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  1. Article ; Online: Le indicazioni al trattamento chirurgico dell’infarto miocardico e delle sue complicanze [riprodotto da G Ital Cardiol 1971;1:1-7].

    Rovelli, Fausto

    Giornale italiano di cardiologia (2006)

    2021  Volume 22, Issue 3, Page(s) 181–187

    Title translation Indications for surgical treatment of acute myocardial infarct and its complications [reproduced from G Ital Cardiol 1971;1:1-7].
    MeSH term(s) Humans ; Myocardial Infarction
    Language Italian
    Publishing date 2021-03-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/3557.35335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Considerazioni sull'articolo di A. Masoni (Medici e medicina: cosa è cambiato) e sulla replica di C. Vecchio (Essere medici oggi).

    Rovelli, F

    Giornale italiano di cardiologia

    1996  Volume 26, Issue 11, Page(s) 1337–1338

    Title translation Considerations on the article by A. Masoni (Physicians and medicine: what has changed) and the reply by C. Vecchio (To be physician today).
    MeSH term(s) Clinical Trials as Topic ; Ethics, Medical ; Physician-Patient Relations ; Physicians/trends
    Language Italian
    Publishing date 1996-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 184670-x
    ISSN 0046-5968
    ISSN 0046-5968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Principles of psychoneuroendocrinoimmunotherapy of cancer.

    Lissoni, Paolo / Rovelli, Franco

    Immunotherapy

    2012  Volume 4, Issue 1, Page(s) 77–86

    Abstract: Recent advances in the knowledge of the mechanisms responsible for antitumor immunity have stimulated the elaboration of new cancer immunotherapeutic strategies. Moreover, more recent discoveries have demonstrated that immune responses are under a ... ...

    Abstract Recent advances in the knowledge of the mechanisms responsible for antitumor immunity have stimulated the elaboration of new cancer immunotherapeutic strategies. Moreover, more recent discoveries have demonstrated that immune responses are under a physiological modulatory control played by several neuroendocrine pathways, which explain the differences between the in vivo and in vitro immune responses. While until a few years ago the evaluation of the immune status of cancer patients was substantially established on the basis of clinical empirical criteria, recent discoveries of the antitumor cytokine network have allowed the biochemical bases of anticancer immunity to be defined, leading to new anticancer immunotherapeutic strategies, on the basis of patient neuroendocrine and neuroimmune status, in an attempt to correct the great number of cancer-related alterations on the basis of knowledge of the physiopathology of anticancer immunity. The rationale for cancer neuroimmunotherapy consists of the possibility to enhance the efficacy of the various immunotherapeutic strategies by a concomitant administration of antitumor cytokines (namely IL-2), in addition to neuroendocrine endogenous molecules (namely the pineal indole hormones), able to stimulate the anticancer immunoresponse by amplifying the anticancer reaction and/or by counteracting the generation of immunosuppressive events.
    MeSH term(s) 5-Methoxytryptamine/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cannabinoid Receptor Modulators/administration & dosage ; Humans ; Immunotherapy/methods ; Immunotherapy/trends ; Interleukin-2/administration & dosage ; Melatonin/administration & dosage ; Naltrexone/administration & dosage ; Neoplasms/immunology ; Neoplasms/therapy ; Neurosecretory Systems/immunology
    Chemical Substances Cannabinoid Receptor Modulators ; Interleukin-2 ; 5-Methoxytryptamine (3VMW6141KC) ; Naltrexone (5S6W795CQM) ; Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2012-01
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1750-7448
    ISSN (online) 1750-7448
    DOI 10.2217/imt.11.158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Modulation of cytokine production from TH2-lymphocytes and monocytes by the pineal neurohormone melatonin.

    Lissoni, P / Pittalis, S / Rovelli, F / Roselli, M / Ardizzoia, A

    Oncology reports

    2011  Volume 3, Issue 3, Page(s) 541–543

    Abstract: Preliminary clinical and experimental studies have suggested that cytokine secretion is not regulated only by immune substances, but also by the neuroendocrine system through the release of immunomodulating neurohormones, such as the pineal hormone ... ...

    Abstract Preliminary clinical and experimental studies have suggested that cytokine secretion is not regulated only by immune substances, but also by the neuroendocrine system through the release of immunomodulating neurohormones, such as the pineal hormone melatonin (MLT). The anticancer immune response would also depend on complex interactions between cytokines and neurohormones. IL-2 is one of the most active antitumor cytokines. However, in addition to the generation of cytotoxic antitumor lymphocytes, IL-2 may concomitantly induce suppressive factors, in particular IL-10 by TH2 lymphocytes and IL-6 by both TH2 lymphocytes and monocytes. IL-10 appeared to inhibit IL-2 secretion and activity, whereas IL-6 has been proven to exert both antineoplastic and proneoplastic immune functions. The present experimental study was performed to evaluate the in vitro effects of MLT on IL-10 and IL-6 secretions, either in basal condition or after IL;2 stimulation. Human pure lymphocyte and pure monocyte cultures were obtained from healthy donors and incubated for 3 days with medium alone, MLT (100 pg/ml), IL-2 (100 Cetus U/ml) or IL-2 plus MLT. IL-2 induced a significant increase in mean medium concentrations of both IL-10 and IL-6. MLT alone had no effect on IL-10 levels, but it was able to significantly reduce IL-2-induced IL-10 release. IL-2-induced IL-6 secretion was not abrogated by a concomitant MLT incubation, whereas MLT alone was able to significantly reduce the basal secretion of IL-6 only in the pure monocyte cultures. These results, by showing a modulatory effect of MLT on lymphocyte and monocyte cytokine secretion, would further confirm the rationale of a concomitant administration of cytokines and immunomodulating neurohormones during cancer immunotherapies.
    Language English
    Publishing date 2011-05-18
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1222484-4
    ISSN 1791-2431 ; 1021-335X
    ISSN (online) 1791-2431
    ISSN 1021-335X
    DOI 10.3892/or.3.3.541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4213: Show issues Location:
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  5. Article ; Online: Predictors of Responsiveness to Bisphosphonate Treatment in Patients with Complex Regional Pain Syndrome Type I: A Retrospective Chart Analysis.

    Varenna, Massimo / Manara, Maria / Rovelli, Francesca / Zucchi, Francesca / Sinigaglia, Luigi

    Pain medicine (Malden, Mass.)

    2016  Volume 18, Issue 6, Page(s) 1131–1138

    Abstract: Objective: The aim of this study was to assess whether the effectiveness of bisphosphonate infusion in patients with complex regional pain syndrome type I (CRPS-I) is influenced by variables related to patient and/or disease characteristics.: Methods!# ...

    Abstract Objective: The aim of this study was to assess whether the effectiveness of bisphosphonate infusion in patients with complex regional pain syndrome type I (CRPS-I) is influenced by variables related to patient and/or disease characteristics.
    Methods: This is a retrospective analysis of patients referred in the last five years to our rheumatologic tertiary care center, all fulfilling the Budapest CRPS-I diagnostic criteria and treated with three different bisphosphonate schedules (clodronate, pamidronate, and neridronate). For every subject, demographic and clinical variables were retrieved and retrospectively analyzed. We identified variables that independently influenced the therapeutic outcome of patients by a logistic regression analysis. For exploratory purposes, the effectiveness of the different bisphosphonate treatments employed was compared.
    Results: Among the 194 patients included in the analysis, the overall therapeutic response rate was 71.6%. Logistic regression analysis showed that the independent predictive variables for therapeutic effectiveness were disease duration (odds ratio [OR] = 0.83, 95% confidence interval [CI] = 0.72-0.96 for a one-month increment), fracture as a predisposing event (OR = 3.23, 95% CI = 1.29-8.03), and "warm" disease subtype (OR = 4.88, 95% CI = 1.57-15.20). These variables were found to influence the odds of responsiveness when analyzed together with age at onset, gender, and disease localization. No significant difference in therapeutic effectiveness was found by comparing the three different bisphosphonate schedules employed.
    Conclusion: Early disease, fracture as a predisposing event, and "warm" disease subtype are predictors of responsiveness to bisphosphonate treatment in patients with CRPS-I.
    MeSH term(s) Adult ; Aged ; Bone Density Conservation Agents/therapeutic use ; Diphosphonates/therapeutic use ; Electronic Health Records/trends ; Female ; Humans ; Male ; Middle Aged ; Pain Measurement/drug effects ; Pain Measurement/methods ; Predictive Value of Tests ; Reflex Sympathetic Dystrophy/diagnosis ; Reflex Sympathetic Dystrophy/drug therapy ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Bone Density Conservation Agents ; Diphosphonates
    Language English
    Publishing date 2016-09-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1093/pm/pnw207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6119: Show issues Location:
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  6. Article: L'esperienza Italiana sulla trombolisi nell'infarto miocardico. Considerazioni sui dati del GISSI.

    Rovelli, F

    Giornale italiano di cardiologia

    1985  Volume 15, Issue 12, Page(s) 1117–1120

    Title translation The Italian experience on the thrombolysis of myocardial infarct. Considerations on data from the Italian Group for the Testing of Streptokinase in Infarct.
    MeSH term(s) Clinical Trials as Topic ; Humans ; Italy ; Myocardial Infarction/drug therapy ; Prognosis ; Recurrence ; Streptokinase/therapeutic use
    Chemical Substances Streptokinase (EC 3.4.-)
    Language Italian
    Publishing date 1985-12
    Publishing country Italy
    Document type Clinical Trial ; Journal Article
    ZDB-ID 184670-x
    ISSN 0046-5968
    ISSN 0046-5968
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    Zs.A 761: Show issues Location:
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  7. Article: Il cardiologo di fronte agli esiti cicatriziali post-infartuali.

    Rovelli, F

    Giornale italiano di cardiologia

    1985  Volume 15, Issue 3, Page(s) 341–342

    Title translation The cardiologist's point of view toward post-infarction scars.
    MeSH term(s) Cicatrix ; Humans ; Myocardial Infarction/complications
    Language Italian
    Publishing date 1985-03
    Publishing country Italy
    Document type Editorial
    ZDB-ID 184670-x
    ISSN 0046-5968
    ISSN 0046-5968
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    Zs.A 761: Show issues Location:
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  8. Article ; Online: Cancer as the main aging factor for humans: the fundamental role of 5-methoxy-tryptamine in reversal of cancer-induced aging processes in metabolic and immune reactions by non-melatonin pineal hormones.

    Lissoni, Paolo / Messina, Giuseppina / Rovelli, Franco

    Current aging science

    2013  Volume 5, Issue 3, Page(s) 231–235

    Abstract: Aging and advanced cancer are characterized by similar neuroendocrine and immune deficiencies; the most important of them consist of diminished nocturnal production of the pineal hormone melatonin (MLT) and decreased production of IL-2. At present, ... ...

    Abstract Aging and advanced cancer are characterized by similar neuroendocrine and immune deficiencies; the most important of them consist of diminished nocturnal production of the pineal hormone melatonin (MLT) and decreased production of IL-2. At present, however, it is known that the pineal gland may produce indole hormones other than MLT. The most investigated of them is represented by 5-methoxy-tryptamine (5-MTT), which may exert antitumor, anticachectic, and immunomodulating effects under experimental conditions, in addition to those effects produced by MLT itself. In an attempt to obtain some preliminary data in human subjects about the potential therapeutic properties of 5-MTT, three different studies of 5-MTT have been carried out in advanced solid tumor patients. The first study of MLT plus 5-MTT included 14 thrombocytopenic cancer patients who did not respond to MLT alone. In the second study we have compared the clinical efficacy of MLT plus 5-MTT in a group of 25 untreatable metastatic cancer patients to the results obtained in a control group of 25 cancer patients receiving MLT alone. Finally, the third study of MLT plus 5-MTT included 14 untreatable metastatic cancer patients who did not respond to MLT alone. In all of these studies, MLT and 5-MTT were given orally at the level of 20 mg/day in the evening and at 5 mg/day during the period of maximum light. A normalization of platelet number was achieved by MLT plus 5-MTT in 5 of 14 (36%) thrombocytopenic cancer patients who did not respond to MLT alone. The percentage of disease control obtained by MLT plus 5-MTT in untreatable metastatic cancer patients was significantly higher than that achieved by MLT alone (15/25 [60%] vs. 8/25 [32%], P < 0.05). Finally, the association of 5-MTT with MLT induced disease stabilization in 4 of 14 (29%) untreatable metastatic cancer patients who did not respond to MLT alone.
    MeSH term(s) 5-Methoxytryptamine/administration & dosage ; 5-Methoxytryptamine/metabolism ; Administration, Oral ; Age Factors ; Aging/metabolism ; Aging/pathology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chi-Square Distribution ; Drug Administration Schedule ; Female ; Humans ; Male ; Melatonin/administration & dosage ; Melatonin/metabolism ; Neoplasms/blood ; Neoplasms/drug therapy ; Neoplasms/pathology ; Pineal Gland/metabolism ; Platelet Count ; Retrospective Studies ; Thrombocytopenia/drug therapy ; Thrombocytopenia/metabolism ; Thrombopoiesis/drug effects ; Time Factors ; Treatment Outcome
    Chemical Substances 5-Methoxytryptamine (3VMW6141KC) ; Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2013-02-18
    Publishing country United Arab Emirates
    Document type Clinical Trial, Phase II ; Journal Article
    ISSN 1874-6128
    ISSN (online) 1874-6128
    DOI 10.2174/1874609811205030010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Psychoimmunological analysis of cancer patients: correlation with the prognosis.

    Messina, Giuseppina / Lissoni, Paolo / Rovelli, Franco

    Current aging science

    2013  Volume 5, Issue 3, Page(s) 263–272

    Abstract: Thanks to the discoveries of psychoneuroendocrinoimmunology, we now know that every psychological state is mediated by a specific neurochemical condition and every neurochemical change in turn influences psychological status. We can now identify three ... ...

    Abstract Thanks to the discoveries of psychoneuroendocrinoimmunology, we now know that every psychological state is mediated by a specific neurochemical condition and every neurochemical change in turn influences psychological status. We can now identify three different levels of neurochemical mediation of the psychological states: neurotransmission, neuromodulation, and the psychoneuromodulation. Neurotransmission is composed of five main neural pathways, noradrenaline, acetylcholine, dopamine, serotonin, and histamine; neuromodulation; and the psychoneuromodulation. We have performed several clinical studies in an attempt to correlate the psychological status of cancer patients with the immune alterations characteristic of the clinical history of neoplastic disease. We have studied the immunologic status by evaluating cytokine blood levels and the lymphocyte subpopulation; the psychological status was assessed by the Rorschach's test; and spiritual status was evaluated by a previously published test to explore spiritual faith. These preliminary psychological studies seem to suggest that a pre-treatment analysis of psychological and spiritual status may predict the efficacy of both chemotherapy and immunotherapy in advanced cancer patients.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Anxiety/etiology ; Biomarkers/blood ; Chi-Square Distribution ; Cytokines/blood ; Depression/etiology ; Disease Progression ; Female ; Humans ; Immunotherapy/methods ; Lymphocyte Count ; Lymphocyte Subsets/immunology ; Male ; Mental Health ; Middle Aged ; Neoplasms/blood ; Neoplasms/complications ; Neoplasms/immunology ; Neoplasms/mortality ; Neoplasms/psychology ; Neoplasms/therapy ; Predictive Value of Tests ; Repression, Psychology ; Rorschach Test ; Sexuality ; Spirituality ; Survival Analysis ; Time Factors ; Treatment Outcome
    Chemical Substances Biomarkers ; Cytokines
    Language English
    Publishing date 2013-03-05
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1874-6128
    ISSN (online) 1874-6128
    DOI 10.2174/1874609811205030014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Nuove tecniche nel trattamento della insufficienza coronarica. Conclusioni.

    Rovelli, F

    Giornale italiano di cardiologia

    1983  Volume 13, Issue 4, Page(s) 357–359

    Title translation New technics in the treatment of the coronary insufficiency. Conclusions.
    MeSH term(s) Angioplasty, Balloon ; Coronary Disease/drug therapy ; Coronary Disease/therapy ; Coronary Vessels ; Endopeptidases/administration & dosage ; Fibrinolytic Agents/administration & dosage ; Humans ; Streptokinase/administration & dosage ; Urokinase-Type Plasminogen Activator/administration & dosage
    Chemical Substances Fibrinolytic Agents ; Endopeptidases (EC 3.4.-) ; Streptokinase (EC 3.4.-) ; Urokinase-Type Plasminogen Activator (EC 3.4.21.73)
    Language Italian
    Publishing date 1983
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ZDB-ID 184670-x
    ISSN 0046-5968
    ISSN 0046-5968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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