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Article: Sleep Attributes Influencing Cardiovascular Morbidity Among Young Adults Pursuing Professional Courses in Dehradun, India: A Cross-Sectional Study.

Nautiyal, Hitesh / Roy, Debabrata / Arya, Anupama / Maheshwari, Sonam / Agarwal, Pratik / Patel, Neil / Sethi, Yashendra

Cureus

2024 Volume 16, Issue 1, Page(s) e52647

Abstract: Cardiovascular diseases (CVDs) are evolving as a cause of mortality and morbidity among young adults. Young adults, particularly those pursuing professional courses in colleges, face unique challenges that may influence their risk of developing CVD. ... ...

Abstract	Cardiovascular diseases (CVDs) are evolving as a cause of mortality and morbidity among young adults. Young adults, particularly those pursuing professional courses in colleges, face unique challenges that may influence their risk of developing CVD. Despite screening guidelines, CVD risk factors often go undetected in the young population, highlighting the need for increased awareness among adolescents. Sleep is an essential indicator of well-being, and its impact on cardiovascular risk factors is increasingly being recognized. An observational cross-sectional study was conducted among young adults aged 18 to 24 years pursuing professional courses in Dehradun, Uttarakhand, India. A total of 156 participants were recruited through multistage, systematic random sampling, and snowball sampling. Data on sleep patterns and cardiovascular morbidity were collected using a pretested questionnaire. Among the study participants, 46.8% reported having less than four hours of sleep on average, and 25% were suffering from sleep problems. The prevalence of diagnosed CVDs was low, with 6.14% reporting arrhythmias and 3.84% reporting hypertension. An association was found between sleep duration, sleep problems, and the presence of CVDs. Participants with shorter sleep durations and more severe sleep problems had a higher prevalence of CVDs. The findings suggest that sleep duration and sleep problems may be modifiable risk factors for CVDs among young adults. Effective health promotion activities focusing on behavior and lifestyle modifications are essential to preventing CVDs from an early age. The study emphasizes the importance of early intervention and health promotion strategies to reduce CVD risk factors in this population. Community-based research and behavior change communication initiatives are recommended to promote healthy sleep habits and prevent cardiovascular diseases among young adults beyond the college setting.
Language	English
Publishing date	2024-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52647
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Utilisation and Safety of Polyethylene Glycol 3350 With Electrolytes in Children Under 2 Years: A Retrospective Cohort.

Roy, Debabrata / Akriche, Fatma / Amlani, Bharat / Shakir, Saad

Journal of pediatric gastroenterology and nutrition

2021 Volume 72, Issue 5, Page(s) 683–689

Abstract: Objectives: In the UK, Movicol paediatric plain (polyethylene glycol 3350 with electrolytes [PEG 3350+E], Norgine, UK), is licensed for chronic constipation in children 2 -11 years of age and faecal impaction (FI) from 5 years. This study aimed to ... ...

Abstract	Objectives: In the UK, Movicol paediatric plain (polyethylene glycol 3350 with electrolytes [PEG 3350+E], Norgine, UK), is licensed for chronic constipation in children 2 -11 years of age and faecal impaction (FI) from 5 years. This study aimed to investigate usage and characterise the risk profile in children under 2 years of age using PEG 3350+E in the UK. Methods: Retrospective, single exposure cohort study, with patients identified from Clinical Practice Research Datalink (CPRD) GOLD. Patients first prescribed PEG 3350+E under 2 years of age for the treatment of constipation or FI, between September 2003 and July 2019, were included. Results: There were 13,235 patients with a constipation indication and 40 patients with FI. For the constipation cohort: median age of PEG 3350+E first prescription was 1.2 years [interquartile range (IQR) 0.9, 1.6] and 68.4% had one treatment episode (TE). The mean duration of exposure, in the first TE, was 88.9 days. The most common total daily dose was one sachet (6.9 g).In terms of incident events on treatment, 0.5% of patients had abdominal pain, 3.0% had diarrhoea (may be attributed to treatment) and 4.1% had vomiting. 2.0% had signs/symptoms which could (in extreme cases) be associated with electrolyte disturbance, however, none had abnormal electrolyte values. Discussion: The safety aspect of this study did not identify any signals of concern in the constipation cohort. The number of patients in the FI cohort were too small for robust conclusions. If information were available, then a safety study would ideally assess treatment intake per kilogram, including electrolyte intake, before reaching safety conclusions. Nevertheless, these data contribute to real-world evidence on the use of PEG 3350+E in this population.
MeSH term(s)	Child ; Cohort Studies ; Constipation/chemically induced ; Constipation/drug therapy ; Constipation/epidemiology ; Electrolytes ; Humans ; Infant ; Polyethylene Glycols/adverse effects ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Electrolytes ; Polyethylene Glycols (3WJQ0SDW1A) ; polyethylene glycol 3350 (G2M7P15E5P)
Language	English
Publishing date	2021-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000003074
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A systematic review of flurbiprofen 8.75 mg dose and risk of adverse events (excluding haemorrhagic) resulting from drug-drug interactions.

Evans, Alison / Roy, Debabrata / Dhanda, Sandeep / Lane, Samantha / Coutinho, Graça / Kulasekaran, Anuradha / Miller-Shakesby, David / Ramamoorthi, Nagalakshmi / Shakir, Saad

Frontiers in pharmacology

2024 Volume 15, Page(s) 1107185

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-03-06
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1107185
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Environmental correlates of infectious diseases in South-East Asia: A perspective on the missed link.

Sethi, Yashendra / Kaka, Nirja / Patel, Neil / Roy, Debabrata / Chopra, Hitesh / Emran, Talha Bin

New microbes and new infections

2023 Volume 53, Page(s) 101118

Abstract: Climate change, essentially due to global warming, the plundering of the earth's ecosystem.•Changing climatic circumstances may affect species' range and density.•Infectious disease can be seen as an outcome derived from multi-factorial correlates.•"One ...

Abstract	•Climate change, essentially due to global warming, the plundering of the earth's ecosystem.•Changing climatic circumstances may affect species' range and density.•Infectious disease can be seen as an outcome derived from multi-factorial correlates.•"One health" needs more attention, specially in regions more prone to environment.
Language	English
Publishing date	2023-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2750179-6
ISSN	2052-2975
ISSN	2052-2975
DOI	10.1016/j.nmni.2023.101118
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Volatile Organic Compound Identification-Based Tuberculosis Screening among TB Suspects: A Diagnostic Accuracy Study.

Badola, Mayank / Agrawal, Anurag / Roy, Debabrata / Sinha, Richa / Goyal, Avisham / Jeet, Narayan

Advances in respiratory medicine

2023 Volume 91, Issue 4, Page(s) 301–309

Abstract: Tuberculosis (TB) affects a third of the global population, and a large population of infected individuals still remain undiagnosed-making the visible burden only the tip of the iceberg. The detection of tuberculosis in close-proximity patients is one of ...

Abstract	Tuberculosis (TB) affects a third of the global population, and a large population of infected individuals still remain undiagnosed-making the visible burden only the tip of the iceberg. The detection of tuberculosis in close-proximity patients is one of the key priorities for attaining the Sustainable Development Goals (SDG) of TB elimination by 2030. With the current battery of screening tests failing to cover this need, the authors of this paper examined a simple and inexpensive point-of-care breath analyzer (TSI-3000(I)), which is based on detecting the volatile organic compounds that are emitted from infected cells and released in exhaled breath as a screening tool for the detection of TB. A single-center pilot study for assessing the diagnostic accuracy of the point-of-care Tuberculosis Breath Analyzer was conducted, and it was compared against the WHO-recommended TrueNat assay, which is a rapid molecular test and was also treated as the reference standard in this study. Of the 334 enrolled participants with TB signs/symptoms, 42.51% were TrueNat positive for Mycobacterium tuberculosis. The sensitivity of the Tuberculosis Breath Analyzer was found to be 95.7%, with a specificity of 91.3% and a ROC area of 0.935. The test kit showed considerable/significant high sensitivity and specificity as reliability indicators. The performance of the Tuberculosis Breath Analyzer tested was found to be comparable in efficiency to that of the TrueNat assay. A large cohort-based multicentric study is feasibly required to further validate and extrapolate the results of the pilot study.
MeSH term(s)	Humans ; Volatile Organic Compounds ; Pilot Projects ; Reproducibility of Results ; Mass Screening ; Tuberculosis
Chemical Substances	Volatile Organic Compounds
Language	English
Publishing date	2023-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2893877-X
ISSN	2543-6031 ; 2451-4934
ISSN (online)	2543-6031
ISSN	2451-4934
DOI	10.3390/arm91040024
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Epidemiological Correlates of Substance Abuse Among In-Facility Clients of De-addiction and Rehabilitation Centres of District Dehradun: A Cross-Sectional Study.

Zahin, Nuzhat / Roy, Debabrata / Sinha, Richa / Maheshwari, Sonam / Sethi, Yashendra / Patel, Neil

Cureus

2023 Volume 15, Issue 8, Page(s) e42826

Abstract: Background The increasing production, distribution, promotion, and availability of substances contemporaneous with the changing values of society have resulted in rising substance abuse as an emerging public health concern in India. A prevalence of 32-37% ...

Abstract	Background The increasing production, distribution, promotion, and availability of substances contemporaneous with the changing values of society have resulted in rising substance abuse as an emerging public health concern in India. A prevalence of 32-37% has been reported for substance abuse in various studies conducted in Uttarakhand but there is a dearth of data on socio-epidemiological factors affecting substance abuse. Materials & methods A facility-based observational cross-sectional study was conducted in selected de-addiction and rehabilitation centers of district Dehradun. Data were collected using multistage systematic random sampling from clients admitted to the facility. Results The mean age of in-facility participants was 28 ± 8 years and most of them started taking drugs after the age of 18 years. The most common substance of abuse was alcohol (61.7%) followed by tobacco smoking (15.6%). Both 'peer pressure' and 'curiosity' play a major role in predisposition to substance use. Further, we found that age (p=0.002), and level of education (p <0.001) were important determinants for substance abuse. At the same time, among other factors, the influence of occupation notably did not have a statistically significant association. Conclusion Sensitization and capacity building of both providers and the community is integral to effective strategizing for the prevention and control of substance abuse. Regional studies including the current study can be of help in framing drug policies and management guidelines including prioritizing the importance of the establishment of de-addiction and rehabilitation centers at the district level.
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.42826
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Early-warning of Cardiac Condition through Detection of Murmur in Heart Sound - A Case Study.

Singh Aditya, Mohan / Rasipuram, Sowmya / Chattopadhyay, Sourav / Maitra, Anutosh / Sanjoy, Paul / Maziyar, Baran Pouyan / Roy, Debabrata / Dey, Subhashis

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2023 Volume 2023, Page(s) 1–6

Abstract: Cardiovascular disease, particularly Rheumatic Heart Disease (RHD), is one of the leading causes of death in many developing countries. RHD is manageable and treatable with early detection. However, multiple countries across the globe suffer from a ... ...

Abstract	Cardiovascular disease, particularly Rheumatic Heart Disease (RHD), is one of the leading causes of death in many developing countries. RHD is manageable and treatable with early detection. However, multiple countries across the globe suffer from a scarcity of experienced physicians who can perform screening at large scales. Advancements in machine learning and signal processing have paved way for Phonocardiogram (PCG)-based automatic heart sound classification. The direct implication of such methods is that it is possible to enable a person without specialized training to detect potential cardiac conditions with just a digital stethoscope. Hospitalization or life-threatening situations can be dramatically reduced via such early screenings. Towards this, we conducted a case study amongst a population from a particular geography using machine learning and deep learning methods for the detection of murmur in heart sounds. The methodology consists of first pre-processing and identifying normal vs. abnormal heart sound signals using 3 state-of-the-art methods. The second step further identifies the murmur to be systolic or diastolic by capturing the auscultation location. Abnormal findings are then sent for early attention of clinicians for proper diagnosis. The case study investigates the efficacy of the automated method employed for early screening of potential RHD and initial encouraging results of the study are presented.
MeSH term(s)	Humans ; Heart Sounds ; Algorithms ; Heart Murmurs/diagnosis ; Heart Diseases ; Heart Auscultation
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC40787.2023.10340924
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Performance of a modified magnetostrictive energy harvester in mechanical vibration.

Dey, Subhasish / Roy, Debabrata / Patra, Soumyabrata / Santra, Tapan

Heliyon

2019 Volume 5, Issue 1, Page(s) e01135

Abstract: The field of harvesting electrical energy from ambient vibration has grown with rapid interest. Perpetual source of electrical energy can be extracted from structural vibrations. The paper deals with a technology for scavenging electricity from vibration ...

Abstract	The field of harvesting electrical energy from ambient vibration has grown with rapid interest. Perpetual source of electrical energy can be extracted from structural vibrations. The paper deals with a technology for scavenging electricity from vibration using iron-gallium alloy. This alloy offers high ductile property and the effect of inverse magnetostriction is also quite high. In this paper, a bending type magnetostrictive prototype energy harvester has been considered. Volume of the used material is 7 × 2 × 42 mm
Language	English
Publishing date	2019-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2019.e01135
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Performance of a modified magnetostrictive energy harvester in mechanical vibration

Dey, Subhasish / Roy, Debabrata / Patra, Soumyabrata / Santra, Tapan

Heliyon. 2019 Jan., v. 5, no. 1

2019

Abstract	The field of harvesting electrical energy from ambient vibration has grown with rapid interest. Perpetual source of electrical energy can be extracted from structural vibrations. The paper deals with a technology for scavenging electricity from vibration using iron-gallium alloy. This alloy offers high ductile property and the effect of inverse magnetostriction is also quite high. In this paper, a bending type magnetostrictive prototype energy harvester has been considered. Volume of the used material is 7 × 2 × 42 mm³. Forced & free vibration characteristics have been examined on this prototype. Maximum conversion efficiency of 49% has been achieved at input frequency of 30 Hz.
Keywords	alloys ; electric power ; electricity ; energy ; prototypes ; vibration
Language	English
Dates of publication	2019-01
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2019.e01135
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Incidence of major and clinically relevant non-major bleeding in patients prescribed rivaroxaban for stroke prevention in non-valvular atrial fibrillation in secondary care: Results from the Rivaroxaban Observational Safety Evaluation (ROSE) study.

Evans, Alison / Davies, Miranda / Osborne, Vicki / Roy, Debabrata / Shakir, Saad

PloS one

2020 Volume 15, Issue 10, Page(s) e0240489

Abstract: Introduction: Although the direct oral anticoagulant rivaroxaban is recommended for stroke prevention in patients with non-valvular atrial fibrillation based on Phase III clinical trials, there is still a need for additional safety data from everyday ... ...

Abstract	Introduction: Although the direct oral anticoagulant rivaroxaban is recommended for stroke prevention in patients with non-valvular atrial fibrillation based on Phase III clinical trials, there is still a need for additional safety data from everyday clinical practice. The ROSE study was initiated to collect further information on the safety and utilisation of rivaroxaban in a broader range of patient groups in routine clinical practice. Methods and results: The ROSE study was conducted in hospitals in England and Wales. Consenting adults with non-valvular atrial fibrillation newly started on rivaroxaban were eligible and followed up for 12 weeks. Data was derived through secondary use of medical records. The primary outcome was major bleeding within gastrointestinal, urogenital and intracranial sites. A total of 4846 patients were enrolled in the study September 2013 to January 2016, 965 of which were treated with rivaroxaban for non-valvular atrial fibrillation. The median age in the rivaroxaban non-valvular atrial fibrillation cohort was 76 years, 53.6% were male. The median HAS-BLED score was 2 and the median CHA2DS2-VASc score was 4. The risk of major bleeding within each of the primary sites of gastrointestinal, urogenital and intracranial during the 12 week observation period was low (0.2%; n = 2). The risk of major bleeding in all sites was 1.0% (n = 10) at a rate of 5.5 events per 100 patient years. Conclusion: In terms of the primary outcome risk of major bleeding within gastrointestinal, urogenital and intracranial sites during the 12 week observation period, the risk estimates in the non-valvular atrial fibrillation rivaroxaban user population were low (<1%), and consistent with risk estimated from clinical trial data and in routine clinical practice.
MeSH term(s)	Administration, Oral ; Aged ; Aged, 80 and over ; Atrial Fibrillation/drug therapy ; England/epidemiology ; Factor Xa Inhibitors/administration & dosage ; Factor Xa Inhibitors/adverse effects ; Female ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Humans ; Incidence ; Male ; Rivaroxaban/administration & dosage ; Rivaroxaban/adverse effects ; Secondary Care ; Stroke/prevention & control ; Wales/epidemiology
Chemical Substances	Factor Xa Inhibitors ; Rivaroxaban (9NDF7JZ4M3)
Language	English
Publishing date	2020-10-09
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0240489
Database	MEDical Literature Analysis and Retrieval System OnLINE

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