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Article ; Online: Untapped Opportunities of Resin-to-Resin Transfer Reactions (RRTR) for the Convergent Assembly of Multivalent Peptide Conjugates.

Verzele, Dieter / Ruiz García, Yara / Madder, Annemieke

Chemistry (Weinheim an der Bergstrasse, Germany)

2020 Volume 26, Issue 21, Page(s) 4701–4705

Abstract: Handling of the individual fragments remains a bottleneck in the convergent assembly of peptides. Overlooked since the emergence of ligation chemistries during the past two decades, so-called resin-to-resin transfer reactions (RRTR) are here described as ...

Abstract	Handling of the individual fragments remains a bottleneck in the convergent assembly of peptides. Overlooked since the emergence of ligation chemistries during the past two decades, so-called resin-to-resin transfer reactions (RRTR) are here described as a strategic shortcut in this context. Condensation of the involved moieties at an acceptor resin is facilitated by shuttling peptide segments directly from a donor resin in a one-pot fashion. The straightforward synthesis of a sterically constrained 13-mer peptidosteroid model illustrates the utility of this approach, presenting the first successful application of the RRTR methodology in the field of multivalent design and bioconjugation. Relying on established procedures to generate, monitor and isolate intermediates and products, the solid-phase nature of the entire strategy allows for the fast construction of polypeptide adducts and libraries thereof. As such, a rejuvenated use and new opportunities for RRTR are reported.
MeSH term(s)	Amino Acid Sequence ; Peptides/chemical synthesis ; Peptides/chemistry ; Resins, Synthetic/chemistry
Chemical Substances	Peptides ; Resins, Synthetic
Language	English
Publishing date	2020-03-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202000434
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Article: A Decade of Fighting Invasive Meningococcal Disease: A Narrative Review of Clinical and Real-World Experience with the MenACWY-CRM Conjugate Vaccine.

Ruiz Garcia, Yara / Abitbol, Véronique / Pellegrini, Michele / Bekkat-Berkani, Rafik / Soumahoro, Lamine

Infectious diseases and therapy

2021 Volume 11, Issue 2, Page(s) 639–655

Abstract: The quadrivalent A, C, W and Y meningococcal vaccine conjugated to nontoxic mutant of diphtheria toxin (MenACWY-CRM) has been licensed since 2010 for the prevention of invasive meningococcal disease (IMD), an uncommon but life-threatening condition. Here, ...

Abstract	The quadrivalent A, C, W and Y meningococcal vaccine conjugated to nontoxic mutant of diphtheria toxin (MenACWY-CRM) has been licensed since 2010 for the prevention of invasive meningococcal disease (IMD), an uncommon but life-threatening condition. Here, we summarize the experience accrued with MenACWY-CRM during the first decade since its licensure, by providing an overview of clinical trials investigating the safety, immunogenicity and co-administration of MenACWY-CRM with other vaccines as well as presenting real-world evidence regarding the impact of MenACWY-CRM vaccination on carriage and IMD incidence. MenACWY-CRM has demonstrated an acceptable clinical safety profile across a wide range of age groups; no safety concerns have been reported in special populations, such as immunocompromised infants and toddlers, or pregnant women. MenACWY-CRM has also been proven to be immunogenic in various age groups and geographic settings, and a booster dose has been shown to elicit strong anamnestic responses in all studied populations, irrespective of the vaccine used for priming. With no clinically relevant vaccine interactions reported, MenACWY-CRM is being conveniently integrated into existing vaccination programs for various age and risk groups; this possibility of co-administration helps improving vaccine coverage and streamlining the healthcare process of fighting preventable infectious diseases. Vaccination of adolescents and adults has been proven to reduce nasopharyngeal carriage for serogroups C, W and Y, which is an important element in reducing transmission. Real-world evidence indicates that MenACWY-CRM can reduce IMD incidence even in high-exposure groups. When combined with vaccines against serogroup B meningococci, MenACWY-CRM can offer protection against five of the most common serogroups responsible for IMD, which is an important advantage in the continuously evolving landscape of meningococcal serogroup epidemiology.
Language	English
Publishing date	2021-09-30
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2701611-0
ISSN	2193-6382 ; 2193-8229
ISSN (online)	2193-6382
ISSN	2193-8229
DOI	10.1007/s40121-021-00519-2
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Article: Correction to: A Decade of Fighting Invasive Meningococcal Disease: A Narrative Review of Clinical and Real-World Experience with the MenACWY-CRM Conjugate Vaccine.

Ruiz Garcia, Yara / Abitbol, Véronique / Pellegrini, Michele / Bekkat-Berkani, Rafik / Soumahoro, Lamine

Infectious diseases and therapy

2021 Volume 11, Issue 2, Page(s) 657–659

Language	English
Publishing date	2021-11-27
Publishing country	New Zealand
Document type	Published Erratum
ZDB-ID	2701611-0
ISSN	2193-6382 ; 2193-8229
ISSN (online)	2193-6382
ISSN	2193-8229
DOI	10.1007/s40121-021-00554-z
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Article ; Online: Range of invasive meningococcal disease sequelae and health economic application - a systematic and clinical review.

Shen, Jing / Begum, Najida / Ruiz-Garcia, Yara / Martinon-Torres, Federico / Bekkat-Berkani, Rafik / Meszaros, Kinga

BMC public health

2022 Volume 22, Issue 1, Page(s) 1078

Abstract: Background: Invasive meningococcal disease (IMD) is uncommon, life-threatening, with many diverse sequelae. The aims were to: 1) comprehensively characterise the sequelae; 2) have a systematic application for sequelae impact in economic evaluation (EE).! ...

Abstract	Background: Invasive meningococcal disease (IMD) is uncommon, life-threatening, with many diverse sequelae. The aims were to: 1) comprehensively characterise the sequelae; 2) have a systematic application for sequelae impact in economic evaluation (EE). Methods: Sequelae categorised as physical/neurological or psychological/behavioural were identified from a systematic review of IMD observational studies (OS) and EEs in high-income countries (published 2001-2020). A comprehensive map and EE-relevant list, respectively, included physical/neurological sequelae reported in ≥2OS and ≥ 2OS + 2EE (≥1OS and ≥ 1OS + 1EE for psychological/behavioural). Sequelae proportions were selected from the highest quality studies reporting most sequelae. Three medical experts independently evaluated the clinical impact of findings. Results: Sixty-Six OS and 34 EE reported IMD sequelae. The comprehensive map included 44 sequelae (30 physical/neurological, 14 psychological/behavioural), of which 18 (14 physical/neurological and 4 psychological/behavioural) were EE-relevant. Experts validated the study and identified gaps due to limited evidence, underreporting of psychological/behavioural sequelae in survivors/their families, and occurrence of multiple sequelae in the acute phase and long-term. Conclusions: The considerable burden of IMD sequelae on survivors and their families is potentially underestimated in EE, due to underreporting and poorly-defined subtle sequelae. When assessing IMD burden and potential interventions e.g., vaccination, sequelae range and duration, underreporting, and indirect burden on dependents should be considered.
MeSH term(s)	Cost-Benefit Analysis ; Disease Progression ; Economics, Medical ; Humans ; Meningococcal Infections/epidemiology ; Survivors
Language	English
Publishing date	2022-05-31
Publishing country	England
Document type	Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-022-13342-2
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Article ; Online: Reduced reactogenicity of primary vaccination with DT3aP-HBV-IPV/Hib compared with DT2aP-HBV-IPV-Hib among infants: Mathematical projections in six countries.

George, Marina / Pérez Martin, Jaime / AbdelGhany, Mohammad / Gkalapi, Foteini / Jamet, Nicolas / Kosse, Richelle C / Ruiz García, Yara / Turriani, Elisa / Berlaimont, Valérie

Human vaccines & immunotherapeutics

2023 Volume 19, Issue 1, Page(s) 2202124

Abstract: The hexavalent vaccines DT3aP-HBV-IPV/Hib and DT2aP-HBV-IPV-Hib are routinely used for primary immunization of infants against diphtheria, tetanus, pertussis, hepatitis B virus, poliomyelitis, ... ...

Abstract	The hexavalent vaccines DT3aP-HBV-IPV/Hib and DT2aP-HBV-IPV-Hib are routinely used for primary immunization of infants against diphtheria, tetanus, pertussis, hepatitis B virus, poliomyelitis, and
MeSH term(s)	Humans ; Infant ; Haemophilus influenzae type b ; Hepatitis B virus ; Diphtheria-Tetanus-Pertussis Vaccine ; Poliovirus Vaccine, Inactivated ; Hepatitis B Vaccines ; Haemophilus Vaccines ; Vaccines, Combined ; Vaccination/adverse effects ; Fever/chemically induced ; Immunization Schedule
Chemical Substances	Diphtheria-Tetanus-Pertussis Vaccine ; Poliovirus Vaccine, Inactivated ; Hepatitis B Vaccines ; Haemophilus Vaccines ; Vaccines, Combined
Language	English
Publishing date	2023-04-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2023.2202124
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Article ; Online: Pandemic's influence on parents' attitudes and behaviors toward meningococcal vaccination.

Tan, Litjen L J / Safadi, Marco Aurelio P / Horn, Michael / Regojo Balboa, Cristina / Moya, Elena / Schanbaum, Jamie / Pimenta, Pedro / Lambert, Emma / Soumahoro, Lamine / Sohn, Woo-Yun / Bruce, Teresa / Ruiz García, Yara

Human vaccines & immunotherapeutics

2023 Volume 19, Issue 1, Page(s) 2179840

Abstract: Invasive meningococcal disease is a life-threatening infection preventable through vaccination. Pediatric vaccination rates have declined during the coronavirus disease 2019 (COVID-19) pandemic. This survey aimed to understand how parents' attitudes and ... ...

Abstract	Invasive meningococcal disease is a life-threatening infection preventable through vaccination. Pediatric vaccination rates have declined during the coronavirus disease 2019 (COVID-19) pandemic. This survey aimed to understand how parents' attitudes and behaviors have changed during the pandemic with regard to immunization and, more specifically, meningococcal vaccination. An online survey was emailed to parents of eligible children 0-4 years, following the selection process from UK, France, Germany, Italy, Brazil, Argentina, and Australia; and of adolescents 11-18 years from US. Data collection took place 19 January-16 February 2021. Quotas were set to ensure a representative sample. Eleven questions relating to general perceptions around vaccination and attitudes and behaviors toward meningitis vaccination were displayed. On 4,962 parents (average 35 years) participating in the survey, most (83%) believed important for their child to continue receiving recommended vaccines during the COVID-19 pandemic. Nearly half of routine vaccine appointments were delayed or canceled due to the pandemic, and 61% of respondents were likely to have their children catch up once COVID-19 restrictions were lifted. 30% of meningitidis vaccination appointments were canceled or delayed during the pandemic, and 21% of parents did not intend to reschedule them because of lockdown/stay at home regulations, and fear of catching COVID-19 in public places. It is crucial to communicate clear instructions to health workers and the general population and to provide appropriate safety precautions in vaccination centers. This will help to maintain vaccination rates and limit infections to prevent future outbreaks.
MeSH term(s)	Adolescent ; Humans ; Child ; Pandemics ; Health Knowledge, Attitudes, Practice ; COVID-19/epidemiology ; COVID-19/prevention & control ; Communicable Disease Control ; Meningococcal Infections/epidemiology ; Meningococcal Infections/prevention & control ; Vaccination ; Meningococcal Vaccines ; Surveys and Questionnaires ; Parents
Chemical Substances	Meningococcal Vaccines
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2023.2179840
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Article ; Online: CIRCULATING CLONAL COMPLEXES AND SEQUENCE TYPES OF STREPTOCOCCUS PNEUMONIAE SEROTYPE 19A WORLDWIDE: THE IMPORTANCE OF MULTIDRUG RESISTANCE: A SYSTEMATIC LITERATURE REVIEW.

Ruiz García, Yara / Nieto Guevara, Javier / Izurieta, Patricia / Vojtek, Ivo / Ortega-Barría, Eduardo / Guzman-Holst, Adriana

Expert review of vaccines

2021 Volume 20, Issue 1, Page(s) 45–57

Abstract: Introduction: Streptococcus pneumoniae: Areas covered: We performed a systematic literature review to analyze the frequency and clonal distribution of serotype 19A isolates in the pre- and post-PCV era worldwide providing a scientific background on ... ...

Abstract	Introduction: Streptococcus pneumoniae Areas covered: We performed a systematic literature review to analyze the frequency and clonal distribution of serotype 19A isolates in the pre- and post-PCV era worldwide providing a scientific background on the factors that influence multidrug resistance in pneumococcal isolates. Expert commentary: Serotype 19A IPD incidence increased in all regions following the introduction of the 7-valent PCV. The higher-valent PCVs have reduced the rates of 19A IPD isolates, but several circulating strains with diverse antibiotic resistance prevailed. Heterogeneous clonal distribution in serotype 19A was observed within countries and regions, irrespective of higher-valent PCV used. An increase of 19A isolates from pre- to post-vaccination periods were associated with frequently occurring serotype switching events and with the prevalence of multidrug resistant strains. Rational antibiotic policies must be implemented to control the emergence of resistance.
MeSH term(s)	Aged ; Anti-Bacterial Agents/pharmacology ; Child ; Drug Resistance, Multiple, Bacterial ; Humans ; Incidence ; Pneumococcal Infections/drug therapy ; Pneumococcal Infections/microbiology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines/administration & dosage ; Pneumococcal Vaccines/immunology ; Serogroup ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/immunology ; Streptococcus pneumoniae/isolation & purification ; Vaccination ; Vaccines, Conjugate/administration & dosage
Chemical Substances	Anti-Bacterial Agents ; Pneumococcal Vaccines ; Vaccines, Conjugate
Language	English
Publishing date	2021-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2181284-6
ISSN	1744-8395 ; 1476-0584
ISSN (online)	1744-8395
ISSN	1476-0584
DOI	10.1080/14760584.2021.1873136
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Article: Specific dsDNA recognition by a mimic of the DNA binding domain of the c-Myc/Max transcription factor

Ruiz García, Yara / Pabon-Martinez, Y. Vladimir / Smith, C. I. Edvard / Madder, Annemieke

Chemical communications. 2017 June 16, v. 53, no. 49

2017

Abstract: We here report on the synthesis of the first mimic of the DNA binding domain of the c-Myc/Max-bHLH-ZIP transcription factor able to selectively recognize its cognate E-box sequence 5′-CACGTG-3′ through the major groove of the double-stranded DNA. The ... ...

Abstract	We here report on the synthesis of the first mimic of the DNA binding domain of the c-Myc/Max-bHLH-ZIP transcription factor able to selectively recognize its cognate E-box sequence 5′-CACGTG-3′ through the major groove of the double-stranded DNA. The designed peptidosteroid conjugate was shown to be effective as DNA binder in the presence of excess competitor DNA.
Keywords	DNA ; DNA-binding domains ; chemical compounds ; chemical reactions ; transcription factors
Language	English
Dates of publication	2017-0616
Size	p. 6653-6656.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c7cc01705g
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Article ; Online: Looking beyond meningococcal B with the 4CMenB vaccine: the Neisseria effect.

Ruiz García, Yara / Sohn, Woo-Yun / Seib, Kate L / Taha, Muhamed-Kheir / Vázquez, Julio A / de Lemos, Ana Paula S / Vadivelu, Kumaran / Pizza, Mariagrazia / Rappuoli, Rino / Bekkat-Berkani, Rafik

NPJ vaccines

2021 Volume 6, Issue 1, Page(s) 130

Abstract: Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical manifestations, but the bacteria share up to 80-90% genome sequence identity. The recombinant meningococcal serogroup B (MenB) vaccine 4CMenB consists of four ... ...

Abstract	Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical manifestations, but the bacteria share up to 80-90% genome sequence identity. The recombinant meningococcal serogroup B (MenB) vaccine 4CMenB consists of four antigenic components that can be present in non-B meningococcal and gonococcal strains. This comprehensive review summarizes scientific evidence on the genotypic and phenotypic similarities between vaccine antigens and their homologs expressed by non-B meningococcal and gonococcal strains. It also includes immune responses of 4CMenB-vaccinated individuals and effectiveness and impact of 4CMenB against these strains. Varying degrees of strain coverage were estimated depending on the non-B meningococcal serogroup and antigenic repertoire. 4CMenB elicits immune responses against non-B meningococcal serogroups and N. gonorrhoeae. Real-world evidence showed risk reductions of 69% for meningococcal serogroup W clonal complex 11 disease and 40% for gonorrhea after 4CMenB immunization. In conclusion, functional antibody activity and real-world evidence indicate that 4CMenB has the potential to provide some protection beyond MenB disease.
Language	English
Publishing date	2021-10-29
Publishing country	England
Document type	Journal Article ; Review
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-021-00388-3
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Article ; Online: Specific dsDNA recognition by a mimic of the DNA binding domain of the c-Myc/Max transcription factor.

Ruiz García, Yara / Pabon-Martinez, Y Vladimir / Smith, C I Edvard / Madder, Annemieke

Chemical communications (Cambridge, England)

2017 Volume 53, Issue 49, Page(s) 6653–6656

Abstract: We here report on the synthesis of the first mimic of the DNA binding domain of the c-Myc/Max-bHLH-ZIP transcription factor able to selectively recognize its cognate E-box sequence 5'-CACGTG-3' through the major groove of the double-stranded DNA. The ... ...

Abstract	We here report on the synthesis of the first mimic of the DNA binding domain of the c-Myc/Max-bHLH-ZIP transcription factor able to selectively recognize its cognate E-box sequence 5'-CACGTG-3' through the major groove of the double-stranded DNA. The designed peptidosteroid conjugate was shown to be effective as DNA binder in the presence of excess competitor DNA.
Language	English
Publishing date	2017-06-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c7cc01705g
Database	MEDical Literature Analysis and Retrieval System OnLINE

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