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  1. Article ; Online: Comparative Analysis of Schistosoma japonicum from Pairing-to-Sexual Maturation based on iTRAQ Proteomics

    Wen-Bin Yang / Fang Luo / Rui-Xiang Zhang / Wei Zhang / Cheng-Song Sun / Qi-Mu-Ge Wu-Yun / Jing-Wei Quan / Yang Luo / Wei Hu

    Zoonoses, Vol 4, Iss 1, p

    2024  Volume 995

    Abstract: Schistosomiasis, which is caused by the schistosome worm, poses significant health challenges. Understanding the sexual development and maturation of schistosomes would provide valuable insight for preventing the transmission of schistosomiasis and ... ...

    Abstract Schistosomiasis, which is caused by the schistosome worm, poses significant health challenges. Understanding the sexual development and maturation of schistosomes would provide valuable insight for preventing the transmission of schistosomiasis and pathologic damage to the host. Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics was performed to monitor the dynamic proteomic profiles in Schistosoma japonicum during development from pairing-to-maturation. RNA interference (RNAi) experiments were used to elucidate sex-biased gene function. Of the 2927 identified proteins, 58.6% showed differential expression after comparing sexes and developmental stages. Both male and female worms displayed a similar number of gender-differentially expressed proteins after pairing. However, these proteins exhibited significant gender-specific functions, with reproduction central in females, while males were enriched in metabolic processes. Females exhibited 73% of their time-variant protein expression during 22-26 days post-infection (dpi), while males had 62% during 18-22 dpi, indicating earlier maturation in males. Functional analysis revealed different peptidases expressed during male and female development and maturation. Sex-biased Sj U2AF exhaustion led to worm development delay, abnormal reproductive organ development, and death. Comparative proteomics enhances our understanding of mechanisms underlying schistosome maturation and reveals a new potential target for chemotherapy and vaccines.
    Keywords Infectious and parasitic diseases ; RC109-216 ; Veterinary medicine ; SF600-1100
    Subject code 590
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Compuscript Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Revisiting the molecular mechanisms and adaptive strategies associated with drought stress tolerance in common wheat (Triticum aestivum L.)

    Nadeem Bhanbhro / Hong-Jin Wang / Hao Yang / Xiao-Jing Xu / Ali Murad Jakhar / Abdullah shalmani / Rui-Xiang Zhang / Qadir Bakhsh / Ghulam Akbar / Muhammad Iqbal Jakhro / Yaseen Khan / Kun-Ming Chen

    Plant Stress, Vol 11, Iss , Pp 100298- (2024)

    1481  

    Abstract: Drought is a misfortune for crops. Wheat is a staple crop and its sustainability and adequate supply are vital to food security around the world. The development of drought-tolerant cultivars in wheat is a major challenge to breeders, therefore there is ... ...

    Abstract Drought is a misfortune for crops. Wheat is a staple crop and its sustainability and adequate supply are vital to food security around the world. The development of drought-tolerant cultivars in wheat is a major challenge to breeders, therefore there is dire need of time to determine the genetic components of drought tolerance in wheat crop. To overcome intense drought stress, wheat plants undergo certain morphological and physiological changes and develop certain genetically adaptive mechanisms. Since wheat is an allotriploid with three sub-genomes, its adaptability molecular mechanisms to drought, particularly needs scientific attention. Here, we systematically and comprehensively reviewed the causes of wheat drought tolerance and the consequences for wheat physiology and genetics. The quantitative trait loci (QTL), which be function on the control of wheat drought tolerance, were comprehensively summarized by a meta-analysis and total 75 meta-QTLs (MQTLs) were identified. In addition, we summarized the genes tightly involved in wheat drought tolerance, and several important genes were selected to elucidate signaling networks related to the wheat drought tolerance. This review is integral to growing suitable strains in the worldwide arid regions to improve wheat yields under recent global climate change scenarios.
    Keywords Drought tolerance ; wheat (Triticum aestivum L.) ; signaling networks ; phytohormones ; quantitative trait loci (QTL) ; Plant ecology ; QK900-989
    Subject code 571
    Language English
    Publishing date 2024-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Comprehensive analysis of miRNA profiles reveals the role of Schistosoma japonicum miRNAs at different developmental stages

    Jie Yu / Ying Yu / Qing Li / Muxin Chen / Haimo Shen / RuiXiang Zhang / Mingxin Song / Wei Hu

    Veterinary Research, Vol 50, Iss 1, Pp 1-

    2019  Volume 13

    Abstract: Abstract Schistosomiasis is an important zoonotic disease affecting up to 40 kinds of animals and 250 million people. It has been reported that the miRNAs play a role in the metabolism, differentiation, development and reproduction in many organisms. ... ...

    Abstract Abstract Schistosomiasis is an important zoonotic disease affecting up to 40 kinds of animals and 250 million people. It has been reported that the miRNAs play a role in the metabolism, differentiation, development and reproduction in many organisms. However, the roles of miRNAs regulating the development, maturation and production in schistosome in both females and males remains unclear. Here we present the dynamic transcriptome analysis of all 79 known Schistosoma japonicum miRNAs from pairing to production, including 14 days post-infection (dpi), 16, 18, 20, 22, 24, 26, 28 dpi female and male, by small RNA sequencing. The miRNA expression profiles showed time-related characteristics in male and female from paring to production, which could be clustered into three patterns, characterized by pairing stage highly expressed (cluster 1), maturating stage highly expressed (cluster 2), and egg producing stage highly expressed (cluster 3). The enrichment of miRNA cluster targeted genes in female and male were distinctly different. Network analysis of miRNAs and their target regulation showed that cluster 1 had 15 miRNAs involved in the regulation of interaction, communication, immune response in female–male and parasite–host. The other 11 miRNAs were involved in gender differentiation and the meiotic cell cycle process. In cluster 2, 11 miRNAs were involved in development and sexual maturation. In cluster 3, 45 miRNAs possibly regulate metabolism and synthesis of the substance for egg production. Analysis of the miRNA regulation network would contribute to understanding the molecular mechanism in S. japonicum development and egg production.
    Keywords Veterinary medicine ; SF600-1100
    Subject code 500
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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