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Article ; Online: An Online Weight Loss Intervention for People With Obesity and Poorly Controlled Asthma.

Johnson, Olivia / Gerald, Lynn B / Harvey, Jean / Roy, Gem / Hazucha, Heather / Large, Chelsey / Burke, Alyce / McCormack, Meredith / Wise, Robert A / Holbrook, Janet T / Dixon, Anne E

The journal of allergy and clinical immunology. In practice

2022 Volume 10, Issue 6, Page(s) 1577–1586.e3

Abstract: Background: Weight loss might improve asthma control in people with obesity. However, people with asthma might have particular challenges losing weight and the amount of weight loss needed to improve asthma control is not clear.: Objectives: To pilot- ...

Abstract	Background: Weight loss might improve asthma control in people with obesity. However, people with asthma might have particular challenges losing weight and the amount of weight loss needed to improve asthma control is not clear. Objectives: To pilot-test an online weight loss intervention and to estimate the impact of weight loss on asthma control. Methods: We performed a 6-month, single-arm, futility trial of an online weight loss intervention at 2 centers. To reject the assumption of futility, 9 or more participants had to lose at least 5% of their body weight. We also assessed the association between weight loss (≥5%) and asthma outcomes. Results: Forty-three participants (85% women) started the weight loss intervention. The median and interquartile range for the body mass index was 40.3 kg/m Conclusions: An online weight loss intervention has the potential to meet U.S. Food and Drug Administration guidance for product evaluation (at least a 5% weight loss in 35% of people) for treating obesity, and is associated with a clinically significant improvement in asthma control, quality of life, and overall health-related quality of life.
MeSH term(s)	Asthma/complications ; Body Mass Index ; Female ; Humans ; Internet-Based Intervention ; Male ; Obesity/therapy ; Quality of Life ; Weight Loss ; Weight Reduction Programs
Language	English
Publishing date	2022-03-15
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2022.02.040
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Article ; Online: Roflumilast May Increase Risk of Exacerbations When Used to Treat Poorly Controlled Asthma in People with Obesity.

Dixon, Anne E / Que, Loretta G / Kalhan, Ravi / Dransfield, Mark T / Rogers, Linda / Gerald, Lynn B / Kraft, Monica / Krishnan, Jerry A / Johnson, Olivia / Hazucha, Heather / Roy, Gem / Holbrook, Janet T / Wise, Robert A

Annals of the American Thoracic Society

2022 Volume 20, Issue 2, Page(s) 206–214

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Asthma/drug therapy ; Asthma/chemically induced ; Aminopyridines/therapeutic use ; Aminopyridines/adverse effects ; Obesity/complications ; Obesity/drug therapy ; Double-Blind Method
Chemical Substances	Roflumilast (0P6C6ZOP5U) ; Aminopyridines
Language	English
Publishing date	2022-09-18
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202204-368OC
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Article ; Online: The challenge of addressing obesity in people with poorly controlled asthma.

Dixon, Anne E / Blake, Kathryn V / DiMango, Emily A / Dransfield, Mark T / Feemster, Laura C / Johnson, Olivia / Roy, Gem / Hazucha, Heather / Harvey, Jean / McCormack, Meredith C / Wise, Robert A / Holbrook, Janet T

Obesity science & practice

2021 Volume 7, Issue 6, Page(s) 682–689

Abstract: Objective: There is a high prevalence of obesity in people with asthma, and obesity is associated with poorly controlled asthma. Significant weight loss might improve asthma control: the purpose of this study was to investigate patient characteristics ... ...

Abstract	Objective: There is a high prevalence of obesity in people with asthma, and obesity is associated with poorly controlled asthma. Significant weight loss might improve asthma control: the purpose of this study was to investigate patient characteristics and factors that might affect implementation of a weight loss and/or roflumilast intervention, to target both obesity and asthma. Methods: A cross-sectional study of people with obesity and poorly controlled asthma performed at 13 sites across the United States. Results: One hundred and two people participated in this study. Median BMI was 37 (IQR 35-42). The majority, 55%, were African American and 76% were female. Fifty two percent had very poorly controlled asthma. Most participants were quite sedentary (70% reported being inactive or participating only in light-intensity activities according to the Stanford Brief Activity Survey). Participants reported significant impairments related to physical function on the Impact of Weight on Quality of Life-Lite questionnaire (median score 67 [IQR 41-84]). Thirty-five percent of participants reported mild, and 2 % moderate, depressive symptoms as assessed by the Patient Health Questionnaire-9. Conclusions: Poorly controlled asthma and obesity often affect minority populations and are associated with significant impairments in health related to physical function and low levels of physical activity that might complicate efforts to lose weight. Interventions targeted at poorly controlled asthma associated with obesity in the United States need to address factors complicating health in underserved communities, such as increasing opportunities for physical activity, while also managing activity limitations related to the combination of asthma and obesity.
Language	English
Publishing date	2021-05-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2836381-4
ISSN	2055-2238 ; 2055-2238
ISSN (online)	2055-2238
ISSN	2055-2238
DOI	10.1002/osp4.533
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Article: The challenge of addressing obesity in people with poorly controlled asthma

Dixon, Anne E. / Blake, Kathryn V. / DiMango, Emily A. / Dransfield, Mark T. / Feemster, Laura C. / Johnson, Olivia / Roy, Gem / Hazucha, Heather / Harvey, Jean / McCormack, Meredith C. / Wise, Robert A. / Holbrook, Janet T.

Obesity science & practice. 2021 Dec., v. 7, no. 6

2021

Abstract: OBJECTIVE: There is a high prevalence of obesity in people with asthma, and obesity is associated with poorly controlled asthma. Significant weight loss might improve asthma control: the purpose of this study was to investigate patient characteristics ... ...

Abstract	OBJECTIVE: There is a high prevalence of obesity in people with asthma, and obesity is associated with poorly controlled asthma. Significant weight loss might improve asthma control: the purpose of this study was to investigate patient characteristics and factors that might affect implementation of a weight loss and/or roflumilast intervention, to target both obesity and asthma. METHODS: A cross‐sectional study of people with obesity and poorly controlled asthma performed at 13 sites across the United States. RESULTS: One hundred and two people participated in this study. Median BMI was 37 (IQR 35–42). The majority, 55%, were African American and 76% were female. Fifty two percent had very poorly controlled asthma. Most participants were quite sedentary (70% reported being inactive or participating only in light‐intensity activities according to the Stanford Brief Activity Survey). Participants reported significant impairments related to physical function on the Impact of Weight on Quality of Life‐Lite questionnaire (median score 67 [IQR 41–84]). Thirty‐five percent of participants reported mild, and 2 % moderate, depressive symptoms as assessed by the Patient Health Questionnaire‐9. CONCLUSIONS: Poorly controlled asthma and obesity often affect minority populations and are associated with significant impairments in health related to physical function and low levels of physical activity that might complicate efforts to lose weight. Interventions targeted at poorly controlled asthma associated with obesity in the United States need to address factors complicating health in underserved communities, such as increasing opportunities for physical activity, while also managing activity limitations related to the combination of asthma and obesity.
Keywords	asthma ; cross-sectional studies ; females ; light intensity ; obesity ; patients ; people ; physical activity ; questionnaires ; surveys ; weight loss
Language	English
Dates of publication	2021-12
Size	p. 682-689.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2836381-4
ISSN	2055-2238
ISSN	2055-2238
DOI	10.1002/osp4.533
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of a randomized trial comparing standard and enhanced counseling for men at high risk of prostate cancer as a function of race and monitoring style.

Roussi, Pagona / Miller, Suzanne M / Giri, Veda N / Obeid, Elias / Wen, Kuang-Yi / Tagai, Erin K / Scarpato, John / Gross, Laura / Roy, Gem

Journal of health psychology

2016 Volume 23, Issue 14, Page(s) 1800–1809

Abstract: Despite conflicting guidelines, a significant subset of high-risk men decide to undergo routine prostate cancer screening. Yet, there is a scarcity of available programs, and no studies evaluating interventions to support men in dealing with the ... ...

Abstract	Despite conflicting guidelines, a significant subset of high-risk men decide to undergo routine prostate cancer screening. Yet, there is a scarcity of available programs, and no studies evaluating interventions to support men in dealing with the psychosocial impact of screening. In this study, one of the first to explore the responses of high-risk men enrolling in a Prostate Cancer Risk Assessment Program ( N = 128), patients underwent a prostate cancer risk counseling visit immediately followed by either a cognitive-affective preparation session designed to help them process the information they received or a general health education session. All men in this self-selected sample chose to participate in prostate cancer screening. Men were assessed 3 weeks and 6 months post-counseling. The impact of the enhanced counseling condition on knowledge, perceived risk, expectancies, and intrusive ideation was a function of racial and coping style group. Implications for tailored interventions to maximize preparedness for risk and screening counseling are discussed.
MeSH term(s)	Adaptation, Psychological ; Adult ; African Americans ; Aged ; Cognition ; Counseling/methods ; Early Detection of Cancer/adverse effects ; Early Detection of Cancer/psychology ; Follow-Up Studies ; Health Education ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Middle Aged ; Outcome Assessment, Health Care ; Prospective Studies ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/ethnology ; Prostatic Neoplasms/psychology ; Risk
Language	English
Publishing date	2016-10-10
Publishing country	England
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2021897-7
ISSN	1461-7277 ; 1359-1053
ISSN (online)	1461-7277
ISSN	1359-1053
DOI	10.1177/1359105316671188
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Article ; Online: Randomized trial of print messaging: the role of the partner and monitoring style in promoting provider discussions about prostate cancer screening among African American men.

Miller, Suzanne M / Roussi, Pagona / Scarpato, John / Wen, Kuang-Yi / Zhu, Fang / Roy, Gem

Psycho-oncology

2013 Volume 23, Issue 4, Page(s) 404–411

Abstract: Objective: Although African American (AA) men are at elevated risk for prostate cancer, medical guidelines do not present consistent screening recommendations for this group. However, all guidelines stress the need for screening decision making with a ... ...

Abstract	Objective: Although African American (AA) men are at elevated risk for prostate cancer, medical guidelines do not present consistent screening recommendations for this group. However, all guidelines stress the need for screening decision making with a provider. This study evaluated the effectiveness of a brochure for the female partners of AA men, designed to help promote such discussion on the part of their mates. We also explored the effect of the partner's monitoring style (i.e., the extent to which the partner typically attends to health threats) on promoting discussion. Methods: Female partners of AA men (N = 231) were randomized to receive either a prostate cancer screening Centers for Disease Control brochure for AA men, combined with a 'partner' brochure containing strategies to promote men's initiation of a provider visit to discuss screening, or the Centers for Disease Control brochure only and completed preintervention and post-intervention surveys online. Results: The message groups did not differ on taking active steps to engage in provider discussion: relative risk ratio (RRR) = 0.99, p = .98; thinking about it: RRR = 1.13, p = .74. However, among partners who received the partner brochure, monitoring style was associated with 'thinking about initiating a provider visit' on the part of the mate (RRR = 1.74, p < .01). Across conditions, monitoring style was also associated with 'taking active steps to initiate a provider visit' on the part of the mate (RRR = 1.38, p < .05). Conclusions: High monitoring partners may be effective in influencing their AA mates to initiate provider discussion, particularly when tailored messaging is provided.
MeSH term(s)	Adult ; Black or African American ; Age Factors ; Decision Making ; Early Detection of Cancer ; Female ; Humans ; Male ; Middle Aged ; Odds Ratio ; Pamphlets ; Patient Education as Topic/methods ; Patient Participation ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/ethnology ; Spouses/education
Language	English
Publishing date	2013-10-15
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	1118536-3
ISSN	1099-1611 ; 1057-9249
ISSN (online)	1099-1611
ISSN	1057-9249
DOI	10.1002/pon.3437
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Article ; Online: Prostate Cancer Patients' Understanding of the Gleason Scoring System: Implications for Shared Decision-Making.

Tagai, Erin K / Miller, Suzanne M / Kutikov, Alexander / Diefenbach, Michael A / Gor, Ronak A / Al-Saleem, Tahseen / Chen, David Y T / Fleszar, Sara / Roy, Gem

Journal of cancer education : the official journal of the American Association for Cancer Education

2018 Volume 34, Issue 3, Page(s) 441–445

Abstract: The Gleason scoring system is a key component of a prostate cancer diagnosis, since it indicates disease aggressiveness. It also serves as a risk communication tool that facilitates shared treatment decision-making. However, the system is highly complex ... ...

Abstract	The Gleason scoring system is a key component of a prostate cancer diagnosis, since it indicates disease aggressiveness. It also serves as a risk communication tool that facilitates shared treatment decision-making. However, the system is highly complex and therefore difficult to communicate: factors which have been shown to undermine well-informed and high-quality shared treatment decision-making. To systematically explore prostate cancer patients' understanding of the Gleason scoring system (GSS), we assessed knowledge and perceived importance among men who had completed treatment (N = 50). Patients were administered a survey that assessed patient knowledge and patients' perceived importance of the GSS, as well as demographics, medical factors (e.g., Gleason score at diagnosis), and health literacy. Bivariate analyses were conducted to identify associations with patient knowledge and perceived importance of the GSS. The sample was generally well-educated (48% with a bachelor's degree or higher) and health literate (M = 12.9, SD = 2.2, range = 3-15). Despite this, patient knowledge of the GSS was low (M = 1.8, SD = 1.4, range = 1-4). Patients' understanding of the importance of the GSS was moderate (M = 2.8, SD = 1.0, range = 0-4) and was positively associated with GSS knowledge (p < .01). Additionally, GSS knowledge was negatively associated with years since biopsy (p < .05). Age and health literacy were positively associated with patients' perceived importance of the GSS (p < .05), but not with GSS knowledge. Patient knowledge is thus less than optimal and would benefit from enhanced communication to maximize shared treatment decision-making. Future studies are needed to explore the potential utility of a simplified Gleason grading system and improved patient-provider communication.
MeSH term(s)	Communication ; Decision Making ; Health Knowledge, Attitudes, Practice ; Health Literacy ; Humans ; Male ; Middle Aged ; Neoplasm Grading/statistics & numerical data ; Patient Education as Topic ; Patient Participation ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy ; Surveys and Questionnaires
Language	English
Publishing date	2018-03-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	632898-2
ISSN	1543-0154 ; 0885-8195 ; 1543-1154
ISSN (online)	1543-0154
ISSN	0885-8195 ; 1543-1154
DOI	10.1007/s13187-018-1320-1
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Article: Preventing postpartum smoking relapse among inner city women: development of a theory-based and evidence-guided text messaging intervention.

Wen, Kuang-Yi / Miller, Suzanne M / Kilby, Linda / Fleisher, Linda / Belton, Tanisha D / Roy, Gem / Hernandez, Enrique

JMIR research protocols

2014 Volume 3, Issue 2, Page(s) e20

Abstract: Background: Underserved women are at high risk for smoking relapse after childbirth due to their unique socioeconomic and postpartum stressors and barriers. Mobile text messaging technology allows delivery of relapse prevention programs targeted to ... ...

Abstract	Background: Underserved women are at high risk for smoking relapse after childbirth due to their unique socioeconomic and postpartum stressors and barriers. Mobile text messaging technology allows delivery of relapse prevention programs targeted to their personal needs over time. Objective: To describe the development of a social-cognitive theory-based and evidence-guided text messaging intervention for preventing postpartum smoking relapse among inner city women. Methods: Guided by the cognitive-social health information processing framework, user-centered design, and health communication best practices, the intervention was developed through a systematic process that included needs assessment, followed by an iterative cycling through message drafting, health literacy evaluation and rewriting, review by target community members and a scientific advisory panel, and message revision, concluding with usability testing. Results: All message content was theory-grounded, derived by needs assessment analysis and evidence-based materials, reviewed and revised by the target population, health literacy experts, and scientific advisors. The final program, "Txt2Commit," was developed as a fully automated system, designed to deliver 3 proactive messages per day for a 1-month postpartum smoking relapse intervention, with crave and lapse user-initiated message functions available when needed. Conclusions: The developmental process suggests that the application of theory and best practices in the design of text messaging smoking cessation interventions is not only feasible but necessary for ensuring that the interventions are evidence based and user-centered.
Language	English
Publishing date	2014-04-03
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2719222-2
ISSN	1929-0748
ISSN	1929-0748
DOI	10.2196/resprot.3059
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Article ; Online: Preventing Postpartum Smoking Relapse Among Inner City Women

Wen, Kuang-Yi / Miller, Suzanne M / Kilby, Linda / Fleisher, Linda / Belton, Tanisha D / Roy, Gem / Hernandez, Enrique

JMIR Research Protocols, Vol 3, Iss 2, p e

Development of a Theory-Based and Evidence-Guided Text Messaging Intervention

2014 Volume 20

Abstract: BackgroundUnderserved women are at high risk for smoking relapse after childbirth due to their unique socioeconomic and postpartum stressors and barriers. Mobile text messaging technology allows delivery of relapse prevention programs targeted to their ... ...

Abstract	BackgroundUnderserved women are at high risk for smoking relapse after childbirth due to their unique socioeconomic and postpartum stressors and barriers. Mobile text messaging technology allows delivery of relapse prevention programs targeted to their personal needs over time. ObjectiveTo describe the development of a social-cognitive theory-based and evidence-guided text messaging intervention for preventing postpartum smoking relapse among inner city women. MethodsGuided by the cognitive-social health information processing framework, user-centered design, and health communication best practices, the intervention was developed through a systematic process that included needs assessment, followed by an iterative cycling through message drafting, health literacy evaluation and rewriting, review by target community members and a scientific advisory panel, and message revision, concluding with usability testing. ResultsAll message content was theory-grounded, derived by needs assessment analysis and evidence-based materials, reviewed and revised by the target population, health literacy experts, and scientific advisors. The final program, “Txt2Commit,” was developed as a fully automated system, designed to deliver 3 proactive messages per day for a 1-month postpartum smoking relapse intervention, with crave and lapse user-initiated message functions available when needed. ConclusionsThe developmental process suggests that the application of theory and best practices in the design of text messaging smoking cessation interventions is not only feasible but necessary for ensuring that the interventions are evidence based and user-centered.
Keywords	Medicine ; R ; Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	360
Language	English
Publishing date	2014-04-01T00:00:00Z
Publisher	JMIR Publications
Document type	Article ; Online
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Article ; Online: Development and preliminary testing of PROGRESS: a Web-based education program for prostate cancer survivors transitioning from active treatment.

Miller, Suzanne M / Hudson, Shawna V / Hui, Siu-Kuen Azor / Diefenbach, Michael A / Fleisher, Linda / Raivitch, Stephanie / Belton, Tanisha / Roy, Gem / Njoku, Anuli / Scarpato, John / Viterbo, Rosalia / Buyyounouski, Mark / Denlinger, Crystal / Miyamoto, Curtis / Reese, Adam / Baman, Jayson

Journal of cancer survivorship : research and practice

2015 Volume 9, Issue 3, Page(s) 541–553

Abstract: Purpose: This formative research study describes the development and preliminary evaluation of a theory-guided, online multimedia psycho-educational program (PROGRESS) designed to facilitate adaptive coping among prostate cancer patients transitioning ... ...

Abstract	Purpose: This formative research study describes the development and preliminary evaluation of a theory-guided, online multimedia psycho-educational program (PROGRESS) designed to facilitate adaptive coping among prostate cancer patients transitioning from treatment into long-term survivorship. Methods: Guided by the Cognitive-Social Health Information Processing Model (C-SHIP) and using health communications best practices, we conducted a two-phase, qualitative formative research study with early stage prostate cancer patients (n = 29) to inform the Web program development. Phase 1 included individual (n = 5) and group (n = 12) interviews to help determine intervention content and interface. Phase 2 employed iterative user/usability testing (n = 12) to finalize the intervention. Interview data were independently coded and collectively analyzed to achieve consensus. Results: Survivors expressed interest in action-oriented content on (1) managing treatment side effects, (2) handling body image and comorbidities related to overweight/obesity, (3) coping with emotional and communication issues, (4) tips to reduce disruptions of daily living activities, and (5) health skills training tools. Patients also desired the use of realistic and diverse survivor images. Conclusions: Incorporation of an established theoretical framework, application of multimedia intervention development best practices, and an evidence-based approach to content and format resulted in a psycho-educational tool that comprehensively addresses survivors' needs in a tailored fashion. Implications for cancer survivors: The results suggest that an interactive Web-based multimedia program is useful for survivors if it covers the key topics of symptom control, emotional well-being, and coping skills training; this tool has the potential to be disseminated and implemented as an adjunct to routine clinical care.
MeSH term(s)	Humans ; Internet/utilization ; Male ; Middle Aged ; Program Development/methods ; Prostatic Neoplasms/mortality ; Qualitative Research ; Survivors/psychology ; Telemedicine/utilization
Language	English
Publishing date	2015-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2388888-X
ISSN	1932-2267 ; 1932-2259
ISSN (online)	1932-2267
ISSN	1932-2259
DOI	10.1007/s11764-015-0431-5
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