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  1. AU="Roy, Antara"
  2. AU="Byeongil Kim"
  3. AU="Bosch, Peter J"
  4. AU="Colin R. Jackson" AU="Colin R. Jackson"
  5. AU="Tan, Bruce K"
  6. AU="Alagappan, Annamalai"
  7. AU="Howard, Lauren L."
  8. AU=Nataraj Gita AU=Nataraj Gita
  9. AU="Zi-Lan Wang"
  10. AU="John F. Whitesides"
  11. AU="Kim, Eun-Kyu"
  12. AU="Shapiro, Anne Nicole"
  13. AU="Joseph R. Francica"
  14. AU="Stringer, Kathleen A."
  15. AU="López-Cobo, Sheila"
  16. AU="Sznitman, Raphael"
  17. AU="Philippe Ciais"
  18. AU="Suprasert, Prapaporn"
  19. AU="Chang, Yinshui"
  20. AU="de Oliveira, Alexandre Adalardo"
  21. AU="D'Angelo Exeni, Maria Eugenia"
  22. AU="Godoy, Carla"

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  1. Artikel: Bicyclic (alkyl)(amino)carbene (BICAAC) in a dual role: activation of primary amides and CO

    Gautam, Nimisha / Logdi, Ratan / P, Sreejyothi / Roy, Antara / Tiwari, Ashwani K / Mandal, Swadhin K

    Chemical science

    2023  Band 14, Heft 19, Seite(n) 5079–5086

    Abstract: Herein, we report the first catalytic methylation of primary amides using ... ...

    Abstract Herein, we report the first catalytic methylation of primary amides using CO
    Sprache Englisch
    Erscheinungsdatum 2023-04-20
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc01216f
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Loss of function of ribosomal protein L13a blocks blastocyst formation and reveals a potential nuclear role in gene expression.

    Kour, Ravinder / Kim, Jaehwan / Roy, Antara / Richardson, Brian / Cameron, Mark J / Knott, Jason G / Mazumder, Barsanjit

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2023  Band 37, Heft 12, Seite(n) e23275

    Abstract: Ribosomal proteins play diverse roles in development and disease. Most ribosomal proteins have canonical roles in protein synthesis, while some exhibit extra-ribosomal functions. Previous studies in our laboratory revealed that ribosomal protein L13a ( ... ...

    Abstract Ribosomal proteins play diverse roles in development and disease. Most ribosomal proteins have canonical roles in protein synthesis, while some exhibit extra-ribosomal functions. Previous studies in our laboratory revealed that ribosomal protein L13a (RPL13a) is involved in the translational silencing of a cohort of inflammatory proteins in myeloid cells. This prompted us to investigate the role of RPL13a in embryonic development. Here we report that RPL13a is required for early development in mice. Crosses between Rpl13a+/- mice resulted in no Rpl13a-/- offspring. Closer examination revealed that Rpl13a-/- embryos were arrested at the morula stage during preimplantation development. RNA sequencing analysis of Rpl13a-/- morulae revealed widespread alterations in gene expression, including but not limited to several genes encoding proteins involved in the inflammatory response, embryogenesis, oocyte maturation, stemness, and pluripotency. Ex vivo analysis revealed that RPL13a was localized to the cytoplasm and nucleus between the two-cell and morula stages. RNAi-mediated depletion of RPL13a phenocopied Rpl13a-/- embryos and knockdown embryos exhibited increased expression of IL-7 and IL-17 and decreased expression of the lineage specifier genes Sox2, Pou5f1, and Cdx2. Lastly, a protein-protein interaction assay revealed that RPL13a is associated with chromatin, suggesting an extra ribosomal function in transcription. In summary, our data demonstrate that RPL13a is essential for the completion of preimplantation embryo development. The mechanistic basis of the absence of RPL13a-mediated embryonic lethality will be addressed in the future through follow-up studies on ribosome biogenesis, global protein synthesis, and identification of RPL13a target genes using chromatin immunoprecipitation and RNA-immunoprecipitation-based sequencing.
    Mesh-Begriff(e) Animals ; Female ; Humans ; Mice ; Pregnancy ; Blastocyst ; Chromatin Immunoprecipitation ; Embryonic Development/genetics ; Gene Expression ; Ribosomal Proteins/genetics
    Chemische Substanzen Ribosomal Proteins ; Rpl13a protein, mouse
    Sprache Englisch
    Erscheinungsdatum 2023-10-12
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202301475R
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Prevalence and correlates of knowledge and practices regarding infection prevention and control, and triage in primary healthcare settings: A cross-sectional study in Bangladesh.

    Talukder, Animesh / Roy, Antara / Islam, Muhammed Nazmul / Chowdhury, Mohiuddin Ahsanul Kabir / Sarker, Malabika / Chowdhury, Morseda / Chowdhury, Imran Ahmed / Hasan, Mehadi / Latif, A H M Mahbub

    Infection prevention in practice

    2022  Band 5, Heft 1, Seite(n) 100258

    Abstract: Background: Despite the high prevalence of healthcare-acquired infection in resource-limited settings, healthcare workers' (HCWs') knowledge and practices of infection prevention and control (IPC) and triage are not well-researched. We examined thisin ... ...

    Abstract Background: Despite the high prevalence of healthcare-acquired infection in resource-limited settings, healthcare workers' (HCWs') knowledge and practices of infection prevention and control (IPC) and triage are not well-researched. We examined thisin Bangladesh's primary healthcare facilities (HCFs) during the COVID-19 pandemic.
    Methods: We surveyed 312 HCWs in 94 community clinics (CCs) and 90 family welfare centres (FWCs) in six districts from February to April 2021. We assessed HCWs' self-reported knowledge and observed practices in four domains: personal hygiene, medical instrument processing, waste management, and triage. We constructed a weighted composite knowledge score and estimated the association between knowledge and background characteristics using a generalised linear mixed effects model. Practices were described through univariate analysis.
    Findings: On a scale of 100, the mean composite knowledge score was 38.3 (SD: 13.3) overall and 44.0 (SD: 13.1) and 33.8 (SD: 11.6) for FWCs and CCs, respectively. The HCWs of FWCs were more aged, experienced, and educated than those of CCs. Knowledge score was the highest in personal hygiene and the lowest in medical waste segregation. Knowledge was significantly associated with HCWs' designation and education. Concerning practices, not more than one-third of the HCWs or HCFs, on average, followed the recommended protocols, except for wearing face masks while on duty (87.1%) and referring potential COVID-19 patients to higher-level facilities (68.3%).
    Conclusions: HCWs' capacity in instrument processing, waste management, and triage needs to be improved through formal education and training initiatives. Our study can contribute to the under-researched IPC and triage domains in resource-limited settings.
    Sprache Englisch
    Erscheinungsdatum 2022-11-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2590-0889
    ISSN (online) 2590-0889
    DOI 10.1016/j.infpip.2022.100258
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Implementation of an aggressive random drug-testing policy in a rural school district: Student attitudes regarding program fairness and effectiveness.

    Evans, Garret D / Reader, Steven / Liss, Heidi J / Wiens, Brenda A / Roy, Antara

    The Journal of school health

    2006  Band 76, Heft 9, Seite(n) 452–458

    Abstract: School districts are increasingly initiating random drug-testing (RDT) programs in an effort to curb substance-use rates among students, yet little is known about student attitudes toward RDT and potential obstacles to program acceptance and ... ...

    Abstract School districts are increasingly initiating random drug-testing (RDT) programs in an effort to curb substance-use rates among students, yet little is known about student attitudes toward RDT and potential obstacles to program acceptance and effectiveness. The authors surveyed 1011 9th through 11th grade students in 2 rural high schools in North Florida regarding the pending implementation of one of the most aggressive RDT programs in the nation. A significant majority of students predicted that RDT would be effective, yet students were more clearly divided in their perceptions of the fairness and the accuracy of testing. Student perceptions of whether there is a drug problem at their school proved to be a robust predictor of perceptions of policy fairness. Student substance-use rates were more limited predictors of policy effectiveness and fairness. These results may prove useful to school administrators, health professionals, and policy makers seeking to build acceptance for RDT in their schools.
    Mesh-Begriff(e) Adolescent ; Attitude ; Drug and Narcotic Control/legislation & jurisprudence ; Female ; Florida ; Health Plan Implementation ; Humans ; Male ; Program Development ; Program Evaluation ; Rural Health Services/legislation & jurisprudence ; School Health Services/legislation & jurisprudence ; Schools/legislation & jurisprudence ; Students/psychology ; Substance Abuse Detection/legislation & jurisprudence ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2006-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 952835-0
    ISSN 1746-1561 ; 0022-4391
    ISSN (online) 1746-1561
    ISSN 0022-4391
    DOI 10.1111/j.1746-1561.2006.00140.x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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