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Article ; Online: Preclinical evaluation of [

Bennacef, Idriss / Rubins, Daniel / Riffel, Kerry / Williams, Mangay / Posavec, Diane J / Holahan, Marie A / Purcell, Mona L / Haley, Hyking D / Wolf, Mary / Stachel, Shawn J / Lubbers, Laura S / Wesolowski, Gregg A / Duong, Le T / Hamill, Terence G / Evelhoch, Jeffrey L / Hostetler, Eric D

Journal of labelled compounds & radiopharmaceuticals

2020 Volume 64, Issue 4, Page(s) 159–167

Abstract: The cathepsin K (CatK) enzyme is abundantly expressed in osteoclasts, and CatK inhibitors have been developed for the treatment of osteoporosis. In our effort to support discovery and clinical evaluations of a CatK inhibitor, we sought to discover a ... ...

Abstract	The cathepsin K (CatK) enzyme is abundantly expressed in osteoclasts, and CatK inhibitors have been developed for the treatment of osteoporosis. In our effort to support discovery and clinical evaluations of a CatK inhibitor, we sought to discover a radioligand to determine target engagement of the enzyme by therapeutic candidates using positron emission tomography (PET). L-235, a potent and selective CatK inhibitor, was labeled with carbon-11. PET imaging studies recording baseline distribution of [
MeSH term(s)	Animals ; Bone and Bones/diagnostic imaging ; Carbon Radioisotopes/chemistry ; Cathepsin K/antagonists & inhibitors ; Cysteine Proteinase Inhibitors/chemistry ; Drug Evaluation, Preclinical ; Female ; Ligands ; Macaca mulatta ; Osteoporosis/diagnostic imaging ; Positron Emission Tomography Computed Tomography/methods ; Protein Binding ; Rabbits ; Radiopharmaceuticals/adverse effects ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/pharmacokinetics ; Tissue Distribution
Chemical Substances	Carbon Radioisotopes ; Cysteine Proteinase Inhibitors ; Ligands ; Radiopharmaceuticals ; Cathepsin K (EC 3.4.22.38)
Language	English
Publishing date	2020-12-02
Publishing country	England
Document type	Journal Article
ZDB-ID	196095-7
ISSN	1099-1344 ; 0362-4803 ; 0022-2135
ISSN (online)	1099-1344
ISSN	0362-4803 ; 0022-2135
DOI	10.1002/jlcr.3896
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Article ; Online: In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1.

Rubins, Daniel J / Meng, Xiangjun / McQuade, Paul / Klimas, Michael / Getty, Krista / Lin, Shu-An / Connolly, Brett M / O'Malley, Stacey S / Haley, Hyking / Purcell, Mona / Gantert, Liza / Holahan, Marie / Lindgren, Joel / Eklund, Pär / Ekblad, Caroline / Frejd, Fredrik Y / Hostetler, Eric D / González Trotter, Dinko E / Evelhoch, Jeffrey L

Molecular imaging and biology

2020 Volume 23, Issue 2, Page(s) 241–249

Abstract: Purpose: In vivo imaging of programmed death ligand 1 (PD-L1) during immunotherapy could potentially monitor changing PD-L1 expression and PD-L1 expression heterogeneity within and across tumors. Some protein constructs can be used for same-day positron ...

Abstract	Purpose: In vivo imaging of programmed death ligand 1 (PD-L1) during immunotherapy could potentially monitor changing PD-L1 expression and PD-L1 expression heterogeneity within and across tumors. Some protein constructs can be used for same-day positron emission tomography (PET) imaging. Previously, we evaluated the PD-L1-targeting Affibody molecule [ Procedures: Z Results: Ex vivo biodistribution measurements showed that both tracers had > 25 fold higher accumulation in LOX tumors than SUDHL6 ([ Conclusions: [
MeSH term(s)	Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/pharmacokinetics ; B7-H1 Antigen/immunology ; B7-H1 Antigen/metabolism ; Cell Line, Tumor ; Fluorine Radioisotopes ; Gallium Radioisotopes ; Humans ; Immunotherapy/methods ; Macaca mulatta ; Mice ; Molecular Imaging/methods ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/metabolism ; Positron-Emission Tomography/methods ; Radiometry/methods ; Radiopharmaceuticals/administration & dosage ; Radiopharmaceuticals/pharmacokinetics ; Tissue Distribution ; Xenograft Model Antitumor Assays
Chemical Substances	Antibodies, Monoclonal ; B7-H1 Antigen ; CD274 protein, human ; Fluorine Radioisotopes ; Gallium Radioisotopes ; Radiopharmaceuticals ; Gallium-68 (98B30EPP5S) ; Fluorine-18 (GZ5I74KB8G)
Language	English
Publishing date	2020-10-23
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ZDB-ID	2079160-4
ISSN	1860-2002 ; 1536-1632
ISSN (online)	1860-2002
ISSN	1536-1632
DOI	10.1007/s11307-020-01544-2
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Article ; Online: PET/CT Imaging of

Li, Wenping / Wang, Yuchuan / Rubins, Daniel / Bennacef, Idriss / Holahan, Marie / Haley, Hyking / Purcell, Mona / Gantert, Liza / Hseih, SuChun / Judo, Michael / Seghezzi, Wolfgang / Zhang, Shuli / van der Veen, Elly L / Lub-de Hooge, Marjolijn N / de Vries, Elisabeth G E / Evelhoch, Jeffrey L / Klimas, Michael / Hostetler, Eric D

Molecular imaging and biology

2020 Volume 23, Issue 2, Page(s) 250–259

Abstract: Purpose: Programmed cell death-1 receptor (PD-1) and its ligand (PD-L1) are the targets for immunotherapy in many cancer types. Although PD-1 blockade has therapeutic effects, the efficacy differs between patients. Factors contributing to this ... ...

Abstract	Purpose: Programmed cell death-1 receptor (PD-1) and its ligand (PD-L1) are the targets for immunotherapy in many cancer types. Although PD-1 blockade has therapeutic effects, the efficacy differs between patients. Factors contributing to this variability are PD-L1 expression levels and immune cells present in tumors. However, it is not well understood how PD-1 expression in the tumor microenvironment impacts immunotherapy response. Thus, imaging of PD-1-expressing immune cells is of interest. This study aims to evaluate the biodistribution of Zirconium-89 ( Procedures: Pembrolizumab was conjugated with the tetrafluorophenol-N-succinyl desferal-Fe(III) ester (TFP-N-sucDf) and subsequently radiolabeled with Results: 89 Conclusions: 89 Trial registration: ClinicalTrials.gov Identifier: NCT02760225.
MeSH term(s)	Animals ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/pharmacokinetics ; Antineoplastic Agents, Immunological/administration & dosage ; Antineoplastic Agents, Immunological/pharmacokinetics ; Female ; Immunotherapy/methods ; Macaca fascicularis ; Male ; Models, Animal ; Molecular Imaging/methods ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/metabolism ; Positron Emission Tomography Computed Tomography/methods ; Programmed Cell Death 1 Receptor/immunology ; Programmed Cell Death 1 Receptor/metabolism ; Radioisotopes ; Tissue Distribution ; Zirconium
Chemical Substances	Antibodies, Monoclonal, Humanized ; Antineoplastic Agents, Immunological ; Programmed Cell Death 1 Receptor ; Radioisotopes ; Zirconium (C6V6S92N3C) ; pembrolizumab (DPT0O3T46P) ; Zirconium-89 (NTM296JU95)
Language	English
Publishing date	2020-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2079160-4
ISSN	1860-2002 ; 1536-1632
ISSN (online)	1860-2002
ISSN	1536-1632
DOI	10.1007/s11307-020-01558-w
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Article ; Online: Al

Cleeren, Frederik / Lecina, Joan / Ahamed, Muneer / Raes, Geert / Devoogdt, Nick / Caveliers, Vicky / McQuade, Paul / Rubins, Daniel J / Li, Wenping / Verbruggen, Alfons / Xavier, Catarina / Bormans, Guy

Theranostics

2017 Volume 7, Issue 11, Page(s) 2924–2939

Abstract: Positron emission tomography (PET) using radiolabeled biomolecules is a translational molecular imaging technology that is increasingly used in support of drug development. Current methods for radiolabeling biomolecules with fluorine-18 are laborious and ...

Abstract	Positron emission tomography (PET) using radiolabeled biomolecules is a translational molecular imaging technology that is increasingly used in support of drug development. Current methods for radiolabeling biomolecules with fluorine-18 are laborious and require multistep procedures with moderate labeling yields. The Al
MeSH term(s)	Aluminum Compounds/administration & dosage ; Animals ; Biological Factors/metabolism ; Chelating Agents/metabolism ; Fluorides/administration & dosage ; Fluorine Radioisotopes/administration & dosage ; Isotope Labeling/methods ; Macaca mulatta ; Positron-Emission Tomography/methods ; Temperature
Chemical Substances	Aluminum Compounds ; Biological Factors ; Chelating Agents ; Fluorine Radioisotopes ; Fluorine-18 (GZ5I74KB8G) ; Fluorides (Q80VPU408O) ; aluminum fluoride (Z77H3IKW94)
Language	English
Publishing date	2017-07-14
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.20094
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Article ; Online: Folate-PEG-NOTA-Al

Chen, Qingshou / Meng, Xiangjun / McQuade, Paul / Rubins, Daniel / Lin, Shu-An / Zeng, Zhizhen / Haley, Hyking / Miller, Patricia / González Trotter, Dinko / Low, Philip S

Molecular pharmaceutics

2017 Volume 14, Issue 12, Page(s) 4353–4361

Abstract: The folate receptor (FR) has been established as a promising target for imaging and therapy of cancer (FR-α), inflammation, and autoimmune diseases (FR-β). Several folate based PET radiotracers have been reported in the literature, but ... ...

Abstract	The folate receptor (FR) has been established as a promising target for imaging and therapy of cancer (FR-α), inflammation, and autoimmune diseases (FR-β). Several folate based PET radiotracers have been reported in the literature, but an
MeSH term(s)	A549 Cells ; Aluminum Compounds/chemistry ; Aluminum Compounds/pharmacokinetics ; Animals ; Drug Evaluation, Preclinical ; Female ; Fluorides/chemistry ; Fluorides/pharmacokinetics ; Fluorine Radioisotopes/chemistry ; Fluorine Radioisotopes/pharmacokinetics ; Folate Receptors, GPI-Anchored/metabolism ; Folic Acid/analogs & derivatives ; Folic Acid/chemistry ; Folic Acid/pharmacokinetics ; Heterocyclic Compounds/chemistry ; Heterocyclic Compounds/pharmacokinetics ; Humans ; Isotope Labeling/methods ; KB Cells ; Mice ; Mice, Nude ; Neoplasms/diagnostic imaging ; Neoplasms/pathology ; Organotechnetium Compounds ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/pharmacokinetics ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/pharmacokinetics ; Tissue Distribution ; X-Ray Microtomography/methods ; Xenograft Model Antitumor Assays
Chemical Substances	Aluminum Compounds ; Fluorine Radioisotopes ; Folate Receptors, GPI-Anchored ; Heterocyclic Compounds ; Organotechnetium Compounds ; Radiopharmaceuticals ; poly(ethylene glycol)-folate ; technetium 99m EC20 folate peptide ; Polyethylene Glycols (3WJQ0SDW1A) ; 1,4,7-triazacyclononane-N,N',N''-triacetic acid (56491-86-2) ; Folic Acid (935E97BOY8) ; Fluorine-18 (GZ5I74KB8G) ; Fluorides (Q80VPU408O) ; aluminum fluoride (Z77H3IKW94)
Language	English
Publishing date	2017-11-01
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.7b00415
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Article ; Online: A novel method for strict intranasal delivery of non-replicating RSV vaccines in cotton rats and non-human primates.

Citron, Michael P / Patel, Manishkumar / Purcell, Mona / Lin, Shu-An / Rubins, Daniel J / McQuade, Paul / Callahan, Cheryl / Gleason, Alexa / Petrescu, Ioan / Knapp, Walter / Orekie, Chinedu / Chamarthy, Sai / Wen, Zhiyun / Touch, Sinoeun / Pine, Matthew / Fontenot, Jane / Douglas, Cameron / Liang, Xiaoping / Espeseth, Amy S

Vaccine

2018 Volume 36, Issue 20, Page(s) 2876–2885

Abstract: Respiratory syncytial virus (RSV) is the most common viral cause of bronchiolitis and pneumonia in children twelve months of age or younger and a significant cause of lower respiratory disease in older adults. As various clinical and preclinical ... ...

Abstract	Respiratory syncytial virus (RSV) is the most common viral cause of bronchiolitis and pneumonia in children twelve months of age or younger and a significant cause of lower respiratory disease in older adults. As various clinical and preclinical candidates advance, cotton rats (Sigmodon hispidus) and non-human primates (NHP) continue to play a valuable role in RSV vaccine development, since both animals are semi-permissive to human RSV (HRSV). However, appropriate utilization of the models is critical to avoid mis-interpretation of the preclinical findings. Using a multimodality imaging approach; a fluorescence based optical imaging technique for the cotton rat and a nuclear medicine based positron emission tomography (PET) imaging technique for monkeys, we demonstrate that many common practices for intranasal immunization in both species result in inoculum delivery to the lower respiratory tract, which can result in poor translation of outcomes from the preclinical to the clinical setting. Using these technologies we define a method to limit the distribution of intranasally administered vaccines solely to the upper airway of each species, which includes volume restrictions in combination with injectable anesthesia. We show using our newly defined methods for strict intranasal immunization that these methods impact the immune responses and efficacy observed when compared to vaccination methods resulting in distribution to both the upper and lower respiratory tracts. These data emphasize the importance of well-characterized immunization methods in the preclinical assessment of intranasally delivered vaccine candidates.
MeSH term(s)	Administration, Intranasal ; Animals ; Cercopithecus aethiops ; Drug Evaluation, Preclinical/methods ; Female ; Models, Animal ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus Vaccines/administration & dosage ; Respiratory Syncytial Virus Vaccines/immunology ; Respiratory Syncytial Virus, Human/immunology ; Sigmodontinae
Chemical Substances	Respiratory Syncytial Virus Vaccines
Language	English
Publishing date	2018-03-26
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2018.02.110
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Article ; Online: Synthesis and Preclinical Evaluation of Folate-NOTA-Al(18)F for PET Imaging of Folate-Receptor-Positive Tumors.

Chen, Qingshou / Meng, Xiangjun / McQuade, Paul / Rubins, Daniel / Lin, Shu-An / Zeng, Zhizhen / Haley, Hyking / Miller, Patricia / González Trotter, Dinko / Low, Philip S

Molecular pharmaceutics

2016 Volume 13, Issue 5, Page(s) 1520–1527

Abstract: Unlabelled: Folate-receptor-targeted PET radiotracers can potentially serve as versatile imaging agents for the diagnosis, staging, and prediction of response to therapy of patients with folate-receptor (FR)-expressing cancers. Because current FR- ... ...

Abstract	Unlabelled: Folate-receptor-targeted PET radiotracers can potentially serve as versatile imaging agents for the diagnosis, staging, and prediction of response to therapy of patients with folate-receptor (FR)-expressing cancers. Because current FR-targeted PET reagents can be compromised by complex labeling procedures, low specific activities, poor radiochemical yields, or unwanted accumulation in FR negative tissues, we have undertaken to design an improved folate-PET agent that might be more amenable for clinical development. For this purpose, we have synthesized a folate-NOTA-Al(18)F radiotracer and examined its properties both in vitro and in vivo. Methods: Radiochemical synthesis of folate-NOTA-Al(18)F was achieved by incubating (18)F(-) with AlCl3 for 2 min followed by heating in the presence of folate-NOTA for 15 min at 100 °C. Binding of folate-NOTA-Al(18)F to FR was quantitated in homogenates of KB and Cal51 tumor xenografts in the presence and absence of excess folic acid as a competitor. In vivo imaging was performed on nu/nu mice bearing either FR+ve (KB cell) or FR-ve (A549 cell) tumor xenografts, and specific accumulation of the radiotracer in tumor and other tissues was assessed by high-resolution micro-PET and ex vivo biodistribution in the presence and absence of excess folic acid. Image quality of folate-NOTA-Al(18)F was compared with that of (99m)Tc-EC20, a clinically established folate-targeted SPECT imaging agent. Results: Total radiochemical synthesis and purification of folate-NOTA-Al(18)F was completed within 37 min, yielding a specific activity of 68.82 ± 18.5 GBq/μmol, radiochemical yield of 18.6 ± 4.5%, and radiochemical purity of 98.3 ± 2.9%. Analysis of FR binding revealed a Kd of ∼1.0 nM, and micro-PET imaging together with ex vivo biodistribution analyses demonstrated high FR-mediated uptake in an FR+ tumor and the kidneys. Conclusions: Folate-NOTA-Al(18)F constitutes an easily prepared FR-targeted PET imaging agent with improved radiopharmaceutical properties and high specificity for folate receptor expressing tumors. Given its improved properties over (99m)Tc-EC20 (i.e., higher resolution, shorter image acquisition time, etc.), we conclude that folate-NOTA-Al(18)F constitutes a viable alternative to (99m)Tc-EC20 for use in identification, diagnosis, and staging of patients with FR-expressing cancers.
MeSH term(s)	A549 Cells ; Animals ; Female ; Fluorine Radioisotopes/chemistry ; Folate Receptors, GPI-Anchored/metabolism ; Folic Acid/administration & dosage ; Folic Acid/chemistry ; Heterocyclic Compounds/chemistry ; Humans ; KB Cells ; Mice ; Mice, Nude ; Neoplasms/diagnosis ; Neoplasms/metabolism ; Positron-Emission Tomography/methods ; Radiochemistry/methods ; Radiopharmaceuticals/chemistry ; Tissue Distribution ; Tomography, Emission-Computed, Single-Photon/methods
Chemical Substances	Fluorine Radioisotopes ; Folate Receptors, GPI-Anchored ; Heterocyclic Compounds ; Radiopharmaceuticals ; 1,4,7-triazacyclononane-N,N',N''-triacetic acid (56491-86-2) ; Folic Acid (935E97BOY8)
Language	English
Publishing date	2016-05-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.5b00989
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Article: Quantitative imaging with the micro-PET small-animal PET tomograph.

Vaska, Paul / Rubins, Daniel J / Alexoff, David L / Schiffer, Wynne K

International review of neurobiology

2006 Volume 73, Page(s) 191–218

MeSH term(s)	Animals ; Animals, Laboratory/anatomy & histology ; Humans ; Image Interpretation, Computer-Assisted/methods ; Positron-Emission Tomography
Language	English
Publishing date	2006
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	209876-3
ISSN	0074-7742
ISSN	0074-7742
DOI	10.1016/S0074-7742(06)73006-9
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Article: A novel method for strict intranasal delivery of non-replicating RSV vaccines in cotton rats and non-human primates

Citron, Michael P / Callahan, Cheryl / Chamarthy, Sai / Douglas, Cameron / Espeseth, Amy S / Fontenot, Jane / Gleason, Alexa / Knapp, Walter / Liang, Xiaoping / Lin, Shu-An / McQuade, Paul / Orekie, Chinedu / Patel, Manishkumar / Petrescu, Ioan / Pine, Matthew / Purcell, Mona / Rubins, Daniel J / Touch, Sinoeun / Wen, Zhiyun

Vaccine. 2018 May 11, v. 36, no. 20

2018

Abstract	Respiratory syncytial virus (RSV) is the most common viral cause of bronchiolitis and pneumonia in children twelve months of age or younger and a significant cause of lower respiratory disease in older adults. As various clinical and preclinical candidates advance, cotton rats (Sigmodon hispidus) and non-human primates (NHP) continue to play a valuable role in RSV vaccine development, since both animals are semi-permissive to human RSV (HRSV). However, appropriate utilization of the models is critical to avoid mis-interpretation of the preclinical findings. Using a multimodality imaging approach; a fluorescence based optical imaging technique for the cotton rat and a nuclear medicine based positron emission tomography (PET) imaging technique for monkeys, we demonstrate that many common practices for intranasal immunization in both species result in inoculum delivery to the lower respiratory tract, which can result in poor translation of outcomes from the preclinical to the clinical setting. Using these technologies we define a method to limit the distribution of intranasally administered vaccines solely to the upper airway of each species, which includes volume restrictions in combination with injectable anesthesia. We show using our newly defined methods for strict intranasal immunization that these methods impact the immune responses and efficacy observed when compared to vaccination methods resulting in distribution to both the upper and lower respiratory tracts. These data emphasize the importance of well-characterized immunization methods in the preclinical assessment of intranasally delivered vaccine candidates.
Keywords	anesthesia ; bronchiolitis ; children ; elderly ; fluorescence ; humans ; image analysis ; immune response ; inoculum ; medicine ; models ; monkeys ; pneumonia ; positron-emission tomography ; Primates ; Respiratory syncytial virus ; respiratory system ; Sigmodon hispidus ; vaccination ; vaccine development ; vaccines
Language	English
Dates of publication	2018-0511
Size	p. 2876-2885.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2018.02.110
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: MK-8719, a Novel and Selective

Wang, Xiaohai / Li, Wenping / Marcus, Jacob / Pearson, Michelle / Song, Lixin / Smith, Karen / Terracina, Giuseppe / Lee, Julie / Hong, Kwok-Lam Karen / Lu, Sherry X / Hyde, Lynn / Chen, Shu-Cheng / Kinsley, David / Melchor, Jerry P / Rubins, Daniel J / Meng, Xiangjun / Hostetler, Eric / Sur, Cyrille / Zhang, Lili /

Schachter, Joel B / Hess, J Fred / Selnick, Harold G / Vocadlo, David J / McEachern, Ernest J / Uslaner, Jason M / Duffy, Joseph L / Smith, Sean M

The Journal of pharmacology and experimental therapeutics

2020 Volume 374, Issue 2, Page(s) 252–263

Abstract: Deposition of hyperphosphorylated and aggregated tau protein in the central nervous system is characteristic of Alzheimer disease and other tauopathies. Tau is subject ... ...

Abstract	Deposition of hyperphosphorylated and aggregated tau protein in the central nervous system is characteristic of Alzheimer disease and other tauopathies. Tau is subject to
MeSH term(s)	Animals ; Atrophy/drug therapy ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Locomotion/drug effects ; Male ; Mice ; PC12 Cells ; Rats ; Tauopathies/drug therapy ; Tauopathies/metabolism ; Tauopathies/pathology ; Tauopathies/physiopathology ; beta-N-Acetylhexosaminidases/antagonists & inhibitors ; tau Proteins/metabolism
Chemical Substances	Enzyme Inhibitors ; tau Proteins ; hexosaminidase C (EC 3.2.1.50) ; beta-N-Acetylhexosaminidases (EC 3.2.1.52)
Language	English
Publishing date	2020-06-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3106-9
ISSN	1521-0103 ; 0022-3565
ISSN (online)	1521-0103
ISSN	0022-3565
DOI	10.1124/jpet.120.266122
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