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  1. Book: Lymphocytes

    Rowland-Jones, Sarah L.

    a pracical approach

    (Practical approach series ; 220)

    2000  

    Author's details ed. by Sarah L. Rowland-Jones
    Series title Practical approach series ; 220
    The practical approach series
    Collection The practical approach series
    Keywords Lymphocytes
    Language English
    Size 320 S.
    Edition 2. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT012795728
    ISBN 0-19963-816-0 ; 978-0-19963-816-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2000 A 4049 order for loan Magazin

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  2. Article ; Online: Chikungunya: out of the tropical forests and heading our way ….

    Rowland-Jones, Sarah L

    Transactions of the Royal Society of Tropical Medicine and Hygiene

    2016  Volume 110, Issue 2, Page(s) 85–86

    MeSH term(s) Aedes/virology ; Animals ; Chikungunya Fever/epidemiology ; Chikungunya Fever/prevention & control ; Chikungunya Fever/transmission ; Chikungunya virus/pathogenicity ; Disease Outbreaks/prevention & control ; Drug Discovery ; Humans ; Insect Vectors ; Mosquito Control/organization & administration ; United States ; Viral Vaccines ; West Indies
    Chemical Substances Viral Vaccines
    Language English
    Publishing date 2016-02
    Publishing country England
    Document type Editorial
    ZDB-ID 441375-1
    ISSN 1878-3503 ; 0035-9203
    ISSN (online) 1878-3503
    ISSN 0035-9203
    DOI 10.1093/trstmh/trw002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design.

    Groves, Danielle C / Rowland-Jones, Sarah L / Angyal, Adrienn

    Biochemical and biophysical research communications

    2020  Volume 538, Page(s) 104–107

    Abstract: The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from ... ...

    Abstract The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly become the dominant form worldwide. Here we review how the D614G variant was identified and discuss recent evidence about the effect of the mutation on the characteristics of the virus, clinical outcome of infection and host immune response.
    MeSH term(s) Amino Acid Substitution ; Aspartic Acid/genetics ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/genetics ; COVID-19 Vaccines/immunology ; Evolution, Molecular ; Glycine/genetics ; Humans ; Immunogenicity, Vaccine ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity ; Severity of Illness Index ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Aspartic Acid (30KYC7MIAI) ; Glycine (TE7660XO1C)
    Keywords covid19
    Language English
    Publishing date 2020-11-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2020.10.109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: IL-15 reprogramming compensates for NK cell mitochondrial dysfunction in HIV-1 infection.

    Moreno-Cubero, Elia / Alrubayyi, Aljawharah / Balint, Stefan / Ogbe, Ane / Gill, Upkar S / Matthews, Rebecca / Kinloch, Sabine / Burns, Fiona / Rowland-Jones, Sarah L / Borrow, Persephone / Schurich, Anna / Dustin, Michael / Peppa, Dimitra

    JCI insight

    2024  Volume 9, Issue 4

    Abstract: Dynamic regulation of cellular metabolism is important for maintaining homeostasis and can directly influence immune cell function and differentiation, including NK cell responses. Persistent HIV-1 infection leads to a state of chronic immune activation, ...

    Abstract Dynamic regulation of cellular metabolism is important for maintaining homeostasis and can directly influence immune cell function and differentiation, including NK cell responses. Persistent HIV-1 infection leads to a state of chronic immune activation, NK cell subset redistribution, and progressive NK cell dysregulation. In this study, we examined the metabolic processes that characterize NK cell subsets in HIV-1 infection, including adaptive NK cell subpopulations expressing the activating receptor NKG2C, which expand during chronic infection. These adaptive NK cells exhibit an enhanced metabolic profile in HIV-1- individuals infected with human cytomegalovirus (HCMV). However, the bioenergetic advantage of adaptive CD57+NKG2C+ NK cells is diminished during chronic HIV-1 infection, where NK cells uniformly display reduced oxidative phosphorylation (OXPHOS). Defective OXPHOS was accompanied by increased mitochondrial depolarization, structural alterations, and increased DRP-1 levels promoting fission, suggesting that mitochondrial defects are restricting the metabolic plasticity of NK cell subsets in HIV-1 infection. The metabolic requirement for the NK cell response to receptor stimulation was alleviated upon IL-15 pretreatment, which enhanced mammalian target of rapamycin complex 1 (mTORC1) activity. IL-15 priming enhanced NK cell functionality to anti-CD16 stimulation in HIV-1 infection, representing an effective strategy for pharmacologically boosting NK cell responses.
    MeSH term(s) Humans ; Cytomegalovirus Infections ; HIV-1 ; Interleukin-15 ; HIV Infections ; Killer Cells, Natural ; Mitochondrial Diseases/complications
    Chemical Substances Interleukin-15
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.173099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: HLA-A*23 Is Associated With Lower Odds of Acute Retroviral Syndrome in Human Immunodeficiency Virus Type 1 Infection: A Multicenter Sub-Saharan African Study.

    Lindquist, Lovisa / Kilembe, William / Karita, Etienne / Price, Matt A / Kamali, Anatoli / Kaleebu, Pontiano / Tang, Jianming / Allen, Susan / Hunter, Eric / Gilmour, Jill / Rowland-Jones, Sarah L / Sanders, Eduard J / Hassan, Amin S / Esbjörnsson, Joakim

    Open forum infectious diseases

    2024  Volume 11, Issue 4, Page(s) ofae129

    Abstract: The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, ...

    Abstract The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, HLA-A*23 was associated with lower odds of ARS (adjusted odds ratio, 0.10 [95% confidence interval, .01-.48];
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design

    Groves, Danielle C / Rowland-Jones, Sarah L / Angyal, Adrienn

    Biochem. biophys. res. commun

    Abstract: The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from ... ...

    Abstract The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly become the dominant form worldwide. Here we review how the D614G variant was identified and discuss recent evidence about the effect of the mutation on the characteristics of the virus, clinical outcome of infection and host immune response.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #908990
    Database COVID19

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  7. Article ; Online: The D614G mutations in the SARS-CoV-2 spike protein

    Groves, Danielle C. / Rowland-Jones, Sarah L. / Angyal, Adrienn

    Biochemical and Biophysical Research Communications ; ISSN 0006-291X

    Implications for viral infectivity, disease severity and vaccine design

    2020  

    Keywords Biophysics ; Cell Biology ; Biochemistry ; Molecular Biology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.bbrc.2020.10.109
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: A novel full-length two-domain KIR2DL5A allele isolated in Zimbabwean samples: KIR2DL5A*0010104.

    van Pul, Lisa / Majonga, Edith / Ferrand, Rashida / Rowland-Jones, Sarah L / Yindom, Louis-Marie

    HLA

    2020  Volume 96, Issue 1, Page(s) 135–136

    Abstract: The novel allele KIR2DL5A*0010104 differs from that of KIR2DL5A*0010101 with eight single intronic nucleotide changes. ...

    Abstract The novel allele KIR2DL5A*0010104 differs from that of KIR2DL5A*0010101 with eight single intronic nucleotide changes.
    MeSH term(s) Alleles ; Humans
    Language English
    Publishing date 2020-03-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.13875
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    Zs.A 661: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Editorial: Immune Mechanisms Underlying the Increased Morbidity and Mortality of HIV-Exposed Uninfected (HEU) Children.

    Goetghebuer, Tessa / Rowland-Jones, Sarah L / Kollmann, Tobias R

    Frontiers in immunology

    2017  Volume 8, Page(s) 1060

    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2017.01060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Collaboration of a Detrimental HLA-B*35:01 Allele with HLA-A*24:02 in Coevolution of HIV-1 with T Cells Leading to Poorer Clinical Outcomes.

    Kuse, Nozomi / Murakoshi, Hayato / Akahoshi, Tomohiro / Chikata, Takayuki / James, Katherine L / Gatanaga, Hiroyuki / Rowland-Jones, Sarah L / Oka, Shinichi / Takiguchi, Masafumi

    Journal of virology

    2021  Volume 95, Issue 23, Page(s) e0125921

    Abstract: Although mutant-specific T cells are elicited in some individuals infected with HIV-1 mutant viruses, the detailed characteristics of these T cells remain unknown. A recent study showed that the accumulation of strains expressing Nef135F, which were ... ...

    Abstract Although mutant-specific T cells are elicited in some individuals infected with HIV-1 mutant viruses, the detailed characteristics of these T cells remain unknown. A recent study showed that the accumulation of strains expressing Nef135F, which were selected by HLA-A*24:02-restricted T cells, was associated with poor outcomes in individuals with the detrimental HLA-B*35:01 allele and that HLA-B*35:01-restricted NefYF9 (Nef135-143)-specific T cells failed to recognize target cells infected with Nef135F mutant viruses. Here, we investigated HLA-B*35:01-restricted T cells specific for the NefFF9 epitope incorporating the Nef135F mutation. Longitudinal T-cell receptor (TCR) clonotype analysis demonstrated that 3 types of HLA-B*35:01-restricted T cells (wild-type [WT] specific, mutant specific, and cross-reactive) with different T cell repertoires were elicited during the clinical course. HLA-B*35:01
    MeSH term(s) Alleles ; CD8-Positive T-Lymphocytes ; Cross-Sectional Studies ; Epitopes, T-Lymphocyte/genetics ; HIV Infections/virology ; HIV-1/genetics ; HLA-A24 Antigen/chemistry ; HLA-A24 Antigen/genetics ; HLA-A24 Antigen/metabolism ; HLA-B Antigens/chemistry ; HLA-B Antigens/genetics ; HLA-B35 Antigen/chemistry ; HLA-B35 Antigen/genetics ; HLA-B35 Antigen/metabolism ; Humans ; Mutation ; Viral Load
    Chemical Substances Epitopes, T-Lymphocyte ; HLA-A*24:02 antigen ; HLA-A24 Antigen ; HLA-B Antigens ; HLA-B*35:01 antigen ; HLA-B35 Antigen
    Language English
    Publishing date 2021-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.01259-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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