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  1. Article ; Online: Principles of regulatory T cell function.

    Dikiy, Stanislav / Rudensky, Alexander Y

    Immunity

    2023  Volume 56, Issue 2, Page(s) 240–255

    Abstract: Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of Treg cells as principal guardians of the immune system can be ... ...

    Abstract Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of Treg cells as principal guardians of the immune system can be attributed to their ability to restrain all currently recognized major types of inflammatory responses through modulating the activity of a wide range of cells of the innate and adaptive immune system. This broad purview over immunity and inflammation is afforded by the multiple modes of action Treg cells exert upon their diverse molecular and cellular targets. Beyond the suppression of autoimmunity for which they were originally recognized, Treg cells have been implicated in tissue maintenance, repair, and regeneration under physiologic and pathologic conditions. Herein, we discuss the current and emerging understanding of Treg cell effector mechanisms in the context of the basic properties of Treg cells that endow them with such functional versatility.
    MeSH term(s) Humans ; T-Lymphocytes, Regulatory ; Autoimmunity ; Immune System ; Inflammation ; Homeostasis
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Spatiotemporal regulation of peripheral T cell tolerance.

    Brown, Chrysothemis C / Rudensky, Alexander Y

    Science (New York, N.Y.)

    2023  Volume 380, Issue 6644, Page(s) 472–478

    Abstract: The incomplete removal of T cells that are reactive against self-proteins during their differentiation in the thymus requires mechanisms of tolerance that prevent their effector function within the periphery. A further challenge is imposed by the need to ...

    Abstract The incomplete removal of T cells that are reactive against self-proteins during their differentiation in the thymus requires mechanisms of tolerance that prevent their effector function within the periphery. A further challenge is imposed by the need to establish tolerance to the holobiont self, which comprises a highly complex community of commensal microorganisms. Here, we review recent advances in the investigation of peripheral T cell tolerance, focusing on new insights into mechanisms of tolerance to the gut microbiota, including tolerogenic antigen-presenting cell types and immunomodulatory lymphocytes, and their layered ontogeny that underlies developmental windows for establishing intestinal tolerance. While emphasizing the intestine as a model tissue for studying peripheral T cell tolerance, we highlight overlapping and distinct pathways that underlie tolerance to self-antigens versus commensal antigens within a broader framework for immune tolerance.
    MeSH term(s) Autoantigens ; Peripheral Tolerance ; T-Lymphocytes/immunology ; Thymus Gland/cytology ; Humans ; Animals ; Mice
    Chemical Substances Autoantigens
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adg6425
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  3. Article ; Online: Editorial overview: The value of commitment in the lymphocyte world.

    Rudensky, Alexander Y

    Current opinion in immunology

    2019  Volume 58, Page(s) v–vii

    MeSH term(s) Adaptive Immunity/immunology ; Animals ; B-Lymphocytes/immunology ; Humans ; Immunity, Innate/immunology ; Lymphocyte Activation/immunology ; Lymphocytes/immunology ; T-Lymphocytes/immunology
    Language English
    Publishing date 2019-07-03
    Publishing country England
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2019.06.004
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  4. Article ; Online: Conceiving the Inconceivable: The Function of Aire in Immune Tolerance to Peripheral Tissue-Restricted Antigens in the Thymus.

    Brown, Chrysothemis C / Rudensky, Alexander Y

    Journal of immunology (Baltimore, Md. : 1950)

    2021  Volume 206, Issue 2, Page(s) 245–247

    MeSH term(s) Adaptive Immunity ; Animals ; Autoantigens/immunology ; Autoimmunity ; Humans ; Immune Tolerance ; Organ Specificity ; Thymus Gland/immunology ; Thymus Gland/metabolism ; Transcription Factors/metabolism ; AIRE Protein
    Chemical Substances Autoantigens ; Transcription Factors
    Language English
    Publishing date 2021-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2001285
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  5. Article ; Online: Immunotherapy breaches low-sugar dieting of tumor Treg cells.

    Campbell, Clarissa / Rudensky, Alexander Y

    Cell metabolism

    2021  Volume 33, Issue 5, Page(s) 851–852

    Abstract: Glycolysis supports effector T cell function but is detrimental to the immunosuppressive activity of regulatory T cells. In a recent issue of Nature, two papers address a role for glucose and lactate availability within the tumor microenvironment for the ...

    Abstract Glycolysis supports effector T cell function but is detrimental to the immunosuppressive activity of regulatory T cells. In a recent issue of Nature, two papers address a role for glucose and lactate availability within the tumor microenvironment for the balance of pro- and anti-tumoral effects of T cells and the efficacy of neoadjuvant cancer immunotherapy.
    MeSH term(s) Humans ; Immunotherapy ; Neoplasms/therapy ; Sugars ; T-Lymphocytes, Regulatory ; Tumor Microenvironment
    Chemical Substances Sugars
    Language English
    Publishing date 2021-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2021.04.010
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  6. Article ; Online: Foxp3: a genetic foundation for regulatory T cell differentiation and function.

    Ramsdell, Fred / Rudensky, Alexander Y

    Nature immunology

    2020  Volume 21, Issue 7, Page(s) 708–709

    MeSH term(s) Allergy and Immunology/history ; Animals ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Diabetes Mellitus, Type 1/congenital ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/immunology ; Diarrhea/genetics ; Diarrhea/immunology ; Disease Models, Animal ; Female ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Gene Expression Regulation/immunology ; Genetic Diseases, X-Linked/genetics ; Genetic Diseases, X-Linked/immunology ; History, 20th Century ; History, 21st Century ; Humans ; Immune System Diseases/congenital ; Immune System Diseases/genetics ; Immune System Diseases/immunology ; Male ; Mice, Transgenic ; Mutation ; Sex Factors ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances FOXP3 protein, human ; Forkhead Transcription Factors ; Foxp3 protein, mouse
    Language English
    Publishing date 2020-06-23
    Publishing country United States
    Document type Historical Article ; Journal Article ; Portrait
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-020-0694-5
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  7. Article ; Online: Enforcing T cell innocence.

    Brown, Chrysothemis / Rudensky, Alexander Y

    Science (New York, N.Y.)

    2020  Volume 367, Issue 6475, Page(s) 247–248

    MeSH term(s) Peripheral Tolerance ; T-Lymphocytes
    Language English
    Publishing date 2020-02-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aaz7741
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  8. Article ; Online: Therapeutic use of regulatory T cells for graft-versus-host disease.

    Elias, Shlomo / Rudensky, Alexander Y

    British journal of haematology

    2019  Volume 187, Issue 1, Page(s) 25–38

    Abstract: Regulatory T cells (Treg cells) represent a ... ...

    Abstract Regulatory T cells (Treg cells) represent a CD4
    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Disease Models, Animal ; Graft vs Host Disease/immunology ; Graft vs Host Disease/therapy ; Humans ; Immunotherapy, Adoptive/methods ; Lymphocyte Activation/immunology ; Lymphocyte Transfusion/methods ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/transplantation
    Language English
    Publishing date 2019-08-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16157
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  9. Article ; Online: Mouse Watch: A Cautionary Tale.

    Dikiy, Stanislav / Rudensky, Alexander Y

    Immunity

    2019  Volume 51, Issue 1, Page(s) 10–12

    Abstract: In this issue of Immunity, Chisolm et al. (2019) issue a "three-alarm fire" warning to the immunology research community of unexpectedly widespread genetic variation in widely used congenic mouse strains and provide a simple method to identify such a ... ...

    Abstract In this issue of Immunity, Chisolm et al. (2019) issue a "three-alarm fire" warning to the immunology research community of unexpectedly widespread genetic variation in widely used congenic mouse strains and provide a simple method to identify such a variation through a re-analysis of existing RNA-seq and ChIP-seq datasets.
    MeSH term(s) Animals ; Chromatin Immunoprecipitation ; DNA Mutational Analysis ; Genetic Variation ; Mice
    Language English
    Publishing date 2019-09-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2019.06.019
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  10. Article ; Online: Inflammatory adaptation in barrier tissues.

    Niec, Rachel E / Rudensky, Alexander Y / Fuchs, Elaine

    Cell

    2021  Volume 184, Issue 13, Page(s) 3361–3375

    Abstract: Surface epithelia provide a critical barrier to the outside world. Upon a barrier breach, resident epithelial and immune cells coordinate efforts to control infections and heal tissue damage. Inflammation can etch lasting marks within tissues, altering ... ...

    Abstract Surface epithelia provide a critical barrier to the outside world. Upon a barrier breach, resident epithelial and immune cells coordinate efforts to control infections and heal tissue damage. Inflammation can etch lasting marks within tissues, altering features such as scope and quality of future responses. By remembering inflammatory experiences, tissues are better equipped to quickly and robustly respond to barrier breaches. Alarmingly, in disease states, memory may fuel the inflammatory fire. Here, we review the cellular communication networks in barrier tissues and the integration between tissue-resident and recruited immune cells and tissue stem cells underlying tissue adaptation to environmental stress.
    MeSH term(s) Adaptation, Physiological ; Animals ; Humans ; Inflammation/pathology ; Lymphocytes/metabolism ; Models, Biological ; Organ Specificity ; Stem Cells
    Language English
    Publishing date 2021-06-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2021.05.036
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