Article ; Online: Gender-dependent multiple cross-phenotype association of interferon lambda genetic variants with peripheral blood profiles in healthy individuals.
Molecular genetics & genomic medicine
2023 Volume 12, Issue 1, Page(s) e2292
Abstract: Background: Type III interferons (IFN), also called as lambda IFNs (IFN-λs), are antiviral and immunomodulatory cytokines that are evolutionarily important in humans. Given their central roles in innate immunity, they could be influencing other aspects ... ...
| Abstract | Background: Type III interferons (IFN), also called as lambda IFNs (IFN-λs), are antiviral and immunomodulatory cytokines that are evolutionarily important in humans. Given their central roles in innate immunity, they could be influencing other aspects of human biology. This study aimed to examine the association of genetic variants that control the expression and/or activity of IFN-λ3 and IFN-λ4 with multiple phenotypes in blood profiles of healthy individuals. Methods: In a cohort of about 550 self-declared healthy individuals, after applying several exclusion criteria to determine their health status, we measured 30 blood parameters, including cellular, biochemical, and metabolic profiles. We genotyped them at rs12979860 and rs28416813 using competitive allele-specific PCR assays and tested their association with the blood profiles under dominant and recessive models for the minor allele. IFN-λ4 variants rs368234815 and rs117648444 were also genotyped or inferred. Results: We saw no association in the combined cohort under either of the models for any of the phenotypes. When we stratified the cohort based on gender, we saw a significant association only in males with monocyte (p = 1 × 10 Conclusions: These results show that lambda interferons can have pleiotropic effects. However, gender seems to be an effect modifier, with males being more sensitive than females to the effect. |
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| MeSH term(s) | Male ; Female ; Humans ; Interferon Lambda ; Interferons/genetics ; Interferons/metabolism ; Uric Acid ; Interleukins/genetics ; Interleukins/metabolism ; Phenotype |
| Chemical Substances | Interferon Lambda ; Interferons (9008-11-1) ; Uric Acid (268B43MJ25) ; Interleukins |
| Language | English |
| Publishing date | 2023-10-05 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2734884-2 |
| ISSN | 2324-9269 ; 2324-9269 |
| ISSN (online) | 2324-9269 |
| ISSN | 2324-9269 |
| DOI | 10.1002/mgg3.2292 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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