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  1. AU="Rowlands, Rachel"
  2. AU="Ferraz, Alexandre de Vicente"
  3. AU="Lee, Sang W."
  4. AU="Lingappa, Jairam"
  5. AU="Suo, Keke"
  6. AU=Tokonami Natsuko
  7. AU="Blevins, Hannah"
  8. AU="Sanders, Barton J."
  9. AU="Park, Hyun Ah"
  10. AU="Fields, Errol L"
  11. AU="Borisov, Alexander"
  12. AU="Ali, Ahmed E"
  13. AU="Carrasco Carrasco, E"
  14. AU="Massa, L"
  15. AU="Seki, Reiko"
  16. AU="Skowno, Justin"
  17. AU="Hikida, Hiroshi"
  18. AU="Wentzel, David C"
  19. AU="Priyadarshini, Subhadra"
  20. AU="Monemi, Sharareh"
  21. AU="Iannuzzi, Gregory"
  22. AU="Zhou, Ning"
  23. AU=Griffith A J
  24. AU="Schmidt-Pogoda, Antje"
  25. AU="A.Aich, "
  26. AU="Anding, Allyson L"

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  1. Artikel ; Online: Assessing under 5s with a fever.

    Prest, Rebecca / Rowlands, Rachel

    BMJ (Clinical research ed.)

    2017  Band 358, Seite(n) j953

    Sprache Englisch
    Erscheinungsdatum 2017-07-31
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/sbmj.j953
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Bedside Ultrasound vs X-Ray for the Diagnosis of Forearm Fractures in Children.

    Rowlands, Rachel / Rippey, James / Tie, Sing / Flynn, James

    The Journal of emergency medicine

    2017  Band 52, Heft 2, Seite(n) 208–215

    Abstract: Background: Painful forearm injuries after a fall occur frequently in children. X-ray study is currently the gold standard investigation. Ultrasound (US) is a potential alternative that avoids exposure to ionizing radiation and may be less painful than ... ...

    Abstract Background: Painful forearm injuries after a fall occur frequently in children. X-ray study is currently the gold standard investigation. Ultrasound (US) is a potential alternative that avoids exposure to ionizing radiation and may be less painful than x-ray study; and familiarity and skill with US is increasing among emergency physicians.
    Objectives: The primary aim of this study was to determine if a cohort of physicians with little or no previous experience with US could, after a short training program, safely exclude forearm fractures in children. Secondary aims were to compare any pain or discomfort associated with clinical examination, US, and x-ray study and to determine the acceptability of US as a diagnostic tool to parents and patients.
    Methods: A prospective, nonrandomized, interventional diagnostic study was performed on children between the ages of 0 and 16 years who had a suspected fracture of the forearm. US scanning was performed by a group of physicians, most with little or no previous US experience.
    Results: After the brief training program, a group of pediatric emergency physicians could diagnose forearm fractures in children with a sensitivity of 91.5% and a specificity of 87.6%. Pain associated with US was no better or worse than pain associated with x-ray study. Patients and parents preferred US over x-ray study as an investigation modality for suspected forearm fractures.
    Conclusion: A group of pediatric emergency physicians with limited previous experience could, after a short training program, diagnose forearm fractures in children. Pain associated with US was no better or worse than pain associated with x-ray study.
    Mesh-Begriff(e) Accidental Falls ; Adolescent ; Australia ; Child ; Child, Preschool ; Female ; Forearm/physiology ; Forearm Injuries/diagnosis ; Fractures, Bone/diagnosis ; Humans ; Infant ; Male ; Pain Management/methods ; Point-of-Care Systems/standards ; Point-of-Care Systems/trends ; Prospective Studies ; Ultrasonography/standards ; X-Rays
    Sprache Englisch
    Erscheinungsdatum 2017-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2016.10.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors.

    Rowlands, Rachel A / Chen, Qiuyan / Bouley, Renee A / Avramova, Larisa V / Tesmer, John J G / White, Andrew D

    Journal of medicinal chemistry

    2021  Band 64, Heft 1, Seite(n) 566–585

    Abstract: The ability of G protein-coupled receptor (GPCR) kinases (GRKs) to regulate the desensitization of GPCRs has made GRK2 and GRK5 attractive targets for treating diseases such as heart failure and cancer. Previously, our work showed that Cys474, a GRK5 ... ...

    Abstract The ability of G protein-coupled receptor (GPCR) kinases (GRKs) to regulate the desensitization of GPCRs has made GRK2 and GRK5 attractive targets for treating diseases such as heart failure and cancer. Previously, our work showed that Cys474, a GRK5 subfamily-specific residue located on a flexible loop adjacent to the active site, can be used as a covalent handle to achieve selective inhibition of GRK5 over GRK2 subfamily members. However, the potency of the most selective inhibitors remained modest. Herein, we describe a successful campaign to adapt an indolinone scaffold with covalent warheads, resulting in a series of 2-haloacetyl-containing compounds that react quickly and exhibit three orders of magnitude selectivity for GRK5 over GRK2 and low nanomolar potency. They however retain a similar selectivity profile across the kinome as the core scaffold, which was based on Sunitinib.
    Mesh-Begriff(e) Animals ; Catalytic Domain ; Cattle ; G-Protein-Coupled Receptor Kinase 5/antagonists & inhibitors ; Humans ; Inhibitory Concentration 50 ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Structure-Activity Relationship
    Chemische Substanzen Protein Kinase Inhibitors ; G-Protein-Coupled Receptor Kinase 5 (EC 2.7.11.16) ; GRK5 protein, human (EC 2.7.11.16)
    Sprache Englisch
    Erscheinungsdatum 2021-01-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.0c01522
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Catastrophic haemorrhage from button battery ingestion in children: a growing problem.

    Wright, Katie / Parkins, Kate / Jahn, Haiko / Rowlands, Rachel / Davies, Ffion

    Acta paediatrica (Oslo, Norway : 1992)

    2017  Band 106, Heft 9, Seite(n) 1391–1393

    Mesh-Begriff(e) Child, Preschool ; Deglutition Disorders/etiology ; Diagnosis, Differential ; Electric Power Supplies ; Esophagus/diagnostic imaging ; Esophagus/injuries ; Foreign Bodies/complications ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/epidemiology ; Hematemesis/etiology ; Hematemesis/therapy ; Hemorrhage/etiology ; Humans ; Peptides ; Polyethylene Glycols ; Radiography ; Tracheoesophageal Fistula/etiology
    Chemische Substanzen Peptides ; hematide ; Polyethylene Glycols (3WJQ0SDW1A)
    Sprache Englisch
    Erscheinungsdatum 2017-08-09
    Erscheinungsland Norway
    Dokumenttyp Editorial
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.13934
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Um IV Zs.95: Hefte anzeigen Standort:
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  5. Artikel ; Online: Female perineal injuries in children and adolescents presenting to a paediatric emergency department.

    Roland, Damian / Lewis, Gareth / Rowlands, Rachel / Davidson, Emmanuel / Davies, Ffion

    Emergency medicine journal : EMJ

    2016  Band 33, Heft 1, Seite(n) 73–75

    Abstract: This retrospective case series determined documentation quality and likelihood of safeguarding issues in girls  aged 0-15 years with perineal and genital injuries presenting to a paediatric emergency department (ED). During the period between 2002 and ... ...

    Abstract This retrospective case series determined documentation quality and likelihood of safeguarding issues in girls  aged 0-15 years with perineal and genital injuries presenting to a paediatric emergency department (ED). During the period between 2002 and 2010, cases were identified and clinical information was recorded. Cases were cross-referenced against the hospital's safeguarding unit's records up to 2011. In total, 181 case notes were available for review with 76.2% of patients discharged home from the ED. Fewer than 50% of case notes contained clear anatomical description of the injuries. In 51 (28.2%) cases, child safeguarding issues were considered, with specific referrals made to safeguarding services in 20 of these (11.0%). Only one case involved subsequent child safeguarding proceedings. Clear documentation of injury patterns by medical staff was poor, but medical and nursing staff should not be anxious about dealing with this cohort of patients as they are no different from other incidental injuries needing diligent levels of child safeguarding awareness.
    Mesh-Begriff(e) Adolescent ; Child ; Child Abuse/prevention & control ; Child Protective Services/statistics & numerical data ; Child, Preschool ; Emergency Service, Hospital/statistics & numerical data ; Female ; Humans ; Infant ; Perineum/injuries ; Retrospective Studies ; Wounds and Injuries/diagnosis ; Wounds and Injuries/etiology
    Sprache Englisch
    Erscheinungsdatum 2016-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2014-204259
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1941: Hefte anzeigen Standort:
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  6. Artikel: Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors.

    Rowlands, Rachel A / Cato, M Claire / Waldschmidt, Helen V / Bouley, Renee A / Chen, Qiuyan / Avramova, Larisa / Larsen, Scott D / Tesmer, John J G / White, Andrew D

    ACS medicinal chemistry letters

    2019  Band 10, Heft 12, Seite(n) 1628–1634

    Abstract: The ability of G protein-coupled receptor (GPCR) kinases (GRKs) to regulate desensitization of GPCRs has made GRK2 and GRK5 attractive targets for treating heart failure and other diseases such as cancer. Although advances have been made toward ... ...

    Abstract The ability of G protein-coupled receptor (GPCR) kinases (GRKs) to regulate desensitization of GPCRs has made GRK2 and GRK5 attractive targets for treating heart failure and other diseases such as cancer. Although advances have been made toward developing inhibitors that are selective for GRK2, there have been far fewer reports of GRK5 selective compounds. Herein, we describe the development of GRK5 subfamily selective inhibitors,
    Sprache Englisch
    Erscheinungsdatum 2019-11-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.9b00365
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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