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Book ; Thesis: Organ motion management for optimisation of fractionated ion therapy of prostate cancer at HIT

Ruciński, Antoni Wojciech

2013

Author's details	vorgelegt von Antoni Wojciech Ruciński
Language	English
Size	VII, 100, XXVIII S. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Heidelberg, Univ., Diss., 2014
HBZ-ID	HT018593434
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Applications of nanodosimetry in particle therapy planning and beyond.

Rucinski, Antoni / Biernacka, Anna / Schulte, Reinhard

Physics in medicine and biology

2021 Volume 66, Issue 24

Abstract: This topical review summarizes underlying concepts of nanodosimetry. It describes the development and current status of nanodosimetric detector technology. It also gives an overview of Monte Carlo track structure simulations that can provide ... ...

Abstract	This topical review summarizes underlying concepts of nanodosimetry. It describes the development and current status of nanodosimetric detector technology. It also gives an overview of Monte Carlo track structure simulations that can provide nanodosimetric parameters for treatment planning of proton and ion therapy. Classical and modern radiobiological assays that can be used to demonstrate the relationship between the frequency and complexity of DNA lesion clusters and nanodosimetric parameters are reviewed. At the end of the review, existing approaches of treatment planning based on relative biological effectiveness (RBE) models or dose-averaged linear energy transfer are contrasted with an RBE-independent approach based on nandosimetric parameters. Beyond treatment planning, nanodosimetry is also expected to have applications and give new insights into radiation protection dosimetry.
MeSH term(s)	Linear Energy Transfer ; Monte Carlo Method ; Proton Therapy ; Radiometry ; Relative Biological Effectiveness
Language	English
Publishing date	2021-12-10
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ac35f1
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Article ; Online: Geant4-DNA modeling of nanodosimetric quantities in the Jet Counter for alpha particles.

Pietrzak, Marcin / Mietelska, Monika / Bancer, Aleksandr / Rucinski, Antoni / Brzozowska, Beata

Physics in medicine and biology

2021 Volume 66, Issue 22

Abstract: The purpose of this work was to validate the calculation accuracy of nanodosimetric quantities in Geant4-DNA track structure simulation code. We implemented the Jet Counter (JC) nanodosimeter geometry in the simulation platform and quantified the impact ... ...

Abstract	The purpose of this work was to validate the calculation accuracy of nanodosimetric quantities in Geant4-DNA track structure simulation code. We implemented the Jet Counter (JC) nanodosimeter geometry in the simulation platform and quantified the impact of the Geant4-DNA physics models and JC detector performance on the ionization cluster size distributions (ICSD). ICSD parameters characterize the quality of radiation field and are supposed to be correlated to the complexity of the initial DNA damage in nanoscale and eventually the response of biological systems to radiation. We compared Monte Carlo simulations of ICSD in JC geometry performed using Geant4-DNA and PTra codes with experimental data collected for alpha particles at 3.8 MeV. We investigated the impact of simulation and experimental settings, i.e., three Geant4-DNA physics models, three sizes of a nanometer sensitive volume, gas to water density scaling procedure, JC ion extraction efficiency and the presence of passive components of the detector on the ICSD and their parameters. We found that ICSD in JC geometry obtained from Geant4-DNA simulations in water correspond well to ICSD measurements in nitrogen gas for all investigated settings, while the best agreement is for Geant4-DNA physics option 4. This work also discusses the accuracy and robustness of ICSD parameters in the context of the application of track structure simulation methods for treatment planning in particle therapy.
MeSH term(s)	Alpha Particles/therapeutic use ; Computer Simulation ; DNA/chemistry ; Monte Carlo Method ; Radiometry/methods ; Water/chemistry
Chemical Substances	Water (059QF0KO0R) ; DNA (9007-49-2)
Language	English
Publishing date	2021-11-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ac33eb
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Article: Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future.

Pakela, Julia M / Knopf, Antje / Dong, Lei / Rucinski, Antoni / Zou, Wei

Frontiers in oncology

2022 Volume 12, Page(s) 806153

Abstract: The major aim of radiation therapy is to provide curative or palliative treatment to cancerous malignancies while minimizing damage to healthy tissues. Charged particle radiotherapy utilizing carbon ions or protons is uniquely suited for this task due to ...

Abstract	The major aim of radiation therapy is to provide curative or palliative treatment to cancerous malignancies while minimizing damage to healthy tissues. Charged particle radiotherapy utilizing carbon ions or protons is uniquely suited for this task due to its ability to achieve highly conformal dose distributions around the tumor volume. For these treatment modalities, uncertainties in the localization of patient anatomy due to inter- and intra-fractional motion present a heightened risk of undesired dose delivery. A diverse range of mitigation strategies have been developed and clinically implemented in various disease sites to monitor and correct for patient motion, but much work remains. This review provides an overview of current clinical practices for inter and intra-fractional motion management in charged particle therapy, including motion control, current imaging and motion tracking modalities, as well as treatment planning and delivery techniques. We also cover progress to date on emerging technologies including particle-based radiography imaging, novel treatment delivery methods such as tumor tracking and FLASH, and artificial intelligence and discuss their potential impact towards improving or increasing the challenge of motion mitigation in charged particle therapy.
Language	English
Publishing date	2022-03-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.806153
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Article ; Online: A review of the clinical introduction of 4D particle therapy research concepts.

Knäusl, Barbara / Belotti, Gabriele / Bertholet, Jenny / Daartz, Juliane / Flampouri, Stella / Hoogeman, Mischa / Knopf, Antje C / Lin, Haibo / Moerman, Astrid / Paganelli, Chiara / Rucinski, Antoni / Schulte, Reinhard / Shimizu, Shing / Stützer, Kristin / Zhang, Xiaodong / Zhang, Ye / Czerska, Katarzyna

Physics and imaging in radiation oncology

2024 Volume 29, Page(s) 100535

Abstract: Background and purpose: Many 4D particle therapy research concepts have been recently translated into clinics, however, remaining substantial differences depend on the indication and institute-related aspects. This work aims to summarise current state- ... ...

Abstract	Background and purpose: Many 4D particle therapy research concepts have been recently translated into clinics, however, remaining substantial differences depend on the indication and institute-related aspects. This work aims to summarise current state-of-the-art 4D particle therapy technology and outline a roadmap for future research and developments. Material and methods: This review focused on the clinical implementation of 4D approaches for imaging, treatment planning, delivery and evaluation based on the 2021 and 2022 Results: Available technological capabilities for motion surveillance and compensation determined the course of each 4D particle treatment. 4D motion management, delivery techniques and strategies including imaging were diverse and depended on many factors. These included aspects of motion amplitude, tumour location, as well as accelerator technology driving the necessity of centre-specific dosimetric validation. Novel methodologies for X-ray based image processing and MRI for real-time tumour tracking and motion management were shown to have a large potential for online and offline adaptation schemes compensating for potential anatomical changes over the treatment course. The latest research developments were dominated by particle imaging, artificial intelligence methods and FLASH adding another level of complexity but also opportunities in the context of 4D treatments. Conclusion: This review showed that the rapid technological advances in radiation oncology together with the available intrafractional motion management and adaptive strategies paved the way towards clinical implementation.
Language	English
Publishing date	2024-01-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2405-6316
ISSN (online)	2405-6316
DOI	10.1016/j.phro.2024.100535
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Article ; Online: Ionization detail parameters and cluster dose: a mathematical model for selection of nanodosimetric quantities for use in treatment planning in charged particle radiotherapy.

Faddegon, Bruce / Blakely, Eleanor A / Burigo, Lucas / Censor, Yair / Dokic, Ivana / Domínguez Kondo, Naoki / Ortiz, Ramon / Ramos Méndez, José / Rucinski, Antoni / Schubert, Keith / Wahl, Niklas / Schulte, Reinhard

Physics in medicine and biology

2023 Volume 68, Issue 17

Abstract: ... ...

Abstract	Objective
MeSH term(s)	Relative Biological Effectiveness ; Cell Line ; Radiation Oncology ; Protons ; Models, Biological
Chemical Substances	Protons
Language	English
Publishing date	2023-08-14
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/acea16
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Article ; Online: Single proton LET characterization with the Timepix detector and artificial intelligence for advanced proton therapy treatment planning.

Stasica, Paulina / Nguyen, Hanh / Granja, Carlos / Kopeć, Renata / Marek, Lukas / Oancea, Cristina / Raczyński, Łukasz / Rucinski, Antoni / Rydygier, Marzena / Schubert, Keith / Schulte, Reinhard / Gajewski, Jan

Physics in medicine and biology

2023 Volume 68, Issue 10

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Humans ; Proton Therapy/methods ; Protons ; Artificial Intelligence ; Linear Energy Transfer ; Radiotherapy Dosage ; Monte Carlo Method ; Radiometry
Chemical Substances	Protons
Language	English
Publishing date	2023-05-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/acc9f8
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Article ; Online: Quantification of biological range uncertainties in patients treated at the Krakow proton therapy centre.

Garbacz, Magdalena / Gajewski, Jan / Durante, Marco / Kisielewicz, Kamil / Krah, Nils / Kopeć, Renata / Olko, Paweł / Patera, Vincenzo / Rinaldi, Ilaria / Rydygier, Marzena / Schiavi, Angelo / Scifoni, Emanuele / Skóra, Tomasz / Skrzypek, Agata / Tommasino, Francesco / Rucinski, Antoni

Radiation oncology (London, England)

2022 Volume 17, Issue 1, Page(s) 50

Abstract: Background: Variable relative biological effectiveness (vRBE) in proton therapy might significantly modify the prediction of RBE-weighted dose delivered to a patient during proton therapy. In this study we will present a method to quantify the ... ...

Abstract	Background: Variable relative biological effectiveness (vRBE) in proton therapy might significantly modify the prediction of RBE-weighted dose delivered to a patient during proton therapy. In this study we will present a method to quantify the biological range extension of the proton beam, which results from the application of vRBE approach in RBE-weighted dose calculation. Methods and materials: The treatment plans of 95 patients (brain and skull base patients) were used for RBE-weighted dose calculation with constant and the McNamara RBE model. For this purpose the Monte Carlo tool FRED was used. The RBE-weighted dose distributions were analysed using indices from dose-volume histograms. We used the volumes receiving at least 95% of the prescribed dose (V95) to estimate the biological range extension resulting from vRBE approach. Results: The vRBE model shows higher median value of relative deposited dose and D95 in the planning target volume by around 1% for brain patients and 4% for skull base patients. The maximum doses in organs at risk calculated with vRBE was up to 14 Gy above dose limit. The mean biological range extension was greater than 0.4 cm. Discussion: Our method of estimation of biological range extension is insensitive for dose inhomogeneities and can be easily used for different proton plans with intensity-modulated proton therapy (IMPT) optimization. Using volumes instead of dose profiles, which is the common method, is more universal. However it was tested only for IMPT plans on fields arranged around the tumor area. Conclusions: Adopting a vRBE model results in an increase in dose and an extension of the beam range, which is especially disadvantageous in cancers close to organs at risk. Our results support the need to re-optimization of proton treatment plans when considering vRBE.
MeSH term(s)	Brain Neoplasms/pathology ; Brain Neoplasms/radiotherapy ; Female ; Humans ; Male ; Monte Carlo Method ; Neoplasm Staging ; Organs at Risk ; Poland ; Proton Therapy/methods ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Relative Biological Effectiveness ; Skull Base Neoplasms/pathology ; Skull Base Neoplasms/radiotherapy ; Tomography, X-Ray Computed
Language	English
Publishing date	2022-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2224965-5
ISSN	1748-717X ; 1748-717X
ISSN (online)	1748-717X
ISSN	1748-717X
DOI	10.1186/s13014-022-02022-5
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Article ; Online: GPU accelerated Monte Carlo scoring of positron emitting isotopes produced during proton therapy for PET verification.

McNamara, Keegan / Schiavi, Angelo / Borys, Damian / Brzezinski, Karol / Gajewski, Jan / Kopeć, Renata / Rucinski, Antoni / Skóra, Tomasz / Makkar, Shubhangi / Hrbacek, Jan / Weber, Damien C / Lomax, Antony J / Winterhalter, Carla

Physics in medicine and biology

2022 Volume 67, Issue 24

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Humans ; Proton Therapy ; Electrons ; Protons ; Positron-Emission Tomography/methods ; Isotopes ; Monte Carlo Method ; Phantoms, Imaging ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy Dosage
Chemical Substances	Protons ; Isotopes
Language	English
Publishing date	2022-12-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/aca515
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Article ; Online: Clinical practice vs. state-of-the-art research and future visions: Report on the 4D treatment planning workshop for particle therapy - Edition 2018 and 2019.

Czerska, Katarzyna / Emert, Frank / Kopec, Renata / Langen, Katja / McClelland, Jamie R / Meijers, Arturs / Miyamoto, Naoki / Riboldi, Marco / Shimizu, Shinichi / Terunuma, Toshiyuki / Zou, Wei / Knopf, Antje / Rucinski, Antoni

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

2021 Volume 82, Page(s) 54–63

Abstract: The 4D Treatment Planning Workshop for Particle Therapy, a workshop dedicated to the treatment of moving targets with scanned particle beams, started in 2009 and since then has been organized annually. The mission of the workshop is to create an informal ...

Abstract	The 4D Treatment Planning Workshop for Particle Therapy, a workshop dedicated to the treatment of moving targets with scanned particle beams, started in 2009 and since then has been organized annually. The mission of the workshop is to create an informal ground for clinical medical physicists, medical physics researchers and medical doctors interested in the development of the 4D technology, protocols and their translation into clinical practice. The 10th and 11th editions of the workshop took place in Sapporo, Japan in 2018 and Krakow, Poland in 2019, respectively. This review report from the Sapporo and Krakow workshops is structured in two parts, according to the workshop programs. The first part comprises clinicians and physicists review of the status of 4D clinical implementations. Corresponding talks were given by speakers from five centers around the world: Maastro Clinic (The Netherlands), University Medical Center Groningen (The Netherlands), MD Anderson Cancer Center (United States), University of Pennsylvania (United States) and The Proton Beam Therapy Center of Hokkaido University Hospital (Japan). The second part is dedicated to novelties in 4D research, i.e. motion modelling, artificial intelligence and new technologies which are currently being investigated in the radiotherapy field.
MeSH term(s)	Artificial Intelligence ; Four-Dimensional Computed Tomography ; Humans ; Japan ; Poland ; Radiotherapy Planning, Computer-Assisted
Language	English
Publishing date	2021-02-13
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	1122650-x
ISSN	1724-191X ; 1120-1797
ISSN (online)	1724-191X
ISSN	1120-1797
DOI	10.1016/j.ejmp.2020.12.013
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