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  1. Article ; Online: Genomic determinants of antibody response to a typhoid vaccine in Indian recipients.

    Roy, Vijay Laxmi / Majumder, Partha Pratim

    Journal of genetics

    2024  Volume 103

    Abstract: Typhoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in ... ...

    Abstract Typhoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 days postvaccination relative to prevaccination. For each vaccinee, wholegenome genotyping was performed using the Infinium Global Screening Array (Illumina). We identified 39 SNPs that mapped to 13 chromosomal regions to be associated with antibody response to the vaccine; these included SNPs on genes
    MeSH term(s) Humans ; Typhoid-Paratyphoid Vaccines/genetics ; Antibody Formation ; Typhoid Fever/epidemiology ; Typhoid Fever/prevention & control ; Genomics ; Polysaccharides ; RGS Proteins
    Chemical Substances Typhoid-Paratyphoid Vaccines ; Polysaccharides ; RGS7 protein, human ; RGS Proteins
    Language English
    Publishing date 2024-03-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 3039-9
    ISSN 0973-7731 ; 0958-8361 ; 0022-1333
    ISSN (online) 0973-7731
    ISSN 0958-8361 ; 0022-1333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Genomic associations with antibody response to an oral cholera vaccine.

    Roy, Vijay Laxmi / Majumder, Partha P

    Vaccine

    2023  Volume 41, Issue 42, Page(s) 6391–6400

    Abstract: Oral cholera vaccine is one of the key interventions used in our fight to end the longest pandemic of our time, cholera. The immune response conferred by the currently available cholera vaccines, as measured by serum antibody levels, is variable amongst ... ...

    Abstract Oral cholera vaccine is one of the key interventions used in our fight to end the longest pandemic of our time, cholera. The immune response conferred by the currently available cholera vaccines, as measured by serum antibody levels, is variable amongst its recipients. We undertook a genome wide association study (GWAS) on antibody response to the cholera vaccine; globally, the first GWAS on cholera vaccine response. We identified three clusters of bi-allelic SNPs, in high within-cluster linkage disequilibrium that were moderately (p < 5 × 10
    MeSH term(s) Humans ; Cholera Vaccines ; Antibody Formation ; Genome-Wide Association Study ; Cholera/prevention & control ; Genomics ; Antibodies, Bacterial ; Administration, Oral
    Chemical Substances Cholera Vaccines ; Antibodies, Bacterial
    Language English
    Publishing date 2023-09-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.09.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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