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  1. AU="Ruiqiang Li"
  2. AU="Marini, Davide"
  3. AU="Tirabassi, Jill N"
  4. AU="Song, Seok-Hwan"
  5. AU="A. Hakeem Anwer"
  6. AU="O'Connell, Jeff R"
  7. AU="Elizabeth C. Saunders"
  8. AU="Pratima Verma"
  9. AU="Nomaguchi, Masako"
  10. AU="Hutson, Alan D"
  11. AU="Jarvis, Deborah"
  12. AU="Yilmaz, Sevdican Ustun"
  13. AU="Kreisel, Wolfgang"
  14. AU="Tracy R. Nichols, Ph.D."
  15. AU="Hellal, Faycel"
  16. AU="Steffen Koschmieder"
  17. AU="Hsin-Hui Yu"
  18. AU="Watanabe, Sadanori"
  19. AU="Swarts, Benjamin M"
  20. AU="Zang, Trinity"
  21. AU="Almayahi, Basim A"
  22. AU="Lupke, Madeleine"
  23. AU="Tweed, Conor"

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  1. Artikel ; Online: Associations between sedentary behaviour patterns and depression among people aged 60 and older in Hebei Province of China

    Jiaqi Wang / Ruiqiang Li / Limin Zhang / Xian Gao / Meiqi Zhou / Xinjing Zhang / Yuxia Ma

    BMC Public Health, Vol 22, Iss 1, Pp 1-

    2022  Band 9

    Abstract: Abstract Background Sedentary behaviours (SBs) are now considered a risk factor for depression. Older adults are sedentary most of the time and are at a high risk of depression. However, not all types of SBs have adverse effects on mental health. Passive ...

    Abstract Abstract Background Sedentary behaviours (SBs) are now considered a risk factor for depression. Older adults are sedentary most of the time and are at a high risk of depression. However, not all types of SBs have adverse effects on mental health. Passive SBs (such as watching TV) increase the risk of depression, whereas mentally active SBs (such as using the internet and reading) decrease the risk of depression. The aim of this study was to explore the associations between type of SBs (i.e., passive and mentally active SBs) and depression among people aged 60 years and older in the Hebei Province of China. Methods This cross-sectional study used data from the baseline survey of the Community-based Cohort Study on Nervous System Diseases. A total of 2679 older adults aged ≥60 years from the Hebei Province of China were included in this study. The type and time spent on SBs were self-reported. Watching TV was defined as a passive SB, whereas internet use, reading, and social SBs (including communicating with others and playing chess) were defined as mentally active SBs. Depression was evaluated using the Geriatric Depression Scale. The maximal possible score was 30 points, and ≥ 11 points indicated depression. Logistic regression analysis was used to assess the relationship between SBs and depression. Covariates included sex, age, education, employment, smoking, alcohol consumption, sleep duration, domestic work, physical exercise, body mass index (BMI), and chronic diseases. Results At baseline, the participants who spent two or more hours and 0 h on passive SBs (i.e., TV viewing) had a greater risk of depression (=0 h: adjusted OR = 2.09, 95% CI = 1.18–3.76; 2–3 h: OR = 2.21, 95% CI = 1.16–4.16; > 3 h: OR = 3.59, 95% CI = 1.93–6.68) than the participants who spent 1–2 h on passive SBs. The participants who spent > 1 h on mentally active SBs had a lower risk of depression (adjusted OR = 0.26, 95% CI = 0.06–0.71) than the participants who did not engage in mentally active SBs. Not all mentally active SBs were linked to depression. The participants who engaged in social SBs had a lower risk of depression (adjusted OR: 0.24, 95% CI: 0.06–0.66) than the participants who did not engage in social SBs. Conclusions Spending 2 h or more per day on passive SBs (watching TV) was associated with a high risk of depression among people aged 60 years and older in the Hebei Province of China. Mentally active SBs (predominantly social SBs) could reduce the risk of depression. Some participants with depression probably did not watch TV. These findings suggested that spending more time on social SBs (such as communicating with others and playing chess) rather than watching TV may have important public health implications for preventing and managing depression among older Chinese adults. Moreover, society should attend to the mental health of elderly adults who do not watch TV as they may be more prone to suffer from depressive symptoms.
    Schlagwörter Depression ; Passive sedentary behaviours ; Mentally active sedentary behaviours ; Older adults ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 300
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Grazing Regulates Changes in Soil Microbial Communities in Plant-Soil Systems

    Yu Zhang / Miao Wang / Xu Wang / Ruiqiang Li / Ruifu Zhang / Weibing Xun / Hui Li / Xiaoping Xin / Ruirui Yan

    Agronomy, Vol 13, Iss 708, p

    2023  Band 708

    Abstract: Soil microorganisms promote material transformation and energy flow in the entire ecological environment and play a key role in the stability and development of grassland ecosystems. Studies on the impacts of grazing on the soil microbial community and ... ...

    Abstract Soil microorganisms promote material transformation and energy flow in the entire ecological environment and play a key role in the stability and development of grassland ecosystems. Studies on the impacts of grazing on the soil microbial community and the establishment of a reasonable grazing intensity are crucial to improve our knowledge of the mechanisms underlying grassland degradation and to accurately assess the influence of grazing management on grassland functions and the nutrient cycle. Based on the grassland grazing control experimental platform, we compared the structure and diversity characteristics of soil microbial communities under six grazing intensities (0.00, 0.23, 0.34, 0.46, 0.69, and 0.92 AU ha −1 ) (1 AU = 500 kg of adult cattle) on the Hulunbuir Leymus chinensis meadow steppe. The results showed that soil microbial biomass carbon (MBC) and nitrogen (MBN) decreased with increasing soil depth. The 0–10 cm soil layer of G0.34 had the highest MBC and MBN, and the G0.92 treatment had the lowest MBC and MBN. Heavy grazing significantly decreased the MBC and MBN contents in the soil surface layer. The soil bacterial diversity under light grazing treatment (0.23 AU ha −1 ) was higher than that under heavy grazing, and the fungal diversity under the no-grazing treatment was higher than that under the grazing treatment. Overgrazing reduced the bacterial species in the soil. The plant belowground biomass significantly ( p = 0.039) influenced the bacterial community structure, and the soil pH ( p = 0.032), total nitrogen ( p = 0.011), and litter ( p = 0.007) significantly influenced the fungal community. The effects of grazing on microbial communities were primarily driven by vegetation productivity, litter mass, and soil geophysical and chemical characteristics. This study deepened our understanding of the impacts of grazing practices on soil microbial communities on the meadow steppe, suggesting that moderate-disturbance grazing can promote the sustainable development of grassland vegetation-soil ...
    Schlagwörter Hulunbuir grassland ; grazing intensity ; soil microorganisms ; Inner Mongolia ; meadow steppe ; Agriculture ; S
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Interannual variation in ecosystem respiration in an Inner Mongolian meadow steppe in response to livestock grazing

    Ruirui Yan / Yu Zhang / Miao Wang / Ruiqiang Li / Dongyan Jin / Xiaoping Xin / Linghao Li

    Ecological Indicators, Vol 131, Iss , Pp 108121- (2021)

    2021  

    Abstract: Understanding the effects of livestock grazing on ecosystem respiration (Re) of grassland ecosystems is critical for accurately assessing the feedback of grazing management to climate change. We examined ecosystem respiration in response to varying ... ...

    Abstract Understanding the effects of livestock grazing on ecosystem respiration (Re) of grassland ecosystems is critical for accurately assessing the feedback of grazing management to climate change. We examined ecosystem respiration in response to varying cattle grazing intensities during growing seasons from 2009 to 2018 in a meadow steppe ecosystem of eastern Inner Mongolia. We found that ungrazed swards had the highest mean annual Re rate, with seasonal CVs in Re ranging from 37.53% to 46.04% for all treatments. When all treatments were analysed as a whole, we identified a significant positive relationship between the annual Re rate and annual peak value of standing plant aboveground biomass. Our findings showed that controlling factors on the mean annual Re differed substantially with grazing intensity. In ungrazed and lightly-grazed plots (G0.00 and G0.23), the mean annual Re rate was controlled mainly by canopy height and/or rainfall, while it was controlled more predominantly by contents of NH4+-N and available phosphorus in moderately and heavily grazed plots. We detected significant positive relationships of the annual Re rate with rainfall, soil moisture, ammonium nitrogen, and soil available phosphorus during the entire study period, whereas significant negative relationships were detected between the annual ecosystem respiration rate and the mean growing season temperature, irrespective of grazing intensity. Our findings revealed that grazing could substantially simplify the relationship between the mean annual Re rate and biotic and abiotic parameters. It may be concluded that the relationship between the annual Re rate and the standing crop aboveground biomass was a principal mechanism underlying the effects of gradient grazing on the Re of Chinese meadow steppe ecosystems.
    Schlagwörter Grazing intensity ; Ecosystem respiration ; Canopy biomass ; Soil nutrient ; Soil moisture ; Temperate steppe ; Ecology ; QH540-549.5
    Sprache Englisch
    Erscheinungsdatum 2021-11-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Association of Dietary Inflammatory Index (DII) and depression in the elderly over 55 years in Northern China

    Wei Bao / Xin Huang / Feifei Huang / Yuxia Ma / Wenqiang Zhan / Ruiqiang Li / Zechen Zhang / Meiqi Zhou

    BMJ Open, Vol 12, Iss

    analysis of data from a multicentre, cohort study

    2022  Band 4

    Schlagwörter Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag BMJ Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Single-base editing in IGF2 improves meat production and intramuscular fat deposition in Liang Guang Small Spotted pigs

    Tianqi Duo / Xiaohong Liu / Delin Mo / Yu Bian / Shufang Cai / Min Wang / Ruiqiang Li / Qi Zhu / Xian Tong / Ziyun Liang / Weilun Jiang / Shiyi Chen / Yaosheng Chen / Zuyong He

    Journal of Animal Science and Biotechnology, Vol 14, Iss 1, Pp 1-

    2023  Band 19

    Abstract: Abstract Background Chinese indigenous pigs are popular with consumers for their juiciness, flavour and meat quality, but they have lower meat production. Insulin-like growth factor 2 (IGF2) is a maternally imprinted growth factor that promotes skeletal ... ...

    Abstract Abstract Background Chinese indigenous pigs are popular with consumers for their juiciness, flavour and meat quality, but they have lower meat production. Insulin-like growth factor 2 (IGF2) is a maternally imprinted growth factor that promotes skeletal muscle growth by regulating cell proliferation and differentiation. A single nucleotide polymorphism (SNP) within intron 3 of porcine IGF2 disrupts a binding site for the repressor, zinc finger BED-type containing 6 (ZBED6), leading to up-regulation of IGF2 and causing major effects on muscle growth, heart size, and backfat thickness. This favorable mutation is common in Western commercial pig populations, but absent in most Chinese indigenous pig breeds. To improve meat production of Chinese indigenous pigs, we used cytosine base editor 3 (CBE3) to introduce IGF2-intron3-C3071T mutation into porcine embryonic fibroblasts (PEFs) isolated from a male Liang Guang Small Spotted pig (LGSS), and single-cell clones harboring the desired mutation were selected for somatic cell nuclear transfer (SCNT) to generate the founder line of IGF2 T/T pigs. Results We found the heterozygous progeny IGF2 C/T pigs exhibited enhanced expression of IGF2, increased lean meat by 18%–36%, enlarged loin muscle area by 3%–17%, improved intramuscular fat (IMF) content by 18%–39%, marbling score by 0.75–1, meat color score by 0.53–1.25, and reduced backfat thickness by 5%–16%. The enhanced accumulation of intramuscular fat in IGF2 C/T pigs was identified to be regulated by the PI3K-AKT/AMPK pathway, which activated SREBP1 to promote adipogenesis. Conclusions We demonstrated the introduction of IGF2-intron3-C3071T in Chinese LGSS can improve both meat production and quality, and first identified the regulation of IMF deposition by IGF2 through SREBP1 via the PI3K-AKT/AMPK signaling pathways. Our study provides a further understanding of the biological functions of IGF2 and an example for improving porcine economic traits through precise base editing.
    Schlagwörter CBE3 ; IGF2 ; Intramuscular fat ; Meat production ; PI3K-AKT/AMPK ; ZBED6 ; Animal culture ; SF1-1100 ; Veterinary medicine ; SF600-1100
    Thema/Rubrik (Code) 630 ; 500
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Antibody response assessment of immediate breakthrough infections after zero-COVID policy adjustment in China

    Yanhua Li / Shitong Qiao / Lei Dong / Rong Zhang / Ruiqiang Li / Shijie Qin / Dongshan Yu / Xianfei Liu / Ying Li / Yueyun Ma / Xin Zhao / George Fu Gao

    The Lancet Regional Health. Western Pacific, Vol 40, Iss , Pp 100945- (2023)

    2023  

    Schlagwörter Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Building a Chinese pan-genome of 486 individuals

    Qiuhui Li / Shilin Tian / Bin Yan / Chi Man Liu / Tak-Wah Lam / Ruiqiang Li / Ruibang Luo

    Communications Biology, Vol 4, Iss 1, Pp 1-

    2021  Band 14

    Abstract: Qiuhui Li et al. report a pan-genome sequence study in Han Chinese genomes. They find 276 Mbp of DNA sequences (absent in the current human reference), and report that 46.646 Mbp common sequences improved the accuracy of variant calling and mapping rate ... ...

    Abstract Qiuhui Li et al. report a pan-genome sequence study in Han Chinese genomes. They find 276 Mbp of DNA sequences (absent in the current human reference), and report that 46.646 Mbp common sequences improved the accuracy of variant calling and mapping rate when added to the reference genome.
    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Role of BMI in the Relationship Between Dietary Inflammatory Index and Depression

    Yuxia Ma / Ruiqiang Li / Wenqiang Zhan / Xin Huang / Zechen Zhang / Shuaishuai Lv / Jiaqi Wang / Luyao Liang / Xiaofang Jia

    Frontiers in Medicine, Vol

    An Intermediary Analysis

    2021  Band 8

    Abstract: Introduction: This study investigated this association and the role of BMI in the inflammatory process in a large population-based observational study.Methods: A total of 1,865 elderly people (≥55 years) were followed from the Community Cohort Study of ... ...

    Abstract Introduction: This study investigated this association and the role of BMI in the inflammatory process in a large population-based observational study.Methods: A total of 1,865 elderly people (≥55 years) were followed from the Community Cohort Study of Nervous System Diseases (CCSNSD) cohort study from 2018 to 2019 (Mean [SD] age, 66.31 [0.32] years; 716 [38.4%] males). The semi-quantitative FFQ and geriatric depression scale (GDS) were used to evaluate the diet and depressive symptoms of the elderly, respectively. The multivariable logistic regression model estimated the OR and 95% CI between Empirical Dietary Inflammatory Index (E-DII) and depression. The interaction of E-DII and BMI on depressive events was tested, and the mediation analysis of BMI was performed.Results: As measured by E-DII, the mean (SE) value of the inflammatory potential of the diet in our study was 1.56 (0.12). E-DII ranged from 5.23 to 5.58. In comparison with the first quartile, the elderly from the second quartile (OR: 1.15 [95% CI: 1.09, 1.28]) to the fourth quartile (OR: 1.31 [95% CI: 1.16, 1.42]) have a higher risk of depression before adjustment for BMI. An interaction was observed between E-DII and BMI in terms of the risk of depression (PInteraction < 0.001). The whole related part is mediated by BMI (31.06%).Conclusion: Our findings indicate that the higher pro-inflammatory potential of diet is associated with a higher risk of depression, and this association may be mediated by BMI. Further research is needed to verify our findings and clarify the latent mechanism.
    Schlagwörter dietary inflammatory index ; depression ; body mass index ; mediation analysis ; diet ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2021-11-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Applying blockchain for primary financial market

    Ji Liu / Zheng Xu / Ruiqiang Li / Hang Zhao / Hongbo Jiang / Jinhui Yao / Dong Yuan / Shiping Chen

    IET Blockchain, Vol 1, Iss 2-4, Pp 65-

    A survey

    2021  Band 81

    Abstract: Abstract In financial market, especially primary market, it is very costly and difficult to make a deal due to discovery difficulty, information asymmetry, lack of trust, complicated trading process and low liquidity. Blockchain is an innovative ... ...

    Abstract Abstract In financial market, especially primary market, it is very costly and difficult to make a deal due to discovery difficulty, information asymmetry, lack of trust, complicated trading process and low liquidity. Blockchain is an innovative technology enabling new business models of distributed data storage, point‐to‐point transaction and decentralized autonomous organizations via consensus. The unique features of blockchain, ‘decentralization, highly transparent, enhanced security and immutability of information’, make it a good solution candidate to meet the needs of private equity exchange. This article focuses on analysing the technical basis of the blockchain financial model and the typical application scenarios of the blockchain in the financial market. It discusses the importance of applying key blockchain technology to the financial market, especially in the primary market. Research has found that the development of blockchain technology, especially the maturity of stabilized token technology, makes it possible for blockchain to become a supporting technology to support the next generation of infrastructure in the future financial market. At present, blockchain technology has been concentrated in the issuance, registration, clearing, settlement and derivatives management of private equity and other over‐the‐counter securities. The use of blockchain to build a decentralized primary market has not received enough attention in research and practice, and the use of blockchain technology to establish a primary market with diverse distribution methods is still in its infancy. On this basis, this article further analyses the current problems and the possibility of solving these problems in the application of blockchain in the primary market and points out several interesting directions for future research in this field.
    Schlagwörter Cryptography ; Data security ; Financial computing ; Electronic computers. Computer science ; QA75.5-76.95
    Thema/Rubrik (Code) 332
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: The effect of Thymosin α1 on mortality of critical COVID-19 patients: A multicenter retrospective study

    Sun, Qin Xie Jianfeng Zheng Ruiqiang Li Xuyan Chen Hui Tong Zhaohui Du Bin Qiu Haibo Yang Yi

    International Immunopharmacology

    Abstract: Background Thymosin α1 therapy was commonly used in patients with coronavirus disease 2019 (COVID-19), while its impact on outcomes and which patients could benefit from thymosin α1 therapy were uncertain Study Design and Methods Patients with COVID-19 ... ...

    Abstract Background Thymosin α1 therapy was commonly used in patients with coronavirus disease 2019 (COVID-19), while its impact on outcomes and which patients could benefit from thymosin α1 therapy were uncertain Study Design and Methods Patients with COVID-19 from 19 designated hospitals between January 1 to February 29, 2020 were included, and the main exposure of interest was administration of thymosin α1 The primary outcome was 28-day mortality Propensity score matching (PSM) was used to account for baseline confounders, cluster analysis and Cox proportional hazard model was used to account for subgroup analysis Results A total of 771 patients were included, and 327/771 (42 4%) patients received thymosin α1 therapy The 28-day mortality in thymosin group was significantly lower than that in control group (41 3% vs 60 6%, p<0 001) After PSM 522 patients were included in analysis and the 28-day mortality in thymosin α1 group and control group were 51 0% and 52 9% respectively, with no significant difference In subgroup analyses, the association between thymosin α1 therapy and 28-day mortality appeared to be stronger among male patients (HR 0 673, 95% CI 0 454-0 998;p=0 049) There were no benefits of thymosin α1 in 28-day mortality in other subgroups There were two phenotypes after cluster analysis, but no benefits of thymosin α1 were shown in phenotype 1 (HR 0 823 95% CI 0 581-1 166;p=0 273) and phenotype 2 (HR 1 148 95% CI 0 710-1 895;p=0 442) Conclusion There was no association between use of thymosin α1 and decreased mortality in critically ill COVID-19 patients Subgroups analysis and phenotype analysis also showed no differences on mortality after thymosin α1 therapy
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #893967
    Datenquelle COVID19

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