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  1. Book ; Online ; E-Book: The Aquarium Fish Medicine Handbook

    Yanong, Roy P. E. / Lewbart, Greg

    2024  

    Author's details Roy P. E. Yanong and Gregory A. Lewbart
    Keywords Fishes/Diseases
    Subject code 639.3
    Language English
    Size 1 online resource (xiv, 285 pages)
    Edition First edition.
    Publisher CRC Press
    Publishing place Boca Raton, FL
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-003-05772-1 ; 1-04-000428-8 ; 1-03-271120-5 ; 0-367-52291-8 ; 978-1-003-05772-7 ; 978-1-04-000428-9 ; 978-1-03-271120-1 ; 978-0-367-52291-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Breast cancer in young Indian women: factors, challenges in screening, and upcoming diagnostics.

    Roy, Pragyan

    Journal of cancer research and clinical oncology

    2023  Volume 149, Issue 15, Page(s) 14409–14427

    Abstract: Breast cancer management for young Indian women are full of challenges. The National Cancer Registry Programme (NCRP) has predicted that nearly 2,30,000 cases of breast cancer will be reported annually by 2025; with a steady increase in cases of young ... ...

    Abstract Breast cancer management for young Indian women are full of challenges. The National Cancer Registry Programme (NCRP) has predicted that nearly 2,30,000 cases of breast cancer will be reported annually by 2025; with a steady increase in cases of young women (< 45 years of age) with breast cancer. In this review, the available literature is evaluated to understand the various risk factors contributing to the rise in cases of breast cancer in young women in India. Further, the challenges that are faced by the technicians in early diagnosis (e.g., physiology of young breasts, limited trained professionals, and awareness among patients, and cost of the treatment) of breast cancer. This review also focuses on the upcoming diagnostics like serum biomarkers and nanosensors for the early identification of the disease. For better prognosis and to reduce the chances of disease reoccurrence and metastasis, it is important that the disease has to be identified at an early stage.
    Language English
    Publishing date 2023-08-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-023-05215-x
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  3. Article: Comparative Assessment of Various Cephalometric Parameters Used for Determining Vertical Skeletal Dysplasia.

    Roy, Pinaki / Roy, Poulomi / Koley, Sourav

    Cureus

    2024  Volume 16, Issue 2, Page(s) e55101

    Abstract: Introduction: The aim of the study is to assess and correlate the different cephalometric parameters used to determine the vertical jaw relationship.: Methods: Cephalometric radiographs from 148 patients were assessed and comparison was made using ... ...

    Abstract Introduction: The aim of the study is to assess and correlate the different cephalometric parameters used to determine the vertical jaw relationship.
    Methods: Cephalometric radiographs from 148 patients were assessed and comparison was made using all eight parameters. Statistical analysis was performed using mean, standard deviation and coefficient of variance. A correlation was found between different variables using the Pearson's correlation coefficient.
    Results: In the entire sample, the basal plane angle displayed the most variable distribution, while the R angle displayed the most homogeneous distribution. There was a significant correlation found between the Jarabak ratio, Steiner's mandibular plane angle (SN-GoGn), Frankfort mandibular plane angle (FMA), R angle, and DR angle. There was a moderate to weak correlation between the Y-axis, basal plane angle, and facial height ratio with other skeletal analyses.
    Conclusion: Among angular variables DR angle, R angle, SN-GoGn and FMA can be used and among linear variables Jarabak ratio could be used reliably to assess the growth pattern. It suggested that in order to obtain an accurate evaluation of the vertical jaw relationship, a variety of measurements should be combined.
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55101
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  4. Book ; Online: Deep Correlation-Aware Kernelized Autoencoders for Anomaly Detection in Cybersecurity

    Roy, Padmaksha

    2023  

    Abstract: Unsupervised learning-based anomaly detection in latent space has gained importance since discriminating anomalies from normal data becomes difficult in high-dimensional space. Both density estimation and distance-based methods to detect anomalies in ... ...

    Abstract Unsupervised learning-based anomaly detection in latent space has gained importance since discriminating anomalies from normal data becomes difficult in high-dimensional space. Both density estimation and distance-based methods to detect anomalies in latent space have been explored in the past. These methods prove that retaining valuable properties of input data in latent space helps in the better reconstruction of test data. Moreover, real-world sensor data is skewed and non-Gaussian in nature, making mean-based estimators unreliable for skewed data. Again, anomaly detection methods based on reconstruction error rely on Euclidean distance, which does not consider useful correlation information in the feature space and also fails to accurately reconstruct the data when it deviates from the training distribution. In this work, we address the limitations of reconstruction error-based autoencoders and propose a kernelized autoencoder that leverages a robust form of Mahalanobis distance (MD) to measure latent dimension correlation to effectively detect both near and far anomalies. This hybrid loss is aided by the principle of maximizing the mutual information gain between the latent dimension and the high-dimensional prior data space by maximizing the entropy of the latent space while preserving useful correlation information of the original data in the low-dimensional latent space. The multi-objective function has two goals -- it measures correlation information in the latent feature space in the form of robust MD distance and simultaneously tries to preserve useful correlation information from the original data space in the latent space by maximizing mutual information between the prior and latent space.
    Keywords Computer Science - Machine Learning
    Subject code 006
    Publishing date 2023-01-01
    Publishing country us
    Document type Book ; Online
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  5. Article ; Online: Recent advances in the development of fluorescent chemosensors for Al

    Roy, Partha

    Dalton transactions (Cambridge, England : 2003)

    2021  Volume 50, Issue 21, Page(s) 7156–7165

    Abstract: Detection of Al3+ has become important as it is related to several health issues and other problems. Different fluorophoric platforms, such as naphthalene, benzene, rhodamine, etc., have been explored to sense Al3+ and a good number of research articles ... ...

    Abstract Detection of Al3+ has become important as it is related to several health issues and other problems. Different fluorophoric platforms, such as naphthalene, benzene, rhodamine, etc., have been explored to sense Al3+ and a good number of research articles are being published. This article focuses on the synthesis of recently reported aluminum sensors constructed from 2-hydroxy-1-naphthaldehyde, salicylaldehyde, rhodamine, coumarin and different metal based-MOFs.
    MeSH term(s) Aluminum ; Fluorescent Dyes ; Naphthalenes ; Optical Imaging ; Rhodamines ; Spectrometry, Fluorescence
    Chemical Substances Fluorescent Dyes ; Naphthalenes ; Rhodamines ; naphthalene (2166IN72UN) ; Aluminum (CPD4NFA903)
    Language English
    Publishing date 2021-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d1dt00901j
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  6. Article ; Online: Multi-Gene Recombinant Baculovirus Expression Systems: From Inception to Contemporary Applications.

    Bissett, Sara L / Roy, Polly

    Viruses

    2024  Volume 16, Issue 4

    Abstract: Many protein expression systems are primarily utilised to produce a single, specific recombinant protein. In contrast, most biological processes such as virus assembly rely upon a complex of several interacting proteins rather than the activity of a sole ...

    Abstract Many protein expression systems are primarily utilised to produce a single, specific recombinant protein. In contrast, most biological processes such as virus assembly rely upon a complex of several interacting proteins rather than the activity of a sole protein. The high complexity of the baculovirus genome, coupled with a multiphase replication cycle incorporating distinct transcriptional steps, made it the ideal system to manipulate for high-level expression of a single, or co-expression of multiple, foreign proteins within a single cell. We have developed and utilised a series of recombinant baculovirus systems to unravel the sequential assembly process of a complex non-enveloped model virus, bluetongue virus (BTV). The high protein yields expressed by the baculovirus system not only facilitated structure-function analysis of each viral protein but were also advantageous to crystallography studies and supported the first atomic-level resolution of a recombinant viral protein, the major BTV capsid protein. Further, the formation of recombinant double-shelled virus-like particles (VLPs) provided insights into the structure-function relationships among the four major structural proteins of the BTV whilst also representing a potential candidate for a viral vaccine. The baculovirus multi-gene expression system facilitated the study of structurally complex viruses (both non-enveloped and enveloped viruses) and heralded a new generation of viral vaccines.
    MeSH term(s) Baculoviridae/genetics ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Animals ; Gene Expression ; Bluetongue virus/genetics ; Genetic Vectors/genetics ; Virus Assembly ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Capsid Proteins/genetics ; Capsid Proteins/metabolism ; Capsid Proteins/chemistry
    Chemical Substances Recombinant Proteins ; Viral Proteins ; Capsid Proteins
    Language English
    Publishing date 2024-03-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16040492
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  7. Conference proceedings ; Online: Modelling of seismic anisotropy with rheologically constrained geodynamic setup

    Roy, P. / Steinberger, B.

    XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

    2023  

    Abstract: Seismic anisotropy is an observation that is believed to yield information on the flow pattern in the mantle. There are many studies of anisotropy in the upper mantle; however, the lower mantle is still underexplored, due to problems in seismic imaging ... ...

    Abstract Seismic anisotropy is an observation that is believed to yield information on the flow pattern in the mantle. There are many studies of anisotropy in the upper mantle; however, the lower mantle is still underexplored, due to problems in seismic imaging and complexities of modelling of flow laws of different minerals. In this study, we modelled the radially anisotropic behavior of two different geodynamic setups, one is the rising of a mantle plume from the core-mantle boundary to the surface, and another is subduction of a slab reaching the lowermost mantle. We use ASPECT for modelling large scale mantle flow and ECOMAN to simulate the development of lattice preferred orientation of mantle fabric. We then couple the results from ASPECT to ECOMAN for modelling the radial anisotropy and maximum shear wave splitting direction. We show that in the part of the lowermost mantle surrounding the plume horizontally polarized shear waves (Vsh ) are faster than the vertically polarized ones (Vsv ) while the inside of the plume tail shows opposite signature. However, Vsh becomes greater than Vsv when the plume flattens out at the surface. We also find that the maximum splitting direction is horizontal outside the base of the plume and it becomes vertical inside the plume tail and again becomes horizontal at the surface. Moreover, our result for the slab setup reveals that as the slab reaches the lowermost mantle, Vsh becomes higher than Vsv and maximum splitting is horizontal at the base of the slab.
    Subject code 550
    Language English
    Publishing date 2023-07-11
    Publishing country de
    Document type Conference proceedings ; Online
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  8. Article ; Online: Bluetongue virus assembly and exit pathways.

    Roy, Polly

    Advances in virus research

    2020  Volume 108, Page(s) 249–273

    Abstract: Bluetongue virus (BTV) is an insect-vectored emerging pathogen of wild ruminants and livestock in many parts of the world. The virion particle is a complex structure of consecutive layers of protein surrounding a genome of 10 double-stranded (ds) RNA ... ...

    Abstract Bluetongue virus (BTV) is an insect-vectored emerging pathogen of wild ruminants and livestock in many parts of the world. The virion particle is a complex structure of consecutive layers of protein surrounding a genome of 10 double-stranded (ds) RNA segments. BTV has been studied extensively as a model system for large, nonenveloped dsRNA viruses. A combination of recombinant proteins and particles together with reverse genetics, high-resolution structural analysis by X-ray crystallography and cryo-electron microscopy techniques have been utilized to provide an order for the assembly of the capsid shell and the protein sequestration required for it. Further, a reconstituted in vitro assembly system and RNA-RNA interaction assay, have defined the individual steps required for the assembly and packaging of the 10-segmented RNA genome. In addition, various microscopic techniques have been utilized to illuminate the stages of virus maturation and its egress via multiple pathways. These findings have not only given an overall understanding of BTV assembly and morphogenesis but also indicated that similar assembly and egress pathways are likely to be used by related viruses and provided an informed starting point for intervention or prevention.
    MeSH term(s) Animals ; Bluetongue virus/genetics ; Bluetongue virus/pathogenicity ; Bluetongue virus/physiology ; Bluetongue virus/ultrastructure ; Books ; Capsid/physiology ; Capsid Proteins/metabolism ; Cryoelectron Microscopy ; Genome, Viral ; Insect Vectors/virology ; Livestock/virology ; Viral Proteins/genetics ; Virion/metabolism ; Virion/pathogenicity ; Virus Assembly ; Virus Release ; Virus Replication
    Chemical Substances Capsid Proteins ; Viral Proteins
    Language English
    Publishing date 2020-09-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 195-8
    ISSN 1557-8399 ; 0065-3527
    ISSN (online) 1557-8399
    ISSN 0065-3527
    DOI 10.1016/bs.aivir.2020.08.002
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  9. Article: The psychology behind response of people in wake of the COVID-19 pandemic in India.

    Roy, Pritha

    Indian journal of psychiatry

    2020  Volume 62, Issue 3, Page(s) 330–331

    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 221523-8
    ISSN 0019-5545
    ISSN 0019-5545
    DOI 10.4103/psychiatry.IndianJPsychiatry_308_20
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  10. Article ; Online: Highly efficient vaccines for Bluetongue virus and a related Orbivirus based on reverse genetics.

    Roy, Polly

    Current opinion in virology

    2020  Volume 44, Page(s) 35–41

    Abstract: Bluetongue virus (BTV) reverse genetics (RG), available since 2007, has allowed the dissection of the virus replication cycle, including discovery of a primary replication stage. This information has allowed the generation of Entry-Competent-Replication- ... ...

    Abstract Bluetongue virus (BTV) reverse genetics (RG), available since 2007, has allowed the dissection of the virus replication cycle, including discovery of a primary replication stage. This information has allowed the generation of Entry-Competent-Replication-Abortive (ECRA) vaccines, which enter cells and complete primary replication but fail to complete the later stage. A series of vaccine trials in sheep and cattle either with a single ECRA serotype or a cocktail of multiple ECRA serotypes have demonstrated that these vaccines provide complete protection against virulent virus challenge without cross-serotype interference. Similarly, an RG system developed for the related African Horse Sickness virus, which causes high mortality in equids has provided AHSV ECRA vaccines that are protective in horses. ECRA vaccines were incapable of productive replication in animals despite being competent for cell entry. This technology allows rapid generation of emerging Orbivirus vaccines and offers immunogenicity and safety levels that surpass attenuated or recombinant routes.
    MeSH term(s) Animals ; Antibodies, Neutralizing ; Antibodies, Viral/immunology ; Bluetongue/immunology ; Bluetongue/prevention & control ; Bluetongue virus/genetics ; Bluetongue virus/immunology ; Cattle ; Orbivirus/genetics ; Orbivirus/immunology ; Reoviridae Infections/immunology ; Reoviridae Infections/prevention & control ; Reoviridae Infections/veterinary ; Reverse Genetics/methods ; Sheep ; Vaccines, Attenuated/genetics ; Vaccines, Attenuated/immunology ; Viral Vaccines/genetics ; Viral Vaccines/immunology ; Virus Replication
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Vaccines, Attenuated ; Viral Vaccines
    Language English
    Publishing date 2020-06-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2020.05.003
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