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Article ; Online: What is in the pipeline for new treatments for bladder pain syndrome/ interstitial cystitis?

Dias, Diogo / Mendes, Pedro Abreu / Oliveira, Paulo Dinis / Pinto, Rui Almeida

2024 Volume 34, Issue 2, Page(s) 58–63

Abstract: Purpose of review: Despite available treatments, many bladder pain syndrome/interstitial cystitis (BPS/IC) patients continue to have poor quality of life. Thus, there is an urge for new therapies. Our manuscript aims to review papers about BPS/IC ... ...

Abstract	Purpose of review: Despite available treatments, many bladder pain syndrome/interstitial cystitis (BPS/IC) patients continue to have poor quality of life. Thus, there is an urge for new therapies. Our manuscript aims to review papers about BPS/IC treatments published in the last 2 years. Recent findings: During this period, several treatments were tested, most of them new and others combining treatments already used. Pentosan polysulfate, interleukin 1 antagonist, low energy shock wave, physical therapy, hypnosis, acupuncture, clorpactin, dimethyl sulfoxide and hyaluronic acid plus botulinum toxin-A showed positive results. ASP3652 and lidocaine-releasing intravesical systems failed to prove their efficacy. Summary: Validation of these studies is arduous due to the broad spectre of BPS/IC phenotypes, small number of patients enrolled, distinct outcome measures and short-term follow-up. It is also important to highlight that some authors combined therapies, and others split central and peripheric phenotypes before treatment. Therefore, soon, phenotyping and combining therapies with a step-by-step approach will be needed in BPS/IC treatment.
MeSH term(s)	Humans ; Cystitis, Interstitial/drug therapy ; Quality of Life ; Administration, Intravesical ; Botulinum Toxins, Type A/therapeutic use ; Lidocaine/therapeutic use
Chemical Substances	Botulinum Toxins, Type A (EC 3.4.24.69) ; Lidocaine (98PI200987)
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1091792-5
ISSN	1473-6586 ; 0963-0643
ISSN (online)	1473-6586
ISSN	0963-0643
DOI	10.1097/MOU.0000000000001159
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effectiveness of ultrasound screening in right upper quadrant pain

Sérgio Miravent / Manuel Lobo / Teresa Figueiredo / Carmen Jiménez / Rui Almeida

Health Science Reports, Vol 6, Iss 5, Pp n/a-n/a (2023)

A comparative study in a basic emergency service

2023

Abstract: Abstract Background and Aims The use of ultrasound screening is primarily facilitated by point‐of‐care ultrasound (POCUS) and its integration into healthcare systems is a result of the versatility of this imaging technique. This study intends to compare ... ...

Abstract	Abstract Background and Aims The use of ultrasound screening is primarily facilitated by point‐of‐care ultrasound (POCUS) and its integration into healthcare systems is a result of the versatility of this imaging technique. This study intends to compare the accuracy and pertinence of sonographic findings obtained by a sonographer in a Basic Emergency Service (BES) with that of radiologists at referral hospital (RH) in Portugal. Methods Twenty patients with right upper quadrant (RUQ) pain and suspected cholecystitis or biliary pathology underwent sonography screening using POCUS in the BES. They were then forwarded to the RH where a radiologist performed a conventional ultrasound exam on the same patients. The results of both exams were compared to determine if the findings obtained in the BES were confirmed by the radiologist in the RH. Results In our sample, 60% of cases were related to biliary pathology, 20% were liver‐related, 10% had hepatopancreatic biliary etiology, and 10% had unknown etiology. A strong association between the sonographic findings in the BES and the RH was found in the variables “Sonographic Murphy sign” (V = 0.859; p = 0.001), “Cholelithiasis/Gallbladder sludge” (V = 0.840; p = 0.001), and “Intrahepatic biliary tract dilatation” (V = 0.717; p = 0.006). Adequate measures of agreement between the findings of the radiographer and radiologist were obtained for the “Sonographic Murphy sign” (k = 0.664; p = 0.001) and the presence of “Cholelithiasis/Gallbladder sludge” (k = 0.712; p = 0.000). Conclusion Major biliary abnormalities were detected in patients with RUQ pain in BES using sonography. The correlation between the sonographic findings obtained by the sonographers at BES and those obtained by radiologists at the RH in Portugal was strong, showing that POCUS screening could be extended to other similar settings; however, more studies are needed.
Keywords	abdominal pain ; patients ; POCUS ; radiologists ; screening ; sonographers ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Revisiting Clinical Autopsies

Rui Almeida / Rui Caetano Oliveira

Acta Médica Portuguesa, Vol 33, Iss 10, Pp 708-

Lessons to be Taken from the COVID-19 Pandemic

2020 Volume 708

Abstract: N/a. ...

Abstract	N/a.
Keywords	autopsy ; covid-19 ; Medicine ; R ; Medicine (General) ; R5-920 ; covid19
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Ordem dos Médicos
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Finteching remittances in paradise

Hongjoo Hahm / Tientip Subhanij / Rui Almeida

Asia & the Pacific Policy Studies, Vol 8, Iss 3, Pp 435-

A path to sustainable development

2021 Volume 453

Abstract: Abstract The costs of sending remittances to Pacific small island developing states (SIDS) are among the highest in the world. Tackling this issue is crucial not only for economic and social development, but also for improving financial inclusion. This ... ...

Abstract	Abstract The costs of sending remittances to Pacific small island developing states (SIDS) are among the highest in the world. Tackling this issue is crucial not only for economic and social development, but also for improving financial inclusion. This article analyses fintech adoption in remittance services, namely the adoption of alternative payment methods in transferring money by using the internet or mobile phones, in the Pacific. It introduces an original framework to assess the current landscape of fintech in the remittance sector and draws tailored policy recommendations. The framework is conceptualised through a ladder with five rungs: availability, accessibility, awareness, literacy and trust. Based on the ladder analysis, the authors observe the lack of basic digital infrastructure and digital platforms in many Pacific SIDS. Where the technological landscape is better developed, fintech services have established strong footholds, but there is a need for greater awareness to broaden its appeal and customer base. The benefits of fintech platforms are high, especially in the context of lower remittance costs which constitute an unduly large share of GDP in Pacific SIDS. The basic infrastructure needed to develop fintech services are equally important for the overall sustainable development of Pacific SIDS. The article observes fintech services in the Pacific are a means for financial inclusion of the unbanked, that can accelerate the economic and social development of the SIDS, and countries in the Pacific region are at different stages in their readiness for fintech adoption.
Keywords	fintech ; Pacific ; remittance transaction costs ; small island developing states ; Political science ; J ; Political science (General) ; JA1-92
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cutaneous mucormycosis in a young immunocompetent trauma patient

André Silva / Christine Paiva / João Pedro Baptista / Rui Almeida / Rita Alves

European Journal of Case Reports in Internal Medicine (2023)

a case report

2023

Abstract: Introduction: Mucormycosis, a rare and life-threatening infection, is caused by microorganisms of the Mucorales order. It affects almost exclusively immunocompromised and diabetic patients, requiring extensive surgical debridement and prolonged ... ...

Abstract	Introduction: Mucormycosis, a rare and life-threatening infection, is caused by microorganisms of the Mucorales order. It affects almost exclusively immunocompromised and diabetic patients, requiring extensive surgical debridement and prolonged antifungal therapy. Discussion/Results: We report the case of a 26-year-old immunocompetent woman, presenting with cutaneous mucormycosis after suffering blunt force trauma. This rare occurrence of mucormycosis in an immunocompetent patient reinforces the importance of elevated clinical suspicion and early initiation of adequate surgical and antifungal treatment. Conclusion: Mucormycosis is a challenging condition with potentially devastating consequences. Timely diagnosis and appropriate management are vital to mitigate the morbidity and mortality associated with this condition.
Keywords	cutaneous mucormycosis ; soft tissue ; fasciitis ; trauma ; Medicine ; R
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	SMC MEDIA SRL
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cystic adventitial disease of the popliteal artery presenting as acute limb ischemia

Duarte Rego / Paulo Almeida / Rui Almeida

Angiologia e Cirurgia Vascular, Vol 13, Iss

2020 Volume 3

Abstract: Introduction: Cystic adventitial disease is a rare cause of intermittent claudication. Its presentation as acute limb ischemia is exceedingly rare. This disease is caused by the growth of multiple cysts within the adventitia. Although its etiopathogeny ... ...

Abstract	Introduction: Cystic adventitial disease is a rare cause of intermittent claudication. Its presentation as acute limb ischemia is exceedingly rare. This disease is caused by the growth of multiple cysts within the adventitia. Although its etiopathogeny isn’t fully understood most evidence supports an embryonic defect during the development of non-axial arteries. Treatment includes several options: adventitial layer excision, percutaneous aspiration of the cysts and segmental arterectomy with bypass. Methods: We present a case of acute limb ischemia caused by popliteal cystic adventitial disease. Clinical Case: A 60 years old male presented with acute limb ischemia of the right leg. Duplex ultrasound showed a tight stenosis of the popliteal artery caused by adventitial cysts. The patient was intervened: from a posterior approach an excision of the cysts and adventitial layer was performed with total recovery of foot’s perfusion and pedal pulse. After 18 months of follow-up the patient is asymptomatic without imagiological evidence of recurrence. Conclusions: Due to the disease’s rarity there are no studies designed to compare the different treatment strategies for this pathology. However, the available data from case series shows that the surgical technique chosen for this patient presents very good results and, therefore, it seems to be a good therapeutic option assuming a patent popliteal artery without intimal lesion. Clinical presentation as acute limb ischemia isn’t described in the literature and isn’t today understandable because the factors affecting mucin secretion rate by cyst’s mesenchymal cells are unknown.
Keywords	Medicine ; R ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
Subject code	610
Language	Portuguese
Publishing date	2020-03-01T00:00:00Z
Publisher	Sociedade Portuguesa de Angiologia e Cirurgia Vascular
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Material removal predictions in the robot glass polishing process using machine learning

Max Schneckenburger / Sven Höfler / Luis Garcia / Rui Almeida / Rainer Börret

SN Applied Sciences, Vol 4, Iss 1, Pp 1-

2021 Volume 14

Abstract: Abstract Robot polishing is increasingly being used in the production of high-end glass workpieces such as astronomy mirrors, lithography lenses, laser gyroscopes or high-precision coordinate measuring machines. The quality of optical components such as ... ...

Abstract	Abstract Robot polishing is increasingly being used in the production of high-end glass workpieces such as astronomy mirrors, lithography lenses, laser gyroscopes or high-precision coordinate measuring machines. The quality of optical components such as lenses or mirrors can be described by shape errors and surface roughness. Whilst the trend towards sub nanometre level surfaces finishes and features progresses, matching both form and finish coherently in complex parts remains a major challenge. With increasing optic sizes, the stability of the polishing process becomes more and more important. If not empirically known, the optical surface must be measured after each polishing step. One approach is to mount sensors on the polishing head in order to measure process-relevant quantities. On the basis of these data, machine learning algorithms can be applied for surface value prediction. Due to the modification of the polishing head by the installation of sensors and the resulting process influences, the first machine learning model could only make removal predictions with insufficient accuracy. The aim of this work is to show a polishing head optimised for the sensors, which is coupled with a machine learning model in order to predict the material removal and failure of the polishing head during robot polishing. The artificial neural network is developed in the Python programming language using the Keras deep learning library. It starts with a simple network architecture and common training parameters. The model will then be optimised step-by-step using different methods and optimised in different steps. The data collected by a design of experiments with the sensor-integrated glass polishing head are used to train the machine learning model and to validate the results. The neural network achieves a prediction accuracy of the material removal of 99.22%. Article highlights First machine learning model application for robot polishing of optical glass ceramics The polishing process is influenced by a large number of ...
Keywords	Artificial intelligence ; Glass ceramic ; Polishing ; Robot ; Machine learning ; Material removal ; Science ; Q ; Technology ; T
Subject code	670
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Springer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessment of suspected cadaver desecration and the role of forensic anthropology

José Carlos Silva / Eduarda Duarte / Ana Rita Flores / Gonçalo Carnim / Rui Almeida

RevSALUS, Vol 4, Iss Sup (2022)

2022

Keywords	forensic anthropology ; exhumation ; skeleton ; desecration of remains ; Medicine ; R
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Rede Académica das Ciências da Saúde da Lusofonia - RACS
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Role of Urinary VEGF in Observational Studies of BPS/IC Patients

Pedro Abreu-Mendes / Aurora Costa / Ana Charrua / Rui Almeida Pinto / Francisco Cruz

Diagnostics, Vol 12, Iss 1037, p

A Systematic Review

2022 Volume 1037

Abstract: Background: Bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic pain condition, often underdiagnosed, with an important impact on patient quality of life. More recently, an association between VEGF and its receptors has been suggested in ... ...

Abstract	Background: Bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic pain condition, often underdiagnosed, with an important impact on patient quality of life. More recently, an association between VEGF and its receptors has been suggested in BPS/IC pathophysiology, due to their role in promoting angiogenesis and inflammation, which can enhance bladder pain. Eventually, VEGF may be used as a biomarker for the diagnosis and prognostication of BPS/IC. To further clarify this issue, this review aims to critically summarize the available information, giving rise to a solid starting point for future studies. Methods: We systematically searched PubMed and Embase, using the queries “urinary VEGF”, “urinary VEGF” AND “pain”, “urinary VEGF” AND “lower urinary tract symptoms” and “urinary VEGF” AND “LUTS” from January 2016 to February 2022. Results: A total of 1026 papers were identified from which 7 articles were included in this study, which assessed 1036 participants. Regarding VEGF levels, overactive bladder (OAB) and healthy patients were used for comparison with BPS/IC patients. VEGF concentration seems to be higher when compared to healthy patients and overactive bladder (OAB) patients. Higher levels of VEGF were associated with pain severity, while a decrease in VEGF concentration was associated with pain and symptom improvement in women. However, these findings were not constant in all studies. Conclusions: There is a trend toward a relevant association between increased VEGF levels and pain or symptom severity in BPS/IC patients. Although there are some discrepancies among the studies and the number of patients included is small, VEGF and its receptors should be considered for future studies regarding its use in BPS/IC pathophysiology, diagnosis and prognostication.
Keywords	interstitial cystitis ; bladder pain syndrome ; urinary VEGF ; VEGF receptors ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Role of Urinary VEGF in Observational Studies of BPS/IC Patients: A Systematic Review.

Abreu-Mendes, Pedro / Costa, Aurora / Charrua, Ana / Pinto, Rui Almeida / Cruz, Francisco

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 5

Abstract	Background: Bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic pain condition, often underdiagnosed, with an important impact on patient quality of life. More recently, an association between VEGF and its receptors has been suggested in BPS/IC pathophysiology, due to their role in promoting angiogenesis and inflammation, which can enhance bladder pain. Eventually, VEGF may be used as a biomarker for the diagnosis and prognostication of BPS/IC. To further clarify this issue, this review aims to critically summarize the available information, giving rise to a solid starting point for future studies. Methods: We systematically searched PubMed and Embase, using the queries "urinary VEGF", "urinary VEGF" AND "pain", "urinary VEGF" AND "lower urinary tract symptoms" and "urinary VEGF" AND "LUTS" from January 2016 to February 2022. Results: A total of 1026 papers were identified from which 7 articles were included in this study, which assessed 1036 participants. Regarding VEGF levels, overactive bladder (OAB) and healthy patients were used for comparison with BPS/IC patients. VEGF concentration seems to be higher when compared to healthy patients and overactive bladder (OAB) patients. Higher levels of VEGF were associated with pain severity, while a decrease in VEGF concentration was associated with pain and symptom improvement in women. However, these findings were not constant in all studies. Conclusions: There is a trend toward a relevant association between increased VEGF levels and pain or symptom severity in BPS/IC patients. Although there are some discrepancies among the studies and the number of patients included is small, VEGF and its receptors should be considered for future studies regarding its use in BPS/IC pathophysiology, diagnosis and prognostication.
Language	English
Publishing date	2022-04-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12051037
Database	MEDical Literature Analysis and Retrieval System OnLINE

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