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  1. Book ; Thesis: 15 Jahre Descensuschirurgie an der Universitätsfrauenklinik Jena

    Jonekeit, Anja / Runnebaum, Ingo B. / Grimm, Marc-Oliver / Gabriel, Boris

    Operationstechniken in der Diskussion um die Organentfernung im kleinen Becken ; [kumulative Dissertation]

    2021  

    Title variant Fünfzehn
    Institution Friedrich-Schiller-Universität Jena
    Author's details von Anja Jonekeit
    Keywords Universitätsklinikum Jena ; Descensus vaginae ; Uterusprolaps ; Operationstechnik ; Geschichte 2001-2015
    Subject Operative Technik ; Chirurgisches Verfahren ; Operationsverfahren ; Gebärmuttervorfall ; Descensus uteri ; Gebärmuttersenkung ; Prolaps uteri ; Beckenbodensenkung ; Scheidensenkung ; Descensus vaginalis
    Language German
    Size IV91 Seiten, Illustrationen, Diagramme, 29,5 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2021
    Note Kumulative Dissertation, enthält Zeitschriftenaufsätze. - Tag der Verteidigung: 04.05.2021
    HBZ-ID HT021003388
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2021 E 855 order for loan Magazin

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  2. Article ; Online: Primary prevention of ovarian cancer by salpingectomy: that's one small step for a surgeon, one giant leap for patients.

    Runnebaum, Ingo B / Kather, Angela

    Journal of cancer research and clinical oncology

    2023  Volume 149, Issue 10, Page(s) 6799–6801

    MeSH term(s) Humans ; Female ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/prevention & control ; Ovarian Neoplasms/surgery ; Salpingectomy ; Primary Prevention ; Surgeons
    Language English
    Publishing date 2023-03-29
    Publishing country Germany
    Document type Editorial
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-023-04697-z
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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Correction: Cost-effectiveness of talazoparib for patients with locally advanced or metastasized breast cancer in Germany.

    Schwarz, Florian / Arefian, Habibollah / Hartmann, Michael / Runnebaum, Ingo

    PloS one

    2024  Volume 19, Issue 5, Page(s) e0303776

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0278460.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0278460.].
    Language English
    Publishing date 2024-05-09
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0303776
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  4. Article ; Online: Opportunistic Salpingectomy for the Primary Prevention of Ovarian Cancer.

    Runnebaum, Ingo B / Kather, Angela / Sehouli, Jalid

    Deutsches Arzteblatt international

    2023  Volume 119, Issue 49, Page(s) 846–847

    MeSH term(s) Female ; Humans ; Ovarian Neoplasms/prevention & control ; Ovarian Neoplasms/surgery ; Hysterectomy ; Salpingectomy ; Primary Prevention
    Language English
    Publishing date 2023-02-13
    Publishing country Germany
    Document type Letter
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2022.0232
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  5. Article ; Online: Synthesis, Characterization and Biological Investigation of the Platinum(IV) Tolfenamato Prodrug-Resolving Cisplatin-Resistance in Ovarian Carcinoma Cell Lines.

    Barth, Marie-Christin / Häfner, Norman / Runnebaum, Ingo B / Weigand, Wolfgang

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: The research on the anticancer potential of platinum(IV) complexes represents one strategy to circumvent the deficits of approved platinum(II) drugs. Regarding the role of inflammation during carcinogenesis, the effects of non-steroidal anti-inflammatory ...

    Abstract The research on the anticancer potential of platinum(IV) complexes represents one strategy to circumvent the deficits of approved platinum(II) drugs. Regarding the role of inflammation during carcinogenesis, the effects of non-steroidal anti-inflammatory drug (NSAID) ligands on the cytotoxicity of platinum(IV) complexes is of special interest. The synthesis of cisplatin- and oxaliplatin-based platinum(IV) complexes with four different NSAID ligands is presented in this work. Nine platinum(IV) complexes were synthesized and characterized by use of nuclear magnetic resonance (NMR) spectroscopy (
    MeSH term(s) Female ; Humans ; Cisplatin/pharmacology ; Cisplatin/chemistry ; Platinum/pharmacology ; Platinum/chemistry ; Prodrugs/pharmacology ; Prodrugs/chemistry ; Cell Line, Tumor ; Antineoplastic Agents/chemistry ; Ovarian Neoplasms/drug therapy ; Carcinoma, Ovarian Epithelial ; Carcinoma
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Platinum (49DFR088MY) ; Prodrugs ; Antineoplastic Agents
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065718
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  6. Article ; Online: Cost-effectiveness of talazoparib for patients with locally advanced or metastasized breast cancer in Germany.

    Schwarz, Florian / Arefian, Habibollah / Hartmann, Michael / Runnebaum, Ingo

    PloS one

    2022  Volume 17, Issue 12, Page(s) e0278460

    Abstract: This study evaluated factors that influence the cost-effectiveness of talazoparib, particularly for patients with a germline breast-cancer-gene-(brca)-mutation and locally advanced or metastasized breast cancer within the context of the German healthcare ...

    Abstract This study evaluated factors that influence the cost-effectiveness of talazoparib, particularly for patients with a germline breast-cancer-gene-(brca)-mutation and locally advanced or metastasized breast cancer within the context of the German healthcare system. We constructed a partitioned survival model to compare medical costs and treatment effectiveness for patients with such cancers over 45 months. Transition probabilities were derived from survival data from a randomized Phase-III EMBRACA trial, utilities based on published reports, and costs in Euros, which included costs for drug acquisition, clinical monitoring, and treatment of adverse events. Willingness-to-pay thresholds were set to be multiples of the current German per capita gross domestic product. Treatment with talazoparib led to a gain of 0.32 life-years (0.22 quality-adjusted life-years). The mean total cost of €84,003 for talazoparib and €12,741 for standard therapy resulted in an incremental cost-effectiveness ratio of €223,246 per life-year and €323,932 per quality-adjusted life-year gained, indicating that talazoparib is unlikely to be cost-effective at current pricing.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Cost-Benefit Analysis ; Breast ; Neoplasms, Second Primary ; Germany
    Chemical Substances talazoparib (9QHX048FRV)
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0278460
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  7. Article: Robotic-assisted Gynecological Surgery in Older Patients - a Comparative Cohort Study of Perioperative Outcomes.

    Mothes, Anke R / Kather, Angela / Cepraga, Irina / Esber, Anke / Kwetkat, Anja / Runnebaum, Ingo B

    Geburtshilfe und Frauenheilkunde

    2023  Volume 83, Issue 4, Page(s) 437–445

    Abstract: ... Study ... ...

    Abstract Study design
    Language English
    Publishing date 2023-04-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80111-2
    ISSN 1438-8804 ; 0016-5751 ; 1615-3359
    ISSN (online) 1438-8804
    ISSN 0016-5751 ; 1615-3359
    DOI 10.1055/a-1902-4577
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    In stock of ZB MED Cologne/Königswinter

    Um I Zs.190: Show issues Location:
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    Zs.MO 655: Show issues

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  8. Article ; Online: Native-tissue pelvic organ prolapse (POP) repair with perineorrhaphy for level III support results in reduced genital hiatus size and improved quality of life in sexually active and inactive patients.

    Mothes, Anke R / Raguse, Isabel / Kather, Angela / Runnebaum, Ingo B

    European journal of obstetrics, gynecology, and reproductive biology

    2022  Volume 280, Page(s) 144–149

    Abstract: Introduction and hypothesis: Recent findings address the importance of Level III defects with increased genital hiatus being associated with pelvic organ prolapse (POP), correlated with Level I defects and strongly related to POP recurrence. We ... ...

    Abstract Introduction and hypothesis: Recent findings address the importance of Level III defects with increased genital hiatus being associated with pelvic organ prolapse (POP), correlated with Level I defects and strongly related to POP recurrence. We hypothesised that concomitant perineorrhaphy in POP repair reduces genital hiatus (gh) and increases perineal body (pb), that gh would be larger with number of vaginal deliveries and that patients' QOL was not different comparing sexually active vs inactive patients with overall judgement of cure comparable to the literature at evaluation.
    Methods: Retrospective observational study including consecutive patients with indications for posterior repair and Level III support between 2016 and 2018. Concomitant perineorrhaphy was indicated due to complaints of wide introitus or genital hiatus of ≥ 3.5 cm. Primary objective was to compare pre- and postoperative gh and pb according to POP-Q. Secondary objectives were preoperative gh and pb values by parity, POMs obtained with P-QOL/D comparing sexually active vs inactive patients, and subjective judgement of cure according to EGGS system.
    Results: In n = 121 patients, mean gh value was reduced postoperatively by 29.5 % (31 ± 6 vs 44 ± 10 mm, p < 0.001), mean pb value increased by 25.5 % (47 ± 8 vs 35 ± 8 mm, p < 0.001). Influence of parity on preoperative gh (p = 0.020), but not pb values (p = 0.119) was observed. All P-QOL/D domain scores improved significantly postoperatively without differences seen in sexually active vs inactive patients. EGGS responses indicated partial/full goal achievement in 90 % and cure in 87 %.
    Conclusions: In the study cohort, perineorrhaphy as concomitant in POP repair led to Level III support reflected by decreased genital hiatus size. Functional QOL was improved regardless of sexual activity status and the majority of patients reported partial or full cure.
    Language English
    Publishing date 2022-11-24
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2022.11.023
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  9. Book ; Thesis: Antigene der Spermatozoonoberfläche

    Runnebaum, Ingo B.

    Nachweis von Concanavalin-A-Rezeptoren durch monoklonale und polyklonale Antikörper

    1990  

    Author's details vorgelegt von Ingo Bernhard Runnebaum
    Size XII, 162 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 1990
    HBZ-ID HT003672956
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    91 D 23 order for loan Magazin

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  10. Conference proceedings: Umgekehrte Korrelation zwischen Urethralänge und Kontinenz nach vaginaler Eigengewebsrekonstruktion im anterioren Kompartiment

    Mothes, Anke R. / Kather, Angela / Runnebaum, Ingo B.

    2022  , Page(s) 36

    Event/congress 33. Kongress der Deutschen Kontinenz Gesellschaft; Frankfurt am Main; Deutsche Kontinenz Gesellschaft e.V.; 2022
    Keywords Medizin, Gesundheit
    Publishing date 2022-11-09
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22dkg36
    Database German Medical Science

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