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  1. Article ; Online: Editorial.

    Rujescu, Dan

    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

    2021  Volume 21, Issue 10, Page(s) 711

    Language English
    Publishing date 2021-01-12
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2051402-5
    ISSN 1814-1412 ; 1562-2975
    ISSN (online) 1814-1412
    ISSN 1562-2975
    DOI 10.1080/15622975.2020.1858577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Suche nach Risikogenen bei Schizophrenie.

    Rujescu, D

    Der Nervenarzt

    2017  Volume 88, Issue 7, Page(s) 751–754

    Abstract: Background: Schizophrenia is a severe psychiatric disease affecting approximately 0.5-1% of the general population. The relative contribution of genetic factors has been estimated to be 64-81%.: Objective: This review summarizes recent efforts to ... ...

    Title translation Search for risk genes in schizophrenia.
    Abstract Background: Schizophrenia is a severe psychiatric disease affecting approximately 0.5-1% of the general population. The relative contribution of genetic factors has been estimated to be 64-81%.
    Objective: This review summarizes recent efforts to identify genetic variants associated with schizophrenia.
    Methods: Relevant linkage and candidate genes as well as genome wide association studies, studies on copy number variants and next generation sequencing are presented and discussed.
    Results: The latest and worldwide largest study on the genetics of schizophrenia found 128 genome wide significant single nucleotide polymorphisms (SNP) and 108 genome wide loci. The most obvious association is with genetic variations in the major histocompatibility complex (MHC). Besides polymorphisms, structural variants in the form of copy number variants (CNV), such as microdeletions and microduplications have a very high impact in a subgroup of patients. These CNVs are mainly microdeletions on 1q21.1, 2p16.3, 3q29, 15q13.3 and 16p11.2 as well as a large deletion on 22q11.21 and a microduplication on 16p11.2.
    Conclusion: A large new body of evidence on the genetics of schizophrenia is expected through next generation sequencing approaches. Future studies will particularly address the functional characterization of genetic variants.
    MeSH term(s) DNA Copy Number Variations ; Genetic Association Studies ; Genetic Linkage ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Humans ; Major Histocompatibility Complex/genetics ; Risk Assessment ; Schizophrenia/diagnosis ; Schizophrenia/genetics ; Sequence Analysis, DNA
    Language German
    Publishing date 2017-07
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 123291-5
    ISSN 1433-0407 ; 0028-2804
    ISSN (online) 1433-0407
    ISSN 0028-2804
    DOI 10.1007/s00115-017-0330-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genetik der Schizophrenie // Genetics in schizophrenia

    Rujescu, D

    Journal für Neurologie, Neurochirurgie und Psychiatrie

    2019  Volume 20, Issue 2, Page(s) 76–79

    Abstract: Schizophrenia is a severe psychiatric disease with a relative contribution of genetic factors of up to 64–81 %. Beside linkage- and candidate gene studies, especially genome wide association studies (GWAS), studies on copy number variants (CNVs) as well ... ...

    Abstract Schizophrenia is a severe psychiatric disease with a relative contribution of genetic factors of up to 64–81 %. Beside linkage- and candidate gene studies, especially genome wide association studies (GWAS), studies on copy number variants (CNVs) as well as studies on next generation sequencing (NGS) were published. The so far latest and worldwide largest study on genetics of schizophrenia showed 128 genome wide significant polymorphisms (SNPs, single nucleotide polymorphisms). Especially the MHC (major histocompatibility complex) association shows highest impact. Beside polymorphisms also structural variants (CNVs, copy number variants) do have a highest impact in a subsample of patients. These CNVs are mainly microdeletions (1q21.1; 2p16.3; 3q29; 15q11.2; 15q13.3; 16p11.2; 17p12; 17q12, 22q11.21) as well as microduplications (1q21.1; 7q11.23; 7q36.3; 15q11-13; 16p11.2; 16p13.11).brA large, new body of evidence on genetics of schizophrenia is expected through next generation sequencing techniques. In the future, these findings could help to improve diagnostics and early detection and to adapt drug treatment on the genetic profile of patients. p bKurzfassung: /bDie Schizophrenie ist eine schwerwiegende psychiatrische Erkrankung mit einem genetischen Anteil von ca. 64–81 %. In den letzten Jahren wurden neben Kopplungs- und Kandidatengenstudien v.a. relevante genomweite Assoziationsstudien (GWAS), Studien zu strukturellen Variationen (CNVs, Copy Number Variants) und Sequenzierungen (NGS, Next Generation Sequencing) publiziert. Die bislang letzte und weltweit größte genetische Studie zur Schizophrenie zeigte 128 genomweit signifikante Polymorphismen (SNPs, single nucleotide polymorphisms) auf. Die deutlichste Assoziation liegt im MHC-Bereich (major histocompatibility complex). Zusätzlich zu Polymorphismen haben strukturelle Variationen (CNVs, copy number variants) bei einer Teilgruppe der Patienten einen sehr hohen, vermutlich ursächlichen Einfluss. Hierzu zählen v.a. Mikrodeletionen (1q21.1; 2p16.3; 3q29; 15q11.2; 15q13.3; 16p11.2; 17p12; 17q12) als auch Mikroduplikationen (1q21.1; 7q11.23; 7q36.3; 15q11-13; 16p11.2; 16p13.11).brEs ist davon auszugehen, dass die neuen Sequenziertechniken zu einem enormen weiteren Wissenszuwachs hinsichtlich der Pathophysiologie der Schizophrenie führen werden. In Zukunft kann dies zum einen dazu beitragen, die Diagnostik und Früherkennung zu verbessern und zum anderen die medikamentöse Behandlung individuell auf das genetische Profil der Patienten anzupassen.
    MeSH term(s) CNV, Copy Number Variant, Genetik, genomweite Assoziationsstudie, GWAS, Next Generation Sequencing, NGS, Psychiatrie, Schizophrenie, genetics, Genome Wide Association Study, schizophrenia
    Publishing date 20190619
    Document type Article ; Online
    ZDB-ID 2151261-9
    ISSN 1680-9440 ; 1608-1587
    ISSN (online) 1680-9440
    ISSN 1608-1587
    Database Krause and Pachernegg publications database

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  4. Article ; Online: Editorial.

    Rujescu, Dan

    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

    2020  Volume 21, Issue 1, Page(s) 1

    MeSH term(s) Biomedical Research ; Humans ; Schizophrenia
    Language English
    Publishing date 2020-04-07
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2051402-5
    ISSN 1814-1412 ; 1562-2975
    ISSN (online) 1814-1412
    ISSN 1562-2975
    DOI 10.1080/15622975.2020.1746103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Editorial.

    Rujescu, Dan

    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

    2020  Volume 21, Issue 5, Page(s) 325

    Language English
    Publishing date 2020-07-07
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2051402-5
    ISSN 1814-1412 ; 1562-2975
    ISSN (online) 1814-1412
    ISSN 1562-2975
    DOI 10.1080/15622975.2020.1786968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Editorial.

    Rujescu, Dan

    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

    2020  Volume 21, Issue 3, Page(s) 155

    Language English
    Publishing date 2020-05-18
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2051402-5
    ISSN 1814-1412 ; 1562-2975
    ISSN (online) 1814-1412
    ISSN 1562-2975
    DOI 10.1080/15622975.2020.1754595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Editorial.

    Rujescu, Dan

    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

    2020  Volume 20, Issue 9, Page(s) 669

    MeSH term(s) Biological Psychiatry ; Humans ; Mental Disorders/metabolism ; Mental Disorders/therapy
    Language English
    Publishing date 2020-01-24
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2051402-5
    ISSN 1814-1412 ; 1562-2975
    ISSN (online) 1814-1412
    ISSN 1562-2975
    DOI 10.1080/15622975.2019.1722508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Editorial.

    Rujescu, Dan

    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

    2020  Volume 21, Issue 2, Page(s) 79

    Language English
    Publishing date 2020-05-01
    Publishing country England
    Document type Editorial
    ZDB-ID 2051402-5
    ISSN 1814-1412 ; 1562-2975
    ISSN (online) 1814-1412
    ISSN 1562-2975
    DOI 10.1080/15622975.2020.1754579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Editorial.

    Rujescu, Dan

    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

    2020  Volume 20, Issue 10, Page(s) 747

    MeSH term(s) Bipolar Disorder/diagnosis ; Bipolar Disorder/therapy ; Humans
    Language English
    Publishing date 2020-02-10
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2051402-5
    ISSN 1814-1412 ; 1562-2975
    ISSN (online) 1814-1412
    ISSN 1562-2975
    DOI 10.1080/15622975.2019.1722509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Editorial.

    Rujescu, Dan

    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

    2019  Volume 20, Issue 8, Page(s) 585

    MeSH term(s) Bipolar Disorder/physiopathology ; Emotional Regulation ; Heart Rate ; Heroin Dependence/genetics ; Humans ; Mental Disorders/drug therapy ; Paraphilic Disorders/drug therapy ; Sex Offenses ; Tourette Syndrome/psychology ; Weight Lifting/psychology
    Language English
    Publishing date 2019-12-18
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2051402-5
    ISSN 1814-1412 ; 1562-2975
    ISSN (online) 1814-1412
    ISSN 1562-2975
    DOI 10.1080/15622975.2019.1705555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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