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Article ; Online: Multidimensional Collaborative Management of Environment and Economy in the Internet-of-Things Environment

Rui Yu / Ling Han

Computational Intelligence and Neuroscience, Vol

2022 Volume 2022

Abstract: In this study, multidimensional collaborative management of the modern environmental economy is proposed for strategic management, distribution management, service quality management, and warehouse management, which the modern environmental economy ... ...

Abstract	In this study, multidimensional collaborative management of the modern environmental economy is proposed for strategic management, distribution management, service quality management, and warehouse management, which the modern environmental economy enterprises face under the internet-of-things environment. This study studies the law of multidimensional coordination of environmental economy and puts forward the classification of the modern multidimensional coordination of environmental economy. The multidimensional synergetic-order parameter equation of the modern environmental economic system is constructed, and the information synergy is the order parameter of the environmental economic system by accurate elimination method, and the fluctuation and balance of the environmental economic system are accurately controlled by the order parameter. By using structural equation modeling and other quantitative research methods, the corresponding planning and decision-making mathematical model is established, which provides relevant support for the realization of informatization and intelligentization of multidimensional collaborative management of the environment and economy. An incentive internal management collaboration model based on right of entry is proposed. Aiming at the problem of multidimensional environmental economic management coordination, a dynamic multidimensional environmental economic coordination management algorithm was designed by using the decomposition method, and the effectiveness of the algorithm was verified by numerical experiments.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
Subject code	650
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Connecting Hippo Pathway and Cytoophidia in

Weng, Rui-Yu / Zhang, Lei / Liu, Ji-Long

International journal of molecular sciences

2024 Volume 25, Issue 3

Abstract: CTP synthase (CTPS), the rate-limiting enzyme in the de novo synthesis of CTP, assembles into a filamentous structure termed the cytoophidium. The Hippo pathway regulates cell proliferation and apoptosis. The relationship of the nucleotide metabolism ... ...

Abstract	CTP synthase (CTPS), the rate-limiting enzyme in the de novo synthesis of CTP, assembles into a filamentous structure termed the cytoophidium. The Hippo pathway regulates cell proliferation and apoptosis. The relationship of the nucleotide metabolism with the Hippo pathway is little known. Here, we study the impact of the Hippo pathway on the cytoophidium in
MeSH term(s)	Animals ; Drosophila/metabolism ; Drosophila melanogaster/metabolism ; Hippo Signaling Pathway ; Cytoskeleton/metabolism ; Nucleotides/metabolism ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism
Chemical Substances	Nucleotides ; hpo protein, Drosophila (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Drosophila Proteins ; Intracellular Signaling Peptides and Proteins
Language	English
Publishing date	2024-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25031453
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Metformin and buparlisib synergistically induce apoptosis of non-small lung cancer (NSCLC) cells via Akt/FoxO3a/Puma axis.

Shanshan, Wang / Hongying, Ma / Jingjing, Fang / Rui, Yu

Toxicology in vitro : an international journal published in association with BIBRA

2024 Volume 97, Page(s) 105801

Abstract: Non-small cell lung cancer (NSCLC) is a global health issue lacking effective treatments. Buparlisib is a pan-PI3K inhibitor that shows promising clinical results in treating NSCLC. However, chemoresistance is inevitable and hampers the application of ... ...

Abstract	Non-small cell lung cancer (NSCLC) is a global health issue lacking effective treatments. Buparlisib is a pan-PI3K inhibitor that shows promising clinical results in treating NSCLC. However, chemoresistance is inevitable and hampers the application of buparlisib. Studies show that a combination of phytochemicals and chemotherapeutics enhances its effectiveness. Here, we evaluated the role of metformin, an agent with multiple pharmacological properties, in enhancing the anti-tumour activities of buparlisib against NSCLC cells. Our results showed that metformin and buparlisib synergistically inhibited cell viability, migration, and invasion of NSCLC cells. In addition, co-treatment of metformin and buparlisib also induced cell cycle arrest and cell death in NSCLC cells. Mechanistically, metformin and buparlisib repressed Mcl-1 and upregulated Puma in NSCLC cells in a p53-independent manner. Moreover, they inhibited the PI3K/Akt signalling pathway, leading to activation of the FoxO3a/Puma signalling in NSCLC cells. Our findings suggest that combined treatment of metformin and buparlisib might provide a promising strategy for treating NSCLC.
MeSH term(s)	Humans ; Lung Neoplasms/metabolism ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Metformin/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Cell Line, Tumor ; Apoptosis Regulatory Proteins ; Apoptosis ; Cell Proliferation ; Aminopyridines ; Morpholines
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; NVP-BKM120 ; Metformin (9100L32L2N) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Apoptosis Regulatory Proteins ; Aminopyridines ; Morpholines
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	639064-x
ISSN	1879-3177 ; 0887-2333
ISSN (online)	1879-3177
ISSN	0887-2333
DOI	10.1016/j.tiv.2024.105801
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Article: Mitochondria transcription and cancer.

Lei, Tang / Rui, Yu / Xiaoshuang, Zhou / Jinglan, Zhang / Jihong, Zhang

Cell death discovery

2024 Volume 10, Issue 1, Page(s) 168

Abstract: Mitochondria are major organelles involved in several processes related to energy supply, metabolism, and cell proliferation. The mitochondria function is transcriptionally regulated by mitochondria DNA (mtDNA), which encodes the key proteins in the ... ...

Abstract	Mitochondria are major organelles involved in several processes related to energy supply, metabolism, and cell proliferation. The mitochondria function is transcriptionally regulated by mitochondria DNA (mtDNA), which encodes the key proteins in the electron transport chain that is indispensable for oxidative phosphorylation (OXPHOS). Mitochondrial transcriptional abnormalities are closely related to a variety of human diseases, such as cardiovascular diseases, and diabetes. The mitochondria transcription is regulated by the mtDNA, mitochondrial RNA polymerase (POLRMT), two transcription factors (TFAM and TF2BM), one transcription elongation (TEFM), and one known transcription termination factor (mTERFs). Dysregulation of these factors directly leads to altered expression of mtDNA in tumor cells, resulting in cellular metabolic reprogramming and mitochondrial dysfunction. This dysregulation plays a role in modulating tumor progression. Therefore, understanding the role of mitochondrial transcription in cancer can have implications for cancer diagnosis, prognosis, and treatment. Targeting mitochondrial transcription or related pathways may provide potential therapeutic strategies for cancer treatment. Additionally, assessing mitochondrial transcriptional profiles or biomarkers in cancer cells or patient samples may offer diagnostic or prognostic information.
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-024-01926-3
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Article ; Online: Current status and future of cancer vaccines

Rui Yu / Fangmin Zhao / Zeting Xu / Gaochenxi Zhang / Bingqing Du / Qijin Shu

Heliyon, Vol 10, Iss 2, Pp e24404- (2024)

A bibliographic study

2024

Abstract: Background: Cancer vaccines are an important component of tumour immunotherapy. An increasing number of studies have shown that cancer vaccines have considerable clinical benefits. With the development of tumour precision medicine, cancer vaccines have ... ...

Abstract	Background: Cancer vaccines are an important component of tumour immunotherapy. An increasing number of studies have shown that cancer vaccines have considerable clinical benefits. With the development of tumour precision medicine, cancer vaccines have become important because of their individualised targeting effects. However, few bibliometric studies have conducted comprehensive systematic reviews in this field. This study aimed to assess the scientific output and trends in cancer vaccine research from a global perspective. Methods: We collected publications on cancer vaccines from the Web of Science Core Collection database, which was limited to articles and reviews in English. Microsoft Excel, VOS Viewer, and CiteSpace V were used for quantitative and visual analyses. Results: A total of 7807 articles were included. From 1991 to 2022, the number of publications increased annually. The United States had the highest number of articles published in this field (48.28 %), the highest citation frequency (183,964 times), and the highest H-index (182). The National Institutes of Health topped the list with 476 articles. Schlom J had the highest number of published articles (128) and was the main investigator in this field. The journal, Cancer Immunology Immunotherapy, had published the highest number of articles in related fields. In recent years, tumour microenvironment, immune checkpoint inhibitors, particle vaccines, tumour antigens, and dendritic cells have become research hotspots related to cancer vaccines. Conclusion: Cancer vaccines are a popular research topic in the field of tumour immunotherapy. Related research and publications will enter a boom stage. “Immune checkpoint inhibitors”, “tumour microenvironment” and “dendritic cells” may become future research hotspots, while “T-cell suppressor” is a potential puzzle to be solved.
Keywords	Cancer vaccine ; Immunotherapy ; Tumor microenvironment ; Dendritic cells ; Bibliometric analysis ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	001
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of transcranial magnetic stimulation on treatment effect and immune function

Shan Liu / Xin Wang / Rui Yu / Yan Sun

Saudi Journal of Biological Sciences, Vol 29, Iss 1, Pp 379-

2022 Volume 384

Abstract: To explore the effect of transcranial stimulation on the therapeutic effect and immune function of patients with post-stroke depression (PSD). Methods Selection in September 2020–April 2021 on the diagnosis of 70 patients with PSD as the research object, ...

Abstract	To explore the effect of transcranial stimulation on the therapeutic effect and immune function of patients with post-stroke depression (PSD). Methods Selection in September 2020–April 2021 on the diagnosis of 70 patients with PSD as the research object, 35 patients were randomly divided into control group and intervention group and control group given conventional treatment, the intervention group in the control group on the basis of the application of transcranial magnetic stimulation treatment, compare the curative effect of two groups of patients after the treatment cycle and the effects on the immune function. Results After treatment, the levels of DA, NE, 5-HT in 2 groups were significantly increased, and those in the observation group were significantly higher than those in the control group (P < 0.05). After 8 weeks of treatment, serum Gly content in 2 groups was significantly increased and Glu content was significantly decreased compared with before treatment. Compared with the control group, serum Gly content in observation group was significantly increased and Glu content was significantly decreased after treatment (P < 0.05). After 8 weeks of treatment, the contents of IL-1β, IL-6 and TNF-α in serum of 2 groups were significantly decreased, compared with the control group, the contents of IL-1β, IL-6 and TNF-α in serum of observation group were significantly decreased (P < 0.05); Before treatment, there was no significant difference in PHQ-9 score and MBI score between the two groups (P > 0.05). After 8 weeks of treatment, PHQ-9 score and MBI score in the two groups were better than before treatment, and the observation group was better than the control group (P < 0.05). Conclusion Transcranial magnetic stimulation therapy can not only effectively promote the synthesis and release of monoamine neurotransmitters in patients with post-stroke depression, regulate the inhibitory/excitatory amino acid neurotransmitters, reduce inflammatory response, improve the clinical treatment effect and ...
Keywords	Transcranial magnetic stimulation ; Poststroke depression ; The neurotransmitter ; The immune function ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Study on the Equivalent Average Temperature Variation of the Coal Core during the Freeze Coring Process

Zhaofeng Wang / Jingnian Liang / Rui Yu / Qiao Wang

ACS Omega, Vol 7, Iss 4, Pp 3557-

2022 Volume 3567

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neuroprotective effect of Phyllanthus urinaria extract on ischemic brain injury in rats

Xiao-Long Wen / Dao-Rui Yu

Journal of Hainan Medical University, Vol 28, Iss 7, Pp 6-

2022 Volume 12

Abstract: Objective: To investigate the neuroprotective effect of Phyllanthus urinaria on ischemic stroke and its primary mechanism. Methods: Adult SD rats were selected as the research object, and the right middle cerebral artery infarction rat model was ... ...

Abstract	Objective: To investigate the neuroprotective effect of Phyllanthus urinaria on ischemic stroke and its primary mechanism. Methods: Adult SD rats were selected as the research object, and the right middle cerebral artery infarction rat model was established by the modified suture method(MCAO).Observe the neurological deficit score at 24h, 48h and 72h after the model is successfully prepared,then TTC staining method to detect the area of cerebral infarction, the content of superoxide dismutase (SOD), nitric oxide (NO) and endothelial NOS (eNOS) in brain tissue;Immunofluorescence method was used to detect the expression of Caspase-3 positive cells in brain tissue; Western blot method was used to detect the expression of PI3K and AKT protein in brain tissue.72 experimental animals were randomly divided into 4 groups, sham operation group, model group (MCAO), extract of Phyllanthus urinaria low dose group(PuL5 g/kg), high dose group (PuL10 g/kg), and make MCAO model after 7 days of continuous administration, and continue to infuse the medicine once/d until the material is obtained. Results: No neurological deficits in the sham operation group, The 24h, 48h and 72h of the modelling showed that the neurological impairment of the two doses of extract of Phyllanthus urinaria and the MCAO group was more severe than that of the sham operation group (P<0.01),however, with the prolongation of the modeling time, the neurological function scores of the two doses of extract of Phyllanthus urinaria were lower than those of the MCAO group, the most significant at 72h (P<0.01);The infarct size of the rats in the two dose groups of extract of Phyllanthus urinaria was lower than that of the MCAO group (P<0.01), and there was no dose dependence between the two groups,the content of SOD in the MCAO group was reduced, and the content of NO and eNOS was increased than the sham operation group(P<0.05),Compared with the MCAO group, the two administration groups significantly increased the content of SOD, decreased the content ...
Keywords	extract of phyllanthus urinaria ; rats ; mcao ; nerve function ; Medicine ; R
Subject code	616
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Editorial Board of Journal of Hainan Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Study on effects of Phyllanthusurinaria L extract Intervene Uric Acid in hyperuricemia mice

Hao Li / Dao-Rui Yu

Journal of Hainan Medical University, Vol 26, Iss 18, Pp 25-

2020 Volume 30

Abstract: School of Basic and Life Science, Hainan Medical University, Haikou Hainan ... ...

Abstract	School of Basic and Life Science, Hainan Medical University, Haikou Hainan 571199
Keywords	extract of phyllanthusurinaria l ; the mice of hyperuricemia ; reducing uric acid ; Medicine ; R
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Editorial Board of Journal of Hainan Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An Adaptive Multi-Mode Navigation Method with Intelligent Virtual Sensor Based on Long Short-Term Memory in GNSS Restricted Environment.

Wang, Rong / Rui, Yu / Zhao, Jingxin / Xiong, Zhi / Liu, Jianye

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 8

Abstract: Aiming at the problem of fast divergence of pure inertial navigation system without correction under the condition of GNSS restricted environment, this paper proposes a multi-mode navigation method with an intelligent virtual sensor based on long short- ... ...

Abstract	Aiming at the problem of fast divergence of pure inertial navigation system without correction under the condition of GNSS restricted environment, this paper proposes a multi-mode navigation method with an intelligent virtual sensor based on long short-term memory (LSTM). The training mode, predicting mode, and validation mode for the intelligent virtual sensor are designed. The modes are switching flexibly according to GNSS rejecting situation and the status of the LSTM network of the intelligent virtual sensor. Then the inertial navigation system (INS) is corrected, and the availability of the LSTM network is also maintained. Meanwhile, the fireworks algorithm is adopted to optimize the learning rate and the number of hidden layers of LSTM hyperparameters to improve the estimation performance. The simulation results show that the proposed method can maintain the prediction accuracy of the intelligent virtual sensor online and shorten the training time according to the performance requirements adaptively. Under small sample conditions, the training efficiency and availability ratio of the proposed intelligent virtual sensor are improved significantly more than the neural network (BP) as well as the conventional LSTM network, improving the navigation performance in GNSS restricted environment effectively and efficiently.
Language	English
Publishing date	2023-04-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23084076
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