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Article ; Online: Salvage transoral robotic surgery in recurrent oropharyngeal carcinoma: a single-center retrospective study.

Ansarin, Mohssen / Pietrobon, Giacomo / Tagliabue, Marta / Mossinelli, Chiara / Ruju, Francesca / Maffini, Fausto / Rocca, Maria Cossu / Alterio, Daniela / Simon, Christian / Zorzi, Stefano Filippo

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2024

Abstract: Purpose: Salvage surgery is still the best therapeutic option for resectable recurrent oropharyngeal squamous cell carcinoma (rOPSCC). Transoral robotic surgery may potentially reduce the morbidity of standard open approaches. The aim of the study is to ...

Abstract	Purpose: Salvage surgery is still the best therapeutic option for resectable recurrent oropharyngeal squamous cell carcinoma (rOPSCC). Transoral robotic surgery may potentially reduce the morbidity of standard open approaches. The aim of the study is to present oncological and functional outcomes of a monocentric experience in salvage transoral robotic surgery. Methods: We performed a single-center retrospective analysis of patients submitted to transoral robotic salvage surgery with or without neck dissection for cT1-3 rOPSCC. We investigated complication rate, survival outcomes (Overall Survival, Disease Specific Survival, Loco-Regional Recurrence Free Survival) and functional outcomes (tracheal tube and/or gastrostomy dependence). Results: Sixty-one patients were included in the analysis. No major complications or perioperative deaths were recorded. The estimated 2-year OS was 76.7%, DSS 81.8% and LRRFS 50.5%. In multivariable analysis rpT, PNI (perineural infiltration) and HPV-positivity were significantly associated with LRRFS (Hazard Ratios: T3 vs T1 6.43, PNI yes vs no 4.19, HPV+ yes vs no 2.63). At last follow up, 97% of patients were tracheal tube-free, while 93% were gastrostomy-free. Conclusion: Transoral robotic salvage surgery is a successful treatment in selected patients affected by rOPSCC because it grants good oncologic and functional outcomes.
Language	English
Publishing date	2024-03-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-024-08590-4
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Article ; Online: Outcomes of mini-invasive transoral surgery without neck dissection in supraglottic laryngeal cancer: Real world data from a tertiary cancer center.

Zorzi, Stefano / Pietrobon, Giacomo / Mossinelli, Chiara / Bandi, Francesco / Chu, Francesco / Tagliabue, Marta / De Berardinis, Rita / Zocchi, Jacopo / Alterio, Daniela / Rocca, Maria Cossu / Ruju, Francesca / Ansarin, Mohssen

American journal of otolaryngology

2023 Volume 45, Issue 1, Page(s) 104113

Abstract: Purpose: The neck management in early-stage cN0 supraglottic cancer represents an argument of debate. The aim of our study is to evaluate the oncological and functional outcomes in patients with early-stage cN0 supraglottic carcinoma treated with a wait- ...

Abstract	Purpose: The neck management in early-stage cN0 supraglottic cancer represents an argument of debate. The aim of our study is to evaluate the oncological and functional outcomes in patients with early-stage cN0 supraglottic carcinoma treated with a wait-and-see policy for the neck. Materials and methods: Retrospective monocentric cohort study in a referral cancer care center. We collected a consecutive sample of patients from 2000 to 2020 with Squamous Cell Carcinoma of the supraglottis without clinical evidence of nodal metastases (cN0), surgically treated with Transoral Surgery (Laser or Robotic) without neck dissection. From 316 supraglottic cancer we finally selected 66 eligible participants that met all inclusion criteria. Results: Sixty-six patients (M 75.8 % vs F 24.2 %), median age 65.8 years (IQR 60.9, 70.5). The most common subsite was the epiglottis (62.1 %). Tumor stage distribution was as follows: 35 % cT1, 53 % cT2, 15.2 % cT3. Neither deaths nor major treatment-related complications were reported after surgery. The median follow-up was 62 months. For oncological outcomes, we evaluated 56 patients (10 excluded for adjuvant radiotherapy): 5-year overall survival rate 87 % (CI 95 %: 73.1-94), disease- specific survival rate 95.3 % (CI 95 %: 82-98.8) and neck recurrence-free survival rate 87 % (CI 95 %: 73.1-94). Six patients developed neck recurrence, with a median time of 13 months. Conclusions: Supraglottic carcinoma has been historically associated to a considerable risk of occult metastasis. However, in early-stage cases data are still inconclusive. Our results suggest that in such patients a wait-and-see policy does not impact negatively on survival outcomes, while granting the reduced morbidity associated to a minimally invasive surgical approach.
MeSH term(s)	Humans ; Aged ; Laryngeal Neoplasms/pathology ; Neck Dissection/methods ; Retrospective Studies ; Cohort Studies ; Neoplasm Staging ; Carcinoma, Squamous Cell/pathology
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2023.104113
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Article ; Online: Upfront transoral robotic surgery (TORS)

Zorzi, Stefano Filippo / Agostini, Giovanni / Chu, Francesco / Tagliabue, Marta / Pietrobon, Giacomo / Corrao, Giulia / Volpe, Stefania / Marvaso, Giulia / Colombo, Francesca / Cossu Rocca, Maria / Gandini, Sara / Gaeta, Aurora / Ruju, Francesca / Alterio, Daniela / Ansarin, Mohssen

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2022 Volume 42, Issue 4, Page(s) 334–347

Abstract: Objective: This study aims to provide real-world data on oncologic and functional outcomes of the most modern surgical and non-surgical treatments of locally advanced HPV-positive oropharyngeal cancer.: Methods: We reviewed data on patients treated ... ...

Abstract	Objective: This study aims to provide real-world data on oncologic and functional outcomes of the most modern surgical and non-surgical treatments of locally advanced HPV-positive oropharyngeal cancer. Methods: We reviewed data on patients treated for stage III and IV HPV-positive oropharyngeal squamous cell carcinoma with either endoscopic surgery (Transoral Robotic Surgery, TORS; Transoral Laser Microsurgery, TLM - group A) or intensity-modulated radiotherapy (IMRT - group B). The minimum follow-up required was 6 months. Survival outcomes and toxicities of treatments were evaluated. Results: 30 patients in group A and 66 in group B were eligible for the analysis. 28% of patients in group A underwent a unimodal treatment, while 42% needed trimodal treatment. 90% of patients in group B underwent concurrent chemoradiation. We found no statistically significant difference in survival outcomes (group A: overall survival 97%, progression-free survival 83%; group B: OS 98%, PFS 86%) or toxicities between groups. Conclusions: Both transoral surgery and IMRT provide excellent outcomes in HPV-positive oropharyngeal cancer. Because of the good prognosis, treatments need to be refined to reduce toxicities while preserving oncologic soundness.
MeSH term(s)	Carcinoma, Squamous Cell/radiotherapy ; Carcinoma, Squamous Cell/surgery ; Head and Neck Neoplasms ; Humans ; Oropharyngeal Neoplasms/pathology ; Oropharyngeal Neoplasms/radiotherapy ; Oropharyngeal Neoplasms/surgery ; Papillomavirus Infections/complications ; Radiotherapy, Intensity-Modulated ; Retrospective Studies ; Robotic Surgical Procedures
Language	English
Publishing date	2022-08-08
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
DOI	10.14639/0392-100X-N2144
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Article: A cancer-mimicking diagnosis of peritoneal carcinosis: report of a case of abdominal non-tuberculous mycobacterial infection.

De Piano, Francesca / Savoldi, Filippo / Ruju, Francesca / Ghioni, Mariacristina / Zanagnolo, Vanna / Rizzo, Stefania

Ecancermedicalscience

2018 Volume 12, Page(s) 860

Abstract: Abdominal non-tuberculous mycobacterial infection is a rare condition in healthy patients. When it occurs, it leads to the appearance of typical findings of peritoneal involvement, such as thickening of the peritoneal leaflets and the omentum, ascites ... ...

Abstract	Abdominal non-tuberculous mycobacterial infection is a rare condition in healthy patients. When it occurs, it leads to the appearance of typical findings of peritoneal involvement, such as thickening of the peritoneal leaflets and the omentum, ascites and enlargement of lymph nodes and of mesenteric nodules. These findings may be misdiagnosed as tumour peritoneal implants. In case of spontaneous regression of the peritoneal involvement and ascites, as well as in the absence of malignancy, the suspicion of infectious disease, including abdominal nontuberculous mycobacterial infection, should be considered.
Language	English
Publishing date	2018-08-21
Publishing country	England
Document type	Case Reports
ISSN	1754-6605
ISSN	1754-6605
DOI	10.3332/ecancer.2018.860
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Article ; Online: The role of radiomics in tongue cancer: A new tool for prognosis prediction.

Head & neck

2023 Volume 45, Issue 4, Page(s) 849–861

Abstract: Background: Radiomics represents an emerging field of precision-medicine. Its application in head and neck is still at the beginning.: Methods: Retrospective study about magnetic resonance imaging (MRI) based radiomics in oral tongue squamous cell ... ...

Abstract	Background: Radiomics represents an emerging field of precision-medicine. Its application in head and neck is still at the beginning. Methods: Retrospective study about magnetic resonance imaging (MRI) based radiomics in oral tongue squamous cell carcinoma (OTSCC) surgically treated (2010-2019; 79 patients). All preoperative MRIs include different sequences (T1, T2, DWI, ADC). Tumor volume was manually segmented and exported to radiomic-software, to perform feature extraction. Statistically significant variables were included in multivariable analysis and related to survival endpoints. Predictive models were elaborated (clinical, radiomic, clinical-radiomic models) and compared using C-index. Results: In almost all clinical-radiomic models radiomic-score maintained statistical significance. In all cases C-index was higher in clinical-radiomic models than in clinical ones. ADC provided the best fit to the models (C-index 0.98, 0.86, 0.84 in loco-regional recurrence, cause-specific mortality, overall survival, respectively). Conclusion: MRI-based radiomics in OTSCC represents a promising noninvasive method of precision medicine, improving prognosis prediction before surgery.
MeSH term(s)	Humans ; Retrospective Studies ; Tongue Neoplasms/diagnostic imaging ; Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/therapy ; Prognosis ; Magnetic Resonance Imaging/methods ; Squamous Cell Carcinoma of Head and Neck ; Head and Neck Neoplasms
Language	English
Publishing date	2023-02-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27299
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Zs.A 1493: Show issues

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Article ; Online: The added value of whole-body magnetic resonance imaging in the management of patients with advanced breast cancer.

Zugni, Fabio / Ruju, Francesca / Pricolo, Paola / Alessi, Sarah / Iorfida, Monica / Colleoni, Marco Angelo / Bellomi, Massimo / Petralia, Giuseppe

PloS one

2018 Volume 13, Issue 10, Page(s) e0205251

Abstract: This study investigates the impact of whole-body MRI (WB-MRI) in addition to CT of chest-abdomen-pelvis (CT-CAP) and 18F-FDG PET/CT (PET/CT) on systemic treatment decisions in standard clinical practice for patients with advanced breast cancer (ABC). WB- ... ...

Abstract	This study investigates the impact of whole-body MRI (WB-MRI) in addition to CT of chest-abdomen-pelvis (CT-CAP) and 18F-FDG PET/CT (PET/CT) on systemic treatment decisions in standard clinical practice for patients with advanced breast cancer (ABC). WB-MRI examinations in ABC patients were extracted from our WB-MRI registry (2009-2017). Patients under systemic treatment who underwent WB-MRI and a control examination (CT-CAP or PET/CT) were included. Data regarding progressive disease (PD) reported either on WB-MRI or on the control examinations were collected. Data regarding eventual change in treatment after the imaging evaluation were collected. It was finally evaluated whether the detection of PD by any of the two modalities had induced a change in treatment. Among 910 WB-MRI examinations in ABC patients, 58 had a paired control examination (16 CT-CAP and 42 PET/CT) and were analysed. In 23/58 paired examinations, additional sites of disease were reported only on WB-MRI and not on the control examination. In 17/28 paired examinations, PD was reported only on WB-MRI and not on the control examination. In 14 out of the 28 pairs of examinations that were followed by a change in treatment, PD had been reported only on WBMRI (14/28; 50%), while stable disease had been reported on the control examination. In conclusion, WB-MRI disclosed PD earlier than the control examination (CT-CAP or PET/CT), and it was responsible alone for 50% of all changes in treatment.
MeSH term(s)	Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/prevention & control ; Bone Neoplasms/secondary ; Breast/diagnostic imaging ; Breast/pathology ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Disease Progression ; Feasibility Studies ; Female ; Fluorodeoxyglucose F18/administration & dosage ; Humans ; Magnetic Resonance Imaging/methods ; Middle Aged ; Patient Selection ; Positron Emission Tomography Computed Tomography/methods ; Radiopharmaceuticals/administration & dosage ; Retrospective Studies ; Sensitivity and Specificity ; Treatment Outcome ; Whole Body Imaging/methods
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2018-10-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0205251
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Article ; Online: The T-N tract involvement as a new prognostic factor for PORT in locally advanced oral cavity tumors.

Oral diseases

2021

Abstract: Objective: The space comprised between tumor and neck lymph nodes (T-N tract) is one of the main routes of tumor spread in oral cavity tumors. Aim of the study was to investigate the impact of T-N tract involvement on the postoperative radiotherapy ( ... ...

Abstract	Objective: The space comprised between tumor and neck lymph nodes (T-N tract) is one of the main routes of tumor spread in oral cavity tumors. Aim of the study was to investigate the impact of T-N tract involvement on the postoperative radiotherapy (PORT) outcomes. Materials and methods: Patients (pts) treated between 2000 and 2016 with indication to PORT were retrospectively retrieved. Inclusion criteria were: (a) locally advanced tumors of the oral cavity, (b) who received with indication to PORT (c) with a minimum follow-up of six months. Results: One hundred and fifty-seven pts met the inclusion criteria (136 pts treated with PORT and 21 pts not treated with PORT). In the PORT cohort, the T-N tract involvement had no impact on both OS (p = .09) and LRFS (p = .2). Among the non-PORT cohort, both OS (p = .007) and LRFS (p = .017) were worse for pts with positive T-N tract compared to those with negative T-N tract. PORT improved both OS (p = .008) and LRFS (p = .003) in pts with positive T-N tract but not in those with negative T-N tract (p = .36 and p = .37, respectively). Conclusions: Our results suggest that involvement of T-N tract should be considered as prognostic factors informing the indication to PORT.
Language	English
Publishing date	2021-04-24
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/odi.13885
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Article ; Online: Endometrial cancer: an overview of novelties in treatment and related imaging keypoints for local staging.

Rizzo, Stefania / Femia, Marco / Buscarino, Valentina / Franchi, Dorella / Garbi, Annalisa / Zanagnolo, Vanna / Del Grande, Maria / Manganaro, Lucia / Alessi, Sarah / Giannitto, Caterina / Ruju, Francesca / Bellomi, Massimo

Cancer imaging : the official publication of the International Cancer Imaging Society

2018 Volume 18, Issue 1, Page(s) 45

Abstract: Endometrial cancer is the most common gynaecologic malignancy in developed countries and its incidence is increasing. First-level treatment, if no contraindicated, is based on surgery. Pre-operative imaging is needed for evaluation of local extent and ... ...

Abstract	Endometrial cancer is the most common gynaecologic malignancy in developed countries and its incidence is increasing. First-level treatment, if no contraindicated, is based on surgery. Pre-operative imaging is needed for evaluation of local extent and detection of distant metastases in order to guide treatment planning. Radiological evaluation, based on transvaginal ultrasound, MR and CT, can make the difference in disease management, paying special attention to assessment of entity of myometrial invasion, cervical stromal extension, and assessment of lymph nodal involvement and distant metastases.
MeSH term(s)	Aged ; Endometrial Neoplasms/diagnostic imaging ; Endometrial Neoplasms/pathology ; Endometrial Neoplasms/therapy ; Female ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Tomography, X-Ray Computed ; Ultrasonography
Language	English
Publishing date	2018-12-04
Publishing country	England
Document type	Journal Article ; Review
ISSN	1470-7330
ISSN (online)	1470-7330
DOI	10.1186/s40644-018-0180-6
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Article ; Online: Combining standardized uptake value of FDG-PET and apparent diffusion coefficient of DW-MRI improves risk stratification in head and neck squamous cell carcinoma.

Preda, Lorenzo / Conte, Giorgio / Bonello, Luke / Giannitto, Caterina / Travaini, Laura L / Raimondi, Sara / Summers, Paul E / Mohssen, Ansarin / Alterio, Daniela / Cossu Rocca, Maria / Grana, Chiara / Ruju, Francesca / Bellomi, Massimo

European radiology

2016 Volume 26, Issue 12, Page(s) 4432–4441

Abstract: Objectives: To assess the independent prognostic value of standardized uptake value (SUV) and apparent diffusion coefficient (ADC), separately and combined, in order to evaluate if the combination of these two variables allows further prognostic ... ...

Abstract	Objectives: To assess the independent prognostic value of standardized uptake value (SUV) and apparent diffusion coefficient (ADC), separately and combined, in order to evaluate if the combination of these two variables allows further prognostic stratification of patients with head and neck squamous cell carcinomas (HNSCC). Methods: Pretreatment SUV and ADC were calculated in 57 patients with HNSCC. Mean follow-up was 21.3 months. Semiquantitative analysis of primary tumours was performed using SUV Results: Patients with SUV Conclusions: The combination of SUV Key points: • High SUV
MeSH term(s)	Adult ; Aged ; Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/metabolism ; Diffusion Magnetic Resonance Imaging ; Disease-Free Survival ; Female ; Fluorodeoxyglucose F18/pharmacokinetics ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/metabolism ; Humans ; Male ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Prognosis ; Proportional Hazards Models ; Radiopharmaceuticals/pharmacokinetics ; Retrospective Studies ; Risk ; Risk Assessment ; Squamous Cell Carcinoma of Head and Neck
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2016-03-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-016-4284-8
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Article: Growth hormone therapy in children with Prader-Willi syndrome.

Franzese, Adriana / Romano, Alfonso / Spagnuolo, Maria Immacolata / Ruju, Francesca / Valerio, Giuliana

The Journal of pediatrics

2006 Volume 148, Issue 6, Page(s) 846; author reply 846–7

MeSH term(s)	Child ; Child, Preschool ; Human Growth Hormone/pharmacology ; Human Growth Hormone/therapeutic use ; Humans ; Male ; Motor Activity/drug effects ; Prader-Willi Syndrome/drug therapy
Chemical Substances	Human Growth Hormone (12629-01-5)
Language	English
Publishing date	2006-06
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2005.10.022
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