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Article: Monitoring the curing efficiency of a plant-based green engineered additive on caprine skin: a spectroscopic and chemometric novel approach.

Hossain, Md Mokarom / Roy, Uttam Kumar

2023 Volume 9, Issue 5, Page(s) e16273

Abstract: Environmental sustainability in industrial processing is one of the most fundamental requirements for sustainable development. The leather industry is known for its vast environmental pollution. But, green engineering may occur a paradigm shift in this ... ...

Abstract	Environmental sustainability in industrial processing is one of the most fundamental requirements for sustainable development. The leather industry is known for its vast environmental pollution. But, green engineering may occur a paradigm shift in this sector. Plant-based goatskins curing is a cutting-edge green technology that holds the concept of pollution reduction through prevention on the upper stream of leather processing. The successful and rapid monitoring of the efficiency of this technology is the foremost demand for mass-level applications. In this study, ATR-FTIR spectroscopy was employed to monitor this technology's efficiency using a plant
Language	English
Publishing date	2023-05-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e16273
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Article ; Online: Monitoring the curing efficiency of a plant-based green engineered additive on caprine skin: a spectroscopic and chemometric novel approach

Hossain, Md. Mokarom / Roy, Uttam Kumar

Heliyon. 2023 May, v. 9, no. 5 p.e16273-

2023

Abstract	Environmental sustainability in industrial processing is one of the most fundamental requirements for sustainable development. The leather industry is known for its vast environmental pollution. But, green engineering may occur a paradigm shift in this sector. Plant-based goatskins curing is a cutting-edge green technology that holds the concept of pollution reduction through prevention on the upper stream of leather processing. The successful and rapid monitoring of the efficiency of this technology is the foremost demand for mass-level applications. In this study, ATR-FTIR spectroscopy was employed to monitor this technology's efficiency using a plant Polygonum hydropiper. Chemometrics was also applied to extract information from spectral data leading to an understanding of the inherent effect of studying preservatives on goatskins collagen chemistry. 10% plant-paste +5% NaCl, 10% plant-paste +10% NaCl, and 15% plant-paste +5% NaCl on goatskin were assessed by ATR-FTIR on 0th, 10th, and 30th days of preservation. The Spectral peak fitting (R² = 0.99) area of amide I and II of collagen peptide bands revealed 2.73 to 1.33 times more structural suitability of studied goatskins than the control. Principal component analysis and Hierarchical cluster analysis showed that, after 30 days of curing, 15% paste +5% salt-rubbed goatskin collagen matrix significantly (around 50%) interacted with P. hydropiper. The interaction was superficial, as it happened before the opening up of collagen fibers. In conclusion, ATR-FTIR spectroscopy with Chemometrics can be an effective tool in evaluating the efficiency of goatskin curing and understanding the entire effect on collagen chemistry quickly.
Keywords	Persicaria hydropiper ; chemometrics ; cluster analysis ; collagen ; goats ; leather ; leather industry ; peptides ; pollution ; principal component analysis ; spectral analysis ; spectroscopy ; sustainable development ; sustainable technology ; Collagen chemistry ; Green chemistry ; P. hydropiper ; ATR-FTIR spectroscopy ; Goatskin preservation ; Environmental sustainability ; ATR-FTIR ; PCA ; HCA ; PC
Language	English
Dates of publication	2023-05
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e16273
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Article ; Online: A Comparative Study on Intranasal Versus Intravenous Lorazepam in the Management of Acute Seizure in Children.

Rudra, Nandan / Ghosh, Taraknath / Roy, Uttam Kumar

Folia medica

2022 Volume 63, Issue 6, Page(s) 958–964

Abstract: Introduction: The acute seizure in childhood is a medical emergency which is usually managed by benzodiazepines used as a first line of therapy. There are no strict guidelines of using intranasal lorazepam in India. Many paediatricians use it in an ... ...

Abstract	Introduction: The acute seizure in childhood is a medical emergency which is usually managed by benzodiazepines used as a first line of therapy. There are no strict guidelines of using intranasal lorazepam in India. Many paediatricians use it in an emergency situation as it is inexpensive, easy to administer and even treatment can be started at home. Very few studies are available to compare efficacy and safety of intravenous lorazepam with intranasal lorazepam in childhood seizure, though both routes have comparable pharmacokinetic profile. Intravenous lorazepam (0.1 mg/kg) is already recommended as a first-line treatment of acute childhood seizures in India. There are very few studies regarding the usefulness of intranasal lorazepam. With this background, we compared intranasal lorazepam with the more widely accepted intravenous lorazepam for control of acute seizure. Aim: To compare effectiveness and safety of intranasal and intravenous lorazepam in acute seizure in children aged 5-12 years. Materials and methods: This is an analytical observational cross-sectional study involving patients with acute seizure who received lorazepam via either the intravenous or intranasal route. Formulation and dosage of lorazepam were the same in both routes. Results: Distributions of patient groups according to sex, age, and weight were statistically not significant (p=0.42, p=0.391, and p=0.605, respectively). Time to control seizure within 10 min and persistent cessation of seizure activity were similar in both groups. Safety parameters showed no differences statistically. Conclusions: Though intravenous lorazepam is recommended as first-line treatment, intranasal lorazepam may be a good alternative choice in a convulsing child.
MeSH term(s)	Administration, Intranasal ; Anticonvulsants/therapeutic use ; Child ; Cross-Sectional Studies ; Humans ; Lorazepam/pharmacokinetics ; Lorazepam/therapeutic use ; Seizures/drug therapy ; Status Epilepticus/drug therapy
Chemical Substances	Anticonvulsants ; Lorazepam (O26FZP769L)
Language	English
Publishing date	2022-07-18
Publishing country	Bulgaria
Document type	Journal Article ; Observational Study
ZDB-ID	300275-5
ISSN	1314-2143 ; 0430-8638 ; 0204-8043
ISSN (online)	1314-2143
ISSN	0430-8638 ; 0204-8043
DOI	10.3897/folmed.63.e60938
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Article: A questionnaire-based study to develop an instrument measuring poor interest in biostatistics among postgraduate medical students and faculties.

Roy, Uttam Kumar / Biswas, Pabitra / Mandal, Purnendu

Journal of education and health promotion

2021 Volume 10, Page(s) 382

Abstract: Background: It has been realized by senior researchers that interest in biostatistics is very poor among medical professionals. Knowledge of biostatistics plays an important role in medical research. Studies conducted about knowledge, attitude toward ... ...

Abstract	Background: It has been realized by senior researchers that interest in biostatistics is very poor among medical professionals. Knowledge of biostatistics plays an important role in medical research. Studies conducted about knowledge, attitude toward biostatistics by many researchers, but there were no works about factors in relation to it. Considering this gap, we tried to develop a new instrument. Materials and methods: Item generation and questionnaire formation were done using focus group discussion involving seven experts from different departments of medical colleges. Face validity and content validity and pilot testing were carried out step by step. In estimating reliability, internal consistency measured after collecting data from 66 study participants. Data were collected through self-administered paper-based questionnaire where response in each item was in five-point Likert scale. Cronbach's alpha for reliability analysis was used. Results: In first stage, item generation through FGD, then face validity was assessed by senior faculties. Content validity was checked by Aiken's V index. In initial stages, with six items, Cronbach's alpha was 0.805. Scale mean and variance were 24.24 and 27.26. After final reliability testing, it became 0.866 with four items where scale mean and variance came to 15.85 and 16.38. Conclusion: All the six items were important factors. Reliability improved when knowledge in statistics in higher secondary level and biostatistics classes in PG course were eliminated as factors. More qualitative research is needed for better understanding of this concept.
Language	English
Publishing date	2021-10-29
Publishing country	India
Document type	Journal Article
ZDB-ID	2715449-X
ISSN	2319-6440 ; 2277-9531
ISSN (online)	2319-6440
ISSN	2277-9531
DOI	10.4103/jehp.jehp_195_21
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Article ; Online: Study of the human liver by ultrasound examination to search for variations of venous anatomy.

Ain, Partha Sarathi / Roy, Uttam Kumar / Meyur, Rudradev / Chattopadhyay, Subhajit

Folia medica

2022 Volume 63, Issue 5, Page(s) 676–685

Abstract: Introduction: Knowledge about venous patterns (especially portal and hepatic venous) and their variations are extremely crucial for liver transplantation and other surgical procedures on liver. Studies have been done at national or international level ... ...

Abstract	Introduction: Knowledge about venous patterns (especially portal and hepatic venous) and their variations are extremely crucial for liver transplantation and other surgical procedures on liver. Studies have been done at national or international level on variations of hepatic venous patterns by CT or MRI or by dissection on cadaveric liver. No definitive or authentic study on this topic could be noted in electronic and print media, as well as in standard textbook. Considering low cost and noninvasive nature, we utilized ultrasonography to bridge this lacuna. Aim: To estimate prevalence and types of anatomical variations of hepatic venous system and to determine association of among variations. Materials and methods: It is an observational cross-sectional study where ultrasonographic evaluation of hepatic venous pattern on adult population of either sex (consecutive sampling) without any major liver disorders was done in RG Kar Medical College and data were analyzed with appropriate statistical procedures. Results: Normal hepatic venous pattern along with normal portal venous pattern is much higher in our study, which is a unique finding. The proportion of normal portal venous pattern is more in extra hepatic bifurcation group. Variations of portal vein and normal hepatic venous pattern are more in case of intrahepatic bifurcation of portal venous branching group. Overall presence of intrahepatic bifurcation of portal vein is significantly higher than extrahepatic bifurcation. Conclusions: This study provides an updated database for the prevalence and distribution of anatomic variations of the hepatic venous and portal venous system.
MeSH term(s)	Adult ; Cross-Sectional Studies ; Hepatic Veins/anatomy & histology ; Hepatic Veins/diagnostic imaging ; Humans ; Liver/diagnostic imaging ; Portal Vein/anatomy & histology ; Portal Vein/diagnostic imaging ; Portal Vein/surgery ; Ultrasonography
Language	English
Publishing date	2022-07-18
Publishing country	Bulgaria
Document type	Journal Article ; Observational Study
ZDB-ID	300275-5
ISSN	1314-2143 ; 0430-8638 ; 0204-8043
ISSN (online)	1314-2143
ISSN	0430-8638 ; 0204-8043
DOI	10.3897/folmed.63.e60772
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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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Article: Taxonomy of urban mixed land use planning

Raman, Rewati / Roy, Uttam Kumar

Land use policy. 2019 Nov., v. 88

2019

Abstract: In classical urban planning, land use segregation and zoning regulations have been practiced by the city planners as the mainstream guiding principles in shaping cities. In spite of many advantages, such land use segregation & zoning regulations, over ... ...

Abstract	In classical urban planning, land use segregation and zoning regulations have been practiced by the city planners as the mainstream guiding principles in shaping cities. In spite of many advantages, such land use segregation & zoning regulations, over the last few decades, have been critiqued by scholars for many adverse conditions. Such as 1) isolation and lack of vitality, 2) longer home-work distance and travel cost, 3) unsuitable environment for small investments, 4) higher travel cost for facilities, amenities and thereby increased expenditure, 5) safety issues, etc. As a solution, mixed land use (MLU) has been advocated as a strategy to avoid such limitations and adverse conditions. In addition, MLU offers other advantages like 1) housing variety and density, 2) creation of an economic blend of compatible land uses, 3) compact development, 4) stronger neighborhood character, 5) walkability, 6) job generation, etc. However, MLU always may not produce such advantages. For example, mixing multiple land uses beyond a suitable proportion can also bring unwanted conditions like traffic congestion, encroachments, unintended very high-density housing, parking spill out, non-residential uses operating on residential premises paying less tax, chaos and noise, stressed infrastructure, etc. Nevertheless, MLU has been advocated largely in all international urban forums and scholarly discourses. Still, operationalizing the concept of MLU in an appropriate balance has not been streamlined due to various confusions and research gaps. The current paper addresses those confusions through a thorough discussion from literature and clarifies the concept of MLU with clear classifications and differentiation as a significant basis for further research and practice.
Keywords	cities ; infrastructure ; land use planning ; mixing ; taxonomy ; traffic ; travel ; urban planning ; zoning
Language	English
Dates of publication	2019-11
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	852476-2
ISSN	0264-8377
ISSN	0264-8377
DOI	10.1016/j.landusepol.2019.104102
Database	NAL-Catalogue (AGRICOLA)

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Article: Polygonum hydropiper in goatskin preservation: A sustainable leather processing approach

Hossain, Md. Mokarom / Ahmed, Sobur / Zaman, Sharmin / Bari, Md. Latiful / Roy, Uttam Kumar

Sustainable chemistry and pharmacy. 2022 Oct., v. 29

2022

Abstract: In conventional preservation of hides and skins, the use of NaCl (50%) evolves enormous salinity and total dissolved solids (TDS) in soaking effluent during leather processing. Plant-based skins preservation is a sustainable solution in reducing salinity ...

Abstract	In conventional preservation of hides and skins, the use of NaCl (50%) evolves enormous salinity and total dissolved solids (TDS) in soaking effluent during leather processing. Plant-based skins preservation is a sustainable solution in reducing salinity and TDS from leather industry to replace conventional curing. In this study, the application of Polygonum hydropiper-based dry powder paste over flesh side of goatskin following 10%, 10%, and 15% paste mixing with 5%, 10%, and 5% salt, respectively, was done with periodical monitoring of organoleptic properties, moisture content, hydrothermal stability, and bacterial load. As compared to conventional curing, these Phyto-based salt minimized curing formulations had preserved goatskin for 30 days, resulting in a maximum 81% and 52% salinity and TDS reduction, respectively, in soaking liquor. The preserved skins were processed into shoe-upper leather in the same manner, and the ultimately produced leather offered the equivalent physical qualities. SEM images corroborated the structural orientation of collagen fibers was more suited than leather produced from salt-preserved skins. The correlation analysis demonstrated strong interdependencies among goatskin preservation efficacy metrics, particularly moisture content and hydrothermal stability, with the highest correlation (r = −0.919). Phytochemicals like alkaloids, flavonoids, coumarin, quinones, terpenoids, tannin, and phlobatannin were present in P. hydropiper extracts. The acetonic and water extract of the examined plant demonstrated modest antibacterial efficacy (11 mm) against Staphylococcus aureus compared to chloramphenicol (27 mm). Therefore, P. hydropiper can be a potential curing agent with comparable leather strength while minimizing the environmental impact and endorsing sustainable developments of leather industry.
Keywords	Persicaria hydropiper ; Polygonum ; Staphylococcus aureus ; antibacterial properties ; chloramphenicol ; collagen ; coumarin ; environmental impact ; flavonoids ; green chemistry ; leather ; leather industry ; microbial load ; quinones ; salinity ; terpenoids ; water content
Language	English
Dates of publication	2022-10
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2352-5541
DOI	10.1016/j.scp.2022.100770
Database	NAL-Catalogue (AGRICOLA)

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Article: Effectiveness and adverse drug reactions of levetiracetam and midazolam in refractory neonatal seizure: A cross-sectional comparative study.

Jayswal, Diptiman / Roy, Uttam Kumar / Ghosh, Taraknath / Mandal, Purnendu

Journal of education and health promotion

2021 Volume 10, Page(s) 118

Abstract: Background: Neonatal seizure (NS) reflects serious underlying brain injury, requiring immediate evaluation and early treatment. In neonates, phenobarbitone and phenytoin are used primarily to control the seizures. If uncontrolled, widespread off-label ... ...

Abstract	Background: Neonatal seizure (NS) reflects serious underlying brain injury, requiring immediate evaluation and early treatment. In neonates, phenobarbitone and phenytoin are used primarily to control the seizures. If uncontrolled, widespread off-label use of midazolam and levetiracetam was practiced. These drugs gained popularity though there are no such studies available on literature search comparing them. The present study was designed to explore these lacunae using these two drugs in refractory cases. To study the efficacy and adverse drug reactions (ADRs) of midazolam and levetiracetam not responding to usual line of therapy. Materials and methods: This was a prospective cross-sectional study conducted on 69 neonates in the NICU and Department of Pharmacology in Burdwan Medical College and Hospital, West Bengal. Patients receiving midazolam or levetiracetam when uncontrolled with first line antiepileptics, namely, phenobarbitone and phenytoin, were considered eligible. The study variables were time to control seizure, seizure recurrence and frequency, and treatment-related adverse events. analysis used Mann-Whitney U-test were applied Comparison with respect to time to control and Chi-square test were applied to detect difference in proportion for ADRs. The SPSS Statistics 17.0 was used for analysis. Results: We compared the time periods to control neonatal seizure for effectiveness between levetiracetam and midazolam showing no significant difference ( Conclusions: Both midazolam and levetiracetam are equally effective and safe in NS not responding to usual line of treatment.
Language	English
Publishing date	2021-03-31
Publishing country	India
Document type	Journal Article
ZDB-ID	2715449-X
ISSN	2319-6440 ; 2277-9531
ISSN (online)	2319-6440
ISSN	2277-9531
DOI	10.4103/jehp.jehp_937_20
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Article: The protective effects of nerol to prevent the toxicity of carbon tetrachloride to the liver in Sprague-Dawley rats.

Mondal, Milon / Bala, Jibanananda / Mondal, Kakoli Rani / Afrin, Sadia / Saha, Protyaee / Saha, Moumita / Jamaddar, Sarmin / Roy, Uttam Kumar / Sarkar, Chandan

Heliyon

2023 Volume 9, Issue 12, Page(s) e23065

Abstract: Introduction: Carbon-tetrachloride (CCl: Materials and methods: For the aim of this experiment, 35 male Sprague-Dawley rats ranging in body weight (BW) from 140 to 180 g were split into five separate groups. With the exception of vehicle control ... ...

Abstract	Introduction: Carbon-tetrachloride (CCl Materials and methods: For the aim of this experiment, 35 male Sprague-Dawley rats ranging in body weight (BW) from 140 to 180 g were split into five separate groups. With the exception of vehicle control group 1, all experimental rats were subjected to carbon tetrachloride exposure through intra-peritoneal injection at a 0.7 mL/kg body weight dose once a week for 4 weeks (28 days). The treatment groups 3 and 4 received oral administration of nerol at 50 and 100 mg/kg BW for 28 days. In the same time period, the standard control group received 100 mg/kg BW silymarin. Results: Serum hepatic markers, lipid profiles, albumin, globulin, bilirubin, and total protein were all substantially improved in nerol-treated rats in a dose-dependent manner that had been exposed to CCl Conclusion: According to the findings of our investigation, nerol has potential as a functional element to shield the liver from harm brought on by ROS that are caused by CCL
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e23065
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Article ; Online: A Study to Compare Hypolipidemic Effects of Allium Sativum (Garlic) Alone and in Combination with Atorvastatin or Ezetimibe in Experimental Model

Sil Sudipta / Roy Uttam Kumar / Biswas Supreeti / Mandal Purnendu / Pal Keya

Serbian Journal of Experimental and Clinical Research, Vol 22, Iss 1, Pp 11-

2021 Volume 19

Abstract: Background: Dyslipidemia is a major cause of atherosclerosis and atherosclerosis induced conditions. Atorvastatin is an effective drug for dyslipidemia and reduce the risk of cardiovascular morbidity and mortality. Ezetimibe is used as an adjunct to ... ...

Abstract	Background: Dyslipidemia is a major cause of atherosclerosis and atherosclerosis induced conditions. Atorvastatin is an effective drug for dyslipidemia and reduce the risk of cardiovascular morbidity and mortality. Ezetimibe is used as an adjunct to statins hypercholesterolemia. Garlic is known for the hypolipidemic effect in traditional medicine. There are very limited studies comparing the additive effects of Allium sativum on atorvastatin and ezetimibe. Aims: To compare the additive hypolipidemic effects of Allium sativum with atorvastatin and ezetimibe. Setting and Design: The experimental study was done in Department of Pharmacology and Biochemistry, Burdwan Medical College, Burdwan from February 2014 - October 2015. Material and Methods: Dyslipidemia rat by (induced by atherogenic diet) were randomized into five groups of six rats in each and each cage was labelled for identification of different groups and treated with drugs (atorvastatin, ezetimibe, garlic homogenate, atorvastatin + garlic homogenate, ezetimibe + garlic homogenate) for twelve weeks and assessment of lipid profiles were done. Change of parameters checked for any significant difference by appropriate statistical tests. Results: Significant TC (Total Cholesterol) & TG (Triglyceride) concentrations reduction were maximum among ezetimibe group (51% and 47%) respectively. LDL (Low Density Lipoprotein) & VLDL (Very Low-Density Lipoprotein) concentrations reduction were maximum (62% and 26%) among combination of atorvastatin and garlic group when compared to other treatment groups. HDL (High Density Lipoprotein) concentration was maximally increased (31%) among combination ezetimibe and garlic group which was also statistically significant. Conclusion: Garlic have significant hypolipidemic effect when used in combination with atorvastatin and ezetimibe.
Keywords	atorvastatin ; dyslipidemia ; experimental ; ezetimibe garlic ; Medicine ; R
Subject code	630
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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