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Article ; Online: Prostate cancer treatment in Portugal

Francisco Botelho / Rui Lopes / Francisco Pina / Carlos Silva / Luís Pacheco-Figueiredo / Nuno Lunet

Scientific Reports, Vol 13, Iss 1, Pp 1-

a nationwide analysis

2023 Volume 7

Abstract: Abstract Different treatment options exist for localized prostate cancer. Treatments performed in high-volume hospitals are associated with better results. Our objective was to describe time trends in prostate cancer treatments in Portugal and case ... ...

Abstract	Abstract Different treatment options exist for localized prostate cancer. Treatments performed in high-volume hospitals are associated with better results. Our objective was to describe time trends in prostate cancer treatments in Portugal and case volume per hospital. We used the national database of diagnosis-related group of the Portuguese Central Administration of the Health System to describe the number of radical prostatectomy (RP), brachytherapy (BT) and external radiotherapy (eRT) treatments performed in all National Health System hospitals. There was a rapid increase in the annual number of RP until 2006 and then a deceleration; BT treatments augmented significantly until 2011. The utilization of eRT also increased, surpassing RP after 2010. From the 46 hospitals performing RP, only eight had a case-volume > 50 treatments/year, and from the nine hospitals performing BT, only four accomplished > 15 treatments/year. In the 11 hospitals with eRT, nine performed > 50/year. Regarding RP, there was negative correlation between the hospital volume and length of stay (r = − 0.303; p = 0.041). In the Portuguese National Health Service there was a steep increase in the number of prostate cancer treatments, and there is an ample margin for concentration of RP and BT treatments, for improvement of the hospitals case volume.
Keywords	Medicine ; R ; Science ; Q
Subject code	027
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A simplified two-resistance model for the description of melting curves obtained through differential scanning calorimetry

Gonçalves, Rui Lopes / Robustillo, María Dolores / Pessoa Filho, Pedro de Alcântara

Thermochimica acta. 2022 Aug., v. 714

2022

Abstract: This paper presents a simplified approach to describe the melting endotherm obtained through differential scanning calorimetry. This description considers two main resistances to the heat transfer: the resistance from the heat source to the sample, and ... ...

Abstract	This paper presents a simplified approach to describe the melting endotherm obtained through differential scanning calorimetry. This description considers two main resistances to the heat transfer: the resistance from the heat source to the sample, and the resistance in the liquid layer formed during the melting. The approach was successfully applied to the modeling of melting endotherms of pure fatty esters obtained in the same apparatus using heating rates from 0.5K·min−1 to 2.5K·min−1. The external resistance can be considered constant and independent on the substance at low heating rates, whereas the parameter related to the resistance of the liquid layer may depend on the substance and the heating rate. The proposed two-resistance approach yielded an adequate description of the melting endotherm.
Keywords	endothermy ; heat transfer ; liquids ; models
Language	English
Dates of publication	2022-08
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500974-9
ISSN	0040-6031
ISSN	0040-6031
DOI	10.1016/j.tca.2022.179269
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Trazodone Addition to Paroxetine and Mirtazapine in a Patient with Treatment-Resistant Depression

Rui Lopes / José Carlos Alves / Raquel Garcia Rego

Case Reports in Medicine, Vol

The Pros and Cons of Combining Three Antidepressants

2016 Volume 2016

Abstract: Dual antidepressant combination for treatment-resistant depression is a strategy well supported by literature and accepted in clinical practice. Rather, the usefulness of the combination of more than two antidepressants is controversial. This may be ... ...

Abstract	Dual antidepressant combination for treatment-resistant depression is a strategy well supported by literature and accepted in clinical practice. Rather, the usefulness of the combination of more than two antidepressants is controversial. This may be related to the possibility of higher side-effect burden and to doubts about its pharmacological effectiveness and therapeutic advantage compared to other standard treatment options. We report a relapse of moderate-to-severe depressive symptoms with insomnia that successfully remitted after the addition of trazodone to a dual combination of paroxetine and mirtazapine (in standard effective doses) in a patient with treatment-resistant depression. We also review the literature and discuss the utility of triple antidepressant combination in treatment-resistant depression. This clinical case highlights the utility of combining trazodone as a third antidepressant for the relapse of depressive symptoms after the failure of a dual antidepressant combination. Trazodone may be advantageous in patients presenting recurrence of moderate-to-severe depressive symptoms that include sleep problems and/or insomnia and may be particularly useful when benzodiazepines are not recommended. Although its use may be controversial and associated with higher risk of side-effects, more investigation is needed to determine the efficacy and safety for triple antidepressant combinations as reliable strategies for treatment-resistant depression in clinical practice.
Keywords	Medicine ; R
Subject code	150 ; 610
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 15

Abstract: Abstract YAP is a key transcriptional co-activator of TEADs, it regulates cell growth and is frequently activated in cancer. In Malignant Pleural Mesothelioma (MPM), YAP is activated by loss-of-function mutations in upstream components of the Hippo ... ...

Abstract	Abstract YAP is a key transcriptional co-activator of TEADs, it regulates cell growth and is frequently activated in cancer. In Malignant Pleural Mesothelioma (MPM), YAP is activated by loss-of-function mutations in upstream components of the Hippo pathway, while, in Uveal Melanoma (UM), YAP is activated in a Hippo-independent manner. To date, it is unclear if and how the different oncogenic lesions activating YAP impact its oncogenic program, which is particularly relevant for designing selective anti-cancer therapies. Here we show that, despite YAP being essential in both MPM and UM, its interaction with TEAD is unexpectedly dispensable in UM, limiting the applicability of TEAD inhibitors in this cancer type. Systematic functional interrogation of YAP regulatory elements in both cancer types reveals convergent regulation of broad oncogenic drivers in both MPM and UM, but also strikingly selective programs. Our work reveals unanticipated lineage-specific features of the YAP regulatory network that provide important insights to guide the design of tailored therapeutic strategies to inhibit YAP signaling across different cancer types.
Keywords	Science ; Q
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Animal models of acute gastric mucosal injury

Sandra Simões / Rui Lopes / Maria Celeste Dias Campos / Maria João Marruz / Maria Eugénia Meirinhos da Cruz / Luísa Corvo

Animal Models and Experimental Medicine, Vol 2, Iss 2, Pp 121-

Macroscopic and microscopic evaluation

2019 Volume 126

Abstract: Abstract Acute gastric mucosal injury is a common disorder of the gastrointestinal tract and the search for new therapeutics is ongoing. The aim of this study is to update and expand the information related to the most widely used rat models of acute ... ...

Abstract	Abstract Acute gastric mucosal injury is a common disorder of the gastrointestinal tract and the search for new therapeutics is ongoing. The aim of this study is to update and expand the information related to the most widely used rat models of acute gastric ulcer, the ethanol‐induced ulcer and the indomethacin‐induced ulcer. These two models are compared in terms of macroscopic and microscopic features. Experimentally, ethanol was given orally in a single dose and indomethacin was subcutaneously injected into male Wistar rats. After ulcerative challenges, the stomachs were removed and visually inspected. Anti‐ulcerative drugs were used to validate the models. Histological analysis of the stomachs determined the microscopic score. The methodology used for model evaluation applied to macroscopic and microscopic gastric lesions. With these methods it was possible to induce lesions in the gastric mucosa. Microscopic evaluation permitted assessment of the inflammatory and apoptotic impact in the mucosa not observable by macroscopic evaluation. Groups of animals were treated with two standard drugs: sulcralfate suspension or lansoprazole solution. Both drugs reduced macroscopic and microscopic lesions, particularly the hemorrhagic ones. Both models induced acute gastric mucosal injury and no single evaluation method can address all the aspects of the pathology of gastric lesions. As a complement to macroscopic evaluation, microscopy appears to be a relevant tool to selectively identify specific aspects of the development of mucosal injury, quantify the extent of lesions, and contribute to an appropriate interpretation of results. The score systems established here offer a reliable method for testing antiulcer drugs.
Keywords	animal models ; gastric ulcer ; histology ; pre‐clinical assays ; Medicine (General) ; R5-920
Subject code	630
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: How brand personality, brand identification and service quality influence service brand equity

Sandra Maria Correia Loureiro / Rui Lopes / Hans Ruediger Kaufmann

Cogent Business & Management, Vol 1, Iss

2014 Volume 1

Abstract: During the past couple of decades, brand equity has emerged as one of the key concepts in marketing. Literature concerned with consumer brand relationship is calling for more studies in order to increase understanding of brand equity dimensions. ... ...

Abstract	During the past couple of decades, brand equity has emerged as one of the key concepts in marketing. Literature concerned with consumer brand relationship is calling for more studies in order to increase understanding of brand equity dimensions. Therefore, this study aims to contribute to the existing body of knowledge by examining the strength of relational variables on brand equity perceived by consumers. Findings support the proposed model in the service industry revealing that brand loyalty, brand identification, trust, brand personality and brand awareness are the variables that have a greatest impact on brand equity. Thus, this study is the first to measure the strength of assorted relational variables, and variables related with identification and personality on brand equity for brands in the service industry. In this vein, brand managers should be aware of the importance of building a brand regarding the way they communicate the features of the brand.
Keywords	brand equity ; brand identification ; perceived quality ; trust ; brand loyalty ; brand awareness ; brand associations ; brand personality ; Social Sciences ; H ; Business ; HF5001-6182
Subject code	330 ; 650
Language	English
Publishing date	2014-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SARS-CoV-2 inhibition using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray

Krzysztof Pyrć / Aleksandra Milewska / Emilia Barreto Duran / Paweł Botwina / Agnieszka Dabrowska / Malwina Jedrysik / Malgorzata Benedyk / Rui Lopes / Alejandro Arenas-Pinto / Moutaz Badr / Ryan Mellor / Tammy L. Kalber / Delmiro Fernandez-Reyes / Andreas G. Schätzlein / Ijeoma F. Uchegbu

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 11

Abstract: Abstract There are currently no cures for coronavirus infections, making the prevention of infections the only course open at the present time. The COVID-19 pandemic has been difficult to prevent, as the infection is spread by respiratory droplets and ... ...

Abstract	Abstract There are currently no cures for coronavirus infections, making the prevention of infections the only course open at the present time. The COVID-19 pandemic has been difficult to prevent, as the infection is spread by respiratory droplets and thus effective, scalable and safe preventive interventions are urgently needed. We hypothesise that preventing viral entry into mammalian nasal epithelial cells may be one way to limit the spread of COVID-19. Here we show that N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan (GCPQ), a positively charged polymer that has been through an extensive Good Laboratory Practice toxicology screen, is able to reduce the infectivity of SARS-COV-2 in A549ACE2+ and Vero E6 cells with a log removal value of − 3 to − 4 at a concentration of 10–100 μg/ mL (p < 0.05 compared to untreated controls) and to limit infectivity in human airway epithelial cells at a concentration of 500 μg/ mL (p < 0.05 compared to untreated controls). In vivo studies using transgenic mice expressing the ACE-2 receptor, dosed nasally with SARS-COV-2 (426,000 TCID50/mL) showed a trend for nasal GCPQ (20 mg/kg) to inhibit viral load in the respiratory tract and brain, although the study was not powered to detect statistical significance. GCPQ’s electrostatic binding to the virus, preventing viral entry into the host cells, is the most likely mechanism of viral inhibition. Radiolabelled GCPQ studies in mice show that at a dose of 10 mg/kg, GCPQ has a long residence time in mouse nares, with 13.1% of the injected dose identified from SPECT/CT in the nares, 24 h after nasal dosing. With a no observed adverse effect level of 18 mg/kg in rats, following a 28-day repeat dose study, clinical testing of this polymer, as a COVID-19 prophylactic is warranted.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Empreiteiros internacionais e mercado do Médio Oriente Los contratistas y el mercado internacional en el Oriente Medio International contractors and Middle East market

Rui Lopes dos Reis / Henrique Reis

Revista Portuguesa e Brasileira de Gestão, Vol 8, Iss 4, Pp 54-

2009 Volume 65

Abstract: As obras públicas são uma actividade de relevo no desenvolvimento económico e social. As grandes empresas do sector actuam em vários mercados dado que, normalmente, os mercados domésticos são exíguos para rentabilizar os activos destes agentes económicos. ...

Abstract	As obras públicas são uma actividade de relevo no desenvolvimento económico e social. As grandes empresas do sector actuam em vários mercados dado que, normalmente, os mercados domésticos são exíguos para rentabilizar os activos destes agentes económicos. A internacionalização pode seguir diferentes estratégias e formas de abordagem dos mercados externos. O Médio Oriente é um mercado interessante nesta temática. A análise das maiores empresas internacionais que ali operam, à luz dos modelos de internacionalização conhecidos, permite verificar que a proximidade geográfica e cultural, bem como o potencial económico e geoestratégico, são variáveis relevantes na decisão do processo de internacionalização. A criação de redes é igualmente importante, associada a questões de relacionamento entre as diversas partes interessadas no processo, embora a ligação entre essas partes interessadas não seja facilmente detectável em muitas situações. Las obras públicas son una actividad importante en el desarrollo económico y social. Las principales empresas del sector operan en varios mercados, ya que, normalmente, los mercados internos son pequeños para monetizar los activos de los agentes económicos. La internacionalización puede seguir diferentes estrategias y enfoques a los mercados exteriores. El Oriente Medio es un mercado interesante en esta cuestión. El análisis de las principales empresas internacionales que operan allí, a la luz de los modelos más conocidos de la internacionalización, muestra que la proximidad geográfica y cultural y el potencial económico y geoestratégico, son las variables relevantes en el proceso de decisión de la internacionalización. Las redes también son importantes cuestiones relacionadas con la relación entre las distintas partes interesadas en el proceso, aunque la conexión entre estos actores no es fácilmente detectable en muchas situaciones. Public works are a relevant activity for economic and social development. The largest companies in this sector operate in several markets, because domestic markets are, usually, too small in order to achieve interesting return levels, which match with the level of investment in assets. Internationalization can use different strategies and different foreign markets approaches. Concerning this theme, Middle East is an interesting market to study. The analysis of largest companies that are working there, considering the well known models of internationalization, allows us to conclude that geographic and cultural proximity are relevant variables supporting the internationalization process decision. Also economic potential and strategic geographic situation are important variables concerning the same set of decisions. Networks creation is also important and, sometimes, the relations between stakeholders of the internationalization process are the most important parameter supporting the market approach, but those relations are often difficult to discover.
Keywords	Internacionalización ; Obras Públicas ; Contratistas ; Oriente Medio ; Internacionalização ; Empreiteiros ; Médio Oriente ; Internationalization ; Public Works ; Contractors ; Middle East ; Business ; HF5001-6182 ; Commerce ; HF1-6182 ; Social Sciences ; H ; DOAJ:Business and Management ; DOAJ:Business and Economics
Language	Portuguese
Publishing date	2009-10-01T00:00:00Z
Publisher	INDEG/ISCTE - Instituto para o Desenvolvimento da Gestão Empresarial
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis

Genome Biology, Vol 22, Iss 1, Pp 1-

2021 Volume 28

Abstract: Abstract Background Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiveness. Although thousands ...

Abstract	Abstract Background Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiveness. Although thousands of YAP/TEAD4 binding-sites are annotated, their functional importance is unknown. Here, we aim at further identification of enhancer elements that are required for YAP functions. Results We first apply genome-wide ChIP profiling of YAP to systematically identify enhancers that are bound by YAP/TEAD4. Next, we implement a genetic approach to uncover functions of YAP/TEAD4-associated enhancers, demonstrate its robustness, and use it to reveal a network of enhancers required for YAP-mediated proliferation. We focus on EnhancerTRAM2, as its target gene TRAM2 shows the strongest expression-correlation with YAP activity in nearly all tumor types. Interestingly, TRAM2 phenocopies the YAP-induced cell proliferation, migration, and invasion phenotypes and correlates with poor patient survival. Mechanistically, we identify FSTL-1 as a major direct client of TRAM2 that is involved in these phenotypes. Thus, TRAM2 is a key novel mediator of YAP-induced oncogenic proliferation and cellular invasiveness. Conclusions YAP is a transcription co-factor that binds to thousands of enhancer loci and stimulates tumor aggressiveness. Using unbiased functional approaches, we dissect YAP enhancer network and characterize TRAM2 as a novel mediator of cellular proliferation, migration, and invasion. Our findings elucidate how YAP induces cancer aggressiveness and may assist diagnosis of cancer metastasis.
Keywords	YAP ; Enhancer ; TRAM2 ; Proliferation ; Migration ; Invasion ; Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A propósito de um caso de mania unipolar

Rui Lopes / Jacinto Azevedo / Rosário Curral / Manuel Esteves / Rui Coelho / António Roma-Torres

Archives of Clinical Psychiatry, Vol 39, Iss 3, Pp 111-

2012 Volume 111

Keywords	Medicine ; R ; Internal medicine ; RC31-1245 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Neurology. Diseases of the nervous system ; RC346-429 ; Psychiatry ; RC435-571
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Universidade de São Paulo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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