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Article ; Online: An environmental risk assessment of IPD079Ea: a protein derived from

O'Neill, Bridget F / Boeckman, Chad / LeRoy, Kristine / Linderblood, Chris / Olson, Taylor / Woods, Rachel / Challender, Mary

GM crops & food

2024 Volume 15, Issue 1, Page(s) 15–31

Abstract: Farmers in North America face significant pressure from insects in their maize fields, particularly from corn rootworm ( ...

Abstract	Farmers in North America face significant pressure from insects in their maize fields, particularly from corn rootworm (
MeSH term(s)	Animals ; Zea mays/genetics ; Zea mays/metabolism ; Endotoxins/metabolism ; Plants, Genetically Modified/metabolism ; Coleoptera/genetics ; Coleoptera/metabolism ; Risk Assessment
Chemical Substances	Endotoxins
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2706099-8
ISSN	2164-5701 ; 2164-5701
ISSN (online)	2164-5701
ISSN	2164-5701
DOI	10.1080/21645698.2023.2299503
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Left Atrial Appendage Occlusion in the Elderly: Insights From PROTECT-AF, PREVAIL, and Continuous Access Registries.

Sulaiman, Samian / Roy, Kristine / Wang, Hong / de Backer, Ole / Alloco, Dominic / Reddy, Vivek Y / Holmes, David R / Alkhouli, Mohamad

JACC. Clinical electrophysiology

2023 Volume 9, Issue 5, Page(s) 669–676

Abstract: Background: Data on the safety and efficacy of left atrial appendage occlusion (LAAO) in elderly patients are limited.: Objectives: This study aimed to compare the outcomes of LAAO between patients ≥80 and <80 years of age.: Methods: We included ... ...

Abstract	Background: Data on the safety and efficacy of left atrial appendage occlusion (LAAO) in elderly patients are limited. Objectives: This study aimed to compare the outcomes of LAAO between patients ≥80 and <80 years of age. Methods: We included patients enrolled in randomized trials and nonrandomized registries of the Watchman 2.5 device. The primary efficacy endpoint was a composite of cardiovascular/unknown death, stroke, or systemic embolism at 5 years. Secondary endpoints included cardiovascular/unknown death, stroke, systemic embolism, and major and nonprocedural bleeding. Survival analyses were performed using the Kaplan-Meier, Cox proportional hazards, and competing risk analysis methods. Interaction terms were used to compare the 2 age groups. We also estimated the average treatment effect of the device with the use of inverse probability weighting. Results: We studied 2,258 patients, of whom 570 (25.2%) were ≥80 years old, and 1,688 (74.8%) were <80 years old. Procedural complications at 7 days were similar in both age groups. The primary endpoint occurred in 12.0% in the device group vs 13.8% in the control group (HR: 0.9; 95% CI: 0.6-1.4) among patients <80 years of age and in 25.3% vs 21.7%, respectively (HR: 1.2; 95% CI: 0.7-2.0) among patients ≥80 (interaction P = 0.48). There was no interaction between age and treatment effect for any of the secondary outcomes. The average treatment effects of LAAO (compared with warfarin) were similar in the elderly population (compared with younger patients). Conclusions: Despite the higher event rates, octogenarians derive similar benefits from LAAO as their younger counterparts. Age alone should not preclude LAAO in otherwise suitable candidates.
MeSH term(s)	Aged, 80 and over ; Humans ; Aged ; Atrial Fibrillation/complications ; Atrial Fibrillation/surgery ; Atrial Appendage/surgery ; Treatment Outcome ; Stroke/epidemiology ; Stroke/prevention & control ; Embolism/complications ; Registries
Language	English
Publishing date	2023-02-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2846739-5
ISSN	2405-5018 ; 2405-500X ; 2405-500X
ISSN (online)	2405-5018 ; 2405-500X
ISSN	2405-500X
DOI	10.1016/j.jacep.2023.02.007
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Article ; Online: Evaluation of an in vitro experimental platform of human polarized intestinal epithelial monolayers for the hazard assessment of insecticidal proteins.

Zimmermann, Cindi S / Snow, Ryan F / Wilson-Mifsud, Brittany / LeRoy, Kristine / Boeckman, Chad / Huang, Emily / Mathesius, Carey A / Roper, Jason M / Hurley, Bryan P

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2023 Volume 181, Page(s) 114106

Abstract: Previous work demonstrated the utility of using human-derived intestinal epithelial cell (IEC) lines cultured as polarized monolayers on Transwell® filters to differentiate between hazardous and non-hazardous proteins. The current study seeks to further ... ...

Abstract	Previous work demonstrated the utility of using human-derived intestinal epithelial cell (IEC) lines cultured as polarized monolayers on Transwell® filters to differentiate between hazardous and non-hazardous proteins. The current study seeks to further resolve appropriate concentrations for evaluating proteins of unknown hazard potential using the IEC experimental platform and leverages these parameters for evaluating the potential toxicity of insecticidal proteins characteristic of those expressed in genetically modified (GM) agricultural biotechnology crops. To establish optimal test protein concentrations, effects of several known hazardous (C. perfringens epsilon toxin, Listeriolysin O, Phaseolus vulgaris erythroagglutinin, E. coli Shiga toxin 1, C. difficile Toxin B and wheat germ agglutinin) and non-hazardous (Ara-h2, β-lactoglobulin, fibronectin and Rubisco) proteins on IEC barrier integrity and cell viability were evaluated at concentration ranges. Two insecticidal proteins (AfIP-1A and AfIP-1B) were evaluated for effects in the IEC assay, a seven-day insecticidal bioassay, and assessed in a high-dose 14-day acute oral toxicity study in mice. The results obtained from the human in vitro IEC assay were consistent with results obtained from an in vivo acute oral toxicity study, both demonstrating that the combination of AfIP-1A and AfIP-1B do not exhibit any identifiable harmful impacts on mammalian cells.
MeSH term(s)	Humans ; Animals ; Mice ; Bacterial Toxins/metabolism ; Escherichia coli ; Clostridioides difficile ; Intestines ; Epithelial Cells ; Intestinal Mucosa/metabolism ; Mammals
Chemical Substances	Bacterial Toxins
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2023.114106
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Zs.A 529: Show issues

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Article ; Online: Intracardiac vs Transesophageal Echocardiography for Left Atrial Appendage Occlusion With Watchman FLX in the U.S.

Ferro, Enrico G / Alkhouli, Mohamad / Nair, Devi G / Kapadia, Samir R / Hsu, Jonathan C / Gibson, Douglas N / Freeman, James V / Price, Matthew J / Roy, Kristine / Allocco, Dominic J / Yeh, Robert W / Piccini, Jonathan P

JACC. Clinical electrophysiology

2023 Volume 9, Issue 12, Page(s) 2587–2599

Abstract: Background: Intraprocedural imaging is critical for device delivery in transcatheter left atrial appendage occlusion (LAAO). Although pivotal trials of LAAO devices were conducted using transesophageal echocardiography (TEE), intracardiac ... ...

Abstract	Background: Intraprocedural imaging is critical for device delivery in transcatheter left atrial appendage occlusion (LAAO). Although pivotal trials of LAAO devices were conducted using transesophageal echocardiography (TEE), intracardiac echocardiography (ICE) is an emerging imaging modality. Objectives: This study compared outcomes after ICE- and TEE-guided Watchman FLX implantation in the SURPASS (SURveillance Post Approval AnalySiS Plan) nationwide LAAO registry. Methods: Baseline characteristics were compared using chi-square and t-tests. Outcomes were reported in unadjusted and adjusted comparisons via propensity weighting. Results: Between August 2020 and September 2021, LAAO was attempted in 39,759 patients at 698 sites, including 2,272 cases (5.7%) with ICE and 31,835 (80.0%) with TEE. ICE and TEE patients had similar baseline characteristics and mean procedural times (ICE 82 minutes vs TEE 78 minutes). ICE patients were less likely to receive general anesthesia (54% vs 98%, P < 0.01). Successful device implantation (98.3% vs 97.6%) and complete seal rates at 45 days were similar (n = 25,280; 83% vs 82%). Most adverse event rates were similar; unadjusted mortality rates at 45 days were 1.1% for ICE vs 0.8% for TEE (P = 0.14), and 1.0% vs 0.7% (P = 0.27) in adjusted analyses. Even after adjustment, pericardial effusion rates requiring intervention were significantly higher with ICE at 45 days (1.0% vs 0.5%; P = 0.02). This rate decreased as operators performed more ICE-guided procedures, although 82% of operators had performed <10 ICE-guided procedures overall. Conclusions: In the largest comparison to date, ICE use was infrequent. ICE and TEE both achieved high rates of complete LAAO. ICE was associated with significantly higher rates of pericardial effusion requiring intervention.
MeSH term(s)	Humans ; Echocardiography, Transesophageal ; Atrial Appendage/diagnostic imaging ; Atrial Appendage/surgery ; Pericardial Effusion/etiology ; Atrial Fibrillation/complications ; Atrial Fibrillation/surgery ; Cardiac Catheterization/methods
Language	English
Publishing date	2023-10-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2846739-5
ISSN	2405-5018 ; 2405-500X ; 2405-500X
ISSN (online)	2405-5018 ; 2405-500X
ISSN	2405-500X
DOI	10.1016/j.jacep.2023.08.004
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Article ; Online: Characterization of the Spectrum of Activity of IPD079Ea: A Protein Derived From Ophioglossum pendulum (Ophioglossales: Ophioglossaceae) With Activity Against Western Corn Rootworm [Diabrotica virgifera virgifera (Coleoptera: Chrysomelidae)].

Boeckman, Chad J / Ballou, Stephan / Gunderson, Tim / Huang, Emily / Linderblood, Chris / Olson, Taylor / Stolte, Brian / LeRoy, Kristine / Walker, Carl / Wang, Yiwei / Woods, Rachel / Zhang, John

Journal of economic entomology

2022 Volume 115, Issue 5, Page(s) 1531–1538

Abstract: Western corn rootworm (Diabrotica virgifera virgifera LeConte) is a major pest of corn in both North America and Europe and as such presents significant challenges for farmers. IPD079Ea protein is encoded by the ipd079Ea gene from Ophioglossum pendulum ( ... ...

Abstract	Western corn rootworm (Diabrotica virgifera virgifera LeConte) is a major pest of corn in both North America and Europe and as such presents significant challenges for farmers. IPD079Ea protein is encoded by the ipd079Ea gene from Ophioglossum pendulum (a species of fern) and was found to have activity against western corn rootworm in multiple corn events transformed to express the IPD079Ea protein. In chronic laboratory hazard studies, IPD079Ea protein was fed to eleven species in the order Coleoptera and four species in the order Lepidoptera to assess the spectrum of activity. Activity was observed on certain species of the Chrysomelidae and Coccinellidae families, with western corn rootworm as the most sensitive insect tested. No adverse effects on mortality or other sublethal endpoints were observed on any species within Lepidoptera. Overall, IPD079Ea protein appears not to have broad insecticidal properties and has potential value as an effective trait to control western corn rootworm in agricultural systems.
MeSH term(s)	Animals ; Bacillus thuringiensis/genetics ; Coleoptera/genetics ; Endotoxins ; Larva ; Pest Control, Biological ; Plants, Genetically Modified/genetics ; Zea mays/genetics
Chemical Substances	Endotoxins
Language	English
Publishing date	2022-05-31
Publishing country	England
Document type	Journal Article
ZDB-ID	3031-4
ISSN	1938-291X ; 0022-0493
ISSN (online)	1938-291X
ISSN	0022-0493
DOI	10.1093/jee/toac079
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Article ; Online: Characterization of the Spectrum of Activity of IPD079Ea: A Protein Derived From Ophioglossum pendulum (Ophioglossales: Ophioglossaceae) With Activity Against Western Corn Rootworm [Diabrotica virgifera virgifera (Coleoptera: Chrysomelidae)]

Boeckman, Chad J. / Ballou, Stephan / Gunderson, Tim / Huang, Emily / Linderblood, Chris / Olson, Taylor / Stolte, Brian / LeRoy, Kristine / Walker, Carl / Wang, Yiwei / Woods, Rachel / Zhang, Jian-xiang

Journal of Economic Entomology. 2022 Oct. 19, v. 115, no. 5 p.1531-1538

2022

Abstract	Western corn rootworm (Diabrotica virgifera virgifera LeConte) is a major pest of corn in both North America and Europe and as such presents significant challenges for farmers. IPD079Ea protein is encoded by the ipd079Ea gene from Ophioglossum pendulum (a species of fern) and was found to have activity against western corn rootworm in multiple corn events transformed to express the IPD079Ea protein. In chronic laboratory hazard studies, IPD079Ea protein was fed to eleven species in the order Coleoptera and four species in the order Lepidoptera to assess the spectrum of activity. Activity was observed on certain species of the Chrysomelidae and Coccinellidae families, with western corn rootworm as the most sensitive insect tested. No adverse effects on mortality or other sublethal endpoints were observed on any species within Lepidoptera. Overall, IPD079Ea protein appears not to have broad insecticidal properties and has potential value as an effective trait to control western corn rootworm in agricultural systems.
Keywords	Coccinellidae ; Diabrotica virgifera virgifera ; Lepidoptera ; Ophioglossum ; corn ; entomology ; ferns and fern allies ; genes ; insects ; mortality ; pests ; Europe ; North America ; western corn rootworm ; spectrum of activity ; insecticidal protein ; Coleoptera ; Ophioglossum pendulum
Language	English
Dates of publication	2022-1019
Size	p. 1531-1538.
Publishing place	Entomological Society of America
Document type	Article ; Online
ZDB-ID	3031-4
ISSN	0022-0493
ISSN	0022-0493
DOI	10.1093/jee/toac079
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Using digital health technology to evaluate the impact of chocolate on blood pressure: Results from the COCOA-BP study.

Christen, Thomas / Nagale, Sandra / Reinitz, Steve / Narayanan, Shruthi / Roy, Kristine / Allocco, Dominic J / Osattin, Alison

Cardiovascular digital health journal

2020 Volume 1, Issue 2, Page(s) 89–96

Abstract: Background: High blood pressure (BP) is a major risk factor for cardiovascular disease (CVD). Consumption of dark chocolate, which is high in flavonoids that may reduce CVD risk, is an attractive intervention to reduce to BP. Additionally, the use of ... ...

Abstract	Background: High blood pressure (BP) is a major risk factor for cardiovascular disease (CVD). Consumption of dark chocolate, which is high in flavonoids that may reduce CVD risk, is an attractive intervention to reduce to BP. Additionally, the use of mobile health (mHealth) technologies (eg, telehealth, smartphones, and wearable devices) can improve outcomes in patients with CVD. Objective: The purpose of this study was to investigate the impact of dark chocolate intake on BP, subject use of mHealth, and integration of mHealth into a clinical trial. Methods: The COCOA-BP (ChOcolate COnsumption And Blood Pressure) study was a prospective, single-center, pre-/postintervention study that enrolled 62 healthy volunteers. The study consisted of 3 phases: smartwatch/smart BP monitor familiarization and washout from chocolate (week 1); control (week 2); and intervention (weeks 3 and 4). During the intervention phase, subjects consumed 50 g of dark chocolate per day. The primary endpoint was change in resting systolic BP between the intervention and control phases. Additional endpoints included device accuracy and correlation with physical activity. Results: Mean resting systolic BP was 116.4 mm Hg before chocolate intake among 62 participants (mean age 37 years; 61% female). After chocolate intake, mean resting systolic BP was 116.0 mm Hg (difference -0.4; Conclusion: In this study, short-term dark chocolate intake did not seem to reduce BP. mHealth technology shows great potential for use in clinical studies, but challenges related to device accuracy and compliance need to be addressed.
Language	English
Publishing date	2020-10-22
Publishing country	United States
Document type	Journal Article
ISSN	2666-6936
ISSN (online)	2666-6936
DOI	10.1016/j.cvdhj.2020.08.002
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Article ; Online: Current State of Bioabsorbable Polymer-Coated Drug-Eluting Stents.

Akinapelli, Abhilash / Chen, Jack P / Roy, Kristine / Donnelly, Joseph / Dawkins, Keith / Huibregtse, Barbara / Hou, Dongming

Current cardiology reviews

2016 Volume 13, Issue 2, Page(s) 139–154

Abstract: Drug-eluting stents (DES) have been shown to significantly reduce clinical and angiographic restenosis compared to bare metal stents (BMS). The polymer coatings on DES elute antiproliferative drugs to inhibit intimal proliferation and prevent restenosis ... ...

Abstract	Drug-eluting stents (DES) have been shown to significantly reduce clinical and angiographic restenosis compared to bare metal stents (BMS). The polymer coatings on DES elute antiproliferative drugs to inhibit intimal proliferation and prevent restenosis after stent implantation. Permanent polymers which do not degrade in vivo may increase the likelihood of stent-related delayed arterial healing or polymer hypersensitivity. In turn, these limitations may contribute to an increased risk of late clinical events. Intuitively, a polymer which degrades after completion of drug release, leaving an inert metal scaffold in place, may improve arterial healing by removing a chronic source of inflammation, neoatherosclerosis, and/or late thrombosis. In this way, a biodegradable polymer may reduce late ischemic events. Additionally, improved healing after stent implantation could reduce the requirement for long-term dual antiplatelet therapy and the associated risk of bleeding and cost. This review will focus on bioabsorbable polymer-coated DES currently being evaluated in clinical trials.
Language	English
Publishing date	2016-12-24
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1875-6557
ISSN (online)	1875-6557
DOI	10.2174/1573403X12666161222155230
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Article: Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia.

Corfas, Gabriel / Roy, Kristine / Buxbaum, Joseph D

Nature neuroscience

2004 Volume 7, Issue 6, Page(s) 575–580

Abstract: Schizophrenia is a devastating psychiatric disease that affects 0.5-1% of the world's adult population. The hypothesis that this disease is a developmental disorder of the nervous system with late onset of its characteristic symptoms has been gaining ... ...

Abstract	Schizophrenia is a devastating psychiatric disease that affects 0.5-1% of the world's adult population. The hypothesis that this disease is a developmental disorder of the nervous system with late onset of its characteristic symptoms has been gaining acceptance in past years. However, the anatomical, cellular and molecular bases of schizophrenia remain unclear. Numerous studies point to alterations in different aspects of brain development as possible causes of schizophrenia, including defects in neuronal migration, neurotransmitter receptor expression and myelination. Recently, the gene that encodes neuregulin-1 (NRG1) has been identified as a potential susceptibility gene for schizophrenia, and defects in the expression of erbB3, one of the NRG1 receptors, have been shown to occur in the prefrontal cortex of schizophrenic patients, suggesting that NRG1-erbB signaling is involved in the pathogenesis of schizophrenia. These findings open new approaches to defining the molecular and cellular basis of schizophrenia in more mechanistic terms.
MeSH term(s)	Animals ; Humans ; Neuregulin-1/biosynthesis ; Neuregulin-1/genetics ; Neuregulin-1/physiology ; Receptor, ErbB-3/biosynthesis ; Receptor, ErbB-3/genetics ; Receptor, ErbB-3/physiology ; Schizophrenia/etiology ; Schizophrenia/genetics ; Schizophrenia/metabolism ; Schizophrenia/physiopathology ; Signal Transduction/physiology
Chemical Substances	Neuregulin-1 ; Receptor, ErbB-3 (EC 2.7.10.1)
Language	English
Publishing date	2004-06
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	1420596-8
ISSN	1546-1726 ; 1097-6256
ISSN (online)	1546-1726
ISSN	1097-6256
DOI	10.1038/nn1258
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Zs.A 4891: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 67: Show issues

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Article: Loss of the tailless gene affects forebrain development and emotional behavior.

Roy, Kristine / Thiels, Edda / Monaghan, A Paula

Physiology & behavior

2002 Volume 77, Issue 4-5, Page(s) 595–600

Abstract: We are studying the role of the evolutionarily conserved tlx gene in forebrain development in mice. Tlx is expressed in the ventricular zone that gives rise to neurons and glia of the forebrain. We have shown by mutating the tlx gene in mice, that in the ...

Abstract	We are studying the role of the evolutionarily conserved tlx gene in forebrain development in mice. Tlx is expressed in the ventricular zone that gives rise to neurons and glia of the forebrain. We have shown by mutating the tlx gene in mice, that in the absence of this transcription factor, mutant animals survive, but suffer specific anatomical defects in the limbic system. Because of these developmentally induced structural changes, mice with a mutation in the tlx gene can function, but exhibit extreme behavioral pathology. Mice show heightened aggressiveness, excitability, and poor cognition. In this article, we present a summary of our findings on the cellular and behavioral changes in the forebrain of mutant animals. We show that absence of the tlx gene leads to abnormal proliferation and differentiation of progenitor cells (PCs) in the forebrain from embryonic day 9 (E9). These abnormalities lead to hypoplasia of superficial cortical layers and subsets of GABAergic interneurons in the neocortex. We examined the behavior of mutant animals in three tests for anxiety/fear: the open field, the elevated plus maze, and fear conditioning. Mutant animals are less anxious and less fearful when assessed in the elevated plus and open-field paradigm. In addition, mutant animals do not condition to either the tone or the context in the fear-conditioning paradigm. These animals, therefore, provide a genetic tool to delineate structure/function relationships in defined regions of the brain and decipher how their disruption leads to behavioral abnormalities.
MeSH term(s)	Aggression/physiology ; Animals ; Anxiety/genetics ; Cerebral Cortex/cytology ; Cerebral Cortex/growth & development ; Emotions/physiology ; Fear/physiology ; Limbic System/cytology ; Limbic System/physiology ; Memory/physiology ; Mice ; Mice, Knockout ; Neurons/physiology ; Pain/genetics ; Pain/physiopathology ; Pain Measurement ; Prosencephalon/cytology ; Prosencephalon/growth & development ; Receptors, Cytoplasmic and Nuclear/genetics
Chemical Substances	Nr2e1 protein, mouse ; Receptors, Cytoplasmic and Nuclear
Language	English
Publishing date	2002-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/s0031-9384(02)00902-2
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