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  1. Article: Thrombolytic therapy in bilateral embolism of renal arteries branches.

    Cassini, Marcelo F / Cassini, Patrícia L / Russo, Rodrigo L

    International braz j urol : official journal of the Brazilian Society of Urology

    2005  Volume 29, Issue 2, Page(s) 147–148

    Abstract: Bilateral renal artery embolism is rare, but it is a significant cause of arterial hypertension and renal failure, and most often is associated with cardiac arrhythmias. We report a case of bilateral renal artery embolism with a satisfactory outcome ... ...

    Abstract Bilateral renal artery embolism is rare, but it is a significant cause of arterial hypertension and renal failure, and most often is associated with cardiac arrhythmias. We report a case of bilateral renal artery embolism with a satisfactory outcome following use of thrombolytic therapy. A 42 year-old Caucasian man presented a sudden complaint of intense abdominal pain, in mesogastrium and left flank with dorsal irradiation, 3 days after electrical cardioversion due to cardiac arrhythmia. Laboratory tests revealed slight leukocytosis, hematuria, and creatinine of 1.8 mg/dL. Chest radiography was normal and computerized tomography showed an area of massive ischemia in left kidney, and focal ischemia in right kidney and spleen. The patient was then submitted to systemic venous therapy with 1.5 million units of streptokinase, with an excellent outcome.
    Language English
    Publishing date 2005-02-28
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2206649-4
    ISSN 1677-5538
    ISSN 1677-5538
    DOI 10.1590/s1677-55382003000200009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Thrombolytic therapy in bilateral embolism of renal arteries branches

    Cassini Marcelo F. / Cassini Patrícia L. / Russo Rodrigo L

    International Brazilian Journal of Urology, Vol 29, Iss 2, Pp 147-

    2003  Volume 148

    Abstract: Bilateral renal artery embolism is rare, but it is a significant cause of arterial hypertension and renal failure, and most often is associated with cardiac arrhythmias. We report a case of bilateral renal artery embolism with a satisfactory outcome ... ...

    Abstract Bilateral renal artery embolism is rare, but it is a significant cause of arterial hypertension and renal failure, and most often is associated with cardiac arrhythmias. We report a case of bilateral renal artery embolism with a satisfactory outcome following use of thrombolytic therapy. A 42 year-old Caucasian man presented a sudden complaint of intense abdominal pain, in mesogastrium and left flank with dorsal irradiation, 3 days after electrical cardioversion due to cardiac arrhythmia. Laboratory tests revealed slight leukocytosis, hematuria, and creatinine of 1.8 mg/dL. Chest radiography was normal and computerized tomography showed an area of massive ischemia in left kidney, and focal ischemia in right kidney and spleen. The patient was then submitted to systemic venous therapy with 1.5 million units of streptokinase, with an excellent outcome.
    Keywords kidney ; renal artery ; embolism ; therapeutics ; thrombolytics ; Diseases of the genitourinary system. Urology ; RC870-923 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Urology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 616
    Language English
    Publishing date 2003-01-01T00:00:00Z
    Publisher Sociedade Brasileira de Urologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Prevalence of alpha-1 antitrypsin deficiency and allele frequency in patients with COPD in Brazil.

    Russo, Rodrigo / Zillmer, Laura Russo / Nascimento, Oliver Augusto / Manzano, Beatriz / Ivanaga, Ivan Teruaki / Fritscher, Leandro / Lundgren, Fernando / Miravitlles, Marc / Gondim, Heicilainy Del Carlos / Santos, Gildo / Alves, Marcela Amorim / Oliveira, Maria Vera / Souza, Altay Alves Lino de / Sales, Maria Penha Uchoa / Jardim, José Roberto

    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

    2016  Volume 42, Issue 5, Page(s) 311–316

    Abstract: Objective:: To determine the prevalence of alpha 1-antitrypsin (AAT) deficiency (AATD), as well as allele frequency, in COPD patients in Brazil.: Methods:: This was a cross-sectional study involving 926 COPD patients 40 years of age or older, from ... ...

    Abstract Objective:: To determine the prevalence of alpha 1-antitrypsin (AAT) deficiency (AATD), as well as allele frequency, in COPD patients in Brazil.
    Methods:: This was a cross-sectional study involving 926 COPD patients 40 years of age or older, from five Brazilian states. All patients underwent determination of AAT levels in dried blood spot (DBS) samples by nephelometry. Those with DBS AAT levels ≤ 2.64 mg/dL underwent determination of serum AAT levels. Those with serum AAT levels of < 113 mg/dL underwent genotyping. In case of conflicting results, SERPINA1 gene sequencing was performed.
    Results:: Of the 926 COPD patients studied, 85 had DBS AAT levels ≤ 2.64 mg/dL, and 24 (2.6% of the study sample) had serum AAT levels of < 113 mg/dL. Genotype distribution in this subset of 24 patients was as follows: PI*MS, in 3 (12.5%); PI*MZ, in 13 (54.2%); PI*SZ, in 1 (4.2%); PI*SS, in 1 (4.2%); and PI*ZZ, in 6 (25.0%). In the sample as a whole, the overall prevalence of AATD was 2.8% and the prevalence of the PI*ZZ genotype (severe AATD) was 0.8.
    Conclusions:: The prevalence of AATD in COPD patients in Brazil is similar to that found in most countries and reinforces the recommendation that AAT levels be measured in all COPD patients.
    Objetivo:: Determinar a prevalência da deficiência de alfa 1-antitripsina (AAT), bem como a frequência alélica, em pacientes com DPOC no Brasil.
    Métodos:: Estudo transversal com 926 pacientes com DPOC, com 40 anos ou mais, oriundos de cinco estados brasileiros. Todos os pacientes foram submetidos a dosagem de AAT em amostras de sangue seco por meio de nefelometria. Aqueles em que a concentração de AAT no sangue seco foi ≤ 2,64 mg/dl foram submetidos a dosagem sérica de AAT. Aqueles em que a concentração sérica de AAT foi < 113 mg/dl foram submetidos a genotipagem. Quando os resultados foram discrepantes, foi realizado o sequenciamento do gene SERPINA1. Dos 926 pacientes com DPOC estudados, 85 apresentaram concentração de AAT em sangue seco ≤ 2,64 mg/dl, e 24 (2,6% da amostra) apresentaram concentração sérica de AAT < 113 mg/dl. A distribuição genotípica nesse subgrupo de 24 pacientes foi a seguinte: PI*MS, em 3 (12,5%); PI*MZ, em 13 (54,2%); PI*SZ, em 1 (4,2%); PI*SS, em 1 (4,2%); e PI*ZZ, em 6 (25,0%). Na amostra estudada, a prevalência global da deficiência de AAT foi de 2,8% e a prevalência do genótipo PI*ZZ (deficiência grave de AAT) foi de 0,8%.
    Conclusões:: A prevalência da deficiência de AAT em pacientes com DPOC no Brasil é semelhante àquela encontrada na maioria dos países e reforça a recomendação de que se deve medir a concentração de AAT em todos pacientes com DPOC.
    MeSH term(s) Aged ; Brazil/epidemiology ; Cross-Sectional Studies ; Female ; Gene Frequency/genetics ; Genotype ; Humans ; Male ; Middle Aged ; Prevalence ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/genetics ; Sequence Analysis, DNA ; alpha 1-Antitrypsin/genetics ; alpha 1-Antitrypsin Deficiency/blood ; alpha 1-Antitrypsin Deficiency/diagnosis ; alpha 1-Antitrypsin Deficiency/epidemiology ; alpha 1-Antitrypsin Deficiency/genetics
    Chemical Substances SERPINA1 protein, human ; alpha 1-Antitrypsin
    Language Portuguese
    Publishing date 2016-08-25
    Publishing country Brazil
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2223157-2
    ISSN 1806-3756 ; 1806-3713
    ISSN (online) 1806-3756
    ISSN 1806-3713
    DOI 10.1590/S1806-37562015000000180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Validation and development of an immunonephelometric assay for the determination of alpha-1 antitrypsin levels in dried blood spots from patients with COPD.

    Zillmer, Laura Russo / Russo, Rodrigo / Manzano, Beatriz Martins / Ivanaga, Ivan / Nascimento, Oliver Augusto / Souza, Altay Alves Lino de / Santos, Gildo / Rodriguez, Francisco / Miravitlles, Marc / Jardim, José Roberto

    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

    2013  Volume 39, Issue 5, Page(s) 547–554

    Abstract: Objective: To validate and develop an immunonephelometric assay for the determination of alpha-1 antitrypsin (AAT) levels in dried blood spots from COPD patients in Brazil.: Methods: We determined AAT levels in serum samples and dried blood spots ... ...

    Abstract Objective: To validate and develop an immunonephelometric assay for the determination of alpha-1 antitrypsin (AAT) levels in dried blood spots from COPD patients in Brazil.
    Methods: We determined AAT levels in serum samples and dried blood spots from 192 COPD patients. For the preparation of dried blood spots, a disk (diameter, 6 mm) was placed into a tube, eluted with 200 µL of PBS, and stored overnight at 4ºC. All of the samples were analyzed by immunonephelometry in duplicate. We used the bootstrap resampling method in order to determine a cut-off point for AAT levels in dried blood spots.
    Results: The correlation coefficient between the AAT levels in serum samples and those in dried blood spots was r = 0.45. For dried blood spots, the cut-off value was 2.02 mg/dL (97% CI: 1.45-2.64 mg/dL), with a sensitivity, specificity, positive predictive value, and negative predictive value of 100%, 95.7%, 27.2%, and 100%, respectively.
    Conclusions: This method for the determination of AAT levels in dried blood spots appears to be a reliable screening tool for patients with AAT deficiency.
    MeSH term(s) Aged ; Brazil ; Cross-Sectional Studies ; Dried Blood Spot Testing/methods ; Female ; Humans ; Immunologic Tests/methods ; Male ; Mass Screening ; Middle Aged ; Nephelometry and Turbidimetry/methods ; Outpatients ; Predictive Value of Tests ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Reference Standards ; alpha 1-Antitrypsin/blood ; alpha 1-Antitrypsin Deficiency/diagnosis
    Chemical Substances alpha 1-Antitrypsin
    Language Portuguese
    Publishing date 2013-12-05
    Publishing country Brazil
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 2223157-2
    ISSN 1806-3756 ; 1806-3713
    ISSN (online) 1806-3756
    ISSN 1806-3713
    DOI 10.1590/S1806-37132013000500004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Recommendations for the pharmacological treatment of COPD: questions and answers.

    Fernandes, Frederico Leon Arrabal / Cukier, Alberto / Camelier, Aquiles Assunção / Fritscher, Carlos Cezar / Costa, Cláudia Henrique da / Pereira, Eanes Delgado Barros / Godoy, Irma / Cançado, José Eduardo Delfini / Romaldini, José Gustavo / Chatkin, Jose Miguel / Jardim, José Roberto / Rabahi, Marcelo Fouad / Nucci, Maria Cecília Nieves Maiorano de / Sales, Maria da Penha Uchoa / Castellano, Maria Vera Cruz de Oliveira / Aidé, Miguel Abidon / Teixeira, Paulo José Zimermann / Maciel, Renato / Corrêa, Ricardo de Amorim /
    Stirbulov, Roberto / Athanazio, Rodrigo Abensur / Russo, Rodrigo / Minamoto, Suzana Tanni / Lundgren, Fernando Luiz Cavalcanti

    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

    2018  Volume 43, Issue 4, Page(s) 290–301

    Abstract: The treatment of COPD has become increasingly effective. Measures that range from behavioral changes, reduction in exposure to risk factors, education about the disease and its course, rehabilitation, oxygen therapy, management of comorbidities, and ... ...

    Abstract The treatment of COPD has become increasingly effective. Measures that range from behavioral changes, reduction in exposure to risk factors, education about the disease and its course, rehabilitation, oxygen therapy, management of comorbidities, and surgical and pharmacological treatments to end-of-life care allow health professionals to provide a personalized and effective therapy. The pharmacological treatment of COPD is one of the cornerstones of COPD management, and there have been many advances in this area in recent years. Given the greater availability of drugs and therapeutic combinations, it has become increasingly challenging to know the indications for, limitations of, and potential risks and benefits of each treatment modality. In order to critically evaluate recent evidence and systematize the major questions regarding the pharmacological treatment of COPD, 24 specialists from all over Brazil gathered to develop the present recommendations. A visual guide was developed for the classification and treatment of COPD, both of which were adapted to fit the situation in Brazil. Ten questions were selected on the basis of their relevance in clinical practice. They address the classification, definitions, treatment, and evidence available for each drug or drug combination. Each question was answered by two specialists, and then the answers were consolidated in two phases: review and consensus by all participants. The questions answered are practical questions and help select from among the many options the best treatment for each patient and his/her peculiarities.
    MeSH term(s) Disease Management ; Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Severity of Illness Index ; Surveys and Questionnaires
    Language Portuguese
    Publishing date 2018-01-24
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2223157-2
    ISSN 1806-3756 ; 1806-3713
    ISSN (online) 1806-3756
    ISSN 1806-3713
    DOI 10.1590/S1806-37562017000000153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Association between Helicobacter pylori genotypes and gastric disorders in relation to the cag pathogenicity island.

    Proença Módena, José Luiz / Lopes Sales, Ana Isabela / Olszanski Acrani, Gustavo / Russo, Rodrigo / Vilela Ribeiro, Marcio Aurélio / Fukuhara, Yara / da Silveira, Wanderley Dias / Módena, José Luiz Pimenta / de Oliveira, Ricardo Brandt / Brocchi, Marcelo

    Diagnostic microbiology and infectious disease

    2007  Volume 59, Issue 1, Page(s) 7–16

    Abstract: Helicobacter pylori is a bacterium associated with upper gastrointestinal diseases in humans. However, only a small proportion of infected people become sick. Although several studies have tried to establish an association between known virulence markers ...

    Abstract Helicobacter pylori is a bacterium associated with upper gastrointestinal diseases in humans. However, only a small proportion of infected people become sick. Although several studies have tried to establish an association between known virulence markers and clinical outcomes, in many cases the results have been conflicting. The aim of this study was to investigate the importance of virulence markers to predict clinical outcome in Brazil. Mixed infections by genetically unrelated strains detected by vacA genotyping were found in 18% of the patients. The cagA and cagE genes and the vacAs1 genotype were associated with the development of peptic ulcer disease (PUD). The cagAvacAs1m1 genotype was associated with PUD and duodenal ulcer (DU). Conversely, jhp947 was not associated with DU or PUD, indicating that this gene is not a universal virulence marker. These results also show that a high proportion of the patients were simultaneously infected by cag-positive and cag-negative H. pylori types. This finding suggests the existence of a dynamic equilibrium between the loss and gain of the cag pathogenicity island, probably depending on the physiologic conditions of the patient's stomach. To the best of our knowledge, this is the first study that has documented this finding in Brazil.
    MeSH term(s) Adult ; Antigens, Bacterial/genetics ; Bacterial Proteins/genetics ; Brazil ; Female ; Genomic Islands/genetics ; Genotype ; Helicobacter Infections/genetics ; Helicobacter Infections/pathology ; Helicobacter pylori/genetics ; Helicobacter pylori/pathogenicity ; Hospitals, University ; Humans ; Male ; Middle Aged ; Peptic Ulcer/microbiology ; Peptic Ulcer/pathology ; Virulence ; Virulence Factors/genetics
    Chemical Substances Antigens, Bacterial ; Bacterial Proteins ; PicB protein, Helicobacter pylori ; Virulence Factors ; cagA protein, Helicobacter pylori
    Language English
    Publishing date 2007-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604920-5
    ISSN 0732-8893
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2007.03.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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