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  1. Article ; Online: Hypocalcemia: low incidence in flares of pustular and chronic plaque psoriasis.

    Ruan, Xucong / Tey, Hong L

    International journal of dermatology

    2017  Volume 56, Issue 6, Page(s) e133–e135

    MeSH term(s) Adult ; Aged ; Body Surface Area ; Calcium/blood ; Female ; Humans ; Hypocalcemia/blood ; Hypocalcemia/epidemiology ; Incidence ; Male ; Middle Aged ; Psoriasis/blood ; Psoriasis/epidemiology ; Retrospective Studies ; Singapore/epidemiology ; Symptom Flare Up
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2017-02-15
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.13549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.189: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A single-center observational study on congenital diaphragmatic hernia: Outcome, predictors of mortality and experience from a tertiary perinatal center in Singapore.

    Teo, Wan-Yee / Sriram, Bhavani / Alim, Aa Abdul / Ruan, Xucong / Rajadurai, V S

    Pediatrics and neonatology

    2020  Volume 61, Issue 4, Page(s) 385–392

    Abstract: Background: Congenital diaphragmatic hernia (CDH) is a common birth defect associated with significant mortality and morbidity. There is limited outcome data on CDH in the Southeast Asian region. Rapid accessibility to our CDH Perinatal Center, as a ... ...

    Abstract Background: Congenital diaphragmatic hernia (CDH) is a common birth defect associated with significant mortality and morbidity. There is limited outcome data on CDH in the Southeast Asian region. Rapid accessibility to our CDH Perinatal Center, as a consequence of the small geographic size of our country and efficient land transportation system, has largely eliminated deaths of live outborn babies prior arrival at our center. We selected a study period when extracorporeal membrane oxygenation (ECMO) support was not available at our institution. The data will therefore be relevant in developing management guidelines and antenatal counselling for perinatal centers in this region managing CDH with limited resources, without ECMO facilities.
    Methods: A retrospective study of antenatally or postnatally diagnosed CDH infants born between January 2002 and June 2005 was performed. We selected this study period as ECMO support was not available over this period. We studied the demographics, clinical characteristics, postnatal predictors of mortality and outcomes of CDH infants in a single tertiary institution.
    Results: A total of 24 patients with CDH were identified. Seventy-nine percent of liveborns with CDH survived to hospital discharge. Antenatal detection rate was 83.3%. Significant postnatal predictors of mortality were preoperative pneumothorax (p = 0.035), high CRIB score (p = 0.007), low one- and five-minute Apgar score (p = 0.011, p = 0.026 respectively) and high pCO2 on initial arterial blood gas (p = 0.007). At one-year follow-up, three patients had delayed gross motor milestones which resolved subsequently. Re-admissions were required for recurrent bronchiolitis (33%) and oesophageal reflux which resolved in all cases. Two (13.3%) infants had surgical complications and needed re-admission for probable adhesive intestinal obstruction; one required adhesiolysis and the other was managed conservatively with good outcome.
    Conclusion: A single-center CDH outcome in Singapore, without ECMO use, was good. This is a cohort now with long-term survival outcome which will be valuable to the neonatology community.
    MeSH term(s) Abortion, Induced ; Apgar Score ; Carbon Dioxide/blood ; Female ; Hernias, Diaphragmatic, Congenital/mortality ; Hernias, Diaphragmatic, Congenital/surgery ; Humans ; Infant, Newborn ; Male ; Patient Readmission ; Pneumothorax/mortality ; Postoperative Complications ; Pregnancy ; Prenatal Diagnosis/statistics & numerical data ; Retrospective Studies ; Singapore/epidemiology ; Stillbirth
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2020-03-13
    Publishing country Singapore
    Document type Journal Article ; Observational Study
    ZDB-ID 2441816-X
    ISSN 2212-1692 ; 1875-9572
    ISSN (online) 2212-1692
    ISSN 1875-9572
    DOI 10.1016/j.pedneo.2020.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1083: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Fabrication of non-dissolving analgesic suppositories using 3D printed moulds.

    Sun, Yuanyuan / Ruan, Xucong / Li, Hairui / Kathuria, Himanshu / Du, Guang / Kang, Lifeng

    International journal of pharmaceutics

    2016  Volume 513, Issue 1-2, Page(s) 717–724

    Abstract: Conventional suppositories sometimes fail in exerting their therapeutic activity as the base materials melt inside body cavities. Also they are not suitable to provide long term treatment. Biomedical grade silicone elastomers may be used to fabricate non- ...

    Abstract Conventional suppositories sometimes fail in exerting their therapeutic activity as the base materials melt inside body cavities. Also they are not suitable to provide long term treatment. Biomedical grade silicone elastomers may be used to fabricate non-dissolvable suppositories to overcome these disadvantages. We kneaded 4 analgesics into the 2 kinds of silicone polymers at 1%, 5% and 10% drug loading, respectively, to test their mechanical properties and drug release profiles. The optimized drug-polymer combinations were used to fabricate suppositories, and three dimensional printing (3DP) was used to create the suppository moulds. Subsequently, the drug release profiles and biocompatibility of the suppositories were studied. It was found that, the mechanical properties of the drug laden silicone elastomers and the rate of drug release from the elastomers can be tuned by varying drug-polymer combinations. The silicone elastomers containing 1% (w/w) and 5% (w/w) diclofenac sodium were the optimal formulations with prolonged drug release and biocompatibility at cellular level. These properties, together with complex geometries offered by 3DP technique, potentially made the non-dissolving suppositories promising therapeutic agents for personalized medicine.
    MeSH term(s) Analgesics/chemistry ; Anesthetics, Local/chemistry ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Cell Line ; Chemistry, Pharmaceutical ; Delayed-Action Preparations/chemistry ; Diclofenac/chemistry ; Drug Liberation ; Elastic Modulus ; Ibuprofen/chemistry ; Ketoprofen/chemistry ; Lidocaine/chemistry ; Mice ; Printing, Three-Dimensional ; Silicone Elastomers/chemistry ; Solubility ; Suppositories/chemistry ; Tensile Strength
    Chemical Substances Analgesics ; Anesthetics, Local ; Anti-Inflammatory Agents, Non-Steroidal ; Delayed-Action Preparations ; Silicone Elastomers ; Suppositories ; Diclofenac (144O8QL0L1) ; Ketoprofen (90Y4QC304K) ; Lidocaine (98PI200987) ; Ibuprofen (WK2XYI10QM)
    Language English
    Publishing date 2016-11-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2016.09.073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Conducting of Web-Based Workshops for Final Year Medical Students Preparing to Enter the Workforce During the COVID-19 Pandemic.

    Kan, Juliana Yin Li / Zhu, Ling / Fong, Nigel Jie Ming / Ruan, Xucong / Ong, Andrew Ming Liang / Lee, Guozhang / Mattar, Shaikh Abdul Matin / Woong, Natalie Liling / Kang, Mei Ling

    Medical science educator

    2020  Volume 31, Issue 1, Page(s) 197–201

    Abstract: Medical students were temporarily removed from direct patient contact activities during the COVID-19 pandemic, shortening the duration of ward-based attachment programs. Web-based workshops were organized to equip final year medical students with ... ...

    Abstract Medical students were temporarily removed from direct patient contact activities during the COVID-19 pandemic, shortening the duration of ward-based attachment programs. Web-based workshops were organized to equip final year medical students with necessary skills to start work in a general medicine setting. Topics included case-based scenarios reviewing patients with new complaints, medical documentation, and inter-professional communication. They were conducted using an online video conference platform and utilized polling platforms, small group discussions, and the "Chat" function to promote interactivity. Web-based learning enables delivery of useful contents without compromising interactivity and clinical applicability during the COVID-19 pandemic.
    Keywords covid19
    Language English
    Publishing date 2020-10-27
    Publishing country United States
    Document type Journal Article
    ISSN 2156-8650
    ISSN (online) 2156-8650
    DOI 10.1007/s40670-020-01125-6
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  5. Article: Conducting of Web-Based Workshops for Final Year Medical Students Preparing to Enter the Workforce During the COVID-19 Pandemic

    Kan, Juliana Yin Li / Zhu, Ling / Fong, Nigel Jie Ming / Ruan, Xucong / Ong, Andrew Ming Liang / Lee, Guozhang / Mattar, Shaikh Abdul Matin / Woong, Natalie Liling / Kang, Mei Ling

    Med Sci Educ

    Abstract: Medical students were temporarily removed from direct patient contact activities during the COVID-19 pandemic, shortening the duration of ward-based attachment programs. Web-based workshops were organized to equip final year medical students with ... ...

    Abstract Medical students were temporarily removed from direct patient contact activities during the COVID-19 pandemic, shortening the duration of ward-based attachment programs. Web-based workshops were organized to equip final year medical students with necessary skills to start work in a general medicine setting. Topics included case-based scenarios reviewing patients with new complaints, medical documentation, and inter-professional communication. They were conducted using an online video conference platform and utilized polling platforms, small group discussions, and the "Chat" function to promote interactivity. Web-based learning enables delivery of useful contents without compromising interactivity and clinical applicability during the COVID-19 pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #898198
    Database COVID19

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