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Article: Daridorexant: A New Dual Orexin Receptor Antagonist for Insomnia.

Onge, Erin St / Phillips, Bradley / Rowe, Casey

The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians

2022 Volume 38, Issue 5, Page(s) 297–303

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2022-07-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	54478-4
ISSN	8755-1225
ISSN	8755-1225
DOI	10.1177/87551225221112546
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Article ; Online: Lymphatic expression of the proliferation marker Ki67 is linked to sentinel node positivity, recurrence and mortality in primary cutaneous melanoma.

Tan, Samuel X / Chong, Sharene / Rowe, Casey / Galbraith, Jack / Dight, James / Zhou, Chenhao / Malt, Maryrose / Smithers, Bernard Mark / Khosrotehrani, Kiarash

Experimental dermatology

2024 Volume 33, Issue 3, Page(s) e15041

Abstract: Lymphangiogenesis is a precursor to lymphovascular invasion, and may therefore signal a higher risk of metastasis and mortality in primary cutaneous melanoma. This retrospective longitudinal study aimed to evaluate whether emergent lymphangiogenesis, as ... ...

Abstract	Lymphangiogenesis is a precursor to lymphovascular invasion, and may therefore signal a higher risk of metastasis and mortality in primary cutaneous melanoma. This retrospective longitudinal study aimed to evaluate whether emergent lymphangiogenesis, as measured through co-expression of endothelial proteins with the proliferation marker Ki67, was associated with poorer prognosis in a cohort of patients with single primary cutaneous melanoma. We screened all patients with a single locally invasive primary cutaneous melanoma who received sentinel lymph node biopsy at a tertiary dermatology centre in Brisbane, Australia between 1994 and 2007. Primary melanoma sections were stained via Opal multiplex immunofluorescence, and categorized according to the presence of Ki67 within either CD31
MeSH term(s)	Humans ; Melanoma ; Skin Neoplasms ; Ki-67 Antigen ; Endothelial Cells ; Longitudinal Studies ; Retrospective Studies ; Cell Proliferation
Chemical Substances	Ki-67 Antigen
Language	English
Publishing date	2024-03-03
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1130936-2
ISSN	1600-0625 ; 0906-6705
ISSN (online)	1600-0625
ISSN	0906-6705
DOI	10.1111/exd.15041
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Zs.A 3508: Show issues

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Article ; Online: A scoping review of artificial intelligence within pharmacy education.

Abdel Aziz, May H / Rowe, Casey / Southwood, Robin / Nogid, Anna / Berman, Sarah / Gustafson, Kyle

American journal of pharmaceutical education

2023 Volume 88, Issue 1, Page(s) 100615

Abstract: Objectives: This scoping review aimed to summarize the available literature on the use of artificial intelligence (AI) in pharmacy education and identify gaps where additional research is needed.: Findings: Seven studies specifically addressing the ... ...

Abstract	Objectives: This scoping review aimed to summarize the available literature on the use of artificial intelligence (AI) in pharmacy education and identify gaps where additional research is needed. Findings: Seven studies specifically addressing the use of AI in pharmacy education were identified. Of these 7 studies, 5 focused on AI use in the context of teaching and learning, 1 on the prediction of academic performance for admissions, and the final study focused on using AI text generation to elucidate the benefits and limitations of ChatGPT use in pharmacy education. Summary: There are currently a limited number of available publications that describe AI use in pharmacy education. Several challenges exist regarding the use of AI in pharmacy education, including the need for faculty expertise and time, limited generalizability of tools, limited outcomes data, and several legal and ethical concerns. As AI use increases and implementation becomes more standardized, opportunities will be created for the inclusion of AI in pharmacy education.
MeSH term(s)	Humans ; Artificial Intelligence ; Education, Pharmacy ; Academic Performance ; Faculty ; Learning
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603807-4
ISSN	1553-6467 ; 0002-9459
ISSN (online)	1553-6467
ISSN	0002-9459
DOI	10.1016/j.ajpe.2023.100615
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Article ; Online: Investigating a Wide Array of Thermally-driven Events: From Understanding the Temperature-induced Structure and Morphology Changes of Metal Chalcogenides to Thermolysis-based Material Generation.

Formo, Eric V / Rowe, Casey F / Allen, John T / Hachtel, Jordan / Threlkeld, Holli L / Ghafouri, Yassamin / Bloodgood, Matthew A / Salguero, Tina T

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

2023 Volume 29, Issue Supplement_1, Page(s) 1485–1486

Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1385710-1
ISSN	1435-8115 ; 1431-9276
ISSN (online)	1435-8115
ISSN	1431-9276
DOI	10.1093/micmic/ozad067.763
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Article ; Online: Enoxaparin-induced bullous haemorrhagic dermatosis.

Lobo, Yolanka / Robertson, Ivan / Stewart, Anne / Rowe, Casey

The Australasian journal of dermatology

2019 Volume 61, Issue 1, Page(s) e124–e125

MeSH term(s)	Anticoagulants/adverse effects ; Enoxaparin/adverse effects ; Female ; Hemorrhage/chemically induced ; Hemorrhage/pathology ; Humans ; Middle Aged ; Skin Diseases, Vesiculobullous/chemically induced ; Skin Diseases, Vesiculobullous/pathology
Chemical Substances	Anticoagulants ; Enoxaparin
Language	English
Publishing date	2019-10-16
Publishing country	Australia
Document type	Case Reports ; Letter
ZDB-ID	138052-7
ISSN	1440-0960 ; 0004-8380
ISSN (online)	1440-0960
ISSN	0004-8380
DOI	10.1111/ajd.13159
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Article ; Online: Clinical and biological determinants of melanoma progression: Should all be considered for clinical management?

Rowe, Casey J / Khosrotehrani, Kiarash

The Australasian journal of dermatology

2015 Volume 57, Issue 3, Page(s) 175–181

Abstract: Cutaneous melanoma is a heterogeneous disease affecting the regulation of multiple genes and proteins that contribute to melanoma progression. Survival for patients with locally invasive disease varies greatly, even within tumour stages based on current ... ...

Abstract	Cutaneous melanoma is a heterogeneous disease affecting the regulation of multiple genes and proteins that contribute to melanoma progression. Survival for patients with locally invasive disease varies greatly, even within tumour stages based on current prognostic criteria. This has prompted investigations into the value of additional clinical or biological parameters predicting survival. In particular, the improved knowledge of tumour biology has fed the hope that the outcome may be predicted at the molecular level. The prognostic value of numerous potential biomarkers has therefore been evaluated in protein and gene expression studies, and genomic associations with melanoma prognosis are beginning to emerge. These potential biomarkers interrogate key tumour and host processes important for tumour development and progression, such as proliferation, invasion and migration through epithelial mesenchymal transition or the host immune or vascular responses. This research may allow more individualised information on prognosis if the challenges regarding the quality and validation of studies are overcome.
MeSH term(s)	Biomarkers, Tumor/blood ; Disease Progression ; Disease-Free Survival ; Female ; Humans ; Male ; Melanoma/mortality ; Melanoma/pathology ; Melanoma/physiopathology ; Monitoring, Physiologic/methods ; Neoplasm Invasiveness/pathology ; Neoplasm Staging ; Prognosis ; Skin Neoplasms/mortality ; Skin Neoplasms/pathology ; Skin Neoplasms/physiopathology ; Survival Analysis ; Melanoma, Cutaneous Malignant
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2015-05-25
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	138052-7
ISSN	1440-0960 ; 0004-8380
ISSN (online)	1440-0960
ISSN	0004-8380
DOI	10.1111/ajd.12348
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Article ; Online: pSTAT5 is associated with improved survival in patients with thick or ulcerated primary cutaneous melanoma.

Tan, Samuel X / Chong, Sharene / Rowe, Casey / Claeson, Magdalena / Dight, James / Zhou, Chenhao / Rodero, Mathieu P / Malt, Maryrose / Smithers, B Mark / Green, Adele C / Khosrotehrani, Kiarash

Melanoma research

2023 Volume 33, Issue 6, Page(s) 506–513

Abstract: Identifying prognostic biomarkers to predict clinical outcomes in stage I and II cutaneous melanomas could guide the clinical application of adjuvant and neoadjuvant therapies. We aimed to investigate the prognostic value of phosphorylated signal ... ...

Abstract	Identifying prognostic biomarkers to predict clinical outcomes in stage I and II cutaneous melanomas could guide the clinical application of adjuvant and neoadjuvant therapies. We aimed to investigate the prognostic value of phosphorylated signal transducer and activator of transcription 5 (pSTAT5) as a biomarker in early-stage melanoma. This study evaluated all initially staged Ib and II melanoma patients undergoing sentinel node biopsy at a tertiary centre in Brisbane, Australia between 1994 and 2007, with survival data collected from the Queensland Cancer Registry. Primary melanoma tissue from 189 patients was analysed for pSTAT5 level through immunohistochemistry. Cox regression modelling, with adjustment for sex, age, ulceration, anatomical location, and Breslow depth, was applied to determine the association between pSTAT5 detection and melanoma-specific survival. Median duration of follow-up was 7.4 years. High pSTAT5 detection was associated with ulceration and increased tumour thickness. However, multivariate analysis indicated that high pSTAT5 detection was associated with improved melanoma-specific survival (hazard ratio: 0.15, 95% confidence interval: 0.03-0.67) as compared to low pSTAT5 detection. This association persisted when pSTAT5 detection was limited to immune infiltrate or the vasculature, as well as when sentinel node positivity was accounted for. In this cohort, staining for high-pSTAT5 tumours identified a subset of melanoma patients with increased survival outcomes as compared to low-pSTAT5 tumours, despite the former having higher-risk clinicopathological characteristics at diagnosis. pSTAT5 is likely an indicator of local immune activation, and its detection could represent a useful tool to stratify the risk of melanoma progression.
MeSH term(s)	Humans ; Melanoma/pathology ; Skin Neoplasms/pathology ; Lymphatic Metastasis ; Disease-Free Survival ; Sentinel Lymph Node Biopsy ; Prognosis ; Melanoma, Cutaneous Malignant
Language	English
Publishing date	2023-08-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1095779-0
ISSN	1473-5636 ; 0960-8931
ISSN (online)	1473-5636
ISSN	0960-8931
DOI	10.1097/CMR.0000000000000915
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Zs.A 3378: Show issues

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Article ; Online: Conditional survival in patients with stage IB-IIIA melanoma undergoing sentinel node biopsy in Queensland: A longitudinal study.

Tedman, Alexander James / Liyanage, Upekha E / Chong, Sharene / Rowe, Casey / von Schuckmann, Lena A / Malt, Maryrose / Green, Adele C / Smithers, B Mark / Khosrotehrani, Kiarash

The Australasian journal of dermatology

2023 Volume 64, Issue 1, Page(s) e34–e40

Abstract: Background: Tumour characteristics such as thickness and ulceration, along with sentinel lymph node (SLN) status, have been essential in predicting survival in patients with locally invasive melanomas at the time of diagnosis. It is unclear if these ... ...

Abstract	Background: Tumour characteristics such as thickness and ulceration, along with sentinel lymph node (SLN) status, have been essential in predicting survival in patients with locally invasive melanomas at the time of diagnosis. It is unclear if these prognostic factors are relevant 1, 2 or 5 years after diagnosis. Objectives: The key aim of this project was to analyse conditional survival in a cohort of Queensland patients with stage IB to IIIA melanomas (American Joint Committee on Cancer's staging system, 8th version) and to test the relevance of clinicopathological prognostic factors for melanoma outcome after varying intervals of survival time. Methods: Patients with primary invasive cutaneous melanoma who were referred to a tertiary melanoma clinic and underwent SLN biopsy between 1994 and 2011 were ascertained. The effect of patient and tumour characteristics on melanoma survival were calculated using multivariate Cox proportional hazard models at diagnosis and at variable times after diagnosis. Results: The final analysis included 651 patients (average age 49 years, 55.5% male) with stage IB to IIIA melanoma. At diagnosis, and after 1 and 2 years survived, SLN positivity, thickness and ulceration were predictive of 10-year survival since diagnosis. However, once patients survived 5 years, only SLN status was predictive. Overall conditional melanoma survival improved with increasing time survived. Five years after diagnosis, 10-year conditional melanoma survival (MSS) was 91% (95% CI 86%-95%) compared with 85% (82%-88%) predicted at diagnosis. The improvement in MSS was observed mainly for Stage II melanoma patients and not for those with a positive SLN biopsy. Conclusions: This study confirms the improvement of prognosis according to time survived since diagnosis suggesting that after 5 years survival the classic prognostic indicators may not have the same influence.
MeSH term(s)	Humans ; Male ; Middle Aged ; Female ; Melanoma/pathology ; Skin Neoplasms/pathology ; Longitudinal Studies ; Queensland/epidemiology ; Lymphatic Metastasis ; Sentinel Lymph Node Biopsy ; Prognosis ; Ulcer/pathology ; Neoplasm Staging ; Retrospective Studies ; Melanoma, Cutaneous Malignant
Language	English
Publishing date	2023-01-18
Publishing country	Australia
Document type	Journal Article
ZDB-ID	138052-7
ISSN	1440-0960 ; 0004-8380
ISSN (online)	1440-0960
ISSN	0004-8380
DOI	10.1111/ajd.13974
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Article ; Online: Rural experience for junior doctors: is it time to make it mandatory?

Rowe, Casey Jane / Campbell, Ian S / Hargrave, Lynton Ashley

The Australian journal of rural health

2014 Volume 22, Issue 2, Page(s) 63–67

Abstract: Objective: To determine whether rural practice terms for junior doctors result in increased interest in rural practice and whether these terms improve learning experiences, clinical skills and insight into difficulties of rural practice.: Design: ... ...

Abstract	Objective: To determine whether rural practice terms for junior doctors result in increased interest in rural practice and whether these terms improve learning experiences, clinical skills and insight into difficulties of rural practice. Design: Semistructured, self-administered survey with questions on respondent demographics, clinical experience during rural practice terms, post-rural experience and personal opinion. Setting: South East Queensland. Participants: Thirty junior doctors from three tertiary hospitals were approached. The response rate was 100%. Main outcome measures: Exploration of junior doctors' rural term experience. Results: Two thirds (67%) of the respondents reported feeling uncomfortable with respect to clinical practice requirements during their rural terms. Half (47%) performed procedures they had only previously performed in simulation environments, and the majority (87%) relied on textbooks or other resources on a daily basis. Two thirds (67%) changed aspects of their usual clinical practice while practising in a rural setting, and 80% reported a change in attitude towards the hardships faced by rural practitioners. The majority of the respondents (87%) enjoyed their rural term, gaining confidence as a result of it, and more than half (53%) reported considering working in rural areas in the future. Conclusions: The results of this survey suggest that junior doctors on rural rotations are required to perform at a clinical level higher than that required of them in metropolitan hospitals. While their clinical experience appears to result in a greater interest in future rural career possibilities for junior doctors, this survey highlights the requirement to improve support for junior doctors undertaking terms in rural areas.
MeSH term(s)	Adult ; Data Collection ; Female ; Humans ; Male ; Mandatory Programs ; Medical Staff, Hospital/psychology ; Queensland ; Rural Health Services/manpower
Language	English
Publishing date	2014-04
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2069573-1
ISSN	1440-1584 ; 1038-5282
ISSN (online)	1440-1584
ISSN	1038-5282
DOI	10.1111/ajr.12082
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Article ; Online: Warfarin-induced erythroderma.

Rowe, Casey J / Robertson, Ivan / James, Daniel / McMeniman, Erin

The Australasian journal of dermatology

2015 Volume 56, Issue 1, Page(s) e15–7

Abstract: Erythroderma is a potentially serious and life-threatening skin disease with a number of possible aetiologies. Drug reactions are well-documented causes, with carbamazepine, penicillin and allopurinol being the most commonly implicated. This case ... ...

Abstract	Erythroderma is a potentially serious and life-threatening skin disease with a number of possible aetiologies. Drug reactions are well-documented causes, with carbamazepine, penicillin and allopurinol being the most commonly implicated. This case describes a unique presentation of warfarin-induced erythroderma in a 78-year-old female patient.
MeSH term(s)	Aged ; Anticoagulants/adverse effects ; Dermatitis, Exfoliative/chemically induced ; Drug Eruptions/etiology ; Female ; Humans ; Warfarin/adverse effects
Chemical Substances	Anticoagulants ; Warfarin (5Q7ZVV76EI)
Language	English
Publishing date	2015-02
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	138052-7
ISSN	1440-0960 ; 0004-8380
ISSN (online)	1440-0960
ISSN	0004-8380
DOI	10.1111/ajd.12140
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