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Book ; Thesis: Art. 321bis StGB: Das Berufsgeheimnis in der medizinischen Forschung

Ruckstuhl, Niklaus

(Basler Studien zur Rechtswissenschaft : C, Strafrecht ; 11)

1999

Author's details	Niklaus Ruckstuhl
Series title	Basler Studien zur Rechtswissenschaft : C, Strafrecht ; 11 Basler Studien zur Rechtswissenschaft Basler Studien zur Rechtswissenschaft ; C, Strafrecht
Collection	Basler Studien zur Rechtswissenschaft Basler Studien zur Rechtswissenschaft ; C, Strafrecht
Keywords	Schweiz ; Medizin ; Forschung ; Ärztliche Schweigepflicht ; Datenschutz
Subject	Datenschutzrecht ; Datenverarbeitung ; Arzt ; Berufsgeheimnis ; Arztgeheimnis ; Wissenschaftliche Forschung ; Forschungen ; Humanmedizin ; Heilkunst ; Medicine
Language	German
Size	XXXV, 366 S.
Publisher	Helbing und Lichtenhahn
Publishing place	Basel u.a.
Publishing country	Switzerland
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Basel, Univ., Diss., 1998
HBZ-ID	HT011264313
ISBN	3-7190-1759-1 ; 978-3-7190-1759-0
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Urinary tract infections in dogs with spontaneous hypercortisolism - frequency, symptoms and involved pathogens.

Dupont, P / Burkhardt, W / Boretti, F / Riond, B / Reusch, C / Willi, B / Sieber-Ruckstuhl, N

Schweizer Archiv fur Tierheilkunde

2020 Volume 162, Issue 7, Page(s) 439–450

Abstract: Introduction: Dogs with hypercortisolism are predisposed to developing bacteriuria associated either with clinical signs of cystitis or without clinical signs (subclinical bacteriuria). Based on current guidelines, dogs with subclinical bacteriuria ... ...

Title translation	Harnwegsinfektionen bei Hunden mit spontanem Hyperkortisolismus – Häufigkeit, Symptome und beteiligte Krankheitserreger.
Abstract	Introduction: Dogs with hypercortisolism are predisposed to developing bacteriuria associated either with clinical signs of cystitis or without clinical signs (subclinical bacteriuria). Based on current guidelines, dogs with subclinical bacteriuria should not be treated with antibiotics because there is no evidence that treatment improves outcome and because unnecessary treatments should be avoided. Before these guidelines were published in 2019, dogs with hypercortisolism and bacteriuria were commonly treated with antibiotics irrespective of clinical signs. Comprehensive data on the frequency of bacterial cystitis, subclinical bacteriuria and the outcome of antimicrobial treatment in dogs with hypercortisolism is sparse. The aims of this study were to investigate dogs with hypercortisolism for the presence of bacterial cystitis and subclinical bacteriuria, to address the pathogens involved, and to assess the outcome of antibiotic treatment. Dogs newly diagnosed with hypercortisolism between 2005 and 2015 from which a urine bacterial culture was available were included. Statistical analysis was performed with non-parametric tests. Of the 161 client-owned dogs included, 29 (18%) showed bacteriuria, which was subclinical in 24 (83%) cases. Escherichia coli was the most commonly isolated pathogen (58%). Bacteriuria was not associated with sex or neutering status. In 14 dogs, follow-up data was available, of which 13 (93%) were treated with antimicrobials for 14 to 28 days. Follow-up bacterial culture (1 to 118 days after cessation of therapy) was negative in 10 (77%) treated dogs; a negative follow-up culture was not associated with gender, age or duration of treatment. Bacteriuria persisted in three treated dogs and the one untreated dog. The prevalence of positive bacterial urinary culture in dogs with hypercortisolism was lower than previously reported. In the majority of dogs, bacteriuria was subclinical. Most dogs had a negative bacterial culture result after antimicrobial treatment; however, more resistant bacteria were detected in persistently positive urine.
MeSH term(s)	Animals ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Bacteria/isolation & purification ; Bacteriuria/complications ; Bacteriuria/drug therapy ; Bacteriuria/microbiology ; Bacteriuria/veterinary ; Cushing Syndrome/complications ; Cushing Syndrome/microbiology ; Cushing Syndrome/veterinary ; Dog Diseases/drug therapy ; Dog Diseases/microbiology ; Dogs ; Urinary Tract Infections/complications ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/microbiology ; Urinary Tract Infections/veterinary
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-07-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	391726-5
ISSN	1664-2848 ; 0036-7281
ISSN (online)	1664-2848
ISSN	0036-7281
DOI	10.17236/sat00265
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Article ; Online: Salivary cortisol in healthy dogs: a randomized cross-over study to evaluate different saliva stimulation methods and their effects on saliva volume and cortisol concentration.

Meunier, Solène / Groessl, Michael / Reusch, Claudia / Boretti, Felicitas / Sieber-Ruckstuhl, Nadja

BMC veterinary research

2021 Volume 17, Issue 1, Page(s) 194

Abstract: Background: Salivary cortisol collected at home is a useful test to diagnose and monitor Cushing's syndrome in humans. The main problem in dogs is to retrieve a sufficient amount of saliva. The aim of this study was to evaluate different salivary ... ...

Abstract	Background: Salivary cortisol collected at home is a useful test to diagnose and monitor Cushing's syndrome in humans. The main problem in dogs is to retrieve a sufficient amount of saliva. The aim of this study was to evaluate different salivary collection methods and compare their effects on volume, pH and cortisol concentration of saliva. Sixteen healthy Beagles were used in a 4 × 4 randomized crossover study with a washout period of 1 week between each of the following collection methods: 1. Salimetrics® cotton swab dipped in ginger powder (ginger group); 2. beef-flavored Salimetrics® (bouillon group); 3. Salivette® cotton swab with an enclosed treat (treat group); 4. plain Salimetrics® (control group). First, baseline saliva (plain cotton swab, S0) and, 2 min later, experimental saliva (according to group allocation above, SExp) were collected. Saliva was gathered by holding the swabs in the animal's mouth for 2 min. After the cross-over study, another saliva sample was collected from all dogs by the ginger method, using a 30 s sampling time (30s-ginger method). Cortisol concentrations were measured by liquid chromatography tandem mass spectrometry. Results: All three stimulation methods increased saliva production significantly (S0 compared to SExp: ginger p = 0.0005; bouillon p = 0.009; treat p = 0.007). Only ginger stimulation, however, generated a significantly higher amount of saliva (SExp) compared to the control group (p = 0.00001; median (range) amount of saliva for SExp: ginger 1200 ul (600-1700), bouillon 650 ul (200-1900), treat 700 ul (300-1000), control 400 ul (0-1100)). The amount of saliva retrieved by the 30s-ginger method was still higher than that from the control group (p = 0.0004). Bouillon and treat stimulation led to decreased pH values (bouillon, p = 0.0028; treat, 0.0018). Excitement was higher in the ginger group (p = 0.01). Chewing was intensified in the ginger and treat group (ginger, p = 0.003; treat, 0.0009). The cortisol concentration SExp was higher compared to that of S0 in the ginger and treat group (p = 0.02, 0.003). The experimental cortisol concentrations (SExp) were not different between groups. Conclusions: The 30s-ginger method could prove useful in evaluating or monitoring dogs with Cushing's syndrome, as sampling at home for 30 s by the owner seems feasible.
MeSH term(s)	Animals ; Dogs/metabolism ; Female ; Male ; Animal Feed ; Cross-Over Studies ; Hydrocortisone/analysis ; Hydrocortisone/metabolism ; Hydrogen-Ion Concentration ; Red Meat ; Saliva/metabolism ; Stimulation, Chemical ; Zingiber officinale ; Cushing Syndrome/diagnosis ; Cushing Syndrome/veterinary ; Salivation
Chemical Substances	Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2021-05-17
Publishing country	England
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial, Veterinary
ZDB-ID	2191675-5
ISSN	1746-6148 ; 1746-6148
ISSN (online)	1746-6148
ISSN	1746-6148
DOI	10.1186/s12917-021-02890-1
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Article ; Online: Akromegalie aufgrund eines Hypophysentumors bei einem Hund – Diagnose, Therapie und Verlauf.

Reusch, C / Burkhardt, W A / Meier, V S / Rohrer Bley, C / Riond, B / Dennler, M / Boretti, F / Sieber-Ruckstuhl, N

Schweizer Archiv fur Tierheilkunde

2019 Volume 161, Issue 5, Page(s) 319–327

Abstract: Introduction: Acromegaly due to a pituitary tumor has so far only been described in 3 dogs. The present case report describes a 7-year-old male-castrated Labrador Retriever which was referred because of difficult-to-control diabetes. Physical ... ...

Title translation	Acromegaly due to a pituitary tumor in a dog - diagnosis, therapy and long-term follow-up.
Abstract	Introduction: Acromegaly due to a pituitary tumor has so far only been described in 3 dogs. The present case report describes a 7-year-old male-castrated Labrador Retriever which was referred because of difficult-to-control diabetes. Physical examination revealed markedly enlarged head, tongue and paws, widened interdental spaces and thickening of the skin in the head and neck area. IGF-1 and GH were increased and the latter continued to be abnormal after somatostatin application. Computed tomography demonstrated a space-occupying lesion in the pituitary gland and the diagnosis of acromegaly due to a GH-producing tumor of the pituitary was made. The dog underwent radiation therapy with a 6MV linear accelerator (3×8Gy) and improved substantially. Two and a half years after radiation therapy the dog developed lethargy and anorexia and was euthanized. Necropsy was not permitted. This case report represents the description of a dog suffering from pituitary-dependent acromegaly which was successfully treated and had a long-term survival.
MeSH term(s)	Animals ; Dog Diseases/blood ; Dog Diseases/diagnosis ; Dog Diseases/therapy ; Dogs ; Growth Hormone/blood ; Growth Hormone-Secreting Pituitary Adenoma/blood ; Growth Hormone-Secreting Pituitary Adenoma/diagnosis ; Growth Hormone-Secreting Pituitary Adenoma/therapy ; Growth Hormone-Secreting Pituitary Adenoma/veterinary ; Hormones/therapeutic use ; Insulin-Like Growth Factor I/analysis ; Male ; Radiotherapy/veterinary ; Somatostatin/therapeutic use ; Tomography, X-Ray Computed ; Treatment Outcome
Chemical Substances	Hormones ; Somatostatin (51110-01-1) ; Insulin-Like Growth Factor I (67763-96-6) ; Growth Hormone (9002-72-6)
Language	German
Publishing date	2019-04-12
Publishing country	Switzerland
Document type	Case Reports ; Journal Article
ZDB-ID	391726-5
ISSN	1664-2848 ; 0036-7281
ISSN (online)	1664-2848
ISSN	0036-7281
DOI	10.17236/sat00208
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Article: Obesity during growth in Switzerland: role of early socio-cultural factors favouring sedentary activities.

Suter, P M / Ruckstuhl, N

International journal of obesity (2005)

2006 Volume 30 Suppl 4, Page(s) S4–10

Abstract: Depending upon age, gender and geographical area, 3-20% of the children and young adolescents in Switzerland are overweight and 0-6% obese, using the criteria of the International Obesity Task Force. The most likely explanation for this increasing ... ...

Abstract	Depending upon age, gender and geographical area, 3-20% of the children and young adolescents in Switzerland are overweight and 0-6% obese, using the criteria of the International Obesity Task Force. The most likely explanation for this increasing prevalence of overweight and obesity is a decline in physical activity, and hence diminished energy expenditure that is not matched by a corresponding reduction in energy intake. In this paper, we first review the epidemiological situation in Switzerland regarding the rising prevalence of obesity and the decline in physical activity, and then focus upon the environmental, social and cultural factors that predispose children to sedentary behaviours. Several of these socio-cultural factors and in particular television viewing and poor-parental model, confer early 'learned behaviours' for low physical activity which track throughout growth into adulthood, and which also predispose to the overconsumption of less healthy foods. It is time to focus on preventive strategies directed at curtailing these 'learned behaviours', that we have acquired during the transition from the stone-age to the chip-age, if we want to hold the current pandemic of obesity.
MeSH term(s)	Adolescent ; Body Mass Index ; Child ; Energy Metabolism/physiology ; Female ; Health Behavior ; Humans ; Male ; Motor Activity/physiology ; Obesity/epidemiology ; Obesity/prevention & control ; Overweight/epidemiology ; Prevalence ; Risk Factors ; Sedentary Lifestyle ; Switzerland/epidemiology
Language	English
Publishing date	2006-12
Publishing country	England
Document type	Journal Article
ZDB-ID	752409-2
ISSN	1476-5497 ; 0307-0565
ISSN (online)	1476-5497
ISSN	0307-0565
DOI	10.1038/sj.ijo.0803513
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Article: Jeder Schritt zäh it: Wie viel bewegen sich unsere Patienten? Eine Pedometer-studie.

Ruckstuhl, N / Vetter, W / Suter, P M

Praxis

2007 Volume 96, Issue 20, Page(s) 805–810

Abstract: The prevalence of obesity is increaseing worldwide and thus enhancing the development of the chronic diseases. Physical activity represents not only an important modulator of the energy balance but physical exercise represents a key feature for chronic ... ...

Title translation	Every step counts: what is the physical activity level of our patients? A pedometer study.
Abstract	The prevalence of obesity is increaseing worldwide and thus enhancing the development of the chronic diseases. Physical activity represents not only an important modulator of the energy balance but physical exercise represents a key feature for chronic disease risk reduction independently from body weight. In this study we assessed physical activity by counting the steps with the help of a pedometer in 49 consecutive patients (33 women and 16 men) of the obesity- and hypertension clinic at the Medical Policlinic at the University Hospital in Zurich. 29 of the patients were obese (mean +/- SD BMI 35.3 +/- 5.5 kg/m(2)), eleven overweight (27.6 +/- 1.1 kg/m(2)) and eight of normal body weight (22.7 +/- 1.5 kg/m(2)) according to the WHO-classification. The mean +/- SD steps per week of the whole population was 67917 +/- 33856. Patients with a normal weight had more steps per week, but the difference did not reach significance as compared to the overweight or obese subjects. Only on Sunday the normal weighted patients had significantly more steps than the other groups. The data suggest that strategies to enhance physical activity on the weekend should be encouraged in all subjects, especially however in those with an increased body weight.
MeSH term(s)	Activities of Daily Living/classification ; Adolescent ; Adult ; Aged ; Body Mass Index ; Female ; Habits ; Health Surveys ; Humans ; Hypertension/etiology ; Hypertension/prevention & control ; Male ; Middle Aged ; Obesity/etiology ; Obesity/prevention & control ; Overweight ; Physical Fitness ; Reference Values ; Switzerland ; Walking
Language	German
Publishing date	2007-05-16
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	209026-0
ISSN	1661-8165 ; 1661-8157 ; 0369-8394
ISSN (online)	1661-8165
ISSN	1661-8157 ; 0369-8394
DOI	10.1024/1661-8157.96.20.805
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Article: Lack of association between clinical signs and laboratory parameters in dogs with hyperadrenocorticism before and during trilostane treatment.

Boretti, F S / Holzthüm, J / Reusch, C E / Sieber-Ruckstuhl, N S

Schweizer Archiv fur Tierheilkunde

2016 Volume 158, Issue 9, Page(s) 631–638

Abstract: Introduction: Trilostane therapy, the treatment of choice for pituitary- dependent hyperadrenocorticism (HAC) in dogs, is monitored by assessing resolution of clinical signs and measuring adrenocortical reserve capacity with an ACTH-stimulation test. ... ...

Title translation	Fehlender Zusammenhang zwischen klinischen Symptomen und Laborwerten von Hunden mit Hyperadrenokortizismus vor und während der Trilostan-Behandlung.
Abstract	Introduction: Trilostane therapy, the treatment of choice for pituitary- dependent hyperadrenocorticism (HAC) in dogs, is monitored by assessing resolution of clinical signs and measuring adrenocortical reserve capacity with an ACTH-stimulation test. The aim of this prospective study was to evaluate agreement between clinical signs reported by owners and cortisol or ACTH concentrations before and during trilostane therapy (starting dose 1-2 mg/kg once daily). A questionnaire on signs of HAC was used and a clinical score calculated as the sum of the 9 questions. Eighteen questionnaires at diagnosis and 97 during therapy were filled out by owners of 32 dogs. An ACTH-stimulation test was performed at each reevaluation. There were weak correlations between abdominal girth, appetite or weight gain and cortisol concentrations during therapy. However, the clinical score did not correlate with cortisol or cACTH values. In 50% of dogs, trilostane application had to be changed from once daily to twice daily during the study. Clinical signs reported by owners matched poorly with cortisol or cACTH concentrations at any time point. If low-dose trilostane is used, treatment frequency often has to be increased.
MeSH term(s)	Adrenocortical Hyperfunction/blood ; Adrenocortical Hyperfunction/drug therapy ; Adrenocortical Hyperfunction/pathology ; Adrenocortical Hyperfunction/veterinary ; Adrenocorticotropic Hormone/blood ; Animals ; Dihydrotestosterone/analogs & derivatives ; Dihydrotestosterone/therapeutic use ; Dog Diseases/blood ; Dog Diseases/drug therapy ; Dog Diseases/pathology ; Dogs ; Enzyme Inhibitors/therapeutic use ; Hydrocortisone/blood ; Surveys and Questionnaires
Chemical Substances	Enzyme Inhibitors ; Dihydrotestosterone (08J2K08A3Y) ; Adrenocorticotropic Hormone (9002-60-2) ; trilostane (L0FPV48Q5R) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2016-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	391726-5
ISSN	0036-7281
ISSN	0036-7281
DOI	10.17236/sat00083
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Article ; Online: Comparison of two prepill cortisol concentrations in dogs with hypercortisolism treated with trilostane.

Boretti, Felicitas / Musella, Caterina / Burkhardt, Wanda / Kuemmerle-Fraune, Claudia / Riond, Barbara / Reusch, Claudia / Sieber-Ruckstuhl, Nadja

BMC veterinary research

2018 Volume 14, Issue 1, Page(s) 417

Abstract: Background: The ideal method for monitoring trilostane therapy in dogs with hypercortisolism is still open to debate. Recently, determination of the pre-trilostane (prepill) cortisol concentration has been proposed to be more repeatable than either post- ...

Abstract	Background: The ideal method for monitoring trilostane therapy in dogs with hypercortisolism is still open to debate. Recently, determination of the pre-trilostane (prepill) cortisol concentration has been proposed to be more repeatable than either post-trilostane or post-ACTH cortisol. The aim of this study was to compare two prepill cortisol concentrations in dogs with hypercortisolism during trilostane therapy. Sixteen client-owned dogs with naturally occurring hypercortisolism were prospectively included and cortisol concentrations were measured twice, 1 h apart, before the morning trilostane dose (prepill 1 and 2 cortisol). Results: A total of 47 prepill cortisol measurement pairs were included. Compared to prepill 1, prepill 2 cortisol was higher in 15, equal in 8 and lower in 24 pairs. Group agreement between prepill 1 and 2 cortisol was 70% (moderate agreement - weighted kappa 0.55). In 30% of the pairs, group assignment was discrepant, implying a different therapeutic decision. In some dogs certain circumstances (e.g. excessive barking, difficulties during blood collection, excitement at arrival) were identified as potential factors explaining the discrepancy between prepill 1 and 2 cortisol measurements. Conclusions: In a substantial number of dogs treated with trilostane, the two prepill cortisol concentrations differed. Part of this difference might be ascribable to stressful events during test performance. When using prepill cortisol measurements to monitor trilostane therapy, recording of any incident during handling that might affect cortisol release might be helpful to make a reliable decision about a trilostane dose adaptation.
MeSH term(s)	Animals ; Blood Chemical Analysis/veterinary ; Dihydrotestosterone/analogs & derivatives ; Dihydrotestosterone/therapeutic use ; Dog Diseases/blood ; Dog Diseases/drug therapy ; Dogs ; Female ; Hydrocortisone/blood ; Male
Chemical Substances	Dihydrotestosterone (08J2K08A3Y) ; trilostane (L0FPV48Q5R) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2018-12-27
Publishing country	England
Document type	Journal Article
ISSN	1746-6148
ISSN (online)	1746-6148
DOI	10.1186/s12917-018-1750-3
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Article: Natürliche Angiostrongylus vasorum Infektion: Charakterisierung des Krankheitsbildes bei drei Hunden mit pulmonärer Hypertonie.

Glaus, T / Schnyder, M / Dennler, M / Tschuor, F / Wenger, M / Sieber-Ruckstuhl, N

Schweizer Archiv fur Tierheilkunde

2010 Volume 152, Issue 7, Page(s) 331–338

Abstract: Pulmonary hypertension (PH), together with its accompanying clinical signs and underlying causes, e.g. pulmonary thrombosis, are more and more recognized as an important clinical entity also in dogs. This article characterizes the clinical picture of 3 ... ...

Title translation	Natural infection with Angiostrongylus vasorum: characterisation of 3 dogs with pulmonary hypertension.
Abstract	Pulmonary hypertension (PH), together with its accompanying clinical signs and underlying causes, e.g. pulmonary thrombosis, are more and more recognized as an important clinical entity also in dogs. This article characterizes the clinical picture of 3 dogs with PH caused by natural infection with Angiostrongylus vasorum. All 3 dogs were of small breeds ( < 10 kg), the age at the time of diagnosis was 1, 2 and 11 years. Clinically, dyspnea and exercise intolerance were the predominating signs, 2 dogs developed hemoptysis, 1 dog developed right sided congestive heart failure. Severe arterial hypoxemia (PaO2 41 - 53 mmHg) reflected the severity of pulmonary parenchymal and vascular damage. Severe hyperglobulinemia (59 und 88 g/l) in two dogs implicated a long lasting infection. Anthelmintic treatment in 2 dogs resulted in quick clinical, radiographic and echocardiographic normalization. PH is the consequence of multiple causes and pathomechanisms, and the recognition of PH is primarily of differential diagnostic relevance. Prognosis and therapy in cases with PH mainly depend on the underlying cause, rather than on the PH and on its degree.
MeSH term(s)	Angiostrongylus ; Animals ; Anthelmintics/therapeutic use ; Dog Diseases/diagnostic imaging ; Dog Diseases/drug therapy ; Dog Diseases/parasitology ; Dogs ; Echocardiography/methods ; Echocardiography/veterinary ; Heart Failure/etiology ; Heart Failure/veterinary ; Male ; Radiography, Thoracic/methods ; Radiography, Thoracic/veterinary ; Strongylida Infections/complications ; Strongylida Infections/diagnostic imaging ; Strongylida Infections/drug therapy ; Strongylida Infections/veterinary ; Treatment Outcome
Chemical Substances	Anthelmintics
Language	German
Publishing date	2010-07
Publishing country	Switzerland
Document type	Case Reports ; Journal Article
ZDB-ID	391726-5
ISSN	0036-7281
ISSN	0036-7281
DOI	10.1024/0036-7281/a000076
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Book: Strafprozessrecht

Ruckstuhl, Niklaus / Arnold, Jörg / Dittmann, Volker

unter Einschluss der forensischen Psychiatrie und Rechtsmedizin sowie des kriminaltechnischen und naturwissenschaftlichen Gutachtens

2011

Author's details	Niklaus Ruckstuhl; Volker Dittmann; Jörg Arnold
Keywords	Gerichtliche Psychiatrie ; Kriminaltechnik ; Strafverfahrensrecht ; Rechtsmedizin ; Schweiz
Language	German
Size	XXXVI, 582 S., 24 cm, 1150 g
Publisher	Schulthess
Publishing place	Zürich u.a.
Document type	Book
Note	Literaturangaben
ISBN	9783725563524 ; 3725563527
Database	Former special subject collection: coastal and deep sea fishing

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