control ; Cholera Vaccines/economics ; Drug Approval ; Female ; Global Health ; Humans ; Infant ; Pregnancy ; Sanitation/economics ; World Health Organization
    Chemical Substances Cholera Vaccines
    Language English
    Publishing date 2014-05-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp1402837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Prevalence and Severity of Chronic Kidney Disease in Haiti.

    Roberts, Nicholas L S / Pierre, Jean L / Rouzier, Vanessa / Sufra, Rodney / St-Preux, Stefano / Yan, Lily D / Metz, Miranda / Clermont, Adrienne / Apollon, Alexandra / Sabwa, Shalom / Deschamps, Marie M / Kingery, Justin R / Peck, Robert / Fitzgerald, Daniel / Pape, Jean W / Tummalapalli, Sri Lekha / McNairy, Margaret L

    Clinical journal of the American Society of Nephrology : CJASN

    2023  Volume 18, Issue 6, Page(s) 739–747

    Abstract: Background: CKD is a major cause of morbidity and mortality in lower-income countries. However, population-based studies characterizing the epidemiology of CKD in these settings are lacking. The study objective was to describe the epidemiology of CKD in ...

    Abstract Background: CKD is a major cause of morbidity and mortality in lower-income countries. However, population-based studies characterizing the epidemiology of CKD in these settings are lacking. The study objective was to describe the epidemiology of CKD in a population-based cohort in urban Haiti, including estimates of the prevalence by CKD stage, the magnitude of associated factors with CKD, and the proportion on guideline-recommended treatment.
    Methods: We assessed the prevalence of CKD and associated risk factors in the population-based Haiti Cardiovascular Disease Cohort. We analyzed cross-sectional data from 2424 adults who completed a clinical examination, risk factor surveys, and laboratory measurements for serum creatinine, urinary albumin, and urinary creatinine. We compared our results with US estimates from the National Health and Nutrition Examination Survey. CKD was defined as either a reduced eGFR <60 ml/min per 1.73 m 2 or urinary albumin-to-creatinine ratio ≥30 mg/g according to the Kidney Disease Improving Global Outcomes guidelines. Multivariable logistic regression identified associated factors with CKD.
    Results: The mean age was 42 years, 57% of participants were female, and 69% lived in extreme poverty on ≤1 US dollar per day. The age-standardized prevalence of CKD was 14% (95% confidence interval [CI], 12% to 15%). The age-standardized prevalence of reduced eGFR and elevated urinary albumin-to-creatinine ratio was 3% (95% CI, 2% to 4%) and 11% (95% CI, 10% to 13%), respectively. Diabetes (adjusted odds ratio, 4.1; 95% CI, 2.7 to 6.2) and hypertension (adjusted odds ratio, 2.9; 95% CI, 2.0 to 4.2) were significantly associated with CKD. Only 12% of participants with CKD and albuminuria were on guideline-recommended agents, such as angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers.
    Conclusions: In a large population-based cohort of Haitian adults, CKD was highly associated with both diabetes and hypertension. The proportion of participants with CKD on treatment was low, underscoring the need for strengthening clinical management and nephrology care health infrastructure in Haiti.
    Clinical trial registry name and registration number: A Longitudinal Cohort Study to Evaluate Cardiovascular Risk Factors and Disease in Haiti, NCT03892265 .
    MeSH term(s) Adult ; Humans ; Female ; Male ; Haiti/epidemiology ; Prevalence ; Creatinine ; Nutrition Surveys ; Longitudinal Studies ; Cross-Sectional Studies ; Glomerular Filtration Rate ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/complications ; Diabetes Mellitus/epidemiology ; Risk Factors ; Hypertension/epidemiology ; Hypertension/complications ; Albumins ; Albuminuria/urine
    Chemical Substances Creatinine (AYI8EX34EU) ; Albumins
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.0000000000000175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Pediatric Tuberculosis Research and Development: Progress, Priorities and Funding Opportunities.

    McKenna, Lindsay / Sari, Ani Herna / Mane, Sushant / Scardigli, Anna / Brigden, Grania / Rouzier, Vanessa / Becerra, Mercedes C / Hesseling, Anneke C / Amanullah, Farhana

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 2

    Abstract: In this article, we highlight technological pediatric TB research advances across the TB care cascade; discuss recently completed or ongoing work in adults and corresponding significant research gaps for children; and offer recommendations and ... ...

    Abstract In this article, we highlight technological pediatric TB research advances across the TB care cascade; discuss recently completed or ongoing work in adults and corresponding significant research gaps for children; and offer recommendations and opportunities to increase investments and accelerate pediatric TB R&D.
    Language English
    Publishing date 2022-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11020128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Extreme Food Insecurity and Malnutrition in Haiti: Findings from a Population-Based Cohort in Port-au-Prince, Haiti.

    Rasul, Rehana / Rouzier, Vanessa / Sufra, Rodney / Yan, Lily D / Joseph, Inddy / Mourra, Nour / Sabwa, Shalom / Deschamps, Marie M / Fitzgerald, Daniel W / Pape, Jean W / Nash, Denis / McNairy, Margaret L

    Nutrients

    2022  Volume 14, Issue 22

    Abstract: Haiti is one of the most food-insecure (FIS) nations in the world, with increasing rates of overweight and obesity. This study aimed to characterize FIS among households in urban Haiti and assess the relationship between FIS and body mass index (BMI) ... ...

    Abstract Haiti is one of the most food-insecure (FIS) nations in the world, with increasing rates of overweight and obesity. This study aimed to characterize FIS among households in urban Haiti and assess the relationship between FIS and body mass index (BMI) using enrollment data from the Haiti Cardiovascular Disease Cohort Study. FIS was characterized as no/low, moderate/high, and extreme based on the Household Food Security Scale. Multinomial logistic generalized estimating equations were used to evaluate the association between FIS categories and BMI, with obesity defined as BMI ≥ 30 kg/m
    MeSH term(s) Humans ; Cohort Studies ; Food Supply ; Haiti/epidemiology ; Food Insecurity ; Malnutrition/epidemiology ; Obesity/epidemiology
    Language English
    Publishing date 2022-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14224854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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