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  1. Book ; Thesis: Untersuchungen zur Länge und Lage der Interkondylarachse

    Rückert, Birgit

    2002  

    Author's details vorgelegt von: Birgit Rückert
    Language German
    Size 76 Bl. in getr. Zählung, graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Greifswald, Univ., Diss., 2002
    HBZ-ID HT013744397
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2003 E 2466 order for loan Magazin

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  2. Book ; Thesis: Zur Frage der Risikofaktoren bei Karotisoperationen

    Rückert, Brigitta

    1983  

    Size S. 85 - 87
    Edition [Sonderdr.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen-Nürnberg, Univ., Diss., 1983
    Note Kurzfassung ; Aus: Lebensversicherungsmedizin ; 35. 1983 u.d.T.: Grobe, Th., B. Rückert, St. Hager, M. Klupp u. D. Raithel: Bedeutung von Begleiterkrankungen für Operationsrisiko und Langzeitverlauf nach Karotisoperationen
    HBZ-ID HT003262975
    Database Catalogue ZB MED Medicine, Health

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    84 E 628 order for loan Magazin

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  3. Book ; Thesis: Direkte Leistungsregelung von doppeltgespeisten Asynchrongeneratoren mit optimaler Gleichtaktspannungsführung zur Minimierung von Lagerströmen

    Rückert, Bastian

    (Dresdner Schriftenreihe zu elektrischen Maschinen und Antrieben ; 4)

    2014  

    Author's details Bastian Rückert
    Series title Dresdner Schriftenreihe zu elektrischen Maschinen und Antrieben ; 4
    Keywords Lagerstrom ; Asynchrongenerator ; Umrichter ; Leistungsregelung ; Doppelt gespeiste Drehstrommaschine ; Gleichtaktspannung
    Language German
    Size XIV, 143 S., Ill., graph. Darst., 21 cm
    Publisher Shaker
    Publishing place Aachen
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Techn. Univ., Diss.--Dresden, 2013
    Note Literaturverz. S. 127 - 143
    ISBN 9783844026559 ; 384402655X
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Article: Environmental exposure and sensitization patterns in a Swiss alpine pediatric cohort.

    Fieten, Karin B / Maya-Manzano, José M / Rückert, Beate / Candeias, Joana / Pusch, Gudrun / Buters, Jeroen / Akdis, Cezmi A / Traidl-Hoffmann, Claudia

    The World Allergy Organization journal

    2023  Volume 16, Issue 12, Page(s) 100847

    Abstract: Background: The level of environmental exposure throughout life may contribute to the prevalence of allergic sensitization and allergic disease. The alpine climate has been considered a healthy climate with little allergen exposure and pollution. We ... ...

    Abstract Background: The level of environmental exposure throughout life may contribute to the prevalence of allergic sensitization and allergic disease. The alpine climate has been considered a healthy climate with little allergen exposure and pollution. We conducted a cross-sectional study to investigate local environmental exposure and concomitant prevalence of allergic sensitization among local school children born and raised in an alpine environment.
    Methods: Clinical and demographic data were collected with a questionnaire. Allergen content was assessed in residential settled dust samples, lifetime exposure to pollen and air pollution was calculated using data from national pollen and air pollution monitoring stations, and the allergic sensitization profile was determined with component resolved diagnostics (ISAC®). Univariate and multivariate regression models were used to estimate the relation between exposure and sensitization.
    Results: In a cohort of children born and raised in an alpine environment, sensitization to aeroallergens is quite common (38%), especially to grass (33%) and cat (16%). House dust mite allergen was detected in up to 38% of residential dust samples, but sensitization to HDM was low (2.5%). Pollutant levels were low, but an increasing trend was observed in the amount of ozone and PM
    Conclusion: In a healthy alpine environment, pollution might still be an important factor contributing to allergic sensitization.
    Language English
    Publishing date 2023-12-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2581968-9
    ISSN 1939-4551
    ISSN 1939-4551
    DOI 10.1016/j.waojou.2023.100847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Differentiation of bronchial epithelial spheroids in the presence of IL-13 recapitulates characteristic features of asthmatic airway epithelia.

    Pat, Yagiz / Rückert, Beate / Ogulur, Ismail / Yazici, Duygu / Pérez-Diego, Mario / Küçükkase, Ozan C / Li, Manru / Akdis, Cezmi A

    Allergy

    2022  Volume 77, Issue 7, Page(s) 2229–2233

    MeSH term(s) Asthma ; Bronchi ; Epithelial Cells ; Humans ; Interleukin-13 ; Respiratory Mucosa
    Chemical Substances Interleukin-13
    Language English
    Publishing date 2022-03-18
    Publishing country Denmark
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 125: Show issues

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  6. Article: Human bocavirus 1 coinfection is associated with decreased cytokine expression in the rhinovirus-induced first wheezing episode in children.

    Hurme, Pekka / Sahla, Reetta / Rückert, Beate / Vahlberg, Tero / Turunen, Riitta / Vuorinen, Tytti / Akdis, Mübeccel / Söderlund-Venermo, Maria / Akdis, Cezmi / Jartti, Tuomas

    Clinical and translational allergy

    2023  Volume 13, Issue 11, Page(s) e12311

    Abstract: Background: Rhinovirus (RV)-induced first wheezing episodes in children are associated with a markedly increased risk of asthma. Previous studies have suggested that human bocavirus 1 (HBoV1) may modify RV-induced immune responses in young children. We ... ...

    Abstract Background: Rhinovirus (RV)-induced first wheezing episodes in children are associated with a markedly increased risk of asthma. Previous studies have suggested that human bocavirus 1 (HBoV1) may modify RV-induced immune responses in young children. We investigated cytokine profiles of sole RV- and dual RV-HBoV1-induced first wheezing episodes, and their association with severity and prognosis.
    Methods: Fifty-two children infected with only RV and nine children infected with dual RV-HBoV1, aged 3-23 months, with severe first wheezing episodes were recruited. At acute illness and 2 weeks later, peripheral blood mononuclear cells were isolated, and stimulated with anti-CD3/anti-CD28 in vitro. Multiplex ELISA was used to quantitatively identify 56 different cytokines at both study points. Patients were prospectively followed for 4 years.
    Results: The mean age of the children was 14.3 months, and 30% were sensitized. During the acute illness, the adjusted analyses revealed a decrease in the expression of IL-1b, MIP-1b, Regulated upon activation, normal T cell expressed and presumably secreted (CCL5), TNF-a, TARC, and ENA-78 in the RV-HBoV1 group compared with the RV group. In the convalescence phase, the RV-HBoV1 group was characterized by decreased expression of Fractalkine, MCP-3, and IL-8 compared to the RV group. Furthermore, the hospitalization time was associated with the virus group and cytokine response (interaction p < 0.05), signifying that increased levels of epidermal growth factor and MIP-1b were related with a shorter duration of hospitalization in the RV-HBoV1 coinfection group but not in the RV group.
    Conclusions: Different cytokine response profiles were detected between the RV and the RV-HBoV1 groups. Our results show the idea that RV-induced immune responses may be suppressed by HBoV1.
    Language English
    Publishing date 2023-11-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630865-4
    ISSN 2045-7022
    ISSN 2045-7022
    DOI 10.1002/clt2.12311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mechanisms of gut epithelial barrier impairment caused by food emulsifiers polysorbate 20 and polysorbate 80.

    Ogulur, Ismail / Yazici, Duygu / Pat, Yagiz / Bingöl, Elif Naz / Babayev, Huseyn / Ardicli, Sena / Heider, Anja / Rückert, Beate / Sampath, Vanitha / Dhir, Raja / Akdis, Mubeccel / Nadeau, Kari / Akdis, Cezmi A

    Allergy

    2023  Volume 78, Issue 9, Page(s) 2441–2455

    Abstract: Background: The rising prevalence of many chronic diseases related to gut barrier dysfunction coincides with the increased global usage of dietary emulsifiers in recent decades. We therefore investigated the effect of the frequently used food ... ...

    Abstract Background: The rising prevalence of many chronic diseases related to gut barrier dysfunction coincides with the increased global usage of dietary emulsifiers in recent decades. We therefore investigated the effect of the frequently used food emulsifiers on cytotoxicity, barrier function, transcriptome alterations, and protein expression in gastrointestinal epithelial cells.
    Methods: Human intestinal organoids originating from induced pluripotent stem cells, colon organoid organ-on-a-chip, and liquid-liquid interface cells were cultured in the presence of two common emulsifiers: polysorbate 20 (P20) and polysorbate 80 (P80). The cytotoxicity, transepithelial electrical resistance (TEER), and paracellular-flux were measured. Immunofluorescence staining of epithelial tight-junctions (TJ), RNA-seq transcriptome, and targeted proteomics were performed.
    Results: Cells showed lysis in response to P20 and P80 exposure starting at a 0.1% (v/v) concentration across all models. Epithelial barrier disruption correlated with decreased TEER, increased paracellular-flux and irregular TJ immunostaining. RNA-seq and targeted proteomics analyses demonstrated upregulation of cell development, signaling, proliferation, apoptosis, inflammatory response, and response to stress at 0.05%, a concentration lower than direct cell toxicity. A proinflammatory response was characterized by the secretion of several cytokines and chemokines, interaction with their receptors, and PI3K-Akt and MAPK signaling pathways. CXCL5, CXCL10, and VEGFA were upregulated in response to P20 and CXCL1, CXCL8 (IL-8), CXCL10, LIF in response to P80.
    Conclusions: The present study provides direct evidence on the detrimental effects of food emulsifiers P20 and P80 on intestinal epithelial integrity. The underlying mechanism of epithelial barrier disruption was cell death at concentrations between 1% and 0.1%. Even at concentrations lower than 0.1%, these polysorbates induced a proinflammatory response suggesting a detrimental effect on gastrointestinal health.
    MeSH term(s) Humans ; Polysorbates/adverse effects ; Polysorbates/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Epithelial Cells/metabolism ; Cytokines/metabolism ; Diet ; Intestinal Mucosa/metabolism
    Chemical Substances Polysorbates ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Cytokines
    Language English
    Publishing date 2023-08-02
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.150: Show issues Location:
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  8. Article: Neue Ursache allergischer Erkrankungen, insbesondere von Nahrungsmittelallergien gefunden - Darmepithelbarriereschäden durch Geschirrspülmittel und Klarspüler

    Ogulur, I. / Pat, Y. / Aydin, T. / Yazici, D. / Rückert, B. / Penq, Y. / Kim, J. / Radzikowska, U. / Westermann, P. / Sokołowska, M. / Dhir, R. / Akdis, M. / Nadeau, K. / Akdis, C. A.

    Wohnmedizin

    2022  Volume 60, Issue 3, Page(s) 124

    Language German
    Document type Article
    ZDB-ID 127391-7
    ISSN 0342-5967
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 915: Show issues Location:
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  9. Book ; Online ; Thesis: Search for a higgs boson produced in association with a W Boson at Atlas

    Ruckert, Benjamin

    2009  

    Author's details von Benjamim Ruckert
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--München, 2009
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Book ; Online ; Thesis: Search for a higgs boson produced in association with a W Boson at Atlas

    Ruckert, Benjamin

    2009  

    Author's details von Benjamim Ruckert
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--München, 2009
    Database Former special subject collection: coastal and deep sea fishing

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