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  1. AU="Rui Pinto"
  2. AU="Feret, Geoff"
  3. AU="Sherrill-Mix, Scott"
  4. AU="Eleanor Eaton"
  5. AU="Latour, Corine H M"
  6. AU="Radetic, Mark"
  7. AU="James Jensen"
  8. AU="McFalls, Jeanne"
  9. AU="Sylvain Sebert"

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Treffer 1 - 10 von insgesamt 47

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  1. Artikel ; Online: Application of Artificial Immune Systems in Advanced Manufacturing

    Rui Pinto / Gil Gonçalves

    Array, Vol 15, Iss , Pp 100238- (2022)

    2022  

    Abstract: In recent years, the application of Advanced Manufacturing Technologies (AMT) in industrial processes represents the introduction of different Advanced Manufacturing Systems (AMS), which encourage enterprises to improve their core competitiveness and ... ...

    Abstract In recent years, the application of Advanced Manufacturing Technologies (AMT) in industrial processes represents the introduction of different Advanced Manufacturing Systems (AMS), which encourage enterprises to improve their core competitiveness and maintain sustainable development when facing the increasing demand for personalized product customization. More recently, AMT led to a new Internet revolution, mostly known as 4th Industrial Revolution. Considering the development and deployment of Artificial Intelligence to enable smart and self-behaving industrial systems, autonomic approaches allow the system to adapt itself, eliminating the need for human intervention for management. This paper presents a systematic literature review regarding Artificial Immune Systems (AIS) approaches to tackle multiple AMS problems requiring levels of autonomy. First, a systematic review of current industrial AIS applications in manufacturing environments is presented. Then, a conceptual framework is proposed to bridge the gap between research in the AIS field and the manufacturing industry while discussing key challenges and opportunities to be addressed by future research. This study aims to build a body of knowledge for researchers and manufacturers regarding AIS solutions under Advanced Manufacturing while suggesting directions for understanding the requirements for designing and managing autonomic industry applications supported by AIS.
    Schlagwörter Artificial Immune Systems ; Autonomic Computing ; Advanced Manufacturing Systems ; Computer engineering. Computer hardware ; TK7885-7895 ; Electronic computers. Computer science ; QA75.5-76.95
    Thema/Rubrik (Code) 670
    Sprache Englisch
    Erscheinungsdatum 2022-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Towards Bio-Inspired Anomaly Detection Using the Cursory Dendritic Cell Algorithm

    Carlos Pinto / Rui Pinto / Gil Gonçalves

    Algorithms, Vol 15, Iss 1, p

    2022  Band 1

    Abstract: The autonomous and adaptable identification of anomalies in industrial contexts, particularly in the physical processes of Cyber-Physical Production Systems (CPPS), requires using critical technologies to identify failures correctly. Most of the existing ...

    Abstract The autonomous and adaptable identification of anomalies in industrial contexts, particularly in the physical processes of Cyber-Physical Production Systems (CPPS), requires using critical technologies to identify failures correctly. Most of the existing solutions in the anomaly detection research area do not consider such systems’ dynamics. Due to the complexity and multidimensionality of CPPS, a scalable, adaptable, and rapid anomaly detection system is needed, considering the new design specifications of Industry 4.0 solutions. Immune-based models, such as the Dendritic Cell Algorithm (DCA), may provide a rich source of inspiration for detecting anomalies, since the anomaly detection problem in CPPS greatly resembles the functionality of the biological dendritic cells in defending the human body from hazardous pathogens. This paper tackles DCA limitations that may compromise its usage in anomaly detection applications, such as the manual characterization of safe and danger signals, data analysis not suitable for online classification, and the lack of an object-oriented implementation of the algorithm. The proposed approach, the Cursory Dendritic Cell Algorithm (CDCA), is a novel variation of the DCA, developed to be flexible and monitor physical industrial processes continually while detecting anomalies in an online fashion. This work’s contribution is threefold. First, it provides a comprehensive review of Artificial Immune Systems (AIS), focusing on AIS applied to the anomaly detection problem. Then, a new object-oriented architecture for the DCA implementation is described, enabling the modularity and abstraction of the algorithm stages into different classes (modules). Finally, the CDCA for the anomaly detection problem is proposed. The CDCA was successfully validated in two industrial-oriented dataset benchmarks for physical anomaly and network intrusion detection, the Skoltech Anomaly Benchmark ( SKAB ) and M2M using OPC UA . When compared to other algorithms, the proposed approach exhibits promising ...
    Schlagwörter Artificial Immune Systems ; Dendritic Cell Algorithm ; Cyber-Physical Production Systems ; anomaly detection ; fault detection ; Industry 4.0 ; Industrial engineering. Management engineering ; T55.4-60.8 ; Electronic computers. Computer science ; QA75.5-76.95
    Thema/Rubrik (Code) 006
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Chronic Experimental Model of TNBS-Induced Colitis to Study Inflammatory Bowel Disease

    Inês Silva / João Solas / Rui Pinto / Vanessa Mateus

    International Journal of Molecular Sciences, Vol 23, Iss 4739, p

    2022  Band 4739

    Abstract: Background: Inflammatory bowel disease (IBD) is a world healthcare problem. In order to evaluate the effect of new pharmacological approaches for IBD, we aim to develop and validate chronic trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. ... ...

    Abstract Background: Inflammatory bowel disease (IBD) is a world healthcare problem. In order to evaluate the effect of new pharmacological approaches for IBD, we aim to develop and validate chronic trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. Methods: Experimental colitis was induced by the rectal administration of multiple doses of TNBS in female CD-1 mice. The protocol was performed with six experimental groups, depending on the TNBS administration frequency, and two control groups (sham and ethanol groups). Results: The survival rate was 73.3% in the first three weeks and, from week 4 until the end of the experimental protocol, the mice’s survival remained unaltered at 70.9%. Fecal hemoglobin presented a progressive increase until week 4 (5.8 ± 0.3 µmol Hg/g feces, p < 0.0001) compared with the ethanol group, with no statistical differences to week 6. The highest level of tumor necrosis factor-α was observed on week 3; however, after week 4, a slight decrease in tumor necrosis factor-α concentration was verified, and the level was maintained until week 6 (71.3 ± 3.3 pg/mL and 72.7 ± 3.6 pg/mL, respectively). Conclusions: These findings allowed the verification of a stable pattern of clinical and inflammation signs after week 4, suggesting that the chronic model of TNBS-induced colitis develops in 4 weeks.
    Schlagwörter inflammatory bowel disease ; TNBS-induced colitis ; chronic animal model ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Enabling data-driven anomaly detection by design in cyber-physical production systems

    Rui Pinto / Gil Gonçalves / Jerker Delsing / Eduardo Tovar

    Cybersecurity, Vol 5, Iss 1, Pp 1-

    2022  Band 18

    Abstract: Abstract Designing and developing distributed cyber-physical production systems (CPPS) is a time-consuming, complex, and error-prone process. These systems are typically heterogeneous, i.e., they consist of multiple components implemented with different ... ...

    Abstract Abstract Designing and developing distributed cyber-physical production systems (CPPS) is a time-consuming, complex, and error-prone process. These systems are typically heterogeneous, i.e., they consist of multiple components implemented with different languages and development tools. One of the main problems nowadays in CPPS implementation is enabling security mechanisms by design while reducing the complexity and increasing the system’s maintainability. Adopting the IEC 61499 standard is an excellent approach to tackle these challenges by enabling the design, deployment, and management of CPPS in a model-based engineering methodology. We propose a method for CPPS design based on the IEC 61499 standard. The method allows designers to embed a bio-inspired anomaly-based host intrusion detection system (A-HIDS) in Edge devices. This A-HIDS is based on the incremental Dendritic Cell Algorithm (iDCA) and can analyze OPC UA network data exchanged between the Edge devices and detect attacks that target the CPPS’ Edge layer. This study’s findings have practical implications on the industrial security community by making novel contributions to the intrusion detection problem in CPPS considering immune-inspired solutions, and cost-effective security by design system implementation. According to the experimental data, the proposed solution can dramatically reduce design and code complexity while improving application maintainability and successfully detecting network attacks without negatively impacting the performance of the CPPS Edge devices.
    Schlagwörter Artificial immune systems ; Cyber-physical production systems ; IEC 61499 ; Function blocks ; Industrial Internet of Things ; Anomaly-based host intrusion detection system ; Computer engineering. Computer hardware ; TK7885-7895 ; Electronic computers. Computer science ; QA75.5-76.95
    Thema/Rubrik (Code) 006
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag SpringerOpen
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Hemin Ameliorates the Inflammatory Activity in the Inflammatory Bowel Disease

    Inês Silva / Rita Correia / Rui Pinto / Vanessa Mateus

    Biomedicines, Vol 10, Iss 8, p

    A Non-Clinical Study in Rodents

    2022  Band 2025

    Abstract: Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Currently, there is no cure, and pharmacological treatment aims to induce and maintain remission in patients, so it is essential to investigate ...

    Abstract Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Currently, there is no cure, and pharmacological treatment aims to induce and maintain remission in patients, so it is essential to investigate new possible treatments. Hemin is a heme-oxygenase inducer which can confer anti-inflammatory, cytoprotective, and antiapoptotic effects; therefore, it can be considered an asset for different gastrointestinal pathologies, namely for IBD. Aim: This experiment aims to evaluate the efficacy and safety of hemin, in a chronic 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis model in rodents. Methods: The induction of chronic colitis consisted of five weekly intrarectal administrations of 1% TNBS. Then, the mice were treated daily with 5 mg/kg/day or 10 mg/kg/day of hemin, through intraperitoneal injections, for 14 days. Results: Hemin demonstrated an anti-inflammatory effect through the reduction in tumor necrosis factor (TNF)-α levels, fecal calprotectin, and fecal hemoglobin. It was also found to be safe in terms of extraintestinal manifestations, since hemin did not promote renal and/or hepatic changes. Conclusions: Hemin could become an interesting tool for new possible pharmacological approaches in the management of IBD.
    Schlagwörter hemin ; inflammatory bowel disease ; experimental colitis ; TNBS-induced colitis ; anti-inflammatory effect ; heme-oxygenase inducer ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Anti-Inflammatory Effect of Topiramate in a Chronic Model of TNBS-Induced Colitis

    Inês Silva / Priscila Mendes / Sofia Guerra / Rui Pinto / Vanessa Mateus

    International Journal of Molecular Sciences, Vol 23, Iss 16, p

    2022  Band 9127

    Abstract: Inflammatory bowel disease (IBD) is characterized by a chronic and relapsing inflammatory response in the gastrointestinal tract, resulting in severe symptoms such as abdominal pain, vomiting, diarrhea, bloody stools, and weight loss. Currently, there is ...

    Abstract Inflammatory bowel disease (IBD) is characterized by a chronic and relapsing inflammatory response in the gastrointestinal tract, resulting in severe symptoms such as abdominal pain, vomiting, diarrhea, bloody stools, and weight loss. Currently, there is no cure, and the pharmacological treatment includes drugs that induce and keep the patient in remission, not reversing the underlying pathogenic mechanism. These therapies, in the long term, may cause various side effects and complications, which has increased the need to investigate new, more effective, and safer pharmacological approaches. In preclinical studies, topiramate has demonstrated a potential anti-inflammatory effect by inhibiting the production of several pro-inflammatory cytokines. This study aimed to investigate the effect of topiramate in a chronic TNBS-induced colitis model in rodents. Experimental colitis was induced by four intrarectal administrations of 1% TNBS in female CD-1 mice. Topiramate 10 and 20 mg were administered intraperitoneally for 14 days. Several parameters were evaluated, such as bodyweight, alkaline phosphatase (ALP), fecal hemoglobin, fecal calprotectin, tumor necrosis factor (TNF)-α, and interleukin (IL)-10. Topiramate reduces TNBS-induced colonic damage in a model of chronic experimental colitis and normalizes the stool consistency and anus appearance. Additionally, topiramate significantly reduced the concentration of ALP, fecal hemoglobin, fecal calprotectin, TNF-α, and IL-10, demonstrating it to be a promising pharmacological approach for the treatment of IBD in the future.
    Schlagwörter inflammatory bowel disease ; TNBS-induced colitis ; topiramate ; anti-inflammatory effect ; experimental colitis model ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: O Garrano como fator de sustentabilidade de territórios de rede natura 2000

    Ana Alexandra Marta-Costa / Rui Pinto / Filipa Torres-Manso

    Revista de Economia e Sociologia Rural, Vol 59, Iss

    2021  Band 1

    Abstract: Resumo: A evolução da população rural e de animais de algumas raças autóctones portuguesas tem demonstrado níveis de regressão preocupantes, com consequências ambientais e ecológicas, na gestão e no ordenamento do território e na sua sustentabilidade, ... ...

    Abstract Resumo: A evolução da população rural e de animais de algumas raças autóctones portuguesas tem demonstrado níveis de regressão preocupantes, com consequências ambientais e ecológicas, na gestão e no ordenamento do território e na sua sustentabilidade, nomeadamente, no que se refere à dimensão socioeconómica e à própria coesão territorial. Neste trabalho, tendo por base entrevistas realizadas a criadores, empresas e associações que se dedicam à criação e proteção da raça de equídeos Garrana, usada para diversos fins, pretende-se identificar os benefícios da adoção de um sistema de exploração que inclua o Garrano destacando, também, as suas principais debilidades. A abordagem será desenvolvida atendendo às dimensões ambiental, económica e social da sustentabilidade. Os resultados evidenciam a importância destes animais, não apenas enquanto património genético vivo, mas também ao nível da defesa da floresta contra incêndios, concretamente, no controlo de biomassa combustível. No entanto, será necessária a definição de uma estratégia concertada que permita valorizar o seu contributo na economia das explorações ou empresas, o que deverá refletir-se no acréscimo do bem-estar da população, na estabilização do efetivo animal e na sustentabilidade do território.
    Schlagwörter Garrano ; biomassa ; valorização ; sustentabilidade ; Agriculture (General) ; S1-972
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Sociedade Brasileira de Economia e Sociologia Rural
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Effect of Intratrigonal Botulinum Toxin in Patients with Bladder Pain Syndrome/Interstitial Cystitis

    Pedro Abreu-Mendes / António Ferrão-Mendes / Francisco Botelho / Francisco Cruz / Rui Pinto

    Toxins, Vol 14, Iss 775, p

    A Long-Term, Single-Center Study in Real-Life Conditions

    2022  Band 775

    Abstract: The high percentage of treatment failures seen in patients with bladder pain syndrome/interstitial cystitis (BPS/IC) managed conservatively frequently demands invasive treatment options. We aimed to evaluate the long-term efficacy and adverse events of ... ...

    Abstract The high percentage of treatment failures seen in patients with bladder pain syndrome/interstitial cystitis (BPS/IC) managed conservatively frequently demands invasive treatment options. We aimed to evaluate the long-term efficacy and adverse events of intratrigonal botulinum toxin injection in such circumstances, as well as to determine possible predictors of response to toxin treatment. A retrospective cohort study included 47 female BPS/IC patients treated with onabotulinum toxin A (OnabotA) in a tertiary hospital between the years 2009 and 2022. All patients received 100 U of OnabotA in ten injections limited to the trigonal area. Patients were divided into three groups based on their treatment response as responders, non-responders and lost to follow-up due to non-medical reasons. The clinical and surgical records of the individuals were retrieved, including the 10-point visual analogue scale (VAS), the number of treatments, the time between injections, and the age at the first injection. A total of 25 patients (>50% of the cohort) were long-term responders, but none of the evaluated parameters was a predictor for this circumstance: age, pain intensity, or duration of improvement following the injection. The time between injections was stable (around 1 year). No severe adverse events were registered. The intratrigonal injection of botulinum toxin in patients with BPS/IC was an effective and safe long-term treatment for patients’ refractory to conservative forms of treatment. Age, basal pain intensity, and time to injection request did not predict long-term response to OnaBotA.
    Schlagwörter botulinum toxin A ; onabotulinum toxin A ; bladder pain syndrome/interstitial cystitis ; long-term treatment ; Medicine ; R
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Chemically Induced Colitis-Associated Cancer Models in Rodents for Pharmacological Modulation

    Rita Modesto / João Estarreja / Inês Silva / João Rocha / Rui Pinto / Vanessa Mateus

    Journal of Clinical Medicine, Vol 11, Iss 2739, p

    A Systematic Review

    2022  Band 2739

    Abstract: Animal models for colitis-associated colorectal cancer (CACC) represent an important tool to explore the mechanistic basis of cancer-related inflammation, providing important evidence that several inflammatory mediators play specific roles in the ... ...

    Abstract Animal models for colitis-associated colorectal cancer (CACC) represent an important tool to explore the mechanistic basis of cancer-related inflammation, providing important evidence that several inflammatory mediators play specific roles in the initiation and perpetuation of colitis and CACC. Although several original articles have been published describing the CACC model in rodents, there is no consensus about the induction method. This review aims to identify, summarize, compare, and discuss the chemical methods for the induction of CACC through the PRISMA methodology. Methods: We searched MEDLINE via the Pubmed platform for studies published through March 2021, using a highly sensitive search expression. The inclusion criteria were only original articles, articles where a chemically-induced animal model of CACC is described, preclinical studies in vivo with rodents, and articles published in English. Results: Chemically inducible models typically begin with the administration of a carcinogenic compound (as azoxymethane (AOM) or 1,2-dimethylhydrazine (DMH)), and inflammation is caused by repeated cycles of colitis-inducing agents (such as 2,4,6-trinitrobenzenesulfonic acid (TNBS) or dextran sulfate sodium (DSS)). The strains mostly used are C57BL/6 and Balb/c with 5–6 weeks. To characterize the preclinical model, the parameters more used include body weight, stool consistency and morbidity, inflammatory biomarkers such as tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β, angiogenesis markers such as proliferating cell nuclear antigen (PCNA), marker of proliferation Ki-67, and caspase 3, the presence of ulcers, thickness or hyperemia in the colon, and histological evaluation of inflammation. Conclusion: The AOM administration seems to be important to the CACC induction method, since the carcinogenic effect is achieved with just one administration. DSS has been the more used inflammatory agent; however, the TNBS contribution should be more studied, since it allows a reliable, robust, and a highly ...
    Schlagwörter colitis-associated colorectal cancer ; preclinical studies ; disease animal models ; animal experimentation ; colorectal cancer ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Effect of Aqueous Extract of Phenolic Compounds Obtained from Red Wine in Experimental Model of Colitis in Mice

    Vanessa Mateus / João Estarreja / Inês Silva / Fernando Gonçalves / Edite Teixeira-Lemos / Rui Pinto

    Current Issues in Molecular Biology, Vol 44, Iss 188, Pp 2745-

    2022  Band 2758

    Abstract: Background: Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder represented by Crohn’s disease and ulcerative colitis. Currently, there is no cure and pharmacological treatment aims to induce and maintain remission on patients. ... ...

    Abstract Background: Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder represented by Crohn’s disease and ulcerative colitis. Currently, there is no cure and pharmacological treatment aims to induce and maintain remission on patients. Because the therapy reveals a relatively high toxicity, during a long-term utilization, it is essential to investigate new pharmacological approaches. Polyphenols, commonly present on red wine, have shown health-beneficial effects related to their antioxidant and anti-inflammatory effects through the inhibition of NF-kB activation, COX-2 and iNOS induction. In this sense, it would be interesting to study their effects in an IBD context. Therefore, this study aims to evaluate the effects of an aqueous extract of phenolic compounds in a 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced model of colitis. Method: Experimental colitis was induced in mice through an intrarectal administration of TNBS and then the mice were treated with an aqueous extract of phenolic compounds intraperitoneally for four days. Results and Discussion: The extract demonstrated an anti-inflammatory effect, reducing TNF-α levels in the colon, and had a beneficial effect on the extraintestinal manifestations related to IBD, without any significant side effects. The extract of phenolic compounds demonstrated to be a valuable object of study for the management of IBD in the future.
    Schlagwörter polyphenols ; red wine ; colitis ; inflammation ; inflammatory bowel disease ; TNBS-induced colitis ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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