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Article: Protective effect of citrulline on the intestinal mucosal barrier of mice during sepsis.

Jianxin Chen, - / Rui Xu, - / Lifang Qiu, -

Pakistan journal of pharmaceutical sciences

2023 Volume 36, Issue 4, Page(s) 1079–1084

Abstract: Excessive inflammation caused by sepsis can disrupt gut mucosal barrier and aggravate sepsis. The purpose of the study was to confirm whether citrulline can protect the intestinal mucosal barrier during sepsis. Citrulline was used to pretreat the sepsis ... ...

Abstract	Excessive inflammation caused by sepsis can disrupt gut mucosal barrier and aggravate sepsis. The purpose of the study was to confirm whether citrulline can protect the intestinal mucosal barrier during sepsis. Citrulline was used to pretreat the sepsis mouse model and then endotoxin levels, intestinal mucosal permeability, intestinal mucosal morphology and tight junction protein expression were detected to analyze the effect of citrulline on the gut barrier during sepsis. Statistics revealed that, the amount of endotoxin and intestinal mucosal penetration and the morphological score of the intestinal mucosa of septic mice with citrulline treatment were significantly decreased (P<0.05), while the claudin-1 and occludin protein expression levels were obviously increased in septic mice with citrulline treatment (P<0.05). This study defined the protective effect of citrulline on the intestinal mucosal barrier of septic mice. Future studies should examine whether it has the same effect on patients with sepsis.
MeSH term(s)	Animals ; Mice ; Citrulline/pharmacology ; Intestinal Mucosa ; Sepsis/drug therapy ; Disease Models, Animal ; Endotoxins
Chemical Substances	Citrulline (29VT07BGDA) ; Endotoxins
Language	English
Publishing date	2023-08-21
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Global dynamics of an epidemiological model with age of infection and disease relapse

Rui Xu

Journal of Biological Dynamics, Vol 12, Iss 1, Pp 118-

2018 Volume 145

Abstract: In this paper, an epidemiological model with age of infection and disease relapse is investigated. The basic reproduction number for the model is identified, and it is shown to be a sharp threshold to completely determine the global dynamics of the model. ...

Abstract	In this paper, an epidemiological model with age of infection and disease relapse is investigated. The basic reproduction number for the model is identified, and it is shown to be a sharp threshold to completely determine the global dynamics of the model. By analysing the corresponding characteristic equations, the local stability of a disease-free steady state and an endemic steady state of the model is established. By means of suitable Lyapunov functionals and LaSalle's invariance principle, it is verified that if the basic reproduction number is less than unity, the disease-free steady state is globally asymptotically stable, and hence the disease dies out; if the basic reproduction number is greater than unity, the endemic steady state is globally asymptotically stable and the disease becomes endemic.
Keywords	age of infection ; disease relapse ; lyapunov functional ; lasalle's invariance principle ; stability ; Environmental sciences ; GE1-350 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Price Controls and Platform Ecosystem

Zhong Wang / Rui Xu

Sustainability, Vol 14, Iss 5485, p

A Comparative Analysis of Parking Applications between Beijing and London

2022 Volume 5485

Abstract: As a platform to improve the efficiency of matching supply and demand, parking applications once blossomed in many cities. However, some have achieved success while others quickly withered. By comparing the development of parking applications between ... ...

Abstract	As a platform to improve the efficiency of matching supply and demand, parking applications once blossomed in many cities. However, some have achieved success while others quickly withered. By comparing the development of parking applications between Beijing and London, it is found that price controls are a key factor. Price controls include price limits and hourly limits. Flexible price or controlled duration facilitate platform sustainability, as these increase the supply side’s digital investment and willingness to access the platform, and also increase demanders’ willingness to use the platform. Meanwhile, flat and low pricing or no time limit will make the platform less attractive, since these reduce the supply and its mobility, and also discourage demanders from using the platform. This paper enriches the literature on the digital platform ecosystem and information systems (IS) and provides practical inspiration for urban parking management.
Keywords	price controls ; parking demand ; parking supply ; platform ecosystem ; parking applications ; comparative analysis ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	380
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An Investigation Into Chinese EFL Teachers’ Self-Efficacy and Stress as Predictors of Engagement and Emotional Exhaustion

Rui Xu / Xun Jia

SAGE Open, Vol

2022 Volume 12

Abstract: Given the role of stress and self-efficacy on educators in the process of language learning and teaching, it is postulated that further elements such as teachers’ emotional exhaustion and work engagement had a remarkable role in the educational process ... ...

Abstract	Given the role of stress and self-efficacy on educators in the process of language learning and teaching, it is postulated that further elements such as teachers’ emotional exhaustion and work engagement had a remarkable role in the educational process both for teachers and learners; however, the predictor role of self-efficacy and stress remains uninvestigated and much ambiguity still exists about the relation between. A total of 295 male and female Chinese EFL teachers who were teaching English in 21 provinces kindly accepted to attend this study. They were asked to fill out four questionnaires, including the teacher self-efficacy scale, work engagement scale, teacher stress scale, and teachers’ emotional exhaustion scale. For the first question of the study, Pearson coefficient of correlation was used while for the second one, a Structural Equation Modeling (SEM) was run. The results of the study demonstrated a positive relationship between teachers’ work engagement and self-efficacy, while a negative correlation exists between overall work engagement and stress, emotional exhaustion and work engagement, and emotional exhaustion and work engagement. Moreover, there is no significant correlation between self-efficacy and stress. The findings of the study also signified that both self-efficacy and stress meaningfully predict students’ emotional exhaustion and work engagement. In conclusion, some implications and suggestions have been presented for language teaching stakeholders in language learning situations.
Keywords	History of scholarship and learning. The humanities ; AZ20-999 ; Social Sciences ; H
Subject code	370
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Recent Advances of Native Mass Spectrometry Techniques

TAN Cong-rui;XU Wei

Zhipu Xuebao, Vol 43, Iss 6, Pp 754-

2022 Volume 767

Abstract: Nearly all the life activities are regulated by the interactions of the protein with other biomolecules, including protein-protein interactions (PPIs) and protein-ligand interactions (PLIs), therefore understanding interaction and structural ... ...

Abstract	Nearly all the life activities are regulated by the interactions of the protein with other biomolecules, including protein-protein interactions (PPIs) and protein-ligand interactions (PLIs), therefore understanding interaction and structural characterization of formed complexes represent a key task for modern bioscience. Conventional biophysical techniques like circular dichroism spectroscopy (CD), fluorescence resonance energy transfer (FRET), surface plasmon resonance (SPR), and isothermal titration calorimetry (ITC), are limited in studying protein complexes structures and interactions, considering sample purity is a major issue for obtaining reliable data with conventional methods mentioned above. Additional technologies are required to complement structural biology and interactomics research, while mass spectrometry (MS) can deal with impurities or even mixtures in principle, therefore native mass spectrometry (nMS) is demonstrated as a powerful tool to bridge the gap between structural biology and interactomics research. As the most widespread soft ionization technique, electrospray ionization is utilized in native mass spectrometry, which employs volatile aqueous solution, near physiological pH and gentle desolvation conditions to make the transfer of weakly bound noncovalent complexes into the gas phase while preserving their integrity and native structure possible. In this way, stoichiometry, binding partners, thermodynamics, structural dynamics, and topology information on transferred noncovalent complexes can be acquired. A recent breakthrough in native MS sample preparation demonstrated direct analysis of overexpressed proteins from crude cell lysates, which significantly simplified sample purification procedures. Innovations in mass spectrometry instruments, such as extended m/z range quadrupole stages or modification of Orbitrap instruments allow access to high mass with little compromise in resolving power. This has promoted the native analysis of protein complexes and diverse protein interaction ...
Keywords	native mass spectrometry (nms) ; electrospray ionization ; ion mobility ; protein complexes ; protein interactions ; Chemistry ; QD1-999
Subject code	612 ; 540
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Editorial Board of Journal of Chinese Mass Spectrometry Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Towards a better understanding on adsorption mechanism of various heavy metal with phosphorus rich hydrochar

Yi Wen / Dingxiang Chen / Yong Zhang / Huabin Wang / Rui Xu

Arabian Journal of Chemistry, Vol 17, Iss 2, Pp 105530- (2024)

2024

Abstract: The heavy metal contents in many rivers and groundwater exceeds safety standards, and hydrochar stands out among many functional materials for environmental protection applications as its efficient and low−cost. The influence of endogenous phosphorus in ... ...

Abstract	The heavy metal contents in many rivers and groundwater exceeds safety standards, and hydrochar stands out among many functional materials for environmental protection applications as its efficient and low−cost. The influence of endogenous phosphorus in the adsorption and the forms of heavy metal combined with phosphorus are not always fully explored. Thus, the purpose of this study was to clarify adsorption mechanism as well as the biological risks. The physisorption and chemisorption likely coexisted during adsorption of Pb(II) and Hg(II), while physisorption dominated Cd(II) adsorption. The adsorption isotherms of three heavy metal were well fitted with the Langmuir model with capacity of 466.45, 339.48, and 264.19 mg·g−1, respectively. The ion−exchange was the dominant mechanism for Pb(II) and Cd(II) adsorptions. The precipitations were mainly phosphate and carbonate, respectively. On the contrary, formation of complexations was considered as the dominant mechanism for Hg(II) adsorption. Thus, the contribution of phosphorus in adsorption was: Pb(II) > Cd(II) > Hg(II). Using CMHCC to remove heavy metal not only had great effect, but also little harm of eutrophication caused by endogenous phosphorus release for the proportion of bioavailable phosphorus decreased. It's worth noting that the biological risk of CMHCC@HM was: CMHCC@Pb > CMHCC@Cd > CMHCC@Hg. The present study explored the role of endogenous phosphorus in the adsorption of different heavy metal, and the forms of heavy metal and phosphorus. The study improved the effect of hydrochar endogenous substances on heavy metal adsorption.
Keywords	Adsorption mechanism ; Heavy metal ; Phosphorus ; Hydrochar ; Cow manure ; Chemistry ; QD1-999
Subject code	500
Language	English
Publishing date	2024-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Study on Optimal Pile Length in Load Section of Double-Row Buried Pile under Overtopping Failure Mode

Xunchang Li / Mingming Wang / Wei Yang / Rui Xu / Xuqing Pang

Applied Sciences, Vol 14, Iss 1, p

2024 Volume 438

Abstract: An anti-slide pile is a common landslide control measure. Compared with the full-length pile whose top extends to the ground, the buried pile is more optimal in internal force distribution, saves material and has remarkable economic benefits. At present, ...

Abstract	An anti-slide pile is a common landslide control measure. Compared with the full-length pile whose top extends to the ground, the buried pile is more optimal in internal force distribution, saves material and has remarkable economic benefits. At present, there is a lack of in-depth theoretical analysis on the pile length of the load section of double-row buried piles. In order to establish the design calculation method of pile length in the load section of double row buried piles, this paper is based on the failure mode of overtopping. The design equation of load section pile length is obtained by using the transfer coefficient and limit equilibrium method. Taking a landslide in Yan’an City, Shaanxi Province, China, as an example, the reliability and economics of double-row buried piles are verified by comparing the treatment effects of single-row, double-row and double-row buried piles, and the engineering design is completed. The results show that the landslide control project using the design calculation method can meet the requirements of slope stability and at the same time save a quarter of the material compared with the double row of full-length piles. The engineering example proves the rationality and practicability of the design method and provides engineering reference value for the use of the double-row buried anti-slide pile structure in large-scale landslide treatment.
Keywords	double-row buried pile ; overtopping failure ; load section pile length ; limit equilibrium theory ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	621
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The global burden of fatty liver disease: the major impact of China.

Lou, Tian-Wen / Yang, Rui-Xu / Fan, Jian-Gao

Hepatobiliary surgery and nutrition

2024 Volume 13, Issue 1, Page(s) 119–123

Language	English
Publishing date	2024-01-12
Publishing country	China (Republic : 1949- )
Document type	Editorial ; Comment
ZDB-ID	2812398-0
ISSN	2304-389X ; 2304-3881
ISSN (online)	2304-389X
ISSN	2304-3881
DOI	10.21037/hbsn-23-556
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Allicin inhibits the biological activities of cervical cancer cells by suppressing circEIF4G2.

Yifan, Mao / Rui, Xu / Yuan, Li / Feiyun, Jiang

Food science & nutrition

2024 Volume 12, Issue 4, Page(s) 2523–2536

Abstract: Allicin is a safe herbal extract believed to have antitumor effects, which, however, remain unclear. The aim of the present work was to discuss Allicin antitumor effects on cervical cancer using cell experiments. Using Hela and Siha to our research ... ...

Abstract	Allicin is a safe herbal extract believed to have antitumor effects, which, however, remain unclear. The aim of the present work was to discuss Allicin antitumor effects on cervical cancer using cell experiments. Using Hela and Siha to our research objectives in our study, first step, difference concentration of Allicin (20, 40, and 80 μM) treated Hela and Siha cell lines, and next step, discuss circEIF4G2 effects in Allicin antitumor effects in Hela and Siha cell lines; the cell proliferation and EdU-positive cell number by CCK-8 and EdU staining; cell apoptosis rate by flow cytometry; invasion cell number by transwell assay; wound healing rate by wound healing assay; and relative mRNA and protein levels using qRT-PCR and WB assay. With Allicin supplement, the cell proliferation and EdU-positive cell number were significantly depressed with cell apoptosis rate significantly increasing; invasion cell number and wound healing rate significantly suppressed with circEIF4G2 mRNA expression significantly down-regulation (
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.3935
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Licensing policy and platform models of telemedicine

Zhong Wang / Rui Xu / Yan Liu / Yiming Li

Frontiers in Public Health, Vol

A multi-case study from China

2023 Volume 11

Abstract: IntroductionAs a form of platform economy, telemedicine is not growing as fast as other digital platforms. The existing literature seldom pays attention to how licensing policy affects the development of telemedicine platform models.MethodsThis paper ... ...

Abstract	IntroductionAs a form of platform economy, telemedicine is not growing as fast as other digital platforms. The existing literature seldom pays attention to how licensing policy affects the development of telemedicine platform models.MethodsThis paper uses the method of multi-case study and the theory of policy implementation as mutual adaptation to research the influence mechanism of telemedicine platform licensing policy on the platform model in China.ResultsThe findings of the current study are as follows: (1) three models can be classified in accordance with different platform providers in China: medical institution platform, Internet company platform and local government platform; (2) bargaining power, reputation mechanism and resource specificity are important dimensions in the analysis of platform models; (3) as an implementer in the process of licensing policy, the platform provider can not only directly determine the establishment and formation of platform model but also indirectly affect the sustainable development of platform model by affecting the supplier and the demander of platform; and (4) The impact between licensing policy and platform model is dynamic and bidirectional, mainly exerted via administrative orders, market-oriented mechanism and medical insurance.ConclusionsThe research enlightens practical exploration in telemedicine and enriches the theoretical innovation in platform.
Keywords	telemedicine ; platform model ; licensing policy ; digital health ; platform economy ; multi-case study ; Public aspects of medicine ; RA1-1270
Subject code	020
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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