LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article: Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation.

    Tundidor, Isabel / Seijo-Vila, Marta / Blasco-Benito, Sandra / Rubert-Hernández, María / Moreno-Bueno, Gema / Bindila, Laura / de la Rosa, Rubén Fernández / Guzmán, Manuel / Sánchez, Cristina / Pérez-Gómez, Eduardo

    Cell death discovery

    2024  Volume 10, Issue 1, Page(s) 12

    Abstract: Mammary gland development occurs primarily in adulthood, undergoing extensive expansion during puberty followed by cycles of functional specialization and regression with every round of pregnancy/lactation/involution. This process is ultimately driven by ...

    Abstract Mammary gland development occurs primarily in adulthood, undergoing extensive expansion during puberty followed by cycles of functional specialization and regression with every round of pregnancy/lactation/involution. This process is ultimately driven by the coordinated proliferation and differentiation of mammary epithelial cells. However, the endogenous molecular factors regulating these developmental dynamics are still poorly defined. Endocannabinoid signaling is known to determine cell fate-related events during the development of different organs in the central nervous system and the periphery. Here, we report that the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) plays a pivotal role in adult mammary gland development. Specifically, it is required for luminal lineage specification in the mammary gland, and it promotes hormone-driven secretory differentiation of mammary epithelial cells by controlling the endogenous levels of anandamide and the subsequent activation of cannabinoid CB
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Journal Article
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-023-01788-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer.

    Tundidor, Isabel / Seijo-Vila, Marta / Blasco-Benito, Sandra / Rubert-Hernández, María / Adámez, Sandra / Andradas, Clara / Manzano, Sara / Álvarez-López, Isabel / Sarasqueta, Cristina / Villa-Morales, María / González-Lois, Carmen / Ramírez-Medina, Esther / Almoguera, Belén / Sánchez-López, Antonio J / Bindila, Laura / Hamann, Sigrid / Arnold, Norbert / Röcken, Christoph / Heras-Murillo, Ignacio /
    Sancho, David / Moreno-Bueno, Gema / Caffarel, María M / Guzmán, Manuel / Sánchez, Cristina / Pérez-Gómez, Eduardo

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 3130

    Abstract: Clinical management of breast cancer (BC) metastasis remains an unmet need as it accounts for 90% of BC-associated mortality. Although the luminal subtype, which represents >70% of BC cases, is generally associated with a favorable outcome, it is ... ...

    Abstract Clinical management of breast cancer (BC) metastasis remains an unmet need as it accounts for 90% of BC-associated mortality. Although the luminal subtype, which represents >70% of BC cases, is generally associated with a favorable outcome, it is susceptible to metastatic relapse as late as 15 years after treatment discontinuation. Seeking therapeutic approaches as well as screening tools to properly identify those patients with a higher risk of recurrence is therefore essential. Here, we report that the lipid-degrading enzyme fatty acid amide hydrolase (FAAH) is a predictor of long-term survival in patients with luminal BC, and that it blocks tumor progression and lung metastasis in cell and mouse models of BC. Together, our findings highlight the potential of FAAH as a biomarker with prognostic value in luminal BC and as a therapeutic target in metastatic disease.
    MeSH term(s) Animals ; Mice ; Amidohydrolases/genetics ; Biomarkers, Tumor ; Lung Neoplasms/pathology ; Neoplasm Recurrence, Local/pathology
    Chemical Substances Amidohydrolases (EC 3.5.-) ; Biomarkers, Tumor ; fatty-acid amide hydrolase (EC 3.5.1.-)
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38750-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top