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  1. Book ; Online ; E-Book: Cancer consult

    Abutalib, Syed A. / Markman, Maurie / Armitage, James O. / Anderson, Kenneth C. / Rugo, Hope S. / Benson, Al B., III.

    solid tumors and supportive care

    2024  

    Language English
    Size 1 online resource (754 pages)
    Edition 2nd ed.
    Publisher John Wiley & Sons, Incorporated
    Publishing place Newark
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-119-82376-5 ; 1-119-82374-9 ; 9781119823735 ; 978-1-119-82376-6 ; 978-1-119-82374-2 ; 1119823730
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article: Highlights from the 2023 American Society of Clinical Oncology Annual Meeting: breast cancer.

    Rugo, Hope S

    Clinical advances in hematology & oncology : H&O

    2023  Volume 21, Issue 7, Page(s) 352–354

    MeSH term(s) Humans ; Female ; Breast Neoplasms/diagnosis ; Breast Neoplasms/drug therapy ; Medical Oncology ; Societies, Medical
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6505: Show issues Location:
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  3. Article: Addressing unmet need in the management of patients with ER+/HER2-, ESR1-mutated metastatic breast cancer: clinician's perspective.

    Rugo, Hope S

    Clinical advances in hematology & oncology : H&O

    2023  Volume 21, Issue 12, Page(s) 623–632

    Abstract: Approximately 70% of breast tumors are ER+ and HER2-. First-line treatment that combines endocrine therapy (AIs, SERMs, and SERDs) with a CDK4/6 inhibitor is the treatment of choice for many patients with ER+/HER2- metastatic breast cancer. However, ESR1 ...

    Abstract Approximately 70% of breast tumors are ER+ and HER2-. First-line treatment that combines endocrine therapy (AIs, SERMs, and SERDs) with a CDK4/6 inhibitor is the treatment of choice for many patients with ER+/HER2- metastatic breast cancer. However, ESR1 mutations develop in up to 40% of patients-more than 90% of these in response to therapy. The presence of ESR1 mutations is associated with a worse prognosis, including faster progression and poorer survival, underscoring the need for routine testing and the urgency of developing novel therapies that address ESR1-mutated breast cancer. For more than 20 years, fulvestrant (given as an intramuscular injection) was the only SERD approved by the US Food and Drug Administration for the treatment of ER+/HER2- metastatic breast cancer, and a standard second-line therapy following progression on an AI. This review discusses (1) the importance of routine testing for ESR1 mutations after disease recurrence or progression and the role of liquid biopsy in this regard; (2) elacestrant, a novel oral SERD approved in 2023 for the treatment of postmenopausal women and adult men with ER+/HER2-, ESR1-mutated advanced or metastatic breast cancer with disease progression following 1 or more lines of endocrine therapy (unlike other SERDs, elacestrant is not associated with cardiac or ocular toxicity); and (3) new agents in development, including SERDs and innovative molecules targeting the ER-PROTACs, SERCAs, and CERANs-currently being tested in early-phase trials in combination with targeted agents, including CDK4/6 inhibitors.
    MeSH term(s) Adult ; Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Estrogen Receptor alpha/genetics ; Neoplasm Recurrence, Local/pathology ; Tetrahydronaphthalenes
    Chemical Substances elacestrant ; Estrogen Receptor alpha ; Tetrahydronaphthalenes
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Highlights in metastatic breast cancer from the 2020 San Antonio Breast Cancer Symposium: commentary.

    Rugo, Hope S

    Clinical advances in hematology & oncology : H&O

    2021  Volume 19 Suppl 1, Issue 1, Page(s) 18–19

    MeSH term(s) Breast ; Breast Neoplasms/drug therapy ; Congresses as Topic ; Female ; Humans ; Neoplasm Metastasis ; Texas
    Language English
    Publishing date 2021-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6505: Show issues Location:
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  5. Book: Emerging treatments in chemotherapy induced nausea and vomiting

    Grunberg, Steven M. / Slusher Barbara / Rugo, Hope S.

    (Clinical advances in hematology & oncology ; 11,2, Suppl. 1)

    2013  

    Title variant Emerging treatments in chemotherapy-induced nausea and vomiting
    Series title Clinical advances in hematology & oncology ; 11,2, Suppl. 1
    Collection
    Language English
    Size 18 S. : Ill., graph. Darst.
    Publisher Millennium Med. Publ
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT018175444
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 6505 -11,Suppl.1- verfügbar in Königswinter Königswinter

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  6. Article ; Online: Can We De-escalate Therapy for HER2-Positive Metastatic Breast Cancer?

    Huppert, Laura A / Rugo, Hope S

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2023  Volume 29, Issue 24, Page(s) 4993–4995

    Abstract: A recent phase Ib/II trial evaluated the combination of tucatinib, letrozole, and palbociclib in patients with HR+/HER2+ metastatic breast cancer, demonstrating a manageable safety profile and encouraging efficacy data. An all-oral, chemotherapy-free ... ...

    Abstract A recent phase Ib/II trial evaluated the combination of tucatinib, letrozole, and palbociclib in patients with HR+/HER2+ metastatic breast cancer, demonstrating a manageable safety profile and encouraging efficacy data. An all-oral, chemotherapy-free regimen is an appealing strategy, and could be a possible maintenance or primary therapy option in select patients. See related article by Shagisultanova et al., p. 5021.
    MeSH term(s) Female ; Humans ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/therapy ; Letrozole/therapeutic use ; Receptor, ErbB-2/genetics
    Chemical Substances Letrozole (7LKK855W8I) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-23-1909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4223: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: New and emerging therapeutic options for the management of chemotherapy-induced nausea and vomiting

    Schwartzberg, Lee S. / Rugo, Hope S. / Aapro, Matti S.

    (Clinical advances in hematology & oncology : Clinical roundtable monograph ; volume 13, issue 3, supplement 3 (March 2015))

    2015  

    Author's details discussants Lee S. Schwartzberg, MD; Hope S. Rugo, MD; Matti S. Aapro, MD
    Series title Clinical advances in hematology & oncology : Clinical roundtable monograph ; volume 13, issue 3, supplement 3 (March 2015)
    Clinical advances in hematology & oncology
    Clinical advances in hematology & oncology
    Collection Clinical advances in hematology & oncology
    Clinical advances in hematology & oncology
    Language English
    Size 14 Seiten, Diagramme
    Publisher Millennium Medical Publishing
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019339121
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 6505 -13,Suppl.3- verfügbar in Königswinter Königswinter

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  8. Article: Treatment of early-stage hormone receptor-positive breast cancer.

    Rugo, Hope S

    Clinical advances in hematology & oncology : H&O

    2020  Volume 17, Issue 11, Page(s) 596–599

    MeSH term(s) Adult ; Antineoplastic Agents, Hormonal/therapeutic use ; Biomarkers, Tumor/genetics ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Clinical Trials as Topic ; Female ; Humans ; Middle Aged ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Survival Rate ; Treatment Outcome
    Chemical Substances Antineoplastic Agents, Hormonal ; Biomarkers, Tumor ; Receptors, Estrogen ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2020-01-08
    Publishing country United States
    Document type Interview
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6505: Show issues Location:
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  9. Article: Highlights from the 2019 San Antonio Breast Cancer Symposium.

    Rugo, Hope S

    Clinical advances in hematology & oncology : H&O

    2020  Volume 18, Issue 3, Page(s) 157–159

    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Agents/therapeutic use ; Breast/drug effects ; Breast/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/drug therapy ; Camptothecin/analogs & derivatives ; Camptothecin/therapeutic use ; Clinical Trials as Topic ; Female ; Humans ; Immunoconjugates/therapeutic use ; Oxazoles/therapeutic use ; Paclitaxel/therapeutic use ; Prognosis ; Pyridines/therapeutic use ; Quinazolines/therapeutic use ; Texas ; Trastuzumab/therapeutic use
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents ; Immunoconjugates ; Oxazoles ; Pyridines ; Quinazolines ; tucatinib (234248D0HH) ; trastuzumab deruxtecan (5384HK7574) ; pertuzumab (K16AIQ8CTM) ; margetuximab (K911R84KEW) ; Trastuzumab (P188ANX8CK) ; Paclitaxel (P88XT4IS4D) ; Camptothecin (XT3Z54Z28A)
    Keywords covid19
    Language English
    Publishing date 2020-07-27
    Publishing country United States
    Document type Congress
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6505: Show issues Location:
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  10. Article ; Online: Little Downside.

    Singer, Lisa / Rugo, Hope S

    International journal of radiation oncology, biology, physics

    2022  Volume 114, Issue 4, Page(s) 573

    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Letter
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2022.04.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1218: Show issues Location:
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