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  1. Article ; Online: Bimodal structural tuning of pyrrole-2-carboxamide-based transmembrane ion transport systems.

    Roy, Naveen J / Pujari, Parappa L / Talukdar, Pinaki

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 16, Page(s) 3323–3329

    Abstract: The pyrrole-2-carboxamide moiety is well known for its presence in various natural products and its use in anion receptor systems. Here we assess the transmembrane anion transport activity of a series of substituted pyrrole-2-carboxamides and show them ... ...

    Abstract The pyrrole-2-carboxamide moiety is well known for its presence in various natural products and its use in anion receptor systems. Here we assess the transmembrane anion transport activity of a series of substituted pyrrole-2-carboxamides and show them to be highly tuneable, versatile systems for anion transport by simple variations of pyrrole ring and amide substituents.
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob00269a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Synthesis of novel seven-membered carbasugars and evaluation of their glycosidase inhibition potentials.

    Athiyarath, Vignesh / Roy, Naveen J / Vijil, A T V / Sureshan, Kana M

    RSC advances

    2021  Volume 11, Issue 16, Page(s) 9410–9420

    Abstract: Here, we report the synthesis of five novel seven-membered carbasugar analogs. We adopted a chiral-pool strategy starting from the cheap and readily available d-mannitol to synthesize these ring-expanded carbasugars. Apart from several regioselective ... ...

    Abstract Here, we report the synthesis of five novel seven-membered carbasugar analogs. We adopted a chiral-pool strategy starting from the cheap and readily available d-mannitol to synthesize these ring-expanded carbasugars. Apart from several regioselective protecting group manipulations, these syntheses involved Wittig olefination and ring-closing metathesis as the key steps. We observed an unprecedented deoxygenation reaction of an allylic benzyl ether upon treatment with H
    Language English
    Publishing date 2021-03-02
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra00804h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Photocontrolled activation of doubly

    Ahmad, Manzoor / Roy, Naveen J / Singh, Anurag / Mondal, Debashis / Mondal, Abhishek / Vijayakanth, Thangavel / Lahiri, Mayurika / Talukdar, Pinaki

    Chemical science

    2023  Volume 14, Issue 33, Page(s) 8897–8904

    Abstract: Artificial biomimetic chloride anionophores have shown promising applications as anticancer scaffolds. Importantly, stimuli-responsive chloride transporters that can be selectively activated inside the cancer cells to avoid undesired toxicity to normal, ... ...

    Abstract Artificial biomimetic chloride anionophores have shown promising applications as anticancer scaffolds. Importantly, stimuli-responsive chloride transporters that can be selectively activated inside the cancer cells to avoid undesired toxicity to normal, healthy cells are very rare. Particularly, light-responsive systems promise better applicability for photodynamic therapy because of their spatiotemporal controllability, low toxicity, and high tunability. Here, in this work, we report
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc01786a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: NAD(P)H:Quinone Acceptor Oxidoreductase 1 (NQO1) Activatable Salicylamide H

    Roy, Naveen J / Save, Shreyada N / Sharma, Virender Kumar / Abraham, Benchamin / Kuttanamkuzhi, Abhijith / Sharma, Shilpy / Lahiri, Mayurika / Talukdar, Pinaki

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 51, Page(s) e202301412

    Abstract: NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a detoxifying enzyme overexpressed in tumors, plays a key role in protecting cancer cells against oxidative stress and thus has been considered an attractive candidate for activating prodrug(s). Herein, ... ...

    Abstract NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a detoxifying enzyme overexpressed in tumors, plays a key role in protecting cancer cells against oxidative stress and thus has been considered an attractive candidate for activating prodrug(s). Herein, we report the first use of NQO1 for the selective activation of 'protransporter' systems in cancer cells leading to the induction of apoptosis. Salicylamides, easily synthesizable small molecules, have been effectively used for efficient H
    MeSH term(s) Humans ; Female ; NAD ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Benzoquinones ; Quinones/metabolism ; Breast Neoplasms
    Chemical Substances quinone (3T006GV98U) ; NAD (0U46U6E8UK) ; NAD(P)H Dehydrogenase (Quinone) (EC 1.6.5.2) ; Benzoquinones ; Quinones ; NQO1 protein, human (EC 1.6.5.2)
    Language English
    Publishing date 2023-08-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202301412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Synthesis of Highly Substituted Furans by a Cascade of Formal anti-Carbopalladation/Hydroxylation and Elimination.

    Schitter, Theresa / Roy, Naveen J / Jones, Peter G / Werz, Daniel B

    Organic letters

    2019  Volume 21, Issue 3, Page(s) 640–643

    Abstract: Highly substituted furans are generated by a cascade of formal anti-carbopalladation, attack of a nucleophilic hydroxy group, and aromatization by elimination of the emerging dihydrofuran derivative. Mono-, di-, and trisubstituted furans were obtained in ...

    Abstract Highly substituted furans are generated by a cascade of formal anti-carbopalladation, attack of a nucleophilic hydroxy group, and aromatization by elimination of the emerging dihydrofuran derivative. Mono-, di-, and trisubstituted furans were obtained in good to excellent yields. When we attempted to access tetrasubstituted furan derivatives, an additional rearrangement was observed that resulted in the formation of chromenes. Follow-up chemistry shows the utility of TMS as a protecting group for the alkyne moiety.
    Language English
    Publishing date 2019-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.8b03732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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