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  1. Article: Fish - a source of dietary exposure to iodine and other chemicals.

    Řehůřková, Irena / Šmoldas, Jan / Dofková, Marcela / Ruprich, Jiří

    Casopis lekaru ceskych

    2021  Volume 160, Issue 6, Page(s) 242–248

    Abstract: Fish, fish products and seafood are an important part of a healthy diet. They make an important contribution as a dietary source of iodine, but also of other substances that have a positive effect on the human body. On the other hand, they contain ... ...

    Title translation Ryby - zdroj jodu, ale i dalších chemických látek.
    Abstract Fish, fish products and seafood are an important part of a healthy diet. They make an important contribution as a dietary source of iodine, but also of other substances that have a positive effect on the human body. On the other hand, they contain contaminants (especially mercury/methylmercury) whose toxic properties affect food safety. Based on the results of dietary exposure monitoring and specialised studies by the National Institute of Health - Centre for Health, Nutrition and Food and international activities it can be concluded that there are clear benefits in terms of human health from the consumption of fishery products. Women and children should take care to include these products in their diets. The mercury/methylmercury content of common products in the Czech Republic is under control and the concentration levels are practically below the legislative limits. Care should be taken with fish and fish products where mercury may accumulate. The response of the European Commission, which is currently calling for a review of the maximum permissible limits for mercury/methylmercury in various fish species, is appropriate. This could help to further reduce dietary exposure to mercury in food and encourage fish consumption.
    MeSH term(s) Academies and Institutes ; Animals ; Child ; Diet ; Dietary Exposure ; Female ; Humans ; Iodine ; Nutritional Status
    Chemical Substances Iodine (9679TC07X4)
    Language English
    Publishing date 2021-09-30
    Publishing country Czech Republic
    Document type Journal Article ; Review
    ZDB-ID 413441-2
    ISSN 1805-4420 ; 0008-7335
    ISSN (online) 1805-4420
    ISSN 0008-7335
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  2. Book ; Thesis: Zum spinozellulären Karzinom der Haut

    Rüprich, Jutta

    e. 30-Jahresanalyse d. an d. Universitätshautklinik Halle erfaßten Fälle

    1986  

    Size 210 Bl.
    Publishing country XA-DDDE
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Halle, Univ., Diss. A, 1986 (Nicht f.d. Austausch.)
    HBZ-ID HT003160423
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Monitoring of genetically modified food on the Czech food market and a cross-country comparison

    Kyrova, V / Ostry, V / Surmanova, P / Ruprich, J

    Acta alimentaria. 2018 Mar., v. 47, no. 1

    2018  

    Abstract: The presence of genetically modified organisms (GMOs) was analysed in food samples from the Czech food markets. Four different types of food samples (soya beans, soya bean products, maize flour, and rice) were collected at twelve places in four terms in ... ...

    Abstract The presence of genetically modified organisms (GMOs) was analysed in food samples from the Czech food markets. Four different types of food samples (soya beans, soya bean products, maize flour, and rice) were collected at twelve places in four terms in the years 2008–2013. It represents a total 1152 food samples. Soya and maize were chosen, because these are the major transgenic crops grown worldwide. Increased cultivation of GM rice in China, India, Indonesia, and the Philippines has been observed. Polymerase chain reaction-based methods were applied to detect GMOs. GMOs were detected in 107 samples (9.3%). The results show that in food from the Czech food market GMOs mainly in maize flour and rice were found. GM maize was detected in 63 (21.9%) maize flour samples. Maize lines MON810, NK603, and Bt176 were detected in 14 (22%), 9 (14%), and 1 (1.6%) maize flour samples, respectively. Unauthorised GM rice was detected in 39 (13.5%) rice samples. Unauthorised rice Bt63 was detected in one sample of rice. Roundup Ready soya was detected in 4 (1.4%) soya bean samples and in 1 (0.35%) soya product sample. These results were compared with results of the world ́s studies.
    Keywords Zea mays ; corn ; corn flour ; genetically modified foods ; glyphosate ; markets ; monitoring ; polymerase chain reaction ; rice ; soybeans ; transgenic plants ; China ; India ; Indonesia ; Philippines
    Language English
    Dates of publication 2018-03
    Size p. 10-16.
    Publishing place Akadémiai Kiadó
    Document type Article
    ISSN 1588-2535
    DOI 10.1556/066.2018.47.1.2
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Dietary exposure assessment of sum deoxynivalenol forms, sum T-2/HT-2 toxins and zearalenone from cereal-based foods and beer.

    Ostry, Vladimir / Dofkova, Marcela / Blahova, Jitka / Malir, Frantisek / Kavrik, Radek / Rehurkova, Irena / Ruprich, Jiri

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2020  Volume 139, Page(s) 111280

    Abstract: A dietary exposure assessment to sum of deoxynivalenol (DON) forms, sum of T-2/HT-2 toxins (T2/HT2) and zearalenone (ZEA) was conducted for Czech children 4-6 years and Czech men and women 18-59 years. Retail foods (25 different commodities, n = 336) ... ...

    Abstract A dietary exposure assessment to sum of deoxynivalenol (DON) forms, sum of T-2/HT-2 toxins (T2/HT2) and zearalenone (ZEA) was conducted for Czech children 4-6 years and Czech men and women 18-59 years. Retail foods (25 different commodities, n = 336) were assessed by LC-MS/MS methods. The 95th percentile chronic exposure to sum of DON forms was determined in children from 648 to 1030 ng/kg bw/day (LB/lower bound/and UB/upper bound/), in men from 362 to 923 ng/kg bw/day and in women from 272 to 490 ng/kg bw/day. The 95th percentile chronic exposure to sum T2/HT2 was determined in children from 6.5 to 31 ng/kg bw/day, in men from 1.9 to 11.2 ng/kg bw/day and in women from 2.5 to 11.5 ng/kg bw/day. The 95th percentile chronic exposure to ZEA was determined in children from 11.9 to 24.9 ng/kg bw/day, in men from 5.9 to 27.5 ng/kg bw/day and in women from 4.8 to 12.6 ng/kg bw/day. The risk linked with the mean and the 95th percentile chronic exposure (LB scenario) to the sum of DON forms, sum of T2/HT2 and ZEA is considered to be out of health concern for the selected population groups.
    MeSH term(s) Adolescent ; Adult ; Beer/analysis ; Child ; Child, Preschool ; Dietary Exposure ; Edible Grain/chemistry ; Female ; Food Contamination/analysis ; Humans ; Male ; Middle Aged ; Mycotoxins/analysis ; T-2 Toxin/analogs & derivatives ; T-2 Toxin/toxicity ; Trichothecenes/toxicity ; Young Adult ; Zearalenone/toxicity
    Chemical Substances Mycotoxins ; Trichothecenes ; Zearalenone (5W827M159J) ; T-2 Toxin (I3FL5NM3MO) ; deoxynivalenol (JT37HYP23V) ; HT-2 toxin (NC6C26RM46)
    Language English
    Publishing date 2020-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2020.111280
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  5. Article: The mycotoxin research in foodstuffs in the Czech Republic in the 90th Years.

    Ostry, V / Ruprich, J / Skarkova, J

    Mycotoxin research

    2011  Volume 17 Suppl 2, Page(s) 183–187

    Abstract: Mycotoxins are naturally occurring secondary metabolites produced by several toxigenic microscopic fungi on a variety of crops, especially cereal grains and further foodstuffs. Series of experimental research projects on the determination of mycotoxins ( ... ...

    Abstract Mycotoxins are naturally occurring secondary metabolites produced by several toxigenic microscopic fungi on a variety of crops, especially cereal grains and further foodstuffs. Series of experimental research projects on the determination of mycotoxins (aflatoxins, cyclopiazonic acid, ochratoxin A, patulin, deoxynivalenol, fumonisin B1, T-2 toxin, zearalenone, sterigmatocystin, alternaria toxins) in several foods were realized in the National Reference Centre for Microscopic Fungi and Mycotoxins in the 90(th) years. The aim of our work was an estimation of dietary exposure to mycotoxins and risk assessment. The method of a solid phase extraction (SPE), liquid - liquid extraction and immunoaffinity chromatography (f. e. R-Biopharm, VICAM) were used to elaborate for sample analyses of mycotoxins in our projects. The mycotoxins were detected most frequently by chromatographic methods (HPTLC, HPLC, GC) and immunochemical methods (ELISA). Average dietary exposure has been calculated by multiplying of concentration data for specific foods with their consumption rates per 1 kg of b. w. per day. The estimation of the dietary exposure dose of mycotoxins for the Czech population is presented.
    Language English
    Publishing date 2011-12-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 14500-2
    ISSN 1867-1632 ; 0178-7888
    ISSN (online) 1867-1632
    ISSN 0178-7888
    DOI 10.1007/BF03036432
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  6. Article ; Online: A case study of neurodevelopmental risks from combined exposures to lead, methyl-mercury, inorganic arsenic, polychlorinated biphenyls, polybrominated diphenyl ethers and fluoride.

    Sprong, Corinne / Te Biesebeek, Jan Dirk / Chatterjee, Mousumi / Wolterink, Gerrit / van den Brand, Annick / Blaznik, Urska / Christodoulou, Despo / Crépet, Amélie / Hamborg Jensen, Bodil / Sokolić, Darja / Rauscher-Gabernig, Elke / Ruprich, Jiri / Kortenkamp, Andreas / van Klaveren, Jacob

    International journal of hygiene and environmental health

    2023  Volume 251, Page(s) 114167

    Abstract: We performed a mixture risk assessment (MRA) case study of dietary exposure to the food contaminants lead, methylmercury, inorganic arsenic (iAs), fluoride, non-dioxin-like polychlorinated biphenyls (NDL-PCBs) and polybrominated diphenyl ethers (PBDEs), ... ...

    Abstract We performed a mixture risk assessment (MRA) case study of dietary exposure to the food contaminants lead, methylmercury, inorganic arsenic (iAs), fluoride, non-dioxin-like polychlorinated biphenyls (NDL-PCBs) and polybrominated diphenyl ethers (PBDEs), all substances associated with declines in cognitive abilities measured as IQ loss. Most of these chemicals are frequently measured in human biomonitoring studies. A component-based, personalised modified reference point index (mRPI) approach, in which we expressed the exposures and potencies of our chosen substances as lead equivalent values, was applied to perform a MRA for dietary exposures. We conducted the assessment for four different age groups (toddlers, children, adolescents, and women aged 18-45 years) in nine European countries. Populations in all countries considered exceeded combined tolerable levels at median exposure levels. NDL-PCBs in fish, other seafood and dairy, lead in grains and fruits, methylmercury in fish and other seafoods, and fluoride in water contributed most to the combined exposure. We identified uncertainties for the likelihood of co-exposure, assessment group membership, endpoint-specific reference values (ESRVs) based on epidemiological (lead, methylmercury, iAs, fluoride and NDL-PCBs) and animal data (PBDE), and exposure data. Those uncertainties lead to a complex pattern of under- and overestimations, which would require probabilistic modelling based on expert knowledge elicitation for integration of the identified uncertainties into an overall uncertainty estimate. In addition, the identified uncertainties could be used to refine future MRA for cognitive decline.
    MeSH term(s) Animals ; Adolescent ; Humans ; Female ; Polychlorinated Biphenyls ; Halogenated Diphenyl Ethers ; Fluorides ; Arsenic ; Methylmercury Compounds ; Lead ; Polychlorinated Dibenzodioxins ; Dioxins ; Mercury ; Polybrominated Biphenyls
    Chemical Substances Polychlorinated Biphenyls (DFC2HB4I0K) ; Halogenated Diphenyl Ethers ; Fluorides (Q80VPU408O) ; Arsenic (N712M78A8G) ; Methylmercury Compounds ; Lead (2P299V784P) ; Polychlorinated Dibenzodioxins ; Dioxins ; Mercury (FXS1BY2PGL) ; Polybrominated Biphenyls
    Language English
    Publishing date 2023-05-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2009176-X
    ISSN 1618-131X ; 1438-4639
    ISSN (online) 1618-131X
    ISSN 1438-4639
    DOI 10.1016/j.ijheh.2023.114167
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  7. Article ; Online: Combined chronic dietary exposure to four nephrotoxic metals exceeds tolerable intake levels in the adult population of 10 European countries.

    Sprong, R Corinne / van den Brand, Annick D / van Donkersgoed, Gerda / Blaznik, Urska / Christodoulou, Despo / Crépet, Amélie / da Graça Dias, Maria / Hamborg Jensen, Bodil / Morretto, Angelo / Rauscher-Gabernig, Elke / Ruprich, Jiri / Sokolić, Darja / van Klaveren, Jacob D / Luijten, Mirjam / Mengelers, Marcel J B

    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

    2023  Volume 40, Issue 12, Page(s) 1568–1588

    Abstract: A mixture risk assessment (MRA) for four metals relevant to chronic kidney disease (CKD) was performed. Dietary exposure to cadmium or lead alone exceeded the respective reference values in the majority of the 10 European countries included in our study. ...

    Abstract A mixture risk assessment (MRA) for four metals relevant to chronic kidney disease (CKD) was performed. Dietary exposure to cadmium or lead alone exceeded the respective reference values in the majority of the 10 European countries included in our study. When the dietary exposure to those metals and inorganic mercury and inorganic arsenic was combined following a classical or personalised modified reference point index (mRPI) approach, not only high exposure (95th percentile) estimates but also the mean exceeded the tolerable intake of the mixture in all countries studied. Cadmium and lead contributed most to the combined exposure, followed by inorganic arsenic and inorganic mercury. The use of conversion factors for inorganic arsenic and inorganic mercury from total arsenic and total mercury concentration data was a source of uncertainty. Other uncertainties were related to the use of different principles to derive reference points. Yet, MRA at the target organ level, as performed in our study, could be used as a way to efficiently prioritise assessment groups for higher-tier MRA. Since the combined exposure to the four metals exceeded the tolerable intake, we recommend a refined MRA based on a common, specific nephrotoxic effect and relative potency factors (RPFs) based on a similar effect size.
    MeSH term(s) Cadmium/analysis ; Arsenic/analysis ; Dietary Exposure ; Mercury/analysis ; Europe
    Chemical Substances Cadmium (00BH33GNGH) ; Arsenic (N712M78A8G) ; Mercury (FXS1BY2PGL)
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2462951-0
    ISSN 1944-0057 ; 1944-0049
    ISSN (online) 1944-0057
    ISSN 1944-0049
    DOI 10.1080/19440049.2023.2272716
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  8. Article: Occurrence ofAlternaria andFusarium mycotoxins in winter wheat from domestic crop in year 2003.

    Ostry, V / Skarkova, J / Nedelnik, J / Ruprich, J / Moravcova, H

    Mycotoxin research

    2012  Volume 21, Issue 1, Page(s) 23–25

    Abstract: The aim of this study was a monitoring of the occurrence ofAlternaria andFusarium mycotoxins in winter wheat from domestic crop in the year 2003. Altenuene was determined in 56 (100%) samples of winter wheat, range 14.5-41 μg/kg, mean 25 μg/kg. ... ...

    Abstract The aim of this study was a monitoring of the occurrence ofAlternaria andFusarium mycotoxins in winter wheat from domestic crop in the year 2003. Altenuene was determined in 56 (100%) samples of winter wheat, range 14.5-41 μg/kg, mean 25 μg/kg. Alternariol was determined in 16 (28.6%) samples of winter wheat, range 6.3-22.1 μg/kg, mean 5.7 μ/kg. DON was determined in 42 (100%) samples of winter wheat, range 250-3500 μg/kg, mean 330 μg/kg. T2-toxin was determined in 42 (100%) samples of winter wheat, range 25-337 μg/kg, mean 99 μg/kg. ZEA was not determined in samples of winter wheat.
    Language English
    Publishing date 2012-11-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 14500-2
    ISSN 1867-1632 ; 0178-7888
    ISSN (online) 1867-1632
    ISSN 0178-7888
    DOI 10.1007/BF02954809
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  9. Article: Occurrence of the toxigenic fungi (producers of aflatoxins and ochratoxin A) in foodstuffs in the Czech Republic 1999-2000.

    Ostry, V / Ruprich, J / Skarkova, J / Prochazkova, I / Kubatova, A

    Mycotoxin research

    2011  Volume 17 Suppl 2, Page(s) 188–192

    Abstract: The occurrence of toxigenic fungi producing aflatoxins and ochratoxin A in foodstuffs was studied in the Czech Republic. Twenty five commodities were collected at twelve collection places in the Czech Republic (300 food samples). The presence of ... ...

    Abstract The occurrence of toxigenic fungi producing aflatoxins and ochratoxin A in foodstuffs was studied in the Czech Republic. Twenty five commodities were collected at twelve collection places in the Czech Republic (300 food samples). The presence of potentially toxigenicAspergillus flavus was observed in 28% of the sampled foods (black pepper, caraway seeds, fruit tea, black tea, oat flakes, fine flour, rolled oat flakes and semolina) in the year 1999, and in 25% of the sampled foods (black pepper, black tea, fine flour) in the year 2000.A tamarii (aflatoxins producer) was found in 3 black pepper samples (25%) in both years. Aflatoxins were detected in black pepper and caraway seed samples in the year 1999 and in sweet red pepper in the year 2000.A parasiticus andA nomius were not isolated. Aspergillus section Nigri (potential producer of ochratoxin A) was detected in some foodstuffs. Ochratoxin A was detected in raisins.Penicillium verrucosum andA ochraceus were not isolated from foodstuffs.
    Language English
    Publishing date 2011-12-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 14500-2
    ISSN 1867-1632 ; 0178-7888
    ISSN (online) 1867-1632
    ISSN 0178-7888
    DOI 10.1007/BF03036433
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  10. Article: The system approach to the identification of aflatoxigenic fungi in foodstuffs and feedstuffs.

    Ostry, V / Ruprich, J / Skarkova, J / Prochazkova, I / Kubatova, A

    Mycotoxin research

    2011  Volume 17 Suppl 2, Page(s) 178–182

    Abstract: Aspergillus flavus, A parasiticus, A nomius, A tamarii andA pseudotamarii are important microorganisms capable of producing aflatoxins and further mycotoxins. Aflatoxigenic Aspergillus species are morphologically similar species belonging to the ... ...

    Abstract Aspergillus flavus, A parasiticus, A nomius, A tamarii andA pseudotamarii are important microorganisms capable of producing aflatoxins and further mycotoxins. Aflatoxigenic Aspergillus species are morphologically similar species belonging to the Aspergillus section Flavi. The aflatoxigenic fungal strains were isolated from foods (cereals, pulses, oilseeds, dried fruit, spices), soil, air and water. Mycological analyses are based on valid standards and recommendations of the International Commission for Food Mycology (ICFM). The identification of isolated aflatoxigenic fungi in foodstuffs and feedstuffs can be proved by using classical mycological cultivation methods, diagnostic nutrient media, chemotaxonomy and molecular biological methods (PCR). The system approach to the identification of aflatoxigenic fungi combines these four methods. Thirty strains of the aflatoxigenic fungi were tested.
    Language English
    Publishing date 2011-12-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 14500-2
    ISSN 1867-1632 ; 0178-7888
    ISSN (online) 1867-1632
    ISSN 0178-7888
    DOI 10.1007/BF03036431
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