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  1. Article ; Online: Pulse oximetry training landscape for healthcare workers in low- and middle-income countries: A scoping review.

    Peterson, Meagan E / Docter, Shgufta / Ruiz-Betancourt, Daniel R / Alawa, Jude / Arimino, Sedera / Weiser, Thomas G

    Journal of global health

    2023  Volume 13, Page(s) 4074

    Abstract: Background: Pulse oximetry has been used in medical care for decades. Its use quickly became standard of care in high resource settings, with delayed widespread availability and use in lower resource settings. Pulse oximetry training initiatives have ... ...

    Abstract Background: Pulse oximetry has been used in medical care for decades. Its use quickly became standard of care in high resource settings, with delayed widespread availability and use in lower resource settings. Pulse oximetry training initiatives have been ongoing for years, but a map of the literature describing such initiatives among health care workers in low- and middle-income countries (LMICs) has not previously been conducted. Additionally, the coronavirus disease 2019 (COVID-19) pandemic further highlighted the inequitable distribution of pulse oximetry use and training. We aimed to characterise the landscape of pulse oximetry training for health care workers in LMICs prior to the COVID-19 pandemic as described in the literature.
    Methods: We systematically searched six databases to identify studies reporting pulse oximetry training among health care workers, broadly defined, in LMICs prior to the COVID-19 pandemic. Two reviewers independently assessed titles and abstracts and relevant full texts for eligibility. Data were charted by one author and reviewed for accuracy by a second. We synthesised the results using a narrative synthesis.
    Results: A total of 7423 studies were identified and 182 screened in full. A total of 55 training initiatives in 42 countries met inclusion criteria, as described in 66 studies since some included studies reported on different aspects of the same training initiative. Five overarching reasons for conducting pulse oximetry training were identified: 1) anaesthesia and perioperative care, 2) respiratory support programme expansion, 3) perinatal assessment and monitoring, 4) assessment and monitoring of children and 5) assessment and monitoring of adults. Educational programmes varied in their purpose with respect to the types of patients being targeted, the health care workers being instructed, and the depth of pulse oximetry specific training.
    Conclusions: Pulse oximetry training initiatives have been ongoing for decades for a variety of purposes, utilising a multitude of approaches to equip health care workers with tools to improve patient care. It is important that these initiatives continue as pulse oximetry availability and knowledge gaps remain. Neither pulse oximetry provision nor training alone is enough to bolster patient care, but sustainable solutions for both must be considered to meet the needs of both health care workers and patients.
    MeSH term(s) Adult ; Child ; Female ; Pregnancy ; Humans ; Developing Countries ; Pandemics ; COVID-19 ; Educational Status ; Health Personnel
    Language English
    Publishing date 2023-09-22
    Publishing country Scotland
    Document type Systematic Review ; Journal Article
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2986
    ISSN (online) 2047-2986
    ISSN 2047-2986
    DOI 10.7189/jogh.13.04074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Anatomical predictors of need for decompressive craniectomy after stroke using voxel-based lesion symptom mapping.

    McCullough-Hicks, Margy / Topiwala, Karan / Christensen, Soren / Ruiz-Betancourt, Daniel / Mlynash, Michael / Albers, Gregory W

    Journal of neuroimaging : official journal of the American Society of Neuroimaging

    2023  Volume 33, Issue 5, Page(s) 737–741

    Abstract: Background and purpose: Malignant cerebral edema (MCE) secondary to ischemic stroke is a highly morbid condition. Decompressive craniectomy (DC) is the only treatment for MCE that has been shown to reduce mortality. We examined whether early infarction ... ...

    Abstract Background and purpose: Malignant cerebral edema (MCE) secondary to ischemic stroke is a highly morbid condition. Decompressive craniectomy (DC) is the only treatment for MCE that has been shown to reduce mortality. We examined whether early infarction and/or hypoperfusion in specific topographic regions was predictive of the need for later DC.
    Methods: A retrospective database of patients evaluated for large vessel occlusion (LVO) stroke at Stanford between 2010 and 2019 was used. Thirty patients with LVO and baseline perfusion MRI who underwent DC were evaluated. Propensity matching based on age, lesion size, and recanalization status was performed on the remaining cohort. Baseline masks of apparent diffusion coefficient (ADC) + T
    Results: Sixty patients were analyzed. After adjusting for age, lesion size, and recanalization status as covariates, scattered cortical regions, predominately within the temporal and frontal lobe, were mildly to moderately predictive of the need for DC (z-scores: 2.4-6.74, p < .01).
    Conclusions: Scattered temporal and frontal lobe regions on baseline diffusion and perfusion MRI were found to be mildly to moderately predictive of the need for subsequent DC in patients with LVO stroke.
    MeSH term(s) Humans ; Retrospective Studies ; Decompressive Craniectomy/methods ; Treatment Outcome ; Stroke/diagnostic imaging ; Stroke/surgery ; Magnetic Resonance Imaging ; Ischemic Stroke
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1071724-9
    ISSN 1552-6569 ; 1051-2284
    ISSN (online) 1552-6569
    ISSN 1051-2284
    DOI 10.1111/jon.13144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Road Not Taken: Disconnection of a Human-Unique Cortical Pathway Underlying Naturalistic Social Perception in Schizophrenia.

    Patel, Gaurav H / Gruskin, David C / Arkin, Sophie C / Jamerson, Emery C / Ruiz-Betancourt, Daniel R / Klim, Casimir C / Sanchez-Peña, Juan P / Bartel, Laura P / Lee, Jessica K / Grinband, Jack / Martinez, Antígona / Berman, Rebecca A / Ochsner, Kevin N / Leopold, David A / Javitt, Daniel C

    Biological psychiatry global open science

    2022  Volume 3, Issue 3, Page(s) 398–408

    Abstract: Background: Efficient processing of complex and dynamic social scenes relies on intact connectivity of many underlying cortical areas and networks, but how connectivity anomalies affect the neural substrates of social perception remains unknown. Here we ...

    Abstract Background: Efficient processing of complex and dynamic social scenes relies on intact connectivity of many underlying cortical areas and networks, but how connectivity anomalies affect the neural substrates of social perception remains unknown. Here we measured these relationships using functionally based localization of social perception areas, resting-state functional connectivity, and movie-watching data.
    Methods: In 42 participants with schizophrenia (SzPs) and 41 healthy control subjects, we measured the functional connectivity of areas localized by face-emotion processing, theory-of-mind (ToM), and attention tasks. We quantified the weighted shortest path length between visual and medial prefrontal ToM areas in both populations to assess the impact of these changes in functional connectivity on network structure. We then correlated connectivity along the shortest path in each group with movie-evoked activity in a key node of the ToM network (posterior temporoparietal junction [TPJp]).
    Results: SzPs had pronounced decreases in connectivity in TPJ/posterior superior temporal sulcus (TPJ-pSTS) areas involved in face-emotion processing (
    Conclusions: These results suggest that connectivity along the human-unique TPJ-pSTS pathway affects both the network architecture and functioning of areas involved in processing complex dynamic social scenes. These results demonstrate how focal connectivity anomalies can have widespread impacts across the cortex.
    Language English
    Publishing date 2022-03-22
    Publishing country United States
    Document type Journal Article
    ISSN 2667-1743
    ISSN (online) 2667-1743
    DOI 10.1016/j.bpsgos.2022.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Deficits and compensation: Attentional control cortical networks in schizophrenia.

    Arkin, Sophie C / Ruiz-Betancourt, Daniel / Jamerson, Emery C / Smith, Roland T / Strauss, Nicole E / Klim, Casimir C / Javitt, Daniel C / Patel, Gaurav H

    NeuroImage. Clinical

    2020  Volume 27, Page(s) 102348

    Abstract: Visual processing and attention deficits are responsible for a substantial portion of the disability caused by schizophrenia, but the source of these deficits remains unclear. In 35 schizophrenia patients (SzP) and 34 healthy controls (HC), we used a ... ...

    Abstract Visual processing and attention deficits are responsible for a substantial portion of the disability caused by schizophrenia, but the source of these deficits remains unclear. In 35 schizophrenia patients (SzP) and 34 healthy controls (HC), we used a rapid serial visual presentation (RSVP) visual search task designed to activate/deactivate the cortical components of the attentional control system (i.e. the dorsal and ventral attention networks, lateral prefrontal regions in the frontoparietal network, and cingulo-opercular/salience networks), along with resting state functional connectivity, to examine the integrity of these components. While we find that behavioral performance and activation/deactivation of the RSVP task are largely similar between groups, SzP exhibited decreased functional connectivity within late visual components and between prefrontal and other components. We also find that performance correlates with the deactivation of the ventral attention network in SzP only. This relationship is mediated by the functional connectivity of critical components of the attentional control system. In summary, our results suggest that the attentional control system is potentially used to compensate for visual cortex deficits. Furthermore, prefrontal deficits in SzP may interfere with this compensatory use of the attentional control system. In addition to highlighting focal deficits and potential compensatory mechanisms in visual processing and attention, our findings point to the attentional control system as a potential target for rehabilitation and neuromodulation-based treatments for visual processing deficits in SzP.
    MeSH term(s) Brain Mapping ; Cerebral Cortex/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Schizophrenia ; Visual Cortex
    Language English
    Publishing date 2020-07-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2020.102348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: What you see is what you get: visual scanning failures of naturalistic social scenes in schizophrenia.

    Patel, Gaurav H / Arkin, Sophie C / Ruiz-Betancourt, Daniel R / DeBaun, Heloise M / Strauss, Nicole E / Bartel, Laura P / Grinband, Jack / Martinez, Antigona / Berman, Rebecca A / Leopold, David A / Javitt, Daniel C

    Psychological medicine

    2020  Volume 51, Issue 16, Page(s) 2923–2932

    Abstract: Background: Impairments in social cognition contribute significantly to disability in schizophrenia patients (SzP). Perception of facial expressions is critical for social cognition. Intact perception requires an individual to visually scan a complex ... ...

    Abstract Background: Impairments in social cognition contribute significantly to disability in schizophrenia patients (SzP). Perception of facial expressions is critical for social cognition. Intact perception requires an individual to visually scan a complex dynamic social scene for transiently moving facial expressions that may be relevant for understanding the scene. The relationship of visual scanning for these facial expressions and social cognition remains unknown.
    Methods: In 39 SzP and 27 healthy controls (HC), we used eye-tracking to examine the relationship between performance on The Awareness of Social Inference Test (TASIT), which tests social cognition using naturalistic video clips of social situations, and visual scanning, measuring each individual's relative to the mean of HC. We then examined the relationship of visual scanning to the specific visual features (motion, contrast, luminance, faces) within the video clips.
    Results: TASIT performance was significantly impaired in SzP for trials involving sarcasm (
    Conclusions: SzP show highly significant deficits in the use of visual scanning of naturalistic social scenes to inform social cognition. Alterations in visual scanning patterns may originate from impaired processing of facial motion within peripheral vision. Overall, these results highlight the utility of naturalistic stimuli in the study of social cognition deficits in schizophrenia.
    MeSH term(s) Humans ; Schizophrenia ; Facial Expression ; Visual Perception ; Emotions ; Social Perception
    Language English
    Publishing date 2020-06-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291720001646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Failure to engage the temporoparietal junction/posterior superior temporal sulcus predicts impaired naturalistic social cognition in schizophrenia.

    Patel, Gaurav H / Arkin, Sophie C / Ruiz-Betancourt, Daniel R / Plaza, Fabiola I / Mirza, Safia A / Vieira, Daniel J / Strauss, Nicole E / Klim, Casimir C / Sanchez-Peña, Juan P / Bartel, Laura P / Grinband, Jack / Martinez, Antigona / Berman, Rebecca A / Ochsner, Kevin N / Leopold, David A / Javitt, Daniel C

    Brain : a journal of neurology

    2021  Volume 144, Issue 6, Page(s) 1898–1910

    Abstract: Schizophrenia is associated with marked impairments in social cognition. However, the neural correlates of these deficits remain unclear. Here we use naturalistic stimuli to examine the role of the right temporoparietal junction/posterior superior ... ...

    Abstract Schizophrenia is associated with marked impairments in social cognition. However, the neural correlates of these deficits remain unclear. Here we use naturalistic stimuli to examine the role of the right temporoparietal junction/posterior superior temporal sulcus (TPJ-pSTS)-an integrative hub for the cortical networks pertinent to the understanding complex social situations-in social inference, a key component of social cognition, in schizophrenia. Twenty-seven schizophrenia participants and 21 healthy control subjects watched a clip of the film The Good, the Bad and the Ugly while high resolution multiband functional MRI images were collected. We used inter-subject correlation to measure the evoked activity, which we then compared to social cognition as measured by The Awareness of Social Inference Test (TASIT). We also compared between groups the TPJ-pSTS blood oxygen level-dependent activity (i) relationship with the motion content in the film; (ii) synchronization with other cortical areas involved in the viewing of the movie; and (iii) relationship with the frequency of saccades made during the movie. Activation deficits were greatest in middle TPJ (TPJm) and correlated significantly with impaired TASIT performance across groups. Follow-up analyses of the TPJ-pSTS revealed decreased synchronization with other cortical areas, decreased correlation with the motion content of the movie, and decreased correlation with the saccades made during the movie. The functional impairment of the TPJm, a hub area in the middle of the TPJ-pSTS, predicts deficits in social inference in schizophrenia participants by disrupting the integration of visual motion processing into the TPJ. This disrupted integration then affects the use of the TPJ to guide saccades during the visual scanning of the movie clip. These findings suggest that the TPJ may be a treatment target for improving deficits in a key component of social cognition in schizophrenia participants.
    MeSH term(s) Adult ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Parietal Lobe/physiopathology ; Schizophrenia/physiopathology ; Social Cognition ; Temporal Lobe/physiopathology
    Language English
    Publishing date 2021-03-12
    Publishing country England
    Document type Clinical Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awab081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: TNF-α

    van der Ploeg, Kattria / Kirosingh, Adam S / Mori, Diego A M / Chakraborty, Saborni / Hu, Zicheng / Sievers, Benjamin L / Jacobson, Karen B / Bonilla, Hector / Parsonnet, Julie / Andrews, Jason R / Press, Kathleen D / Ty, Maureen C / Ruiz-Betancourt, Daniel R / de la Parte, Lauren / Tan, Gene S / Blish, Catherine A / Takahashi, Saki / Rodriguez-Barraquer, Isabel / Greenhouse, Bryan /
    Singh, Upinder / Wang, Taia T / Jagannathan, Prasanna

    Cell reports. Medicine

    2022  Volume 3, Issue 6, Page(s) 100640

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific CD4
    MeSH term(s) Antibodies, Neutralizing ; CD4-Positive T-Lymphocytes ; COVID-19 ; Humans ; Outpatients ; SARS-CoV-2 ; T-Lymphocytes ; Tumor Necrosis Factor-alpha
    Chemical Substances Antibodies, Neutralizing ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2022.100640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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